Propionibacterium spp.—source of propionic acid, vitamin B12, and other metabolites important for the industry

Applied Microbiology and Biotechnology

Volumn 102, Issue 2, 2018, Pages 515-538

  Piwowarek, Kamil ^a   Lipińska, Edyta ^a   Hać Szymańczuk, Elżbieta ^a   Kieliszek, Marek ^a   Ścibisz, Iwona ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Bacteriocins; Propionibacterium; Propionic acid; Trehalose; Vitamin B12

Indexed keywords

AGRICULTURE; BACTERIA; BIOMOLECULES; METABOLITES;

'CURRENT; BACTERIOCINS; BIOSYNTHETIC PATHWAY; FOOD INDUSTRIES; GENETIC FACTORS; PHARMACEUTICAL INDUSTRY; PROPERTY; PROPIONIBACTERIA; TREHALOSE; VITAMIN B12;

PROPIONIC ACID;

BACTERIOCIN; CYANOCOBALAMIN; PROPIONIC ACID; TREHALOSE; PROPIONIC ACID DERIVATIVE;

BACTERIUM; BIOMASS; CARBOXYLIC ACID; ENVIRONMENTAL FACTOR; METABOLITE; PHARMACEUTICAL INDUSTRY; VITAMIN;

BIOSYNTHESIS; BIOTECHNOLOGICAL PRODUCTION; ENVIRONMENTAL FACTOR; GENETIC ENGINEERING; HUMAN; INDUSTRIAL PRODUCTION; METABOLITE; NONHUMAN; PROPIONIBACTERIUM; REVIEW; BIOMASS; FERMENTATION; METABOLISM; MICROBIOLOGY;

PROPIONIBACTERIUM;

BACTERIOCINS; BIOMASS; BIOSYNTHETIC PATHWAYS; FERMENTATION; INDUSTRIAL MICROBIOLOGY; PROPIONATES; PROPIONIBACTERIUM; TREHALOSE; VITAMIN B 12;

EID: 85034626904     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-017-8616-7     Document Type: Review

References (214)

