-
1
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
Martinon, F., K. Burns, and J. Tschopp. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10:417-426.
-
(2002)
Mol. Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
2
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Roberts, T. L., A. Idris, J. A. Dunn, G. M. Kelly, C. M. Burnton, S. Hodgson, L. L. Hardy, V. Garceau, M. J. Sweet, I. L. Ross, et al. 2009. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323:1057-1060.
-
(2009)
Science
, vol.323
, pp. 1057-1060
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
Kelly, G.M.4
Burnton, C.M.5
Hodgson, S.6
Hardy, L.L.7
Garceau, V.8
Sweet, M.J.9
Ross, I.L.10
-
3
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung, V., A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, G. Horvath, D. R. Caffrey, E. Latz, and K. A. Fitzgerald. 2009. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514-518.
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
Caffrey, D.R.6
Latz, E.7
Fitzgerald, K.A.8
-
4
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri, T., J. W. Yu, P. Datta, J. Wu, and E. S. Alnemri. 2009. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509-513.
-
(2009)
Nature
, vol.458
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
Wu, J.4
Alnemri, E.S.5
-
5
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Bürckstümmer, T., C. Baumann, S. Blüml, E. Dixit, G. Dürnberger, H. Jahn, M. Planyavsky, M. Bilban, J. Colinge, K. L. Bennett, and G. Superti-Furga. 2009. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10:266-272.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 266-272
-
-
Bürckstümmer, T.1
Baumann, C.2
Blüml, S.3
Dixit, E.4
Dürnberger, G.5
Jahn, H.6
Planyavsky, M.7
Bilban, M.8
Colinge, J.9
Bennett, K.L.10
Superti-Furga, G.11
-
6
-
-
77955294800
-
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
-
Sauer, J. D., C. E. Witte, J. Zemansky, B. Hanson, P. Lauer, and D. A. Portnoy. 2010. Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microbe 7:412-419.
-
(2010)
Cell Host Microbe
, vol.7
, pp. 412-419
-
-
Sauer, J.D.1
Witte, C.E.2
Zemansky, J.3
Hanson, B.4
Lauer, P.5
Portnoy, D.A.6
-
7
-
-
77951269392
-
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
-
Rathinam, V. A., Z. Jiang, S. N. Waggoner, S. Sharma, L. E. Cole, L. Waggoner, S. K. Vanaja, B. G. Monks, S. Ganesan, E. Latz, et al. 2010. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11:395-402.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 395-402
-
-
Rathinam, V.A.1
Jiang, Z.2
Waggoner, S.N.3
Sharma, S.4
Cole, L.E.5
Waggoner, L.6
Vanaja, S.K.7
Monks, B.G.8
Ganesan, S.9
Latz, E.10
-
8
-
-
77953116282
-
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
-
Jones, J. W., N. Kayagaki, P. Broz, T. Henry, K. Newton, K. O'Rourke, S. Chan, J. Dong, Y. Qu, M. Roose-Girma, et al. 2010. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc. Natl. Acad. Sci. USA 107:9771-9776.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 9771-9776
-
-
Jones, J.W.1
Kayagaki, N.2
Broz, P.3
Henry, T.4
Newton, K.5
O'Rourke, K.6
Chan, S.7
Dong, J.8
Qu, Y.9
Roose-Girma, M.10
-
9
-
-
77951263260
-
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
-
Fernandes-Alnemri, T., J. W. Yu, C. Juliana, L. Solorzano, S. Kang, J. Wu, P. Datta, M. McCormick, L. Huang, E. McDermott, et al. 2010. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11:385-393.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 385-393
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Juliana, C.3
Solorzano, L.4
Kang, S.5
Wu, J.6
Datta, P.7
McCormick, M.8
Huang, L.9
McDermott, E.10
-
10
-
-
34748915252
-
Molecular epidemiology, evolution, and ecology of Francisella
-
Keim, P. S., A. Johansson, and D. M. Wagner. 2007. Molecular epidemiology, evolution, and ecology of Francisella. Ann. N. Y. Acad. Sci. 1105:30-66.
