Effect of solvent type on the nanoparticle formation of atorvastatin calcium by the supercritical antisolvent process

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 4, 2012, Pages 543-547

  Kim, Min Soo ^a   Song, Ha Seung ^a   Park, Hee Jun ^a,b   Hwang, Sung Joo ^b  

^a Chungnam National University   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Amorphous; Atorvastatin; Nanoparticle; Supercritical antisolvent

Indexed keywords

1 METHYL 2 PYRROLIDINONE; ACETIC ACID; ACETONE; ATORVASTATIN; DIMETHYL SULFOXIDE; DRUG SOLVENT; NANOPARTICLE; ORGANIC SOLVENT; TETRAHYDROFURAN;

ARTICLE; DRUG SOLUTION; EVAPORATION; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL FLUID; X RAY DIFFRACTION;

ACETONE; CHEMISTRY, PHARMACEUTICAL; DIMETHYL SULFOXIDE; FURANS; HEPTANOIC ACIDS; NANOPARTICLES; PARTICLE SIZE; PYRROLES; PYRROLIDINONES; SOLVENTS;

EID: 84859474061     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.60.543     Document Type: Article

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