Solubilization of the poorly water soluble drug, telmisartan, using supercritical anti-solvent (SAS) process

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 50-55

  Park, Junsung ^a,b   Cho, Wonkyung ^a,b   Cha, Kwang Ho ^a,b   Ahn, Junhyun ^a   Han, Kang ^a   Hwang, Sung Joo ^a  

^a Yonsei University   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Solid dispersion; Solubility; Supercritical anti solvent process; Telmisartan

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; POVIDONE; TELMISARTAN;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DISSOLUTION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; PARTICLE SIZE; PRIORITY JOURNAL; SOLUBILIZATION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BENZOATES; CRYSTALLIZATION; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; METHYLCELLULOSE; NANOPARTICLES; PARTICLE SIZE; POVIDONE; SOLUBILITY; SOLVENTS; TIME FACTORS;

EID: 84871865358     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.12.020     Document Type: Article

References (33)

1. A.M. Abdul-Fattah, and H.N. Bhargava Preparation and in vitro evaluation of solid dispersions of halofantrine Int. J. Pharm. 235 2002 17 33
2. J. Akbuga, A. Gursoy, and E. Kendi The preparation and stability of fast release furosemide-PVP solid dispersion Drug Dev. Ind. Pharm. 14 1988 1439 1464
3. A.H. Al-Marzouqi, I. Shehatta, B. Jobe, and A. Dowaidar Phase solubility and inclusion complex of itraconazole with beta-cyclodextrin using supercritical carbon dioxide J. Pharm. Sci. 95 2006 292 304
4. G.E. Amidon, W.I. Higuchi, and N.F.H. Ho Theoretical and experimental studies of transport of micelle-solubilized solutes J. Pharm. Sci. 71 1982 77 84
5. S.N. Bhattachar, J.A. Wesley, A. Fioritto, P.J. Martin, and S.R. Babu Dissolution testing of a poorly soluble compound using the flow-through cell dissolution apparatus Int. J. Pharm. 236 2002 135 143
6. W.L. Chiou, and S. Riegelman Pharmaceutical applications of solid dispersion systems J. Pharm. Sci. 60 1971 1281 1302
7. F. Cilurzo, P. Minghetti, A. Casiraghi, and L. Montanari Characterization of nifedipine solid dispersions Int. J. Pharm. 242 2002 313 317
8. M.G. Fakes, B.J. Vakkalagadda, F. Qian, S. Desikan, R.B. Gandhi, C. Lai, A. Hsieh, M.K. Franchini, H. Toale, and J. Brown Enhancement of oral bioavailability of an HIV-attachment inhibitor by nanosizing and amorphous formulation approaches Int. J. Pharm. 370 2009 167 174
9. J.L. Ford, and P.N.C. Elliott The effect of particle size on some in-vitro and in-vivo properties of indomethacin-polyethylene glycol 6000 solid dispersions Drug Dev. Ind. Pharm. 11 1985 537 549
10. A. Hasegawa, R. Kawamura, H. Nakagawa, and I. Sugimoto Dissolution mechanism of solid dispersions of nifedipine with enteric coating agents Yakugaku Zasshi 105 1985 586 592
11. T. Ishikawa, Y. Watanabe, K. Takayama, H. Endo, and M. Matsumoto Effect of hydroxypropylmethylcellulose (HPMC) on the release profiles and bioavailability of a poorly water-soluble drug from tablets prepared using macrogol and HPMC Int. J. Pharm. 202 2000 173 178
12. R.T.C. Ju, P.R. Nixon, and M.V. Patel Drug release from hydrophilic matrices. 1. New scaling laws for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer J. Pharm. Sci. 84 1995 1455 1463
13. S.W. Jun, M.-S. Kim, G.H. Jo, S. Lee, J.S. Woo, J.-S. Park, and S.-J. Hwang Cefuroxime axetil solid dispersions prepared using solution enhanced dispersion by supercritical fluids J. Pharm. Pharmacol. 57 2005 1529 1537