-
(2007)
Ann. N. Y. Acad. Sci.
, vol.1105
, pp. 30-66
-
-
Keim, P.S.1
Johansson, A.2
Wagner, D.M.3
-
11
-
-
57349174394
-
Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112
-
Hall, J. D., M. D. Woolard, B. M. Gunn, R. R. Craven, S. Taft-Benz, J. A. Frelinger, and T. H. Kawula. 2008. Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112. Infect. Immun. 76:5843-5852.
-
(2008)
Infect. Immun.
, vol.76
, pp. 5843-5852
-
-
Hall, J.D.1
Woolard, M.D.2
Gunn, B.M.3
Craven, R.R.4
Taft-Benz, S.5
Frelinger, J.A.6
Kawula, T.H.7
-
12
-
-
0141446069
-
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells
-
Golovliov, I., V. Baranov, Z. Krocova, H. Kovarova, and A. Sjöstedt. 2003. An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells. Infect. Immun. 71:5940-5950.
-
(2003)
Infect. Immun.
, vol.71
, pp. 5940-5950
-
-
Golovliov, I.1
Baranov, V.2
Krocova, Z.3
Kovarova, H.4
Sjöstedt, A.5
-
13
-
-
2542552050
-
Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages
-
Clemens, D. L., B. Y. Lee, and M. A. Horwitz. 2004. Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect. Immun. 72:3204-3217.
-
(2004)
Infect. Immun.
, vol.72
, pp. 3204-3217
-
-
Clemens, D.L.1
Lee, B.Y.2
Horwitz, M.A.3
-
14
-
-
80455176839
-
Non-canonical inflammasome activation targets caspase-11
-
Kayagaki, N., S. Warming, M. Lamkanfi, L. Vande Walle, S. Louie, J. Dong, K. Newton, Y. Qu, J. Liu, S. Heldens, et al. 2011. Non-canonical inflammasome activation targets caspase-11. Nature 479:117-121.
-
(2011)
Nature
, vol.479
, pp. 117-121
-
-
Kayagaki, N.1
Warming, S.2
Lamkanfi, M.3
Vande Walle, L.4
Louie, S.5
Dong, J.6
Newton, K.7
Qu, Y.8
Liu, J.9
Heldens, S.10
-
15
-
-
34848884287
-
Activation of the inflammasome upon Francisella tularensis infection: Interplay of innate immune pathways and virulence factors
-
Henry, T., and D. M. Monack. 2007. Activation of the inflammasome upon Francisella tularensis infection: interplay of innate immune pathways and virulence factors. Cell. Microbiol. 9:2543-2551.
-
(2007)
Cell. Microbiol.
, vol.9
, pp. 2543-2551
-
-
Henry, T.1
Monack, D.M.2
-
16
-
-
26844452231
-
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
-
Mariathasan, S., D. S. Weiss, V. M. Dixit, and D. M. Monack. 2005. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J. Exp. Med. 202:1043-1049.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1043-1049
-
-
Mariathasan, S.1
Weiss, D.S.2
Dixit, V.M.3
Monack, D.M.4
-
17
-
-
78449269290
-
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
-
Miao, E. A., I. A. Leaf, P. M. Treuting, D. P. Mao, M. Dors, A. Sarkar, S. E. Warren, M. D. Wewers, and A. Aderem. 2010. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11:1136-1142.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1136-1142
-
-
Miao, E.A.1
Leaf, I.A.2
Treuting, P.M.3
Mao, D.P.4
Dors, M.5
Sarkar, A.6
Warren, S.E.7
Wewers, M.D.8
Aderem, A.9
-
18
-
-
84866087868
-
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
-
Pierini, R., C. Juruj, M. Perret, C. L. Jones, P. Mangeot, D. S. Weiss, and T. Henry. 2012. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ. 19:1709-1721.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 1709-1721
-
-
Pierini, R.1
Juruj, C.2
Perret, M.3
Jones, C.L.4
Mangeot, P.5
Weiss, D.S.6
Henry, T.7
-
19
-
-
84864292536
-
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization
-
Akhter, A., K. Caution, A. Abu Khweek, M. Tazi, B. A. Abdulrahman, D. H. Abdelaziz, O. H. Voss, A. I. Doseff, H. Hassan, A. K. Azad, et al. 2012. Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity 37:35-47.