1. Aleman G, Tovar AR, Torres N (2001) Homocysteine metabolism and risk of cardiovascular diseases: importance of the nutritional status on folic acid, vitamins B6 and B12. Rev Investig Clin 53:141–151
2. Al-Zoreky NJ, Ayres W, Sandine WE (1991) Antimicrobial activity of Microgard™ against food spoilage and pathogenic microorganisms. J Dairy Sci 74:758–763. https://doi.org/10.3168/jds.S0022-0302(91)78222-2
3. Ammar EM, Jin Y, Wang Z, Yang ST (2014) Metabolic engineering of Propionibacterium freudenreichii: effect of expressing phosphoenolpyruvate carboxylase on propionic acid production. Appl Microbiol Biotechnol 98:77–61. https://doi.org/10.1007/s00253-014-5836-y
4. Angelopoulou A, Alexandraki V, Georgalaki M, Anastasiou R, Manolopoulou E, Tsakalidou E, Papadimitriou K (2017) Production of probiotic Feta cheese using Propionibacterium freudenreichii subsp. shermanii as adjunct. Int Dairy J 66:135–139. https://doi.org/10.1016/j.idairyj.2016.11.011
5. Avonce N, Mendoza-Vargas A, Morett E, Iturriaga G (2006) Insights on the evolution of trehalose biosynthesis. BMC Evol Biol 6:1–15. https://doi.org/10.1186/1471-2148-6-109
6. Barbirato F, Chedaille D, Bories A (1997) Propionic acid fermentation from glycerol: comparison with conventional substrates. Appl Microbiol Biotechnol 47:441–446. https://doi.org/10.1007/s002530050953
7. Baumann I, Westermann P (2016) Microbial production of short chain fatty acids from lignocellulosic biomass: current processes and market, Hindawi publishing Corporation. BioMed Res Int 2016:1–15. https://doi.org/10.1155/2016/8469357
8. Beck WS (2001) Cobalamin (Vitamin B12). In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ (eds) Handbook of Vitamins. Marcel Dekker Inc., New York, pp 466–476
9. Ben-Shushan G, Zakin V, Gollop N (2003) Two different propionicins produced by Propionibacterium thoenii P-127. Peptides 24:1733–1740. https://doi.org/10.1016/j.peptides.2003.08.018
10. Benaroudj N, Lee DH, Goldberg AL (2001) Trehalose accumulation during cellular stress protect cells and cellular proteins from damage by oxygen radicals. J Biol Chem 276:24261–24267. https://doi.org/10.1074/jbc.M101487200
11. Benjelloun H, Rabe Ravelona M, Lebeault JM (2007) Characterization of growth and metabolism of commercial strains of propionic acid bacteria by pressure measurement. Eng Life Sci 7:143–148. https://doi.org/10.1002/elsc.200620180
12. Bhunia AK, Johnson MC, Ray B, Kalchayanad N (1991) Mode of action of pediocin AcH from Pediococcus acidilactici H on sensitive bacterial strains. J Appl Bacteriol 70:25–30
13. Blanche F, Debussche L, Thibaut D, Crouzet J, Cameron B (1989) Purification and characteriztationof S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Pseudomonas denitrificans. J Bacteriol 171:4222–4231
14. Blanche F, Cameron B, Crouzet J, Debussche L, Thibaut D, Vuilhorgne M, Lepper FJ, Battersby AR (1995) Vitamin B12: how the problem of its biosynthesis was solved. Angew Chem Int Ed Engl 34:383–411. https://doi.org/10.1002/anie.199503831
15. Blanche F, Cameron B, Crouzet J, Debussche L, Levy-Schil S, Thibaut D (1998) Rhône- Poulenc Biochimie. Eur Patent B1:0516647
16. Borawska J, Warmińska-Radyko I, Darewicz M (2010) Charakterystyka i znaczenie bakterii rodzaju Propionibacterium w produkcji żywności i pasz. Med Wet 66:534–537
17. Boyaval P, Corre C (1987) Continuous fermentation of sweet whey permeate for propionic acid production in a CSTR with UF recycle. Biotechnol Lett 9:801–806. https://doi.org/10.1007/BF01028287
18. Boyaval P, Deborde C, Corre C, Blanco C, Bégué É (1999) Stress and osmoprotection in propionibacteria. Lait 79:59–69. https://doi.org/10.1051/lait:199914
19. Brede DA, Faye T, Johnsborg O, Ødegård I, Nes IF, Holo H (2004) Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii. Appl Environ Microbiol 70:7303–7310. https://doi.org/10.1128/AEM.70.12.7303-7310.2004
20. Brede DA, Faye T, Stierli MP, Dasen G, Theiler A, Nes IF, Meile L, Holo H (2005) Heterologous production of antimicrobial peptides in Propionibacterium freudenreichii. Appl Environ Microbiol 71:8077–8084. https://doi.org/10.1128/AEM.71.12.8077-8084.2005
21. Brede DA, Lothe S, Salehian Z, Faye T, Nes IF (2007) Identification of the propionicin F bacteriocin immunity gene (pcfI) and development of a food-grade cloning system for Propionibacterium freudenreichii. Appl Environ Microbiol 73:7542–7547. https://doi.org/10.1128/AEM.01023-07
22. Breed RS, Murray EGD, Smithh NR (1957) Bergey’s manual of determinative bacteriology. Seventh edition. The Williams & Wilkins Company, pp 1346-1353
23. Cabo ML, Murado MA, González MP, Pastoriza L (2001) Effects of aeration and pH gradient on nisin production. A mathematical model. Enzym Microb Technol 29:264–273. https://doi.org/10.1016/S0141-0229(01)00378-7
24. Cánovas D, Fletcher SA, Hayashi M, Csonka LN (2001) Role of trehalose in growth at high temperature of Salmonella enterica serovar typhimurium. J Bacteriol 183:3365–3371. https://doi.org/10.1128/JB.183.11.3365-3371.2001
25. Cardoso S, Gaspar P, Hugenholtz J, Ramos A, Santos H (2004) Enhancement of trehalose production in dairy propionibacteria through manipulation of environmental conditions. Int J Food Microbiol 91:195–204. https://doi.org/10.1016/S0168-1605(03)00387-8
26. Cardoso FS, Castro RF, Borges N, Santos H (2007) Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response. Microbiology 153:270–280. https://doi.org/10.1099/mic.0.29262-0
27. Carrondo MJ, Crespo JP, Moura M (1988) Production of propionic acid using a xylose utilizing Propionibacterium. Appl Biochem Biotechnol 17:295–312. https://doi.org/10.1007/BF02779164
28. Carvalho AL, Cardoso FS, Bohn A, Neves AR, Santos H (2011) Engineering trehalose synthesis in Lactococcus lactis for improved stress tolerance. Appl Environ Microbiol 77:4189–4199. https://doi.org/10.1128/AEM.02922-10
29. Chamlagain B, Deptula P, Edelmann M, Kariluoto S, Grattepanche F, Lacroix C, Varmanen P, Piironen V (2016) Effect of the lower ligand precursors on vitamin B12 production by food-grade Propionibacteria. LWT - Food Sci Technol 72:117–124. https://doi.org/10.1016/j.lwt.2016.04.023
30. Chamlagain B (2016) Fermentation fortification of active vitamin B12 in food matrices using Propionibacterium freudenreichii: analysis, production and stability. University of Helsinki, Faculty of Agriculture and Forestry, Department of Food and Environmental Sciences, Dissertation
