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Volumn 18, Issue 11, 2017, Pages

ABC transporters in cancer stem cells: Beyond chemoresistance

Author keywords

ABC transporters; Cancer stem cells; Cell signalling; Chemoresistance

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER A7; ACETYL COENZYME A; ALDEHYDE DEHYDROGENASE; ANTIGEN PEPTIDE TRANSPORTER 2; CD133 ANTIGEN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; OCTAMER TRANSCRIPTION FACTOR 4; PEPTIDES AND PROTEINS; TRANSCRIPTION FACTOR SOX2; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

EID: 85033574271     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18112362     Document Type: Review
Times cited : (280)

References (173)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R.A.; McGranahan, N.; Bartek, J.; Swanton, C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 2013, 501, 338-345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 3
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham, C.E.; Morrison, S.J. Tumour heterogeneity and cancer cell plasticity. Nature 2013, 501, 328-337.
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 5
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan, D.; Coussens, L.M. Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21, 309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 9
    • 79953191123 scopus 로고    scopus 로고
    • Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation
    • Copsel, S.; Garcia, C.; Diez, F.; Vermeulem, M.; Baldi, A.; Bianciotti, L.G.; Russel, F.G.M.; Shayo, C.; Davio, C. Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation. J. Biol. Chem. 2011, 286, 6979-6988.
    • (2011) J. Biol. Chem , vol.286 , pp. 6979-6988
    • Copsel, S.1    Garcia, C.2    Diez, F.3    Vermeulem, M.4    Baldi, A.5    Bianciotti, L.G.6    Russel, F.G.M.7    Shayo, C.8    Davio, C.9
  • 12
    • 84910084359 scopus 로고    scopus 로고
    • Multidrug resistance protein 4/ATP binding cassette transporter 4: A new potential therapeutic target for acute myeloid leukemia
    • Copsel, S.; Bruzzone, A.; May, M.; Beyrath, J.; Wargon, V.; Cany, J.; Russel, F.G.M.; Shayo, C.; Davio, C. Multidrug resistance protein 4/ATP binding cassette transporter 4: A new potential therapeutic target for acute myeloid leukemia. Oncotarget 2014, 5, 9308-9321.
    • (2014) Oncotarget , vol.5 , pp. 9308-9321
    • Copsel, S.1    Bruzzone, A.2    May, M.3    Beyrath, J.4    Wargon, V.5    Cany, J.6    Russel, F.G.M.7    Shayo, C.8    Davio, C.9
  • 15
    • 59149089885 scopus 로고    scopus 로고
    • The role of ATP binding cassette transporters in tissue defense and organ regeneration
    • Huls, M.; Russel, F.G.M.; Masereeuw, R. The role of ATP binding cassette transporters in tissue defense and organ regeneration. J. Pharmacol. Exp. Ther. 2009, 328, 3-9.
    • (2009) J. Pharmacol. Exp. Ther , vol.328 , pp. 3-9
    • Huls, M.1    Russel, F.G.M.2    Masereeuw, R.3
  • 16
    • 84925285641 scopus 로고    scopus 로고
    • What do drug transporters really do?
    • Nigam, S.K. What do drug transporters really do? Nat. Rev. Drug Discov. 2015, 14, 29-44.
    • (2015) Nat. Rev. Drug Discov , vol.14 , pp. 29-44
    • Nigam, S.K.1
  • 23
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean, M.; Fojo, T.; Bates, S. Tumour stem cells and drug resistance. Nat. Rev. Cancer 2005, 5, 275-284.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 25
    • 0014078332 scopus 로고
    • Studies of cellular proliferation in human leukemia. I. Estimation of growth rates of leukemic and normal hematopoietic cells in two adults with acute leukemia given single injections of tritiated thymidine
    • Clarkson, B.; Ohkita, T.; Ota, K.; Fried, J. Studies of cellular proliferation in human leukemia. I. Estimation of growth rates of leukemic and normal hematopoietic cells in two adults with acute leukemia given single injections of tritiated thymidine. J. Clin. Investig. 1967, 46, 506-529.
    • (1967) J. Clin. Investig , vol.46 , pp. 506-529
    • Clarkson, B.1    Ohkita, T.2    Ota, K.3    Fried, J.4
  • 27
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D.; Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3, 730-737.
    • (1997) Nat. Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 31
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O’Brien, C.A.; Pollett, A.; Gallinger, S.; Dick, J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445, 106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O’Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 34
    • 84857789336 scopus 로고    scopus 로고
    • Understanding cancer stem cell heterogeneity and plasticity
    • Tang, D.G. Understanding cancer stem cell heterogeneity and plasticity. Cell Res. 2012, 22, 457-472.
    • (2012) Cell Res , vol.22 , pp. 457-472
    • Tang, D.G.1
  • 35
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suvà, M.L.; Riggi, N.; Bernstein, B.E. Epigenetic reprogramming in cancer. Science 2013, 339, 1567-1570.
    • (2013) Science , vol.339 , pp. 1567-1570
    • Suvà, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 36
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: The challenges ahead
    • Medema, J.P. Cancer stem cells: The challenges ahead. Nat. Cell Biol. 2013, 15, 338-344.
    • (2013) Nat. Cell Biol , vol.15 , pp. 338-344
    • Medema, J.P.1
  • 37
    • 84862517728 scopus 로고    scopus 로고
    • Cancer Stem Cells: Current Status and Evolving Complexities
    • Visvader, J.E.; Lindeman, G.J. Cancer Stem Cells: Current Status and Evolving Complexities. Cell Stem Cell 2012, 10, 717-728.
