Zidovudine - Poly(L-lactic acid) solid dispersions with improved intestinal permeability prepared by supercritical antisolvent process

Journal of Pharmaceutical Sciences

Volumn 104, Issue 5, 2015, Pages 1691-1700

  Yoshida, Valquíria M H ^a,b   Balcão, Victor M ^a,c   Vila, Marta M D C ^a   Oliveira, José M ^a   Aranha, Norberto ^a   Chaud, Marco V ^a   Gremião, Maria P D ^b  

^a UNIVERSITY OF SOROCABA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF MINHO   (Portugal)

Author keywords

Everted rat intestinal sacs; Gastrointestinal transit; Oral absorption; Permeability; Poly(L lactic acid); Solid dispersion; Supercritical antisolvent process; Supercritical fluids; Zidovudine

Indexed keywords

DRUG CARRIER; POLYLACTIC ACID; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE POLYLACTIC ACID; LACTIC ACID; SOLVENT;

ANALYTICAL EQUIPMENT; ANIMAL TISSUE; ARTICLE; CALORIMETER; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; INTESTINE MUCOSA PERMEABILITY; MALE; MATHEMATICAL MODEL; NONHUMAN; PRESSURE; RAT; SCANNING ELECTRON MICROSCOPE; SCANNING ELECTRON MICROSCOPY; SOLID DISPERSION; SOLID STATE; SPECTROPHOTOMETER; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL FLUID; TEMPERATURE DEPENDENCE; X RAY DIFFRACTION; X RAY DIFFRACTOMETER; ANIMAL; CHEMISTRY; DRUG EFFECTS; INTESTINE ABSORPTION; PERMEABILITY; PHYSIOLOGY; PROCEDURES; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, SUPERCRITICAL FLUID; INTESTINAL ABSORPTION; LACTIC ACID; MALE; PERMEABILITY; RATS; RATS, WISTAR; SOLVENTS; ZIDOVUDINE;

EID: 84927133306     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24377     Document Type: Article

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