31. Chaudhary RK, Kardani J, Singh K (2014) Deciphering the roles of trehalose and Hsp104 in the inhibition of aggregation of mutant huntingtin in a yeast model of Huntington’s disease. NeuroMolecular Med 16:280–291. https://doi.org/10.1007/s12017-013-8275-5
32. Chen Y, Shapira R, Einstein M, Montville TJ (1997) Functional characterization of pediocin PA-1 binding to liposomes in the absence of a protein receptor and its relationship to a predicted tertiary structure. Appl Environ Microbiol 63:524–531
33. Chen F, Feng XH, Xu H, Zhang D, Ouyang PK (2012) Propionic acid production in a plant fibrous-bed bioreactor with immobilized Propionibacterium freudenreichii CCTCC M207015. J Biotechnol 164:202–210. https://doi.org/10.1016/j.jbiotec.2012.08.025
34. Chi Z, Liu J, Zhang W (2001) Trehalose accumulation from soluble starch by Saccharomycopsis fibuligera sdu. Enzyme Microb Tech 28:240–245. https://doi.org/10.1016/S0141-0229(00)00318-5
35. Chi Z, Liu J, Ji J, Meng Z (2003) Enhanced conversion of soluble starch to trehalose by a mutant of Saccharomycopsis fibuligera sdu. J Biotech 102:135–141. https://doi.org/10.1016/S0168-1656(03)00021-X
36. Chiliveri SR, Yeruva T, Panda SH, Linga VR (2010) Optimization of fermentation parameters for vitamin B12 production using Propionibacterium freudertreichii subsp. shermanii OLP-5 by Taguchi method. J Pure Appl Microbiol 4:647–658
37. Cintas LM, Casaus P, Herranz C, Nes IF, Hernandez PE (2001) Review: bacteriocins of lactic acid bacteria. Food Sci Tech Int 7:281–305
38. Cleveland J, Montville T, Nes IF, Chikindas M (2001) Bacteriocins: safe, natural antimicrobials for food preservation. Int J Food Microbiol 71:1–20. https://doi.org/10.1016/S0168-1605(01)00560-8
39. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA (2013) Multiplex genome engineering using CRISPR/Cas systems. Science 339:819–823. https://doi.org/10.1126/science.1231143
40. Cousin FJ, Jouan-Lanhouet S, Théret N (2016) The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. Oncotarget 7:7161–7178. 10.18632/oncotarget.6881
41. Crofts TS, Seth EC, Hazra AB, Taga ME (2013) Cobamide structure depends on both lower ligand availability and CobT substrate specificity. Chem Biol 20:1265–1274. https://doi.org/10.1016/j.chembiol.2013.08.006
42. Cybulska J, Zdunek A, Sitkiewicz I, Galus S, Janiszewska E, Łaba S, Nowacka M (2013) Możliwości zagospodarowywania wytłoków i innych odpadów przemysłu owocowo-warzywnego. Przem Ferm i Owoc-Warzyw 9:27–29
43. Czaczyk K, Trojanowska K, Stachowiak B (1997a) The effect of immobilization of propionic acid bacteria in alginate gel on the course of fermentation. Pol J Food Nutr Sci 4:55–60
44. Czaczyk K, Trojanowska K, Grajek W (1997b) The influence of a specific microelemental environment in alginate gel beads on the course of propionic acid fermentation. Appl Microbiol Biotechnol 48:630–635. https://doi.org/10.1007/s002530051107
45. Dalmasso M, Aubert J, Briard-Bion V, Chuat V, Deutsch SM, Even S, Falentin H, Jan G, Jardin J, Maillard MB, Parayre S, Piot M, Tanskanen J, Thierry A, Gilbert A (2012) A Temporal -omic Study of Propionibacterium freudenreichii CIRM-BIA1T Adaptation Strategies in Conditions Mimicking Cheese Ripening in the Cold. PLoS ONE 7(4):1–15. https://doi.org/10.1371/annotation/e0ff065d-a52d-44f2-8727-328393ed60b6
46. Daly DFM, McSweeney PLH, Sheehan JJ (2010) Split defect and secondary fermentation in Swiss-type cheeses: a review. Dairy Sci Technol 90:3–26. https://doi.org/10.1051/dst/2009036
47. 12 by Propionibacterium freudenreichii. Microb Cell Factories 14:1–12. https://doi.org/10.1186/s12934-015-0363-9
48. De Smet KAL, Weston W, Brown IN, Young D, Robertson BD (2000) Three pathways for trehalose biosynthesis in mycobacteria. Microbiology 146:199–208. https://doi.org/10.1099/00221287-146-1-199
49. de Virgilio C, Hottiger T, Dominguez J, Boller T, Wiemken A (1994) The role of trehalose synthesis for the acquisition of thermotolerance in yeast. FEBS J 219:179–186. https://doi.org/10.1111/j.1432-1033.1994.tb19928.x
50. De Vuyst L, Vandamme EJ (1994) Antimicrobial potential of lactic acid bacteria. In: de Vuyst L, Vandamme EJ (eds) Bacteriocins of lactic acid bacteria. Blackie Academic & Proffesional, London, pp 151–221
51. Dharmarajan TS, Adiga GU, Norkus EP (2003) Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Geriat 58:30–34
52. Divek VTN, Kollanoor-Johny A (2016) Effect of Propionibacterium freudenreichii on salmonella multiplication, motility, and association with avian epithelial cells1. Poult Sci 96:1376–1386. https://doi.org/10.3382/ps/pew367
53. Ekİncİ FY, Barefoot SF (1999) Production of bacteriocin jenseniin G by Propionibacterium is pH sensitive. Lett Appl Microbiol 29:176–180. https://doi.org/10.1046/j.1365-2672.1999.00609.x
54. Ekİncİ FY, Candoğan K (2014) Control of foodborne pathogens on fresh beef by jenseniin G, a bacteriocin produced by Propionibacterium thoenii (jensenii) P126. Ar Latinoam Prod Animal 22:210–213
55. Elbein AD, Pan YT, Pastuszak I, Carroll D (2003) New insights on trehalose: a multifunctional molecule. Glycobiology 13:17–24. https://doi.org/10.1093/glycob/cwg047
56. Erickson LE, Minkevich IG, Eroshin VK (1979) Utilization of mass-energy balance regularities in the analysis of continuous-culture data. Biotechnol Bioeng 21:575–591. https://doi.org/10.1002/bit.260210405
57. T, a hardy Actinobacterium with food and probiotic applications. PLoS One 5:1–12. https://doi.org/10.1371/journal.pone.0011748
58. Faye T, Langsrud T, Nes IF, Holo H (2000) Biochemical and genetic characterization of propionicin T1, a new bacteriocin from Propionibacterium thoenii. Appl Environ Microbiol 66:4230–4236. https://doi.org/10.1128/AEM.66.10.4230-4236.2000
59. Faye T, Brede DA, Lansgrud T, Nes IF, Holo H (2002) An antimicrobial peptide is produced by extracellular processing of a protein from Propionibacterium jensenii. J Bacteriol 184:3649–3656. https://doi.org/10.1128/JB.184.13.3649-3656.2002
60. Faye T, Lansgrud T, Nes IF, Holo H (2004) Prevalence of the genes encoding Propionicin T1 and protease-activated antimicrobial peptide and their expression in classical Propionibacteria. Appl Environ Microbiol 66:4230–4236. https://doi.org/10.1128/AEM.70.4.2240-2244.2004