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 39
    • 84892814234 scopus 로고    scopus 로고
    • Chromatin modifiers and remodellers: Regulators of cellular differentiation
    • Chen, T.; Dent, S.Y.R. Chromatin modifiers and remodellers: Regulators of cellular differentiation. Nat. Rev. Genet. 2014, 15, 93-106.
    • (2014) Nat. Rev. Genet , vol.15 , pp. 93-106
    • Chen, T.1    Dent, S.Y.R.2
  • 40
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta, P.B.; Fillmore, C.M.; Jiang, G.; Shapira, S.D.; Tao, K.; Kuperwasser, C.; Lander, E.S. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 2011, 146, 633-644.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 41
    • 84876801482 scopus 로고    scopus 로고
    • Biology and clinical applications of pancreatic cancer stem cells
    • Abel, E.V.; Simeone, D.M. Biology and clinical applications of pancreatic cancer stem cells. Gastroenterology 2013, 144, 1241-1248.
    • (2013) Gastroenterology , vol.144 , pp. 1241-1248
    • Abel, E.V.1    Simeone, D.M.2
  • 42
    • 84948753065 scopus 로고    scopus 로고
    • Overcoming Multidrug Resistance in Cancer Stem Cells
    • Moitra, K. Overcoming Multidrug Resistance in Cancer Stem Cells. BioMed Res. Int. 2015, 2015, 635745.
    • (2015) BioMed Res. Int , vol.2015 , pp. 635745
    • Moitra, K.1
  • 43
    • 2542491777 scopus 로고    scopus 로고
    • The Role of ABC Transporters in Drug Resistance, Metabolism and Toxicity
    • Glavinas, H.; Krajcsi, P.; Cserepes, J.; Sarkadi, B. The Role of ABC Transporters in Drug Resistance, Metabolism and Toxicity. Curr. Drug Deliv. 2004, 1, 27-42.
    • (2004) Curr. Drug Deliv , vol.1 , pp. 27-42
    • Glavinas, H.1    Krajcsi, P.2    Cserepes, J.3    Sarkadi, B.4
  • 44
    • 78651383853 scopus 로고    scopus 로고
    • The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
    • Piñeiro, R.; Maffucci, T.; Falasca, M. The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. Oncogene 2011, 30, 142-152.
    • (2011) Oncogene , vol.30 , pp. 142-152
    • Piñeiro, R.1    Maffucci, T.2    Falasca, M.3
  • 46
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug Resistance in Cancer: Role of ATP-Dependent transporters
    • Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug Resistance in Cancer: Role of ATP-Dependent transporters. Nat. Rev. Cancer 2002, 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 47
    • 0034917716 scopus 로고    scopus 로고
    • The Human ATP-Binding Cassette (ABC) Transporter Superfamily
    • Dean, M.; Rzhetsky, A.; Allikmets, R. The Human ATP-Binding Cassette (ABC) Transporter Superfamily. Genome Res. 2001, 11, 1156-1166.
    • (2001) Genome Res , vol.11 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 48
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins, C.F. ABC transporters: From microorganisms to man. Annu. Rev. Cell Biol. 1992, 8, 67-113.
    • (1992) Annu. Rev. Cell Biol , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 49
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho, M.M.; Ng, A.V.; Lam, S.; Hung, J.Y. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res. 2007, 67, 4827-4833.
    • (2007) Cancer Res , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 50
    • 77950862035 scopus 로고    scopus 로고
    • Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant
    • Hu, L.; McArthur, C.; Jaffe, R.B. Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br. J. Cancer 2010, 102, 1276-1283.
    • (2010) Br. J. Cancer , vol.102 , pp. 1276-1283
    • Hu, L.1    McArthur, C.2    Jaffe, R.B.3
  • 52
    • 0037079708 scopus 로고    scopus 로고
    • The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    • Scharenberg, C.W.; Harkey, M.A.; Torok-Storb, B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 2002, 99, 507-512.
    • (2002) Blood , vol.99 , pp. 507-512
    • Scharenberg, C.W.1    Harkey, M.A.2    Torok-Storb, B.3
  • 53
    • 75849125982 scopus 로고    scopus 로고
    • Breast cancer chemoresistance: Emerging importance of cancer stem cells
    • Chuthapisith, S.; Eremin, J.; El-Sheemey, M.; Eremin, O. Breast cancer chemoresistance: Emerging importance of cancer stem cells. Surg. Oncol. 2010, 19, 27-32.
    • (2010) Surg. Oncol , vol.19 , pp. 27-32
    • Chuthapisith, S.1    Eremin, J.2    El-Sheemey, M.3    Eremin, O.4
  • 54
    • 84922394984 scopus 로고    scopus 로고
    • Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population
    • Eyre, R.; Harvey, I.; Stemke-hale, K.; Lennard, T.W.; Tyson-capper, A.; Meeson, A.P. Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population. Tumor Biol. 2014, 35, 9879-9892.
    • (2014) Tumor Biol , vol.35 , pp. 9879-9892
    • Eyre, R.1    Harvey, I.2    Stemke-Hale, K.3    Lennard, T.W.4    Tyson-Capper, A.5    Meeson, A.P.6
  • 57
    • 84876880512 scopus 로고    scopus 로고
    • Differences in transcript levels of ABC transporters between pancreatic adenocarcinoma and nonneoplastic tissues
    • Mohelnikova-Duchonova, B.; Brynychova, V.; Oliverius, M.; Honsova, E.; Kala, Z.; Muckova, K.; Soucek, P. Differences in transcript levels of ABC transporters between pancreatic adenocarcinoma and nonneoplastic tissues. Pancreas 2013, 42, 707-716.