-
(2012)
Immunity
, vol.37
, pp. 35-47
-
-
Akhter, A.1
Caution, K.2
Abu Khweek, A.3
Tazi, M.4
Abdulrahman, B.A.5
Abdelaziz, D.H.6
Voss, O.H.7
Doseff, A.I.8
Hassan, H.9
Azad, A.K.10
-
20
-
-
84865339202
-
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
-
Puri, A. W., P. Broz, A. Shen, D. M. Monack, and M. Bogyo. 2012. Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection. Nat. Chem. Biol. 8:745-747.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 745-747
-
-
Puri, A.W.1
Broz, P.2
Shen, A.3
Monack, D.M.4
Bogyo, M.5
-
21
-
-
84857175933
-
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
-
Gringhuis, S. I., T. M. Kaptein, B. A. Wevers, B. Theelen, M. van der Vlist, T. Boekhout, and T. B. Geijtenbeek. 2012. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat. Immunol. 13:246-254.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 246-254
-
-
Gringhuis, S.I.1
Kaptein, T.M.2
Wevers, B.A.3
Theelen, B.4
Van Der Vlist, M.5
Boekhout, T.6
Geijtenbeek, T.B.7
-
22
-
-
81855167230
-
Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages
-
Abdelaziz, D. H., M. A. Gavrilin, A. Akhter, K. Caution, S. Kotrange, A. A. Khweek, B. A. Abdulrahman, Z. A. Hassan, F. Z. El-Sharkawi, S. S. Bedi, et al. 2011. Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages. Front. Microbiol. 2:18.
-
(2011)
Front. Microbiol.
, vol.2
, pp. 18
-
-
Abdelaziz, D.H.1
Gavrilin, M.A.2
Akhter, A.3
Caution, K.4
Kotrange, S.5
Khweek, A.A.6
Abdulrahman, B.A.7
Hassan, Z.A.8
El-Sharkawi, F.Z.9
Bedi, S.S.10
-
23
-
-
84882280029
-
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
-
DOI:10.1038/cdd.2013.37
-
Sagulenko, V., S. J. Thygesen, D. P. Sester, A. Idris, J. A. Cridland, P. R. Vajjhala, T. L. Roberts, K. Schroder, J. E. Vince, J. M. Hill, J. Silke, and K. J. Stacey. 2013 AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ. DOI:10.1038/cdd.2013.37
-
(2013)
Cell Death Differ.
-
-
Sagulenko, V.1
Thygesen, S.J.2
Sester, D.P.3
Idris, A.4
Cridland, J.A.5
Vajjhala, P.R.6
Roberts, T.L.7
Schroder, K.8
Vince, J.E.9
Hill, J.M.10
Silke, J.11
Stacey, K.J.12
-
24
-
-
79952609213
-
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59
-
Ellebedy, A. H., C. Lupfer, H. E. Ghoneim, J. De Beauchamp, T. D. Kanneganti, and R. J. Webby. 2011. Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. Proc. Natl. Acad. Sci. USA 108:2927-2932.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 2927-2932
-
-
Ellebedy, A.H.1
Lupfer, C.2
Ghoneim, H.E.3
De Beauchamp, J.4
Kanneganti, T.D.5
Webby, R.J.6
-
25
-
-
70349331255
-
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF
-
Kolly, L., M. Karababa, L. A. Joosten, S. Narayan, R. Salvi, V. Pétrilli, J. Tschopp, W. B. van den Berg, A. K. So, and N. Busso. 2009. Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF. J. Immunol. 183:4003-4012.