61. Faye T, Holo H, Langsrud T (2011) The unconventional antimicrobial peptides of the classical propionibacteria. Appl Microbiol Biotechnol 89:549–554. https://doi.org/10.1007/s00253-010-2967-7
62. Feng X, Chen F, Xu H, Wu B, Li H, Li S, Ouyang P (2011) Green and economical production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 in plant fibrous-bed bioreactor. Bioresour Technol 102:6141–6146. https://doi.org/10.1016/j.biortech.2011.02.087
63. Fenech M (2001) The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res 475:57–67
64. Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N, Brok-Simoni F, Gadoth N, Sela BA, Seligsohn U (2003) High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel. Br J Haematol 123:696–701. https://doi.org/10.1046/j.1365-2141.2003.04658.x
65. Fröhlich-Wyder MT, Bachmann HP, Casey MG (2002) Interaction between propionibacteria and starter/non-starter lactic acid bacteria in Swiss-type cheeses. Lait 82:1–15. https://doi.org/10.1051/lait:2001001
66. González B, Arca P, Mayo B, Suárez JE (1994) Detection, purification, and partial characterization of plantaricin C, a bacteriocin produced by a Lactobacillus plantarum strain of dairy origin. Appl Environ Microbiol 60:2158–2163
67. Gardner N, Champagne CP (2005) Production of Propionibacterium shermanii biomass and vitamin B12 on spent media. J Appl Microbiol 99:1236–1245. https://doi.org/10.1111/j.1365-2672.2005.02696.x
68. Grinstead DA, Barefoot SF (1992) Jenseniin G, a heat-stable bacteriocin produced by Propionibacterium jensenii P126. Appl Environ Microbiol 1:215–220
69. Guan N, Liu L, Zhuge X, Xu Q, Li J, Du C, Chen J (2012) Genome shuffling improves acid tolerance of Propionibacterium acidipropionici and propionic acid production. Adv Chem Res 15:143–152
70. Guan N, Liu L, H-d S, Chen RR, Zhang J, Li J, Du G, Shi Z, Chen J (2013) Systems-level understanding how Propionibacterium acidipropionici respond to propionic acid stress at the microenvironment levels: mechanism and application. J Biotechnol 167:56–63. https://doi.org/10.1016/j.jbiotec.2013.06.008
71. Guan N, Shin HD, Chen RR, Li J, Liu L, Du G, Chen J (2014) Understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the level of proteomics. Sci Rep 6951:1–8. https://doi.org/10.1038/srep06951
72. Guan N, Li J, Shin H, Du G, Chen J, Liu L (2015a) Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii. Biotechnol Bioeng 113:1294–1304. https://doi.org/10.1002/bit.25902
73. Guan N, Li J, Shin H, Wu J, Du G, Shi Z, Liu L, Chen J (2015b) Comparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici. Metabolomics 11:1106–1116. https://doi.org/10.1007/s11306-014-0766-3
74. Guan N, Zhuge X, Li J (2015c) Engineering propionibacteria as versatile cell factories for the production of industrially important chemicals: advances, challenges, and prospects. Appl Microbiol Biotechnol 99:585–600. https://doi.org/10.1007/s00253-014-6228-z
75. Gwiazdowska D, Trojanowska K (2005) Bakteriocyny – właściwości i aktywność przeciwdrobnoustrojowa. Biotechnologia 68:114–130
76. Gwiazdowska D (2010) Biochemiczna i molekularna charakterystyka bakteriocyn wytwarzanych przez bakterie z rodzaju Propionibacterium. Biotechnologia 90:75–93
77. Hatanaka H, Wang E, Taniguchi M, Iijima S, Kobayashi T (1998) Production of vitamin B12 by a fermentor with a hollow-fiber module. Appl Microbiol Biotechnol 27:470–473. https://doi.org/10.1007/BF00451615
78. Higashiyama T (2002) Novel functions and applications of trehalose. Pure Appl Chem 74:1263–1269. https://doi.org/10.1351/pac200274071263
79. Himmi E, Bories A, Boussaid A, Hassani L (2000) Propionic acid fermentation of glycerol and glucose by Propionibacterium acidipropionici and Propionibacterium freudenreichii ssp. shermanii. Appl Microbiol Biotechnol 53:435–440
80. Hojo K, Watanabe R, Mori T, Taketomo N (2007) Quantitative measurement of tetrahydromenaquinone-9 in cheese fermented by propionibacteria. J Dairy Sci 90:4078–4083. https://doi.org/10.3168/jds.2006-892
81. Hsieh H, Paik H, Glatz B (1996) Improvement of detection and production of propionicin PLG-1, a bacteriocin produced by Propionibacterium thoenii. J Food Protect 7:734–738. https://doi.org/10.4315/0362-028X-59.7.734
82. Hsu ST, Yang ST (1991) Propionic acid fermentation of lactose by Propionibacterium acidipropionici: effects of pH. Biotechnol Bioeng 38:571–578. https://doi.org/10.1002/bit.260380603
83. Huang YL, Wu Z, Zhang L, Ming Cheung C, Yang ST (2002) Production of carboxylic acids from hydrolyzed corn meal by immobilized cell fermentation in a fibrous-bed bioreactor. Bioresour Technol 82:51–59
84. Hugenholtz J, Hunik J, Santos H, Smid E (2002) Nutraceutical production by propionibacteria. Lait 82:103–112. https://doi.org/10.1051/lait:2001009
85. Jack RW, Tagg JR, Ray B (1995) Bacteriocins of gram-positive bacteria. Microbiol Rev 59:171–200
86. Jan G, Leverrier P, Proudy I, Roland N (2002) Survival and beneficial effects of propionibacteria in the human gut: in vivo and in vitro investigations. Lait 82:131–144. https://doi.org/10.1051/lait:2001012
87. Jain NK, Roy I (2008) Effect of trehalose on protein structure. Protein Sci 18(1):24–36. https://doi.org/10.1002/pro.3
88. Jiang W, Bikard D, Cox D, Zhang F, Marraffini LA (2013) RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol 31:233–239. https://doi.org/10.1038/nbt.2508
89. Jin Z, Yang ST (1998) Extractive fermentation for enhanced propionic acid production from lactose by Propionibacterium acidipropionici. Biotechnol Prog 14:457–465. https://doi.org/10.1021/bp980026i
90. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337:816–821. https://doi.org/10.1126/science.1225829
91. Jordan PM (1994) Highlights in haem biosynthesis. Curr Opin Struct Biol 4:902–911
92. 12 by improved strains of Propionibacterium freudenreichii. Biotechnol Bioinf Bioeng 1:19–24
93. Klaenhammer TR (1993) Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev 12:39–86. https://doi.org/10.1016/0168-6445(93)90057-G
94. Klein C, Entian KD (1994) Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633. Appl Environ Microbiol 60:2793–2801
95. Knasmüller S, Verhagen H (2002) Impact of dietary on cancer causes and DNA integrity: new trends and aspects. Food Chem Toxicol 40:1047–1050
