Supercritical AntiSolvent micronization of PVA by semi-continuous and batch processing

Journal of Supercritical Fluids

Volumn 42, Issue 2, 2007, Pages 288-298

  Adami, Renata ^a,b   Osséo, Libero Sesti ^b   Huopalahti, Rainer ^a   Reverchon, Ernesto ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Batch; Biopolymer; PVA; Semi continuous; Supercritical AntiSolvent

Indexed keywords

BIOCOMPATIBILITY; MORPHOLOGY; NANOPARTICLES; POLYMER BLENDS; PRESSURIZATION; SUPERCRITICAL FLUID EXTRACTION;

MICRONS; MICROPARTICLES; SEMI-CONTINUOUS (SAS); SUPERCRITICAL ANTISOLVENT TECHNIQUE;

POLYVINYL ALCOHOLS;

EID: 34250199042     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2007.04.002     Document Type: Article

References (39)

1. Reverchon E. Supercritical antisolvent precipitation of micro- and nano-particles. J. Supercrit. Fluids 15 (1999) 1
2. J. Jung, M. Perrut, Particle design using supercritical fluids: literature and patent survey, J. Supercrit. Fluids 20 (2001) 179.
3. Shariati A., and Peters C.J. Recent developments in particle design using supercritical fluids. Curr. Opin. Solid St. M. 7 (2003) 371
4. Yeo S.-D., and Kiran E. Formation of polymer particles with supercritical fluids: a review. J. Supercrit. Fluids 34 (2005) 287
5. Reverchon E., and Adami R. Nanomaterials and supercritical fluids. J. Supercrit. Fluids 37 (2006) 1
6. Werling J.O., and Debenedetti P.G. Numerical modeling of mass transfer in the supercritical antisolvent process. J. Supercrit. Fluids 16 (1999) 167
7. Werling J.O., and Debenedetti P.G. Numerical modeling of mass transfer in the supercritical antisolvent process: miscible conditions. J. Supercrit. Fluids 18 (2000) 11
8. Lengsfeld C.S., Delplanque J.P., Barocas V.H., and Randolph T.W. Mechanism governing microparticle morphology during precipitation by a compressed antisolvent: atomization vs. nucleation and growth. J. Phys. Chem. B 104 (2000) 2725
9. 2 antisolvent techniques. Biotechnol. Bioeng. 73 (2001) 449
10. Perez Y., Wubbolts F.E., Witkamp G.J., Jansens P.J., and de Loos Th.W. Improved PCA process for the production of nano- and microparticles of polymers. AIChE J. 50 (2004) 2408
11. Perez de Diego Y., Pellikaan H.C., Wubbolts F.E., Witkamp G.J., and Jansens P.J. Operating regimes and mechanism of particle formation during the precipitation of polymers using the PCA process. J. Supercrit. Fluids 35 (2005) 147
12. Reverchon E., Caputo G., and De Marco I. Role of phase behavior and atomization in the supercritical antisolvent precipitation. Ind. Eng. Chem. Res. 42 (2003) 6406
13. Reverchon E., and De Marco I. Supercritical antisolvent micronization of cefonicid: thermodynamic interpretation of results. J. Supercrit. Fluids 31 (2004) 207
14. Reverchon E., and De Marco I. Supercritical antisolvent precipitation of cephalosporins. Powder Technol. 164 (2006) 139
15. Palakodaty S., and York P. Phase behavioral effects on particle formation processes using supercritical fluids. Pharm. Res. 16 (1999) 976
16. 2-philic antisolvents. AIChE J. 46 (2000) 1850
17. Dukhin S.S., Shen Y., Dave R., and Pfeffer R. Droplet mass transfer, intradroplet nucleation and submicron particle production in two-phase flow of solvent-supercritical antisolvent emulsion. Colloids Surf. A-Physicochem. Eng. Asp. 261 (2005) 163
18. Fusaro F., Mazzotti M., and Muhrer G. Gas antisolvent recrystallization of paracetamol from acetone using compressed carbon dioxide as antisolvent. Crystal Growth Des. 4 (2004) 881
19. Muhrer G., and Mazzotti M. Precipitation of lysozyme nanoparticles from dimethyl sulfoxide using carbon dioxide as antisolvent. Biotechnol. Progr. 19 (2003) 549