-
(2009)
J. Immunol.
, vol.183
, pp. 4003-4012
-
-
Kolly, L.1
Karababa, M.2
Joosten, L.A.3
Narayan, S.4
Salvi, R.5
Pétrilli, V.6
Tschopp, J.7
Van Den Berg, W.B.8
So, A.K.9
Busso, N.10
-
26
-
-
77954478334
-
Cutting edge: Critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis
-
Shaw, P. J., J. R. Lukens, S. Burns, H. Chi, M. A. McGargill, and T. D. Kanneganti. 2010. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J. Immunol. 184:4610-4614.
-
(2010)
J. Immunol.
, vol.184
, pp. 4610-4614
-
-
Shaw, P.J.1
Lukens, J.R.2
Burns, S.3
Chi, H.4
McGargill, M.A.5
Kanneganti, T.D.6
-
27
-
-
77957908944
-
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
-
McElvania Tekippe, E., I. C. Allen, P. D. Hulseberg, J. T. Sullivan, J. R. McCann, M. Sandor, M. Braunstein, and J. P. Ting. 2010. Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PLoS ONE 5:e12320.
-
(2010)
PLoS ONE
, vol.5
-
-
McElvania Tekippe, E.1
Allen, I.C.2
Hulseberg, P.D.3
Sullivan, J.T.4
McCann, J.R.5
Sandor, M.6
Braunstein, M.7
Ting, J.P.8
-
28
-
-
84865827014
-
Addendum: Defective Dock2 expression in a subset of ASC-deficient mouse lines
-
Ippagunta, S. K., R. K. Malireddi, P. J. Shaw, G. A. Neale, L. V. Walle, Y. Fukui, D. R. Green, M. Lamkanfi, and T. D. Kanneganti. 2012. Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines. Nat. Immunol. 13:701-702.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 701-702
-
-
Ippagunta, S.K.1
Malireddi, R.K.2
Shaw, P.J.3
Neale, G.A.4
Walle, L.V.5
Fukui, Y.6
Green, D.R.7
Lamkanfi, M.8
Kanneganti, T.D.9
-
29
-
-
80052968438
-
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization
-
Ippagunta, S. K., R. K. Malireddi, P. J. Shaw, G. A. Neale, L. V. Walle, D. R. Green, Y. Fukui, M. Lamkanfi, and T. D. Kanneganti. 2011. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat. Immunol. 12:1010-1016.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1010-1016
-
-
Ippagunta, S.K.1
Malireddi, R.K.2
Shaw, P.J.3
Neale, G.A.4
Walle, L.V.5
Green, D.R.6
Fukui, Y.7
Lamkanfi, M.8
Kanneganti, T.D.9
-
30
-
-
3142654767
-
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
-
Mariathasan, S., K. Newton, D. M. Monack, D. Vucic, D. M. French, W. P. Lee, M. Roose-Girma, S. Erickson, and V. M. Dixit. 2004. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218.
-
(2004)
Nature
, vol.430
, pp. 213-218
-
-
Mariathasan, S.1
Newton, K.2
Monack, D.M.3
Vucic, D.4
French, D.M.5
Lee, W.P.6
Roose-Girma, M.7
Erickson, S.8
Dixit, V.M.9
-
31
-
-
0037262797
-
Anti-interleukin-18 therapy in murine models of inflammatory bowel disease
-
Lochner, M., and I. Förster. 2002-2003. Anti-interleukin-18 therapy in murine models of inflammatory bowel disease. Pathobiology 70:164-169.
-
(2002)
Pathobiology
, vol.70
, pp. 164-169
-
-
Lochner, M.1
Förster, I.2
-
32
-
-
67049114093
-
Maturation of mouse NK cells is a 4-stage developmental program
-
Chiossone, L., J. Chaix, N. Fuseri, C. Roth, E. Vivier, and T. Walzer. 2009. Maturation of mouse NK cells is a 4-stage developmental program. Blood 113:5488-5496.