    • (2013) Pancreas , vol.42 , pp. 707-716
    • Mohelnikova-Duchonova, B.1    Brynychova, V.2    Oliverius, M.3    Honsova, E.4    Kala, Z.5    Muckova, K.6    Soucek, P.7
  • 61
    • 84889068294 scopus 로고    scopus 로고
    • Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants
    • Quazi, F.; Molday, R.S. Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J. Biol. Chem. 2013, 288, 34414-34426.
    • (2013) J. Biol. Chem , vol.288 , pp. 34414-34426
    • Quazi, F.1    Molday, R.S.2
  • 62
    • 33748746595 scopus 로고    scopus 로고
    • ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis
    • Iwamoto, N.; Abe-Dohmae, S.; Sato, R.; Yokoyama, S. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J. Lipid Res. 2006, 47, 1915-1927.
    • (2006) J. Lipid Res , vol.47 , pp. 1915-1927
    • Iwamoto, N.1    Abe-Dohmae, S.2    Sato, R.3    Yokoyama, S.4
  • 63
    • 84947228722 scopus 로고    scopus 로고
    • Understanding the function of ABCA7 in Alzheimer’s disease
    • Li, H.; Karl, T.; Garner, B. Understanding the function of ABCA7 in Alzheimer’s disease. Biochem. Soc. Trans. 2015, 43, 920-923.
    • (2015) Biochem. Soc. Trans , vol.43 , pp. 920-923
    • Li, H.1    Karl, T.2    Garner, B.3
  • 66
  • 68
    • 84955207765 scopus 로고    scopus 로고
    • CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro
    • Xi, G.; Hayes, E.; Lewis, R.; Ichi, S.; Mania-Farnell, B.; Shim, K.; Takao, T.; Allender, E.; Mayanil, C.S.; Tomita, T. CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro. Oncogene 2016, 35, 241-250.
    • (2016) Oncogene , vol.35 , pp. 241-250
    • Xi, G.1    Hayes, E.2    Lewis, R.3    Ichi, S.4    Mania-Farnell, B.5    Shim, K.6    Takao, T.7    Allender, E.8    Mayanil, C.S.9    Tomita, T.10
  • 69
    • 84930520744 scopus 로고    scopus 로고
    • Lapatinib enhances the cytotoxic effects of doxorubicin in MCF-7 tumorspheres by inhibiting the drug efflux function of ABC transporters
    • Chun, S.-Y.; Kwon, Y.-S.; Nam, K.-S.; Kim, S. Lapatinib enhances the cytotoxic effects of doxorubicin in MCF-7 tumorspheres by inhibiting the drug efflux function of ABC transporters. Biomed. Pharmacother. 2015, 72, 37-43.
    • (2015) Biomed. Pharmacother , vol.72 , pp. 37-43
    • Chun, S.-Y.1    Kwon, Y.-S.2    Nam, K.-S.3    Kim, S.4
  • 70
    • 84962232304 scopus 로고    scopus 로고
    • PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P
    • Huang, B.; Fu, S.J.; Fan, W.Z.; Wang, Z.H.; Chen, Z.B.; Guo, S.J.; Chen, J.X.; Qiu, S.P. PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P. Cancer Lett. 2016, 376, 148-154.
    • (2016) Cancer Lett , vol.376 , pp. 148-154
    • Huang, B.1    Fu, S.J.2    Fan, W.Z.3    Wang, Z.H.4    Chen, Z.B.5    Guo, S.J.6    Chen, J.X.7    Qiu, S.P.8
  • 71
    • 17144410320 scopus 로고    scopus 로고
    • Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain
    • Johnson, R.A.; Shepard, E.M.; Scotto, K.W. Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain. J. Biol. Chem. 2005, 280, 13213-13219.
    • (2005) J. Biol. Chem , vol.280 , pp. 13213-13219
    • Johnson, R.A.1    Shepard, E.M.2    Scotto, K.W.3
  • 72
    • 84922004408 scopus 로고    scopus 로고
    • OCT4 mutations in human erythroleukemic cells: Implications for multiple drug resistance (MDR) phenotype
    • Oliveira, B.R.; Figueiredo, M.A.; Trindade, G.S.; Marins, L.F. OCT4 mutations in human erythroleukemic cells: Implications for multiple drug resistance (MDR) phenotype. Mol. Cell. Biochem. 2015, 400, 41-50.
    • (2015) Mol. Cell. Biochem , vol.400 , pp. 41-50
    • Oliveira, B.R.1    Figueiredo, M.A.2    Trindade, G.S.3    Marins, L.F.4
  • 73
    • 84962839081 scopus 로고    scopus 로고
    • Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression
    • Zhou, Y.; Zhao, R.-H.; Tseng, K.-F.; Li, K.-P.; Lu, Z.-G.; Liu, Y.; Han, K.; Gan, Z.-H.; Lin, S.-C.; Hu, H.-Y.; et al. Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression. Acta Pharmacol. Sin. 2016, 37, 519-529.
    • (2016) Acta Pharmacol. Sin , vol.37 , pp. 519-529
    • Zhou, Y.1    Zhao, R.-H.2    Tseng, K.-F.3    Li, K.-P.4    Lu, Z.-G.5    Liu, Y.6    Han, K.7    Gan, Z.-H.8    Lin, S.-C.9    Hu, H.-Y.10
  • 74
    • 49149114863 scopus 로고    scopus 로고
    • Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P- glycoprotein expression in human cancer cells
    • Zhu, H.; Wu, H.; Liu, X.; Evans, B.R.; Medina, D.J.; Liu, C.-G.; Yang, J.-M. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P- glycoprotein expression in human cancer cells. Biochem. Pharmacol. 2008, 76, 582-588.
