The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Cell Reports

Volumn 21, Issue 13, 2017, Pages 3846-3859

  Schneider, Katharina S ^a   Groß, Christina J ^a,b   Dreier, Roland F ^c   Saller, Benedikt S ^d   Mishra, Ritu ^a,e   Gorka, Oliver ^d   Heilig, Rosalie ^c   Meunier, Etienne ^c   Dick, Mathias S ^c   Ćiković, Tamara ^a,e   Sodenkamp, Jan ^a,e,f   Médard, Guillaume ^e   Naumann, Ronald ^g   Ruland, Jürgen ^a,e,f,h   Kuster, Bernhard ^e,i   Broz, Petr ^c,j   Groß, Olaf ^a,b,d,e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF FREIBURG   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^h German Center for Infection Research   (Germany)

ⁱ Munich Center for Integrated Protein Science   (Germany)

^j UNIVERSITY OF LAUSANNE   (Switzerland)

more..

Author keywords

ASC; caspase 1; caspase 8; gasdermin; IL 1; inflammasome; pyroptosis; regulated necrosis

Indexed keywords

CASPASE 8; CELL PROTEIN; GASDERMIN D; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CASPASE INHIBITOR; GSDMD PROTEIN, MOUSE; INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FRANCISELLA NOVICIDA; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PYROPTOSIS; SPLEEN; ANIMAL; C57BL MOUSE; DRUG EFFECT; ENZYME ACTIVATION; FRANCISELLA; METABOLISM; PHYSIOLOGY;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; CASPASE 8; CASPASE INHIBITORS; ENZYME ACTIVATION; FRANCISELLA; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1; INTERLEUKIN-1BETA; MICE, INBRED C57BL; PYROPTOSIS;

EID: 85039941671     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.12.018     Document Type: Article

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