-
(2009)
Blood
, vol.113
, pp. 5488-5496
-
-
Chiossone, L.1
Chaix, J.2
Fuseri, N.3
Roth, C.4
Vivier, E.5
Walzer, T.6
-
33
-
-
49649105001
-
Cutting edge: Priming of NK cells by IL-18
-
Chaix, J., M. S. Tessmer, K. Hoebe, N. Fuséri, B. Ryffel, M. Dalod, L. Alexopoulou, B. Beutler, L. Brossay, E. Vivier, and T. Walzer. 2008. Cutting edge: priming of NK cells by IL-18. J. Immunol. 181:1627-1631.
-
(2008)
J. Immunol.
, vol.181
, pp. 1627-1631
-
-
Chaix, J.1
Tessmer, M.S.2
Hoebe, K.3
Fuséri, N.4
Ryffel, B.5
Dalod, M.6
Alexopoulou, L.7
Beutler, B.8
Brossay, L.9
Vivier, E.10
Walzer, T.11
-
34
-
-
77951626413
-
Type I IFN signaling constrains IL-17A/F secretion by γδ T cells during bacterial infections
-
Henry, T., G. S. Kirimanjeswara, T. Ruby, J. W. Jones, K. Peng, M. Perret, L. Ho, J. D. Sauer, Y. Iwakura, D. W. Metzger, and D. M. Monack. 2010. Type I IFN signaling constrains IL-17A/F secretion by γδ T cells during bacterial infections. J. Immunol. 184:3755-3767.
-
(2010)
J. Immunol.
, vol.184
, pp. 3755-3767
-
-
Henry, T.1
Kirimanjeswara, G.S.2
Ruby, T.3
Jones, J.W.4
Peng, K.5
Perret, M.6
Ho, L.7
Sauer, J.D.8
Iwakura, Y.9
Metzger, D.W.10
Monack, D.M.11
-
35
-
-
34249044447
-
Type I interferon signaling is required for activation of the inflammasome during Francisella infection
-
Henry, T., A. Brotcke, D. S. Weiss, L. J. Thompson, and D. M. Monack. 2007. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J. Exp. Med. 204:987-994.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 987-994
-
-
Henry, T.1
Brotcke, A.2
Weiss, D.S.3
Thompson, L.J.4
Monack, D.M.5
-
36
-
-
0023889012
-
Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen
-
Lanier, L. L., D. W. Buck, L. Rhodes, A. Ding, E. Evans, C. Barney, and J. H. Phillips. 1988. Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. J. Exp. Med. 167:1572-1585.
-
(1988)
J. Exp. Med.
, vol.167
, pp. 1572-1585
-
-
Lanier, L.L.1
Buck, D.W.2
Rhodes, L.3
Ding, A.4
Evans, E.5
Barney, C.6
Phillips, J.H.7
-
37
-
-
52649097448
-
The Immunological Genome Project: Networks of gene expression in immune cells
-
Immunological Genome Project Consortium
-
Heng, T. S., M. W. Painter; Immunological Genome Project Consortium. 2008. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9:1091-1094.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1091-1094
-
-
Heng, T.S.1
Painter, M.W.2
-
38
-
-
77954067489
-
Salmonella induced IL-23 and IL-1β allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells
-
van de Wetering, D., R. A. de Paus, J. T. van Dissel, and E. van de Vosse. 2009. Salmonella induced IL-23 and IL-1β allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE 4:e8396.
-
(2009)
PLoS ONE
, vol.4
-
-
Van De Wetering, D.1
De Paus, R.A.2
Van Dissel, J.T.3
Van De Vosse, E.4
-
39
-
-
0028973003
-
IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1β in the T cellindependent mechanism of resistance against intracellular pathogens
-
Hunter, C. A., R. Chizzonite, and J. S. Remington. 1995. IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1β in the T cellindependent mechanism of resistance against intracellular pathogens. J. Immunol. 155:4347-4354.