    • (2008) Biochem. Pharmacol , vol.76 , pp. 582-588
    • Zhu, H.1    Wu, H.2    Liu, X.3    Evans, B.R.4    Medina, D.J.5    Liu, C.-G.6    Yang, J.-M.7
  • 76
    • 84904066523 scopus 로고    scopus 로고
    • Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer
    • Chen, Y.; Bieber, M.M.; Teng, N.N.H. Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer. Mol. Carcinog. 2014, 53, 625-634.
    • (2014) Mol. Carcinog , vol.53 , pp. 625-634
    • Chen, Y.1    Bieber, M.M.2    Teng, N.N.H.3
  • 77
    • 84918530536 scopus 로고    scopus 로고
    • Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
    • Samanta, D.; Gilkes, D.M.; Chaturvedi, P.; Xiang, L.; Semenza, G.L. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc. Natl. Acad. Sci. USA 2014, 111, E5429-E5438.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. E5429-E5438
    • Samanta, D.1    Gilkes, D.M.2    Chaturvedi, P.3    Xiang, L.4    Semenza, G.L.5
  • 78
    • 0036229852 scopus 로고    scopus 로고
    • Drugs as P-glycoprotein substrates, inhibitors, and inducers
    • Kim, R.B. Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab. Rev. 2002, 34, 47-54.
    • (2002) Drug Metab. Rev , vol.34 , pp. 47-54
    • Kim, R.B.1
  • 79
    • 27644577664 scopus 로고    scopus 로고
    • ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
    • Choi, C.-H. ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. Cancer Cell Int. 2005, 5, 30.
    • (2005) Cancer Cell Int , vol.5 , pp. 30
    • Choi, C.-H.1
  • 80
    • 0344012471 scopus 로고    scopus 로고
    • Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter
    • Frank, N.Y.; Pendse, S.S.; Lapchak, P.H.; Margaryan, A.; Shlain, D.; Doeing, C.; Sayegh, M.H.; Frank, M.H. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J. Biol. Chem. 2003, 278, 47156-47165.
    • (2003) J. Biol. Chem , vol.278 , pp. 47156-47165
    • Frank, N.Y.1    Pendse, S.S.2    Lapchak, P.H.3    Margaryan, A.4    Shlain, D.5    Doeing, C.6    Sayegh, M.H.7    Frank, M.H.8
  • 81
    • 84861371742 scopus 로고    scopus 로고
    • Expression of ABCB5 gene in hematological malignances and its significance
    • Yang, M.; Li, W.; Fan, D.; Yan, Y.; Zhang, X.; Zhang, Y.; Xiong, D. Expression of ABCB5 gene in hematological malignances and its significance. Leuk. Lymphoma 2012, 53, 1211-1215.
    • (2012) Leuk. Lymphoma , vol.53 , pp. 1211-1215
    • Yang, M.1    Li, W.2    Fan, D.3    Yan, Y.4    Zhang, X.5    Zhang, Y.6    Xiong, D.7
  • 85
    • 77953515718 scopus 로고    scopus 로고
    • Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells
    • Porro, A.; Haber, M.; Diolaiti, D.; Iraci, N.; Henderson, M.; Gherardi, S.; Valli, E.; Munoz, M.A.; Xue, C.; Flemming, C.; et al. Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells. J. Biol. Chem. 2010, 285, 19532-19543.
    • (2010) J. Biol. Chem , vol.285 , pp. 19532-19543
    • Porro, A.1    Haber, M.2    Diolaiti, D.3    Iraci, N.4    Henderson, M.5    Gherardi, S.6    Valli, E.7    Munoz, M.A.8    Xue, C.9    Flemming, C.10
  • 86
    • 74149092809 scopus 로고    scopus 로고
    • Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1
    • Liang, Z.; Wu, H.; Xia, J.; Li, Y.; Zhang, Y.; Huang, K.; Wagar, N.; Yoon, Y.; Cho, H.T.; Scala, S.; et al. Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem. Pharmacol. 2010, 79, 817-824.
    • (2010) Biochem. Pharmacol , vol.79 , pp. 817-824
    • Liang, Z.1    Wu, H.2    Xia, J.3    Li, Y.4    Zhang, Y.5    Huang, K.6    Wagar, N.7    Yoon, Y.8    Cho, H.T.9    Scala, S.10
  • 87
    • 31844455959 scopus 로고    scopus 로고
    • Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
    • Deeley, R.G.; Cole, S.P.C. Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS Lett. 2006, 580, 1103-1111.
    • (2006) FEBS Lett , vol.580 , pp. 1103-1111
    • Deeley, R.G.1    Cole, S.P.C.2
  • 88
    • 53349117254 scopus 로고    scopus 로고
    • Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development
    • Zhou, S.-F.; Wang, L.-L.; Di, Y.M.; Xue, C.C.; Duan, W.; Li, C.G.; Li, Y. Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development. Curr. Med. Chem. 2008, 15, 1981-2039.
    • (2008) Curr. Med. Chem , vol.15 , pp. 1981-2039
    • Zhou, S.-F.1    Wang, L.-L.2    Di, Y.M.3    Xue, C.C.4    Duan, W.5    Li, C.G.6    Li, Y.7
  • 89
    • 20244386956 scopus 로고    scopus 로고
    • Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
    • Wijnholds, J.; Evers, R.; Leusden, V.; Mol, C.; Zaman, G.J.R.; Mayer, U.; Beijnen, J.H.; Van der Valk, M.; Krimpenfort, P.; Borst, P. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat. Med. 1997, 3, 1275-1279.