96. Kolling K, Ndrepepa G, Koch W, Braun S, Mehilli J, Schoming A, Kastrati A (2004) Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphism, plasma homocysteine, folate and vitamin B12 levels and the extent of coronary artery disease. Am J Cardiol 93:1201–1206. https://doi.org/10.1016/j.amjcard.2004.02.009
97. Kośmider A, Drożdżyńska A, Blaszka K, Leja K, Czaczyk K (2010) Propionic acid production by Propionibacterium freudenreichii ssp. shermanii using crude glycerol and whey lactose industrial wastes. Polish J of Environ Stud 19:1249–1253
98. 12 – budowa, biosynteza, funkcje i metody oznaczania. ŻNTJ 72:17–32
99. Kourkoutas Y, Xolias V, Kallis M, Bezirtzoglou E, Kanellaki M (2005) Lactobacillus casei cell immobilization on fruit pieces for probiotic additive, fermented milk and lactic acid production. Process Biochem 40:411–416. https://doi.org/10.1016/j.procbio.2004.01.029
100. Koussémon M, Combet-Blanc Y, Ollivier B (2003) Glucose fermentation by Propionibacterium microaerophilum: effect of pH on metabolism and bioenergetics. Curr Microbiol 46:141–145. https://doi.org/10.1007/s00284-002-3839-x
101. Kroger M, Meister K, Kava R (2006) Low-calorie sweeteners and other sugar substitutes: a review of the safety issues. Compr Rev Food Sci F 5:35–47. https://doi.org/10.1111/j.1541-4337.2006.tb00081.x
102. Kujawski M, Rymaszewski J, Cichosz G, Łaniewska-Moroz Ł, Fetliński A (1994) Wpływ bakterii fermentacji propionowej na tworzenie cech smakowo-zapachowych sera i twarogów. Przegl Mlecz 10:263–266
103. Kusano K, Yamada H, Niwa M, Yamasato K (1997) Propionibacterium cyclohexanicum sp. nov., a new acid-tolerant ω-Cyclohexyl fatty acid-containing Propionibacterium isolated from spoiled orange juice. Int J Sys Evol Microb 47:825–831. https://doi.org/10.1099/00207713-47-3-825
104. Lamm L, Heckman G, Renz P (1982) Biosynthesis of vitamin BI2 in anaerobic bacteria, mode of incorporation of glycine into the 5,6-dimethylbenzimidazole moiety in Eubacteviumlimosum. Eur J Biochem 22:569–571
105. Langsrud T, Sorhauq T, Vegarud GE (1995) Protein degradation and amine acid metabolism by propionibacteria. Lait 75:325–330. https://doi.org/10.1051/lait:19954-524
106. Lee J, Lin EW, Lau UY, Hedrick JL, Bat E, Maynard HD (2013) Trehalose glycopolymers as excipients for protein stabilization. Biomacromolecules 14:2561–2569. https://doi.org/10.1021/bm4003046
107. Leman J (2007) Podstawy technologii wybranych bioproduktów. In: Bednarski W, Fiedurek J (eds) Podstawy biotechnologii przemysłowej. WNT, Warszawa, pp 448–449
108. Leverrier P, Vissers JPC, Rouault A, Boyaval P, Jan G (2004) Mass spectrometry proteomic analysis of stress adaptation reveals both common and distinct response pathways in Propionibacterium freudenreichii. Arch Microbiol 181:215–230. https://doi.org/10.1007/s00203-003-0646-0
109. Lewis VP, Yang ST (1992) A novel extractive fermentation process for propionic acid production from whey lactose. Biotechnol Prog 8:104–110. https://doi.org/10.1021/bp00014a003
110. Li HW, Zang BS, Deng XW (2011) Overexpression of the trehalose-6-phosphate synthase gene OsTPS1 enhances abiotic stress tolerance in rice. Planta 234:1007–1018. https://doi.org/10.1007/s00425-011-1458-0
111. Liu R, Barkhordarian H, Emadi S, Park CB, Sierks MR (2005) Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. Neurobiol Dis 20:74–81. https://doi.org/10.1016/j.nbd.2005.02.003
112. Liu Z, Ma C, Gao C, Xu P (2012) Efficient utilization of hemicellulose hydrolysate for propionic acid production using Propionibacterium acidipropionici. Bioresour Technol 114:711–714. https://doi.org/10.1016/j.biortech.2012.02.118
113. Liu L, Zhuge X, Shin H, Chen RR, Li J, Du G, Chen J (2015) Improved production of propionic acid in Propionibacterium jensenii via combinational overexpression of glycerol dehydrogenase and malate dehydrogenase from Klebsiella pneumoniae. Appl Environ Microbiol 81:2256–2264. https://doi.org/10.1128/AEM.03572-14
114. Louie G, Brownlie P, Lambert R, Cooper JB, Blundell TL, Wood SP, Warren MJ, Woodcock SC, Jordan PM (1992) Structure of porphobilinogen deaminase reveals a flexible multi domain polymerase with a single catalytic site. Nature 359:33–39. https://doi.org/10.1038/359033a0
115. Lu P, Ma D, Chen Y, Guo Y, Chen GQ, Deng H, Shi Y (2013) L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia. Cell Res 23:635–644. https://doi.org/10.1038/cr.2013.13
116. Luggen AS (2006) Gerontologic nurse practicioner care guidelines: vitamin B12 deficiency in older adults. Geriat Nurs 27:32–33. https://doi.org/10.1016/j.gerinurse.2005.12.010
117. Lyon W, Glatz B (1991) Partial purification and characterization of a bacteriocin produced by Propionibacterium thoenii. Appl Environ Microbiol 57:701–706
118. Lyon W, Sethi JK, Glatz B (1993) Inhibition of psychotrophic ogranisms by propionisin PLG-1, a bacteriocin produced by Propionibacterium thoeni. J Dairy Sci 76:1506–1513
119. Makihara F, Tsuzuki M, Sato K (2005) Role of trehalose synthesis pathways in salt tolerance mechanism of Rhodobacter sphaeroides f. sp. denitrificans IL106. Arch Microbiol 184:56. https://doi.org/10.1007/s00203-005-0012-5
120. Mancini RJ, Lee J, Maynard HD (2011) Trehalose glycopolymers for stabilization of protein conjugates to environmental stressors. J Am Chem Soc 134:8474–8479. https://doi.org/10.1021/ja2120234
121. Mantere-Alhonen S (1995) Propionibacteria used as probiotics: a review. Lait 75:447–452. https://doi.org/10.1051/lait:19954-534
122. Marciset O, Jeronimus-Stratinh MC, Mollet B, Poolman B (1997) Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor. J Biol Chem 272:14277–14284. https://doi.org/10.1074/jbc.272.22.14277
123. Martens JH, Barg H, Warren MJ, Jahn D (2002) Microbial production of vitamin B12. Appl Microbiol Biotechnol 58:275–285. https://doi.org/10.1007/s00253-001-0902-7
124. Marwaha S, Sethi R, Kennedy J (1983) Influence of 5,6dimethylbenzimidazole (DMB) on vitamin B12 biosynthesis by strains of Propionibacterium. Enzym Microb Technol 5:361–364
125. Meile L, Dasen G, Miescher S, Stierli M, Teuber M (1999) Classification of propionic acid bacteria and approaches to applied genetics. Lait 79:71–78. https://doi.org/10.1051/lait:199915