-
(1995)
J. Immunol.
, vol.155
, pp. 4347-4354
-
-
Hunter, C.A.1
Chizzonite, R.2
Remington, J.S.3
-
40
-
-
77953910523
-
+ immature human natural killer cells in secondary lymphoid tissue
-
+ immature human natural killer cells in secondary lymphoid tissue. Immunity 32:803-814.
-
(2010)
Immunity
, vol.32
, pp. 803-814
-
-
Hughes, T.1
Becknell, B.2
Freud, A.G.3
McClory, S.4
Briercheck, E.5
Yu, J.6
Mao, C.7
Giovenzana, C.8
Nuovo, G.9
Wei, L.10
-
41
-
-
15644369352
-
Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
-
Gu, Y., K. Kuida, H. Tsutsui, G. Ku, K. Hsiao, M. A. Fleming, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, et al. 1997. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science 275:206-209.
-
(1997)
Science
, vol.275
, pp. 206-209
-
-
Gu, Y.1
Kuida, K.2
Tsutsui, H.3
Ku, G.4
Hsiao, K.5
Fleming, M.A.6
Hayashi, N.7
Higashino, K.8
Okamura, H.9
Nakanishi, K.10
-
42
-
-
0031004174
-
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
-
Ghayur, T., S. Banerjee, M. Hugunin, D. Butler, L. Herzog, A. Carter, L. Quintal, L. Sekut, R. Talanian, M. Paskind, et al. 1997. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386:619-623.
-
(1997)
Nature
, vol.386
, pp. 619-623
-
-
Ghayur, T.1
Banerjee, S.2
Hugunin, M.3
Butler, D.4
Herzog, L.5
Carter, A.6
Quintal, L.7
Sekut, L.8
Talanian, R.9
Paskind, M.10
-
43
-
-
56049116880
-
Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
-
Pereira, N. A., and Z. Song. 2008. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem. Biophys. Res. Commun. 377:873-877.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 873-877
-
-
Pereira, N.A.1
Song, Z.2
-
44
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
Dinarello, C. A. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519-550.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
45
-
-
0028845730
-
Cloning of a new cytokine that induces IFN-γ production by T cells
-
Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88-91.
-
(1995)
Nature
, vol.378
, pp. 88-91
-
-
Okamura, H.1
Tsutsi, H.2
Komatsu, T.3
Yutsudo, M.4
Hakura, A.5
Tanimoto, T.6
Torigoe, K.7
Okura, T.8
Nukada, Y.9
Hattori, K.10
-
46
-
-
84857885765
-
DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection
-
Oertli, M., M. Sundquist, I. Hitzler, D. B. Engler, I. C. Arnold, S. Reuter, J. Maxeiner, M. Hansson, C. Taube, M. Quiding-Järbrink, and A. Müller. 2012. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J. Clin. Invest. 122:1082-1096.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1082-1096
-
-
Oertli, M.1
Sundquist, M.2
Hitzler, I.3
Engler, D.B.4
Arnold, I.C.5
Reuter, S.6
Maxeiner, J.7
Hansson, M.8
Taube, C.9
Quiding-Järbrink, M.10
Müller, A.11
-
47
-
-
84861888837
-
Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells
-
Terme, M., E. Ullrich, L. Aymeric, K. Meinhardt, J. D. Coudert, M. Desbois, F. Ghiringhelli, S. Viaud, B. Ryffel, H. Yagita, et al. 2012. Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Res. 72:2757-2767.
-
(2012)
Cancer Res.
, vol.72
, pp. 2757-2767
-
-
Terme, M.1
Ullrich, E.2
Aymeric, L.3
Meinhardt, K.4
Coudert, J.D.5
Desbois, M.6
Ghiringhelli, F.7
Viaud, S.8
Ryffel, B.9
Yagita, H.10
-
48
-
-
77949965210
-
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
-
Dupaul-Chicoine, J., G. Yeretssian, K. Doiron, K. S. Bergstrom, C. R. McIntire, P. M. LeBlanc, C. Meunier, C. Turbide, P. Gros, N. Beauchemin, et al. 2010. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32:367-378.