    • (1997) Nat. Med , vol.3 , pp. 1275-1279
    • Wijnholds, J.1    Evers, R.2    Leusden, V.3    Mol, C.4    Zaman, G.J.R.5    Mayer, U.6    Beijnen, J.H.7    Van Der Valk, M.8    Krimpenfort, P.9    Borst, P.10
  • 92
    • 0043132421 scopus 로고    scopus 로고
    • The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
    • Reid, G.; Wielinga, P.; Zelcer, N.; Van der Heijden, I.; Kuil, A.; De Haas, M.; Wijnholds, J.; Borst, P. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc. Natl. Acad. Sci. USA 2003, 100, 9244-9249.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9244-9249
    • Reid, G.1    Wielinga, P.2    Zelcer, N.3    Van Der Heijden, I.4    Kuil, A.5    De Haas, M.6    Wijnholds, J.7    Borst, P.8
  • 93
    • 0032404092 scopus 로고    scopus 로고
    • A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
    • Allikmets, R.; Schriml, L.M.; Hutchinson, A.; Romano-Spica, V.; Dean, M. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 1998, 58, 5337-5339.
    • (1998) Cancer Res , vol.58 , pp. 5337-5339
    • Allikmets, R.1    Schriml, L.M.2    Hutchinson, A.3    Romano-Spica, V.4    Dean, M.5
  • 96
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • Chiba, T.; Kita, K.; Zheng, Y.-W.; Yokosuka, O.; Saisho, H.; Iwama, A.; Nakauchi, H.; Taniguchi, H. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 2006, 44, 240-251.
    • (2006) Hepatology , vol.44 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.-W.3    Yokosuka, O.4    Saisho, H.5    Iwama, A.6    Nakauchi, H.7    Taniguchi, H.8
  • 98
    • 85027922548 scopus 로고    scopus 로고
    • MicroRNA profiling in K-562 cells under imatinib treatment: Influence of miR-212 and miR-328 on ABCG2 expression
    • Turrini, E.; Haenisch, S.; Laechelt, S.; Diewock, T.; Bruhn, O.; Cascorbi, I. MicroRNA profiling in K-562 cells under imatinib treatment: Influence of miR-212 and miR-328 on ABCG2 expression. Pharmacogenet. Genom. 2012, 22, 198-205.
    • (2012) Pharmacogenet. Genom , vol.22 , pp. 198-205
    • Turrini, E.1    Haenisch, S.2    Laechelt, S.3    Diewock, T.4    Bruhn, O.5    Cascorbi, I.6
  • 99
    • 84962687847 scopus 로고    scopus 로고
    • ABCG2 inhibition as a therapeutic approach for overcoming multidrug resistance in cancer
    • Hasanabady, M.H.; Kalalinia, F. ABCG2 inhibition as a therapeutic approach for overcoming multidrug resistance in cancer. J. Biosci. 2016, 41, 313-324.
    • (2016) J. Biosci , vol.41 , pp. 313-324
    • Hasanabady, M.H.1    Kalalinia, F.2
  • 100
    • 84922002485 scopus 로고    scopus 로고
    • Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport-An update
    • Mao, Q.; Unadkat, J.D. Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport-An update. AAPS J. 2015, 17, 65-82.
    • (2015) AAPS J , vol.17 , pp. 65-82
    • Mao, Q.1    Unadkat, J.D.2
  • 101
    • 85011990264 scopus 로고    scopus 로고
    • The Efflux Transporter ABCG2 Maintains Prostate Stem Cells
    • Sabnis, N.G.; Miller, A.; Titus, M.A.; Huss, W.J. The Efflux Transporter ABCG2 Maintains Prostate Stem Cells. Mol. Cancer Res. 2017, 15, 128-140.
    • (2017) Mol. Cancer Res , vol.15 , pp. 128-140
    • Sabnis, N.G.1    Miller, A.2    Titus, M.A.3    Huss, W.J.4
  • 102
    • 65649142529 scopus 로고    scopus 로고
    • ABCG2 is up-regulated in Alzheimer’s brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Aβ(1-40) peptides
    • Xiong, H.; Callaghan, D.; Jones, A.; Bai, J.; Rasquinha, I.; Smith, C.; Pei, K.; Walker, D.; Lue, L.-F.; Stanimirovic, D.; et al. ABCG2 is up-regulated in Alzheimer’s brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Aβ(1-40) peptides. J. Neurosci. 2009, 29, 5463-5475.
    • (2009) J. Neurosci , vol.29 , pp. 5463-5475
    • Xiong, H.1    Callaghan, D.2    Jones, A.3    Bai, J.4    Rasquinha, I.5    Smith, C.6    Pei, K.7    Walker, D.8    Lue, L.-F.9    Stanimirovic, D.10
  • 103
  • 104
    • 0026555717 scopus 로고
    • Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
    • Chin, K.V.; Ueda, K.; Pastan, I.; Gottesman, M.M. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 1992, 255, 459-462.
    • (1992) Science , vol.255 , pp. 459-462
    • Chin, K.V.1    Ueda, K.2    Pastan, I.3    Gottesman, M.M.4
  • 105
    • 72949111146 scopus 로고    scopus 로고
    • MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications
    • Desano, J.T.; Xu, L. MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications. AAPS J. 2009, 11, 682-692.
    • (2009) AAPS J , vol.11 , pp. 682-692
    • Desano, J.T.1    Xu, L.2
  • 106
    • 50849090600 scopus 로고    scopus 로고
    • Recent progress on tissue-resident adult stem cell biology and their therapeutic implications
    • Mimeault, M.; Batra, S.K. Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. Stem Cell Rev. 2008, 4, 27-49.