126. Meile L, Gwenaelle LB, Thierry A (2008) Safety assessment of dairy microorganisms: Propionibacterium and Bifidobacterium. Int J Food Microbiol 126:316–320. https://doi.org/10.1016/j.ijfoodmicro.2007.08.019
127. Meynial-Salles I, Dorotyn S, Soucaille P (2008) A new process for the continuous production of succinic acid from glucose at high yield, titer and productivity. Biotechnol Bioeng 99:129–135. https://doi.org/10.1002/bit.21521
128. Miescher SM, Stierli MP, Teuber M, Meile L (2000) Propionicin SM1, a bacteriocin from Propionibacterium jensenii DF1: isolation and characterization of the protein and its gene. Syst Appl Microbiol 23:174–184. https://doi.org/10.1016/S0723-2020(00)80002-8
129. Miks-Krajnik MH (2012) Rola paciorkowców mlekowych i pałeczek propionowych w procesie dojrzewania sera typu szwajcarsko-holenderskiego. ŻNTJ 80:45–59
130. Miura Y, You C, Ohnishi R (2008) Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose. Sci Tech of Adv Mat 9:1–6. https://doi.org/10.1088/1468-6996/9/2/024407
131. Miyano K, Ye K, Shimizu K (2000) Improvement of vitamin B12 fermentation by reducing in the inhibitory metabolites by cell recycle system and mixed culture. J Biochem Eng 6:207–214. https://doi.org/10.1016/S1369-703X(00)00089-9
132. Moll GN, Konings WN, Driessen AJ (1999) Bacteriocins: mechanism of membrane insertion and pore formation. Anton Leeuw Int J G 69:185–191. https://doi.org/10.1023/A:1002002718501
133. Morgan SM, Galvin M, Kelly J, Sletten K, Hill C (1999) Development of a lacticin 3147-enriched whey powder with inhibitory activity against foodborne pathogens. J Food Protect 62:1011–1016. https://doi.org/10.4315/0362-028X-62.9.1011
134. Murooka Y, Piao Y, Kiatpapan P, Yamashita M (2005) Production of tetrapyrrole compounds and vitamin B12 using genetically engineering of Propionibacterium freudenreichii. Lait 85:9–22. https://doi.org/10.1051/lait:2004035
135. Nakano K, Kataoka H, Matsumara M (1996) High density culture of Propionibacterium freudenreichii coupled with propionic acid removal system with activated charcoal. J Ferment Bioeng 81:37–41. https://doi.org/10.1016/0922-338X(96)83117-5
136. Neumann VC, Heath HE, LeBlanc PA, Sloan GL (1993) Extracellular proteolytic activation of bacteriolytic peptidoglycan hydrolases of Staphylococcus simulans biovar staphylolyticus. FEMS Microbiol Lett 110:205–211
137. Nielsen H, Engelbrecht S, Brunak S, von Heijne G (1997) Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng 10:1–6
138. Ortigues-Marty I, Thomas E, Prévéraud DP, Girard CL, Bauchart D, Durand D, Peyron A (2006) Influence of maturation and cooking treatments on the nutritional value of bovine meats: water losses and vitamin B12. Meat Sci 73:451–458. https://doi.org/10.1016/j.meatsci.2006.01.003
139. Othake S, Wang YJ (2010) Trehalose: current use and future applications. J Pharm Sci 100:2020–2053. https://doi.org/10.1002/jps.22458
140. Ousterout DG, Kabadi AM, Thakore PI, Majoros WH, Reddy TE, Gersbach CA (2014) Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy. Nat Commun 6244:1–13. https://doi.org/10.1038/ncomms7244
141. Paoloni-Giacombino A, Grimble R, Pichard C (2003) Genetics and nutrition. Clinic Nutr 22:429–435
142. Piao Y, Kiatpapan P, Yamashita M, Murooka Y (2004a) Effects of expression of hemA and hemB genes on production of porphyrin in Propionibacterium freudenreichii. Appl Environ Microbiol 70:7561–7566. https://doi.org/10.1128/AEM.70.12.7561-7566.2004
143. Piao Y, Yamashita M, Kawaraichi N, Asegawa R, Ono H, Murooka Y (2004b) Production of vitamin B12 in genetically engineered Propionibacterium freudenreichii. J Biosci Bioeng 98:167–173. https://doi.org/10.1016/S1389-1723(04)00261-0
144. Piveteau P (1999) Metabolism of lactate and sugars by dairy propionibacteria: a review. Lait 79:33–41. https://doi.org/10.1051/lait:199912
145. Piwowarek K, Lipińska E (2015) Bakterie propionowe użyteczne w przemyśle spożywczym. Przem Spoż 60:26–30. 10.15199/65.2015.5.4
146. Piwowarek K, Lipińska E, Hać-Szymańczuk E (2016) Possibility of using apple pomaces in the process of propionic-acetic fermentation. Electron J Biotechnol 23:1–6. https://doi.org/10.1016/j.ejbt.2016.07.004
147. Qu Q, Lee SJ, Boos W (2004) TreT, a novel Trehalose Glycosyltransferring synthase of the Hyperthermophilic Archaeon Thermococcus litoralis. J Biol Chem 279:47890–47897. https://doi.org/10.1074/jbc.M404955200
148. Quesada-Chanto A, Afschar S, Wagner F (1994) Microbial production of propionic acid and vitamin B12 using molasses or sugar. Appl Microbiol Biotechnol 41:378–383. https://doi.org/10.1007/BF01982523
149. Ramsay J, Aly Hassan M, Ramsay B (1998) Biological conversion of hemicellulose to propionic acid. Enzym Microb Technol 22:292–295. https://doi.org/10.1016/S0141-0229(97)00196-8
150. Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (2013) Genome engineering usingt he CRISPR-Cas9 system. Nat Protoc 8:2281–2308. https://doi.org/10.1038/nprot.2013.143
151. Ranadheera RDCS, Baines SK, Adams MC (2010) Importance of food in probiotic efficacy. Food Res Int 43:1–7. https://doi.org/10.1016/j.foodres.2009.09.009
152. Ratnam P, Barefoot S, Prince L, Bodine A, McCaskill LH (1999) Partial purification and characterization of a bacteriocin produced by Propionibacterium jenseni B1264. Lait 79:125–136. https://doi.org/10.1051/lait:1999110
153. Raux E, Lanois A, Levillayer F, Warren MJ, Brody E, Rambach A, Thermes C (1996) Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli. J Bacteriol 178:753–767
154. Raux E, Lanois A, Rambach A, Warren A, Hermes C (1998) Cobalamin (vitamin B12) biosynthesis: identification and characterization of Bacillus megaterium cobI operon. Biochem J 335:159–166
155. Raux E, Schubert HL, Roper JM, Wilson KS, Warren MJ (1999) Vitamin B12: insights into biosynthesis’s mount improbable. Bioorg Chem 27:100–118. https://doi.org/10.1006/bioo.1998.1125
156. Reichardt N, Duncan S, Young P, Belenguer A, McWilliam Leitch C, Scott C, Flint H, Louis P (2014) Phylogenetic distribution of three pathways for propionate production within the human gut microbiota. ISME J 8:1323–1335. https://doi.org/10.1038/ismej.2014.14
157. Rince A, Dufour A, Uguen P, le Pennec JP, Haras D (1997) Characterization of the lacticin 481 operon: the Lactococcus lactis genes lctF, lctE, and lctG encode a putative ABC transporter involved in bacteriocin immunity. Appl Environ Microbiol 63:4252–4260
158. Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS (2003) Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes. J Biol Chem 278:41148–41159. https://doi.org/10.1074/jbc.M305837200
159. Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI (2002) Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) of Propionibacterium freidenreichii (P. shermani). Microbiology 148:1845–1853
160. Roman RV, Iluc E, Mustea A, Neacsu A, Asandului V (2001) Optimisation of medium components in vitamin B12 biosynthesis. Roum Biotechnol Lett 6:343–350
161. Roth JR, Lawrence JG, Rubenfield M, Dieffer-Higgins S, Church GM (1993) Characterization of cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J Bacteriol 175:3303–3316
162. Ruhal R, Aggarwal S, Choudhury B (2011) Suitability of crude glycerol obtained from biodiesel waste for the production of trehalose and propionic acid. Green Chem 12:3492–3498. https://doi.org/10.1039/C1GC15847C
163. Ruhal R, Choudhury B (2012a) Use of an osmotically sensitive mutant of Propionibacterium freudenreichii subsp. shermanii for the simultaneous productions of organic acids and trehalose from biodiesel waste based crude glycerol. Bioresour Technol 109:131–139. https://doi.org/10.1016/j.biortech.2012.01.039
164. Ruhal R, Choudhury B (2012b) Improved trehalose production from biodiesel waste using parent and osmotically sensitive mutant of Propionibacterium freudenreichii subsp. shermanii under aerobic conditions. J Ind Microbiol Biotechnol 39:1153–1160. https://doi.org/10.1007/s10295-012-1124-y
165. Ruhal R, Kataria R, Choudhury B (2013) Trends in bacterial trehalose metabolism and significant nodes of metabolic pathway in the direction of trehalose accumulation. Microb Biotechnol 6:493–502. https://doi.org/10.1111/1751-7915.12029
166. Ryan MP, Jack RW, Josten M, Sahl HG, Jung G, Ross RP, Hill C (1999) Extensive post-translational modification, including serine to D-alanine conversion, in the two-component lantibiotic, lacticin 3147. J Biol Chem 274:37544–37550
167. Ryu SI, Park CS, Cha J, Woo EJ, Lee SB (2005) A novel trehalose-synthesizing glycosyltransferase from Pyrococcus horikoshii: molecular cloning and characterization. Biochem Bioph Res Co 329:429–436. https://doi.org/10.1016/j.bbrc.2005.01.149
168. Santos F, Vera JL, Lamosa P, de Valdez GF, de Vos WM, Santos H (2007) Pseudovitamin B12 is the corrinoid produced by Lactobacillus reuteri CRL1098 under anaerobic conditions. FEBS Lett 58:4865–4870. https://doi.org/10.1016/j.febslet.2007.09.012
169. Sattler I, Roessner CA, Stolowich NJ, Hardin SH, Haris-Haller LW, Yokubaitis NT, Murooka Y, Hashimoto Y, Scott AI (1995) Cloning, sequencing, and expression of the uroporphyrinogen III metyltransferase cobA gene of Propionibacterium freidenreichii (shermani). J Bacteriol 177:1564–1569
170. Schillinger U, Geisen R, Holzapfel WH (1996) Potential of antagonistic microorganisms and bacteriocins for the biological preservation of foods. Trends Food Sci 7:158–164. https://doi.org/10.1016/0924-2244(96)81256-8
171. Scott AI (1994) The discovery of nature’s pathway to vitamin B12. A 25 year odyssey. Tetrahedron 50:13315–13333. https://doi.org/10.1016/S0040-4020(01)89341-8
172. Seidametova E, Shakirzyanova M, Ruzieva D, Gulyamova T (2004) Isolation of cobalt-resistant strains of propionic acid bacteria, potent producers of vitamin B12. Appl Biochem Biotechnol 40:560–562. https://doi.org/10.1023/B:ABIM.0000046990.49021.07
173. Siegers K, Entian KD (1995) Genes involved in immunity to the lantibiotic nisin produced by Lactococcus lactis 6F3. Appl Environ Microbiol 61:1082–1089
174. Sip A, Krasowska M, Więckiewicz M (2009) Zastosowanie bakteriocyn klasy IIa bakterii fermentacji mlekowej. Biotechnologia 86:129–147
175. Smith AG, Croft MT, Moulin M, Webb ME (2007) Plants need their vitamins too. Curr Opin Plant Biol 10:266–275. https://doi.org/10.1016/j.pbi.2007.04.009
176. Stjernholm R (1958) Formation of trehalose during dissimilation of glucose by Propionibacterium. ACTA Chem Scan 12:646–649
177. Strom AR, Kaasen (1993) Trehalose metabolism in Escherichia coli: stress protection and stress regulation of gene expression. Mol Microbiol 8:205–210. https://doi.org/10.1111/j.1365-2958.1993.tb01564.x
178. Suomalainen TH, Sigvart-Mattila P, Mättö J, Tynkkynen S (2008) In vitro and in vivo gastrointestinal survival, antibiotic susceptibility and genetic identification of Propionibacterium freudenreichii ssp. shermanii JS. Int Dairy J 18:271–278. https://doi.org/10.1016/j.idairyj.2007.09.004
179. Suwannakham S, Yang S (2005) Enhanced propionic acid fermentation by Propionibacterium acidipropionici mutant obtained by adaptation in a fibrous-bed bioreactor. Biotechnol Bioeng 91:325–337. https://doi.org/10.1002/bit.20473
180. Suwannakham S, Huang Y, Yang ST (2006) Construction and characterization of ack knock-out mutants of Propionibacterium acidipropionici for enhanced propionic acid fermentation. Biotechnol Bioeng 94:383–395. https://doi.org/10.1002/bit.20866
181. Teramoto N, Sachinvala ND, Shibata M (2008) Trehalose and trehalose-based polymers for environmentally benign, biocompatible and bioactive materials. Molecules 13:1773–1816. https://doi.org/10.3390/molecules13081773
182. Thierry A, Maillard MB (2002) Production of cheese flavour compounds derived from amino acid catabolism by Propionibacterium freudenreichii. Lait 82:17–32. https://doi.org/10.1051/lait:2001002
183. Thierry A, Maillard MB, Richoux R, Kerjean JR, Lortal S (2005) Propionibacterium freudenreichii strains quantitatively affect production of volatile compounds in Swiss cheese. Lait 85:57–74. https://doi.org/10.1051/lait:2004036
184. 12. World J Microbiol Biotechnol 28:2267–2271. https://doi.org/10.1007/s11274-012-1011-8
185. Trojanowska K, Czaczyk K (1996) The effect of Co++, Mg ++, Zn ++, Mn++, Fe++ ions on the course of propionic acid fermentation. Ann Univ Agric Poznan 20:25–34
186. Upreti GC (1994) In: de Vuyst L, Vandamme EJ (eds) Bacteriocins of lactic acid bacteria. Blackie Academic& Proffesionals, London, pp 331–335
187. van der Merwe IR, Bauer R, Britz TJ, Dicks LMT (2004) Characterization of Thoeniicin 447, a bacteriocin isolated from Propionibacterium thoenii strain 447. Int J Food Microbiol 92:153–160. https://doi.org/10.1016/j.ijfoodmicro.2003.09.004
