Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Molecular Cell

Volumn 64, Issue 2, 2016, Pages 236-250

  Fu, Tian Min ^a,b   Li, Yang ^a,b   Lu, Alvin ^a,b   Li, Zongli ^a,c   Vajjhala, Parimala R ^d   Cruz, Anthony C ^e   Srivastava, Devendra B ^a,b   DiMaio, Frank ^f   Penczek, Pawel A ^g   Siegel, Richard M ^e   Stacey, Katryn J ^d   Egelman, Edward H ^h   Wu, Hao ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF VIRGINIA   (United States)

Author keywords

caspase 8; cFLIP; death domain; DED; DISC; FADD; Fas; filament; MC159; vFLIP

Indexed keywords

CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; CASP8 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; FADD PROTEIN, HUMAN; FAS ANTIGEN; FAS PROTEIN, HUMAN; HYBRID PROTEIN; PROTEIN BINDING; PYCARD PROTEIN, HUMAN; VIRAL FLIP PROTEIN, MOLLUSCUM CONTAGIOSUM VIRUS; VIRAL PROTEIN;

APOPTOSIS; ARTICLE; CRYOELECTRON MICROSCOPY; ENZYME REGULATION; ENZYME STRUCTURE; IN VITRO STUDY; MUTAGENESIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TANDEM DEATH EFFECTOR DOMAIN; ALPHA HELIX; AMINO ACID SEQUENCE; BETA SHEET; BINDING SITE; CHEMISTRY; DEATH EFFECTOR DOMAIN; DRUG EFFECTS; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; JURKAT CELL LINE; METABOLISM; PLASMID; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTIGENS, CD95; APOPTOSIS; BINDING SITES; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CRYOELECTRON MICROSCOPY; CYTOSKELETAL PROTEINS; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DEATH EFFECTOR DOMAIN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION; HUMANS; JURKAT CELLS; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; VIRAL PROTEINS;

EID: 84994807436     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.09.009     Document Type: Article

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