-
(2010)
Immunity
, vol.32
, pp. 367-378
-
-
Dupaul-Chicoine, J.1
Yeretssian, G.2
Doiron, K.3
Bergstrom, K.S.4
McIntire, C.R.5
Le Blanc, P.M.6
Meunier, C.7
Turbide, C.8
Gros, P.9
Beauchemin, N.10
-
49
-
-
77950002937
-
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
-
Zaki, M. H., K. L. Boyd, P. Vogel, M. B. Kastan, M. Lamkanfi, and T. D. Kanneganti. 2010. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32:379-391.
-
(2010)
Immunity
, vol.32
, pp. 379-391
-
-
Zaki, M.H.1
Boyd, K.L.2
Vogel, P.3
Kastan, M.B.4
Lamkanfi, M.5
Kanneganti, T.D.6
-
50
-
-
84860342710
-
Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18
-
Hitzler, I., A. Sayi, E. Kohler, D. B. Engler, K. N. Koch, W. D. Hardt, and A. Müller. 2012. Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18. J. Immunol. 188:3594-3602.
-
(2012)
J. Immunol.
, vol.188
, pp. 3594-3602
-
-
Hitzler, I.1
Sayi, A.2
Kohler, E.3
Engler, D.B.4
Koch, K.N.5
Hardt, W.D.6
Müller, A.7
-
51
-
-
0033514959
-
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells
-
Puren, A. J., G. Fantuzzi, and C. A. Dinarello. 1999. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. USA 96:2256-2261.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2256-2261
-
-
Puren, A.J.1
Fantuzzi, G.2
Dinarello, C.A.3
-
52
-
-
79952102031
-
Inflammasome activation and IL-1β and IL-18 processing during infection
-
van de Veerdonk, F. L., M. G. Netea, C. A. Dinarello, and L. A. Joosten. 2011. Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol. 32:110-116.
-
(2011)
Trends Immunol.
, vol.32
, pp. 110-116
-
-
Van De Veerdonk, F.L.1
Netea, M.G.2
Dinarello, C.A.3
Joosten, L.A.4
-
53
-
-
77955050873
-
Granzyme B is a novel interleukin-18 converting enzyme
-
Omoto, Y., K. Yamanaka, K. Tokime, S. Kitano, M. Kakeda, T. Akeda, I. Kurokawa, E. C. Gabazza, H. Tsutsui, N. Katayama, et al. 2010. Granzyme B is a novel interleukin-18 converting enzyme. J. Dermatol. Sci. 59:129-135.
-
(2010)
J. Dermatol. Sci.
, vol.59
, pp. 129-135
-
-
Omoto, Y.1
Yamanaka, K.2
Tokime, K.3
Kitano, S.4
Kakeda, M.5
Akeda, T.6
Kurokawa, I.7
Gabazza, E.C.8
Tsutsui, H.9
Katayama, N.10
-
54
-
-
33644934188
-
Expression and alternative processing of IL-18 in human neutrophils
-
Robertson, S. E., J. D. Young, S. Kitson, A. Pitt, J. Evans, J. Roes, D. Karaoglu, L. Santora, T. Ghayur, F. Y. Liew, et al. 2006. Expression and alternative processing of IL-18 in human neutrophils. Eur. J. Immunol. 36:722-731.
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 722-731
-
-
Robertson, S.E.1
Young, J.D.2
Kitson, S.3
Pitt, A.4
Evans, J.5
Roes, J.6
Karaoglu, D.7
Santora, L.8
Ghayur, T.9
Liew, F.Y.10
-
55
-
-
0035575705
-
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells
-
Sugawara, S., A. Uehara, T. Nochi, T. Yamaguchi, H. Ueda, A. Sugiyama, K. Hanzawa, K. Kumagai, H. Okamura, and H. Takada. 2001. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J. Immunol. 167:6568-6575.