188. Van Luijk N, Stierli MP, Schwenninger SM, Hervé C, Dasen G, Jore JP, Pouwels PH, Van Der Werf MJ, Teuber M, Meile L (2002) Genetics and molecular biology of propionibacteria. Lait 82:45–57. https://doi.org/10.1051/lait:201004
189. Van Wyk J, Witthuhn RC, Britz TJ (2011) Optimisation of vitamin B12 and folate production by Propionibacterium freudenreichii strains in kefir. Int Dairy J 21:69–74. https://doi.org/10.1016/j.idairyj.2010.09.004
190. von Heijne G (1988) Transcending the impenetrable: how proteins come to terms with membranes. Biochim Biophys Acta 947:307–333. https://doi.org/10.1016/0304-4157(88)90013-5
191. Wang P, Wang Y, Liu Y, Shi H, Su Z (2012) Novel in situ product removal technique for simultaneous production of propionic acid and vitamin B12 by expanded bed adsorption bioreactor. Bioresour Technol 104:652–659. https://doi.org/10.1016/j.biortech.2011.10.047
192. Wang Z, Sun J, Zhang A, Yang ST (2013) Propionic acid fermentation. In: Yang ST, El-Enshasy HA, Thongchul N (eds) Bioprocessing technologies in biorefinery for sustainable production of fuels, chemicals, and polymers. Wiley, New York, pp 331–334
193. Wang Z, Yang ST (2013) Propionic acid production in glycerol/glucose co-fermentation by Propionibacterium freudenreichii subsp. shermanii. Bioresour Technol 137:116–123. https://doi.org/10.1016/j.biortech.2013.03.012
194. Wang G, Abercrombie JG, Huang G (2014) Enhanced fed-batch production, partial purification, characterization of jenseniin P, and discovery of a new bacteriocin-like substance produced by Propionibacterium jensenii B1264. Eur Food Res Technol 239:79–86. https://doi.org/10.1007/s00217-014-2199-7
195. Wang Z, Ammar EM, Zhang A, Wang L, Lin M, Yang ST (2015b) Engineering Propionibacterium freudenreichii subsp. shermanii for enhanced propionic acid fermentation: effects of overexpressing propionyl-CoA:succinate CoA transferase. Metab Eng 27:46–56. https://doi.org/10.1016/j.ymben.2014.10.005
196. Wang Z, Lin M, Wang L, Ammar EM, Yang ST (2015a) Metabolic engineering of Propionibacterium freudenreichii subsp. shermanii for enhanced propionic acid fermentation: effects of overexpressing three biotin-dependent carboxylases. Process Biochem 50:194–204. https://doi.org/10.1016/j.procbio.2014.11.012
197. Wang P, Zhang Z, Jiao Y, Liu S, Wang Y (2015) Improved propionic acid and 5,6-dimethylbenzimidazole control strategy for vitamin B12 fermentation by Propionibacterium freudenreichii. J Biotechnol 193:123–129. https://doi.org/10.1016/j.jbiotec.2014.11.019
198. Warren MJ, Roessner CA, Santander PJ, Scott AI (1990) The Escherichia coli cysG gene encodesS-adenosyl-methionine-dependent uroporphyrinogen III methylase. Biochem J 165:725–729
199. Warren MJ, Cooper JB, Woods SP, Shoolingin-Jordan PM (1998) Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase. Trends Biochem Sci 23:217–221
200. Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002) The biosynthesis of adenosylcobalamin (vitamin B12). Nat Prod Rep 19:390–412. https://doi.org/10.1039/B108967F
201. Wei P, Lin M, Wang Z, Fu H, Yang H, Jiang W, Yang ST (2016) Metabolic engineering of Propionibacterium freudenreichii subsp. shermanii for xylose fermentation. Bioresour Technol 219:91–97. https://doi.org/10.1016/j.biortech.2016.07.056
202. Wiedenheft B, Sternberg SH, Jennifer A, Doudna JA (2012) RNA-guided genetic silencing systems in bacteria and archaea. Nature 482:331–338. https://doi.org/10.1038/nature10886
203. Weinbrenner DR, Barefoot SF, Grinstead DA (1997) Inhibition of yoghurt starter cultures by jenseniin G, a Propionibacterium bacteriocins. J Dairy Sci 80:1246–1253. https://doi.org/10.3168/jds.S0022-0302(97)76053-3
204. Wolf A, Krämer R, Morbach S (2003) Three pathways for trehalose metabolism in Corynebacterium glutamicum ATCC13032 and their significance in response to osmotic stress. Mol Microbiol 49:1119–1134. https://doi.org/10.1046/j.1365-2958.2003.03625.x
205. Yang ST, Huang Y (1995) A novel recycle batch immobilized cell bioreactor for propionate production from whey lactose. Biotechnol Bioeng 45:379–386. https://doi.org/10.1002/bit.260450502
206. Yazdani SS, Gonzales R (2007) Anaerobic fermentation of glycerol: a path to economic viability for the biofuels industry. Curr Opini Biotech 18:213–219. https://doi.org/10.1016/j.copbio.2007.05.002
207. Yu WB, Jiang T, Lan DM, Lu JH, Yue ZY, Wang J, Zhou P (2012) Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils. Arch Biochem Bioph 523:144–150. https://doi.org/10.1016/j.abb.2012.04.021
208. Yu Y, Zhu X, Shen Y (2015) Enhancing the vitamin B12 production and growth of Propionibacterium freudenreichii in tofu wastewater via a light-induced vitamin B12 riboswitch. Appl Microbiol Biotechnol 99:10481–10488. https://doi.org/10.1007/s00253-015-6958-6
209. Zang C, Brandt M, Schwab C, Ganzle M (2010) Propionic acid production by cofermentation of Lactobacillus buchneri and Lactobacillus diolivorans in sourdough. Food Microbiol 27:390–395. https://doi.org/10.1016/j.fm.2009.11.019
210. Zárate G, Pérez-Chaia A, Oliver G (2002) Some characteristics of practical relevance of the α-galactosidase from potential probiotic strains of Propionibacterium acidipropionici. Anaerobe 8:259–267. https://doi.org/10.1006/anae.2002.0440
211. Zhang ST, Matsuoka H, Toda K (1993) Production and recovery of propionic and acetic acid in electrodialysis culture of Propionibacterium shermani. J Ferment Bioeng 75:276–282. https://doi.org/10.1016/0922-338X(93)90151-W
212. Zhang A, Yang ST (2009) Engineering Propionibacterium acidipropionici for enhanced propionic acid tolerance and fermentation. Biotechnol Bioeng 104:766–777. https://doi.org/10.1002/bit.22437
213. Zhu Y, Li J, Tan M, Liu L, Jiang L, Sun J, Lee P, Du G, Chen J (2010) Optimization and scale-up of propionic acid production by propionic acid-tolerant Propionibacterium acidipropionici with glycerol as the carbon source. Bioresour Technol 101:8902–8906. https://doi.org/10.1016/j.biortech.2010.06.070
214. Zhu L, Wei P, Cai J, Zhu X, Wang Z, Huang L, Xu Z (2012) Improving the productivity of propionic acid with FBB-immobilized cells of an adapted acid-tolerant Propionibacterium acidipropionici. Bioresour Technol 112:248–253. https://doi.org/10.1016/j.biortech.2012.01.055