20. Muhrer G., Mazzotti M., and Muller M. Gas antisolvent recrystallization of an organic compound. Tailoring product PSD and scaling-up. J. Supercrit. Fluids 27 (2003) 195
21. Mueller M., Meier U., Kessler A., and Mazzotti M. Experimental study of the effect of process parameters in the recrystallization of an organic compound using compressed carbon dioxide as antisolvent. Ind. Eng. Chem. Res. 39 (2000) 2260
22. Warwick B., Dehghani F., Foster N.R., Biffin J.R., and Regtop H.L. Micronization of copper indomethacin using gas antisolvent processes. Ind. Eng. Chem. Res. 41 (2002) 1993
23. Muhrer G., Meier U., Fusaro F., Albano S., and Mazzotti M. Use of compressed gas precipitation to enhance the dissolution behavior of a poorly water-soluble drug: generation of drug microparticles and drug-polymer solid dispersions. Int. J. Pharm. 308 (2006) 69
24. Randolph T.W., Randolph A.D., Mebes M., and Yeung S. Sub-micrometer-sized biodegradable particles of poly(l-lactic acid) via the gas antisolvent spray precipitation process. Biotechnol. Progr. 9 (1993) 429
25. Mawson S., Kanakia S., and Johnston K.P. Coaxial nozzle for control of particle morphology in precipitation with a compressed fluid antisolvent. J. Appl. Polym. Sci. 64 (1997) 2105
26. Mawson S., Johnston K.P., Betts D.E., McClain J.B., and DeSimone J.M. Stabilized polymer microparticles by precipitation with a compressed fluid antisolvent. 1. Poly(fluoro acrylates). Macromolecules 30 (1997) 71
27. Reverchon E., Della Porta G., De Rosa I., Subra P., and Letourneur D. Supercritical antisolvent micronization of some biopolymers. J. Supercrit. Fluids 18 (2000) 239
28. Reverchon E., Della Porta G., Di Trolio A., and Pace S. Supercritical antisolvent precipitation of nanoparticles of superconductor precursors. Ind. Eng. Chem. Res. 37 (1998) 952
29. Reverchon E., Celano C., Della Porta G., Di Trolio A., and Pace S. Supercritical antisolvent precipitation: a new technique for preparing submicronic yttrium powders to improve YBCO superconductors. J. Mater. Res. 13 (1998) 284
30. Chavez F., Debenedetti P.G., Luo J.J., Dave R.N., and Pfeffer R. Estimation of the characteristic time scales in the supercritical antisolvent process. Ind. Eng. Chem. Res. 42 (2003) 3156
31. Kikic I., Lora M., and Bertucco A. A thermodynamic analysis of three-phase equilibria in binary and ternary systems for applications in rapid expansion of a supercritical solution (RESS), particles from gas-saturated solutions (PGSS), and supercritical antisolvent (SAS). Ind. Eng. Chem. Res. 36 (1997) 5507
32. Laidler K.J., and Meiser J.H. Physical Chemistry (1982), Benjamin/Cummings, Menlo Park, California
33. S. Gentile, Thermodynamic analysis of supercritical antisolvent micronization process using view cells, MSc Thesis, University of Salerno, Salerno, Italy, 2003.
34. Reverchon E., and Cardea S. Formation of cellulose acetate membranes using a supercritical fluid assisted process. J. Membr. Sci. 240 (2004) 187
35. 2. J. Supercrit. Fluids 35 (2005) 140
36. 2 processing: elucidation of formation mechanisms. Ind. Eng. Chem. Res. 45 (2006) 8939
37. Fusaro F., Haenchen M., Mazzotti M., Muhrer G., and Subramaniam B. Dense gas antisolvent precipitation: a comparative investigation of the gas and PCA techniques. Ind. Eng. Chem. Res. 44 (2005) 1502
38. Lin C., Muhrer G., Mazzotti M., and Subramaniam B. Vapor-liquid mass transfer during gas antisolvent recrystallization: modeling and experiments. Ind. Eng. Chem. Res. 42 (2003) 2171
39. Dixon D.J., Johnston K.P., and Bodmeier R.A. Polymeric materials formed by precipitation with a compressed fluid antisolvent. AIChE J. 39 (1993) 127