14. S.W. Jun, M.-S. Kim, J.-S. Kim, H.J. Park, S. Lee, J.-S. Woo, and S.-J. Hwang Preparation and characterization of simvastatin/hydroxypropyl-[beta]- cyclodextrin inclusion complex using supercritical antisolvent (SAS) process Eur. J. Pharm. Biopharm. 66 2007 413 421
15. E.-J. Kim, M.-K. Chun, J.-S. Jang, I.-H. Lee, K.-R. Lee, and H.-K. Choi Preparation of a solid dispersion of felodipine using a solvent wetting method Eur. J. Pharm. Biopharm. 64 2006 200 205
16. M.-S. Kim, S.-J. Jin, J.-S. Kim, H.J. Park, H.-S. Song, R.H.H. Neubert, and S.-J. Hwang Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process Eur. J. Pharm. Biopharm. 69 2008 454 465
17. M.-S. Kim, S. Lee, J.-S. Park, J.-S. Woo, and S.-J. Hwang Micronization of cilostazol using supercritical antisolvent (SAS) process: effect of process parameters Powder Technol. 177 2007 64 70
18. N. Kohri, Y. Yamayoshi, H. Xin, K. Iseki, N. Sato, S. Todo, and K. Miyazaki Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique J. Pharm. Pharmacol. 51 1999 159 164
19. H. Konno, and L.S. Taylor Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine J. Pharm. Sci. 95 2006 2692 2705
20. R. Löbenberg, and G.L. Amidon Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards Eur. J. Pharm. Biopharm. 50 2000 3 12
21. C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. Biopharm. 50 2000 47 60
22. A.F. Nielsen, P. Bertelsen, H.G. Kristensen, J. Kristensen, and L. Hovgaard Investigation and comparison of performance of effervescent and standard pneumatic atomizer intended for soluble aqueous coating Pharm. Dev. Technol. 11 2006 243 253
23. J.K. Pandit, and B.K. Khakurel In vitro and in vivo evaluation of some fast release dosage forms of hydrochlorothiazide Drug Dev. Ind. Pharm. 10 1984 1709 1724
24. J. Park, H. Park, W. Cho, K.-H. Cha, W. Yeon, M.-S. Kim, J.-S. Kim, and S.-J. Hwang Comparative study of telmisartan tablets prepared via the wet granulation method and pritor™ prepared using the spray-drying method Arch. Pharmacal Res. 34 2011 463 468
25. J. Peeters, P. Neeskens, J.P. Tollenaere, P.V. Remoortere, and M.E. Brewster Characterization of the interaction of 2-hydroxypropyl-beta- cyclodextrin with itraconazole at pH 2, 4, and 7 J. Pharm. Sci. 91 2002 1414 1422
26. M. Perrut, J. Jung, and F. Leboeuf Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes. Part I. Micronization of neat particles Int. J. Pharm. 288 2005 3 10
27. H. Suzuki, and H. Sunada Influence of water-soluble polymers on the dissolution of Nifedipine solid dispersions with combined carriers Chem. Pharm. Bull. 46 1998 482 487
28. V. Tantishaiyakul, N. Kaewnopparat, and S. Ingkatawornwong Properties of solid dispersions of piroxicam in polyvinylpyrrolidone K-30 Int. J. Pharm. 143 1996 59 66
29. P. Thybo, J. Kristensen, and L. Hovgaard Characterization and physical stability of tolfenamic acid-PVP K30 solid dispersions Pharm. Dev. Technol. 12 2007 43 53
30. P.H.L. Tran, H.T.T. Tran, and B.-J. Lee Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release J. Control. Release 129 2008 59 65
31. N. Yagi, Y. Terashima, H. Kenmotsu, H. Sekikawa, and M. Takada Dissolution behavior of probucol from solid dispersion system of probucol-polyvinylpyrrolidone Chem. Pharm. Bull. 44 1996 241 244
32. M. Yoshioka, B.C. Hancock, and G. Zografi Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates J. Pharm. Sci. 84 1995 983 986
33. H.-X. Zhang, J.-X. Wang, Z.-B. Zhang, Y. Le, Z.-G. Shen, and J.-F. Chen Micronization of atorvastatin calcium by antisolvent precipitation process Int. J. Pharm. 374 2009 106 113