    • (2008) Stem Cell Rev , vol.4 , pp. 27-49
    • Mimeault, M.1    Batra, S.K.2
  • 107
    • 84864220149 scopus 로고    scopus 로고
    • Low Molecular Weight Heparin Ablates Lung Cancer Cisplatin-Resistance by Inducing Proteasome-Mediated ABCG2 Protein Degradation
    • Niu, Q.; Wang, W.; Li, Y.; Ruden, D.M.; Wang, F.; Li, Y.; Wang, F.; Song, J.; Zheng, K. Low Molecular Weight Heparin Ablates Lung Cancer Cisplatin-Resistance by Inducing Proteasome-Mediated ABCG2 Protein Degradation. PLoS ONE 2012, 7, e41035.
    • (2012) PLoS ONE , vol.7
    • Niu, Q.1    Wang, W.2    Li, Y.3    Ruden, D.M.4    Wang, F.5    Li, Y.6    Wang, F.7    Song, J.8    Zheng, K.9
  • 108
    • 0035991239 scopus 로고    scopus 로고
    • The role of arachidonic acid in normal and malignant hematopoiesis
    • Rizzo, M.T. The role of arachidonic acid in normal and malignant hematopoiesis. Prostaglandins Leukot. Essent. Fat. Acids 2002, 66, 57-69.
    • (2002) Prostaglandins Leukot. Essent. Fat. Acids , vol.66 , pp. 57-69
    • Rizzo, M.T.1
  • 109
    • 84888866083 scopus 로고    scopus 로고
    • Hooked on fat: The role of lipid synthesis in cancer metabolism and tumour development
    • Baenke, F.; Peck, B.; Miess, H.; Schulze, A. Hooked on fat: The role of lipid synthesis in cancer metabolism and tumour development. Dis. Models Mech. 2013, 6, 1353-1363.
    • (2013) Dis. Models Mech , vol.6 , pp. 1353-1363
    • Baenke, F.1    Peck, B.2    Miess, H.3    Schulze, A.4
  • 110
    • 84907194605 scopus 로고    scopus 로고
    • Lysophosphatidylinositol: A novel link between ABC transporters and G-protein-coupled receptors
    • Ruban, E.L.; Ferro, R.; Arifin, S.A.; Falasca, M. Lysophosphatidylinositol: A novel link between ABC transporters and G-protein-coupled receptors. Biochem. Soc. Trans. 2014, 42, 1372-1377.
    • (2014) Biochem. Soc. Trans , vol.42 , pp. 1372-1377
    • Ruban, E.L.1    Ferro, R.2    Arifin, S.A.3    Falasca, M.4
  • 112
    • 79955073961 scopus 로고    scopus 로고
    • Lipid rafts: Signaling and sorting platforms of cells and their roles in cancer
    • Staubach, S.; Hanisch, F.-G. Lipid rafts: Signaling and sorting platforms of cells and their roles in cancer. Expert Rev. Proteom. 2011, 8, 263-277.
    • (2011) Expert Rev. Proteom , vol.8 , pp. 263-277
    • Staubach, S.1    Hanisch, F.-G.2
  • 114
    • 0034753508 scopus 로고    scopus 로고
    • Role of ABCG1 and other ABCG family members in lipid metabolism
    • Schmitz, G.; Langmann, T.; Heimerl, S. Role of ABCG1 and other ABCG family members in lipid metabolism. J. Lipid Res. 2001, 42, 1513-1520.
    • (2001) J. Lipid Res , vol.42 , pp. 1513-1520
    • Schmitz, G.1    Langmann, T.2    Heimerl, S.3
  • 115
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra, J.; Samali, A.; Orrenius, S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 2000, 29, 323-333.
    • (2000) Free Radic. Biol. Med , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 117
    • 33745265207 scopus 로고    scopus 로고
    • Reactive oxygen species: Role in the development of cancer and various chronic conditions
    • Waris, G.; Ahsan, H. Reactive oxygen species: Role in the development of cancer and various chronic conditions. J. Carcinog. 2006, 5.
    • (2006) J. Carcinog , vol.5
    • Waris, G.1    Ahsan, H.2
  • 118
    • 33746898269 scopus 로고    scopus 로고
    • Novel aspects of oxidative stress-associated carcinogenesis
    • Toyokuni, S. Novel aspects of oxidative stress-associated carcinogenesis. Antioxid. Redox Signal. 2006, 8, 1373-1377.
    • (2006) Antioxid. Redox Signal , vol.8 , pp. 1373-1377
    • Toyokuni, S.1
  • 119
    • 84865298912 scopus 로고    scopus 로고
    • Mitochondrial ABC transporters function: The role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species
    • Liesa, M.; Qiu, W.; Shirihai, O.S. Mitochondrial ABC transporters function: The role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim. Biophys. Acta Mol. Cell Res. 2012, 1823, 1945-1957.
    • (2012) Biochim. Biophys. Acta Mol. Cell Res , vol.1823 , pp. 1945-1957
    • Liesa, M.1    Qiu, W.2    Shirihai, O.S.3
  • 120
    • 27644494143 scopus 로고    scopus 로고
    • RelB/p52 NF-κB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IκB-α expression and promote carcinogenesis of the mammary gland
    • Demicco, E.G.; Kavanagh, K.T.; Romieu-Mourez, R.; Wang, X.; Shin, S.R.; Landesman-Bollag, E.; Seldin, D.C.; Sonenshein, G.E. RelB/p52 NF-κB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IκB-α expression and promote carcinogenesis of the mammary gland. Mol. Cell. Biol. 2005, 25, 10136-10147.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 10136-10147
    • Demicco, E.G.1    Kavanagh, K.T.2    Romieu-Mourez, R.3    Wang, X.4    Shin, S.R.5    Landesman-Bollag, E.6    Seldin, D.C.7    Sonenshein, G.E.8
  • 121
    • 84902436456 scopus 로고    scopus 로고
    • Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers
    • Wang, X.; Campos, C.R.; Peart, J.C.; Smith, L.K.; Boni, J.L.; Cannon, R.E.; Miller, D.S. Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers. J. Neurosci. 2014, 34, 8585-8593.