-
(2001)
J. Immunol.
, vol.167
, pp. 6568-6575
-
-
Sugawara, S.1
Uehara, A.2
Nochi, T.3
Yamaguchi, T.4
Ueda, H.5
Sugiyama, A.6
Hanzawa, K.7
Kumagai, K.8
Okamura, H.9
Takada, H.10
-
56
-
-
84871125002
-
Cutting edge: FAS (CD95) mediates noncanonical IL-1b and IL-18 maturation via caspase-8 in an RIP3-independent manner
-
Bossaller, L., P. I. Chiang, C. Schmidt-Lauber, S. Ganesan, W. J. Kaiser, V. A. Rathinam, E. S. Mocarski, D. Subramanian, D. R. Green, N. Silverman, et al. 2012. Cutting edge: FAS (CD95) mediates noncanonical IL-1b and IL-18 maturation via caspase-8 in an RIP3-independent manner. J. Immunol. 189:5508-5512.
-
(2012)
J. Immunol.
, vol.189
, pp. 5508-5512
-
-
Bossaller, L.1
Chiang, P.I.2
Schmidt-Lauber, C.3
Ganesan, S.4
Kaiser, W.J.5
Rathinam, V.A.6
Mocarski, E.S.7
Subramanian, D.8
Green, D.R.9
Silverman, N.10
-
57
-
-
0031730436
-
Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand
-
Miwa, K., M. Asano, R. Horai, Y. Iwakura, S. Nagata, and T. Suda. 1998. Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand. Nat. Med. 4:1287-1292.
-
(1998)
Nat. Med.
, vol.4
, pp. 1287-1292
-
-
Miwa, K.1
Asano, M.2
Horai, R.3
Iwakura, Y.4
Nagata, S.5
Suda, T.6
-
58
-
-
84255178199
-
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome
-
Labbé, K., C. R. McIntire, K. Doiron, P. M. Leblanc, and M. Saleh. 2011. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity 35:897-907.
-
(2011)
Immunity
, vol.35
, pp. 897-907
-
-
Labbé, K.1
McIntire, C.R.2
Doiron, K.3
Leblanc, P.M.4
Saleh, M.5
-
59
-
-
84862777872
-
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
-
Shimada, K., T. R. Crother, J. Karlin, J. Dagvadorj, N. Chiba, S. Chen, V. K. Ramanujan, A. J. Wolf, L. Vergnes, D. M. Ojcius, et al. 2012. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36:401-414.
-
(2012)
Immunity
, vol.36
, pp. 401-414
-
-
Shimada, K.1
Crother, T.R.2
Karlin, J.3
Dagvadorj, J.4
Chiba, N.5
Chen, S.6
Ramanujan, V.K.7
Wolf, A.J.8
Vergnes, L.9
Ojcius, D.M.10
-
60
-
-
84865266480
-
Genetics: The rate of human mutation
-
Kondrashov, A. 2012. Genetics: the rate of human mutation. Nature 488:467-468.
-
(2012)
Nature
, vol.488
, pp. 467-468
-
-
Kondrashov, A.1
-
61
-
-
84871608014
-
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1b
-
Luksch, H., M. J. Romanowski, O. Chara, V. Tungler, E. R. Caffarena, M. C. Heymann, P. Lohse, I. Aksentijevich, E. F. Remmers, S. Flecks, et al. 2013. Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1b. Hum. Mutat. 34:122-131.
-
(2013)
Hum. Mutat.
, vol.34
, pp. 122-131
-
-
Luksch, H.1
Romanowski, M.J.2
Chara, O.3
Tungler, V.4
Caffarena, E.R.5
Heymann, M.C.6
Lohse, P.7
Aksentijevich, I.8
Remmers, E.F.9
Flecks, S.10
|