    • (2014) J. Neurosci , vol.34 , pp. 8585-8593
    • Wang, X.1    Campos, C.R.2    Peart, J.C.3    Smith, L.K.4    Boni, J.L.5    Cannon, R.E.6    Miller, D.S.7
  • 123
    • 84890563878 scopus 로고    scopus 로고
    • PPARγ maintains ERBB2-positive breast cancer stem cells
    • Wang, X.; Sun, Y.; Wong, J.; Conklin, D.S. PPARγ maintains ERBB2-positive breast cancer stem cells. Oncogene 2013, 32, 5512-5521.
    • (2013) Oncogene , vol.32 , pp. 5512-5521
    • Wang, X.1    Sun, Y.2    Wong, J.3    Conklin, D.S.4
  • 126
    • 85000910724 scopus 로고    scopus 로고
    • Diverse relations between ABC transporters and lipids: An overview
    • Neumann, J.; Rose-Sperling, D.; Hellmich, U.A. Diverse relations between ABC transporters and lipids: An overview. Biochim. Biophys. Acta 2017, 1859, 605-618.
    • (2017) Biochim. Biophys. Acta , vol.1859 , pp. 605-618
    • Neumann, J.1    Rose-Sperling, D.2    Hellmich, U.A.3
  • 130
    • 84872543301 scopus 로고    scopus 로고
    • Lipid Bilayer Properties Control Membrane Partitioning, Binding, and Transport of P-Glycoprotein Substrates
    • Clay, A.T.; Sharom, F.J. Lipid Bilayer Properties Control Membrane Partitioning, Binding, and Transport of P-Glycoprotein Substrates. Biochemistry 2013, 52, 343-354.
    • (2013) Biochemistry , vol.52 , pp. 343-354
    • Clay, A.T.1    Sharom, F.J.2
  • 131
    • 0033602840 scopus 로고    scopus 로고
    • The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter
    • Romsicki, Y.; Sharom, F.J. The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry 1999, 38, 6887-6896.
    • (1999) Biochemistry , vol.38 , pp. 6887-6896
    • Romsicki, Y.1    Sharom, F.J.2
  • 132
    • 0027397883 scopus 로고
    • Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties
    • Callaghan, R.; Stafford, A.; Epand, R.M. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. Biochim. Biophys. Acta 1993, 1175, 277-282.
    • (1993) Biochim. Biophys. Acta , vol.1175 , pp. 277-282
    • Callaghan, R.1    Stafford, A.2    Epand, R.M.3
  • 134
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg, O.; Wind, F.; Negelein, E. The metabolism of tumors in the body. J. Gen. Physiol. 1927, 8, 519-530.
    • (1927) J. Gen. Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 135
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
    • Ward, P.S.; Thompson, C.B. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012, 21, 297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 136
    • 84919489013 scopus 로고    scopus 로고
    • Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer?
    • Wolf, D.A. Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer? Cancer Cell 2014, 26, 788-795.
    • (2014) Cancer Cell , vol.26 , pp. 788-795
    • Wolf, D.A.1
  • 137
    • 43549121719 scopus 로고    scopus 로고
    • The Warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen?
    • López-Lázaro, M. The Warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen? Anti-Cancer Agents Med. Chem. 2008, 8, 305-312.
    • (2008) Anti-Cancer Agents Med. Chem , vol.8 , pp. 305-312
    • López-Lázaro, M.1
  • 138
    • 85018222039 scopus 로고    scopus 로고
    • AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis
    • Chaube, B.; Malvi, P.; Singh, S.V.; Mohammad, N.; Viollet, B.; Bhat, M.K. AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis. Cell Death Discov. 2015, 1, 15063.
    • (2015) Cell Death Discov , vol.1 , pp. 15063
    • Chaube, B.1    Malvi, P.2    Singh, S.V.3    Mohammad, N.4    Viollet, B.5    Bhat, M.K.6
  • 139
    • 33749478922 scopus 로고    scopus 로고
    • Cancer’s molecular sweet tooth and the Warburg effect
    • Kim, J.-W.; Dang, C.V. Cancer’s molecular sweet tooth and the Warburg effect. Cancer Res. 2006, 66, 8927-8930.
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.-W.1    Dang, C.V.2
  • 141
    • 77949901183 scopus 로고    scopus 로고
    • Cell Respiration Under Hypoxia: Facts and Artefacts in Mitochondrial Oxygen Kinetics
    • Takahashi, E., Bruley, D.F., Eds.; Springer: Boston, MA, USA
    • Scandurra, F.M.; Gnaiger, E. Cell Respiration Under Hypoxia: Facts and Artefacts in Mitochondrial Oxygen Kinetics. In Oxygen Transport to Tissue XXXI; Takahashi, E., Bruley, D.F., Eds.; Springer: Boston, MA, USA, 2010; pp. 7-25.
    • (2010) Oxygen Transport to Tissue XXXI , pp. 7-25
    • Scandurra, F.M.1    Gnaiger, E.2
  • 142
    • 0025005012 scopus 로고
    • Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat
    • Rumsey, W.L.; Schlosser, C.; Nuutinen, E.M.; Robiolio, M.; Wilson, D.F. Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat. J. Biol. Chem. 1990, 265, 15392-15402.
    • (1990) J. Biol. Chem , vol.265 , pp. 15392-15402
    • Rumsey, W.L.1    Schlosser, C.2    Nuutinen, E.M.3    Robiolio, M.4    Wilson, D.F.5
  • 143
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • Ezashi, T.; Das, P.; Roberts, R.M. Low O2 tensions and the prevention of differentiation of hES cells. Proc. Natl. Acad. Sci. USA 2005, 102, 4783-4788.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3
  • 144
    • 84983407936 scopus 로고    scopus 로고
    • Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches
    • Huang, W.-J.; Chen, W.-W.; Zhang, X. Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches. Oncol. Lett. 2016, 12, 2283-2288.
    • (2016) Oncol. Lett , vol.12 , pp. 2283-2288
    • Huang, W.-J.1    Chen, W.-W.2    Zhang, X.3
  • 145
    • 84855708762 scopus 로고    scopus 로고
    • HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
    • Qiang, L.; Wu, T.; Zhang, H.W.; Lu, N.; Hu, R.; Wang, Y.J.; Zhao, L.; Chen, F.H.; Wang, X.T.; You, Q.D.; et al. HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ. 2012, 19, 284-294.
    • (2012) Cell Death Differ , vol.19 , pp. 284-294
    • Qiang, L.1    Wu, T.2    Zhang, H.W.3    Lu, N.4    Hu, R.5    Wang, Y.J.6    Zhao, L.7    Chen, F.H.8    Wang, X.T.9    You, Q.D.10
  • 147
    • 84874786113 scopus 로고    scopus 로고
    • Hypoxia enhances stemness of cancer stem cells in glioblastoma: An in vitro study
    • Li, P.; Zhou, C.; Xu, L.; Xiao, H. Hypoxia enhances stemness of cancer stem cells in glioblastoma: An in vitro study. Int. J. Med. Sci. 2013, 10, 399-407.
    • (2013) Int. J. Med. Sci , vol.10 , pp. 399-407
    • Li, P.1    Zhou, C.2    Xu, L.3    Xiao, H.4
  • 148
    • 84925946155 scopus 로고    scopus 로고
    • Chemoresistance in high-grade gliomas: Relevance of adenosine signalling in stem-like cells of glioblastoma multiforme
    • Garrido, W.; Rocha, J.D.; Jaramillo, C.; Fernandez, K.; Oyarzun, C.; San Martin, R.; Quezada, C. Chemoresistance in high-grade gliomas: Relevance of adenosine signalling in stem-like cells of glioblastoma multiforme. Curr. Drug Targets 2014, 15, 931-942.
    • (2014) Curr. Drug Targets , vol.15 , pp. 931-942
    • Garrido, W.1    Rocha, J.D.2    Jaramillo, C.3    Fernandez, K.4    Oyarzun, C.5    San Martin, R.6    Quezada, C.7
  • 150
    • 84868007565 scopus 로고    scopus 로고
    • Physiological Roles of Mitochondrial Reactive Oxygen Species
    • Sena, L.A.; Chandel, N.S. Physiological Roles of Mitochondrial Reactive Oxygen Species. Mol. Cell 2012, 48, 158-167.
    • (2012) Mol. Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 151
    • 23844558266 scopus 로고    scopus 로고
    • A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
    • Wallace, D.C. A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine. Annu. Rev. Genet. 2005, 39, 359-407.
    • (2005) Annu. Rev. Genet , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 152
    • 84883513587 scopus 로고    scopus 로고
    • Oncometabolites: Linking altered metabolism with cancer
    • Yang, M.; Soga, T.; Pollard, P.J. Oncometabolites: Linking altered metabolism with cancer. J. Clin. Investig. 2013, 123, 3652-3658.
    • (2013) J. Clin. Investig , vol.123 , pp. 3652-3658
    • Yang, M.1    Soga, T.2    Pollard, P.J.3
  • 153
    • 84957810905 scopus 로고    scopus 로고
    • Glioblastoma: Defining Tumor Niches
    • Hambardzumyan, D.; Bergers, G. Glioblastoma: Defining Tumor Niches. Trends Cancer 2015, 1, 252-265.
    • (2015) Trends Cancer , vol.1 , pp. 252-265
    • Hambardzumyan, D.1    Bergers, G.2
  • 154
    • 84882830371 scopus 로고    scopus 로고
    • Perivascular stem cell niche in head and neck cancer
    • Ritchie, K.E.; Nör, J.E. Perivascular stem cell niche in head and neck cancer. Cancer Lett. 2013, 338, 41-46.
    • (2013) Cancer Lett , vol.338 , pp. 41-46
    • Ritchie, K.E.1    Nör, J.E.2
  • 155
    • 84872496776 scopus 로고    scopus 로고
    • The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment
    • Filatova, A.; Acker, T.; Garvalov, B.K. The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment. Biochim. Biophys. Acta 2013, 1830, 2496-2508.
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 2496-2508
    • Filatova, A.1    Acker, T.2    Garvalov, B.K.3
  • 158
    • 84934974754 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factors in Cancer Stem Cells and Inflammation
    • Peng, G.; Liu, Y. Hypoxia-Inducible Factors in Cancer Stem Cells and Inflammation. Trends Pharmacol. Sci. 2015, 36, 374-383.
    • (2015) Trends Pharmacol. Sci , vol.36 , pp. 374-383
    • Peng, G.1    Liu, Y.2
  • 160
    • 85013379897 scopus 로고    scopus 로고
    • Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling
    • Uribe, D.; Torres, Á.; Rocha, J.D.; Niechi, I.; Oyarzún, C.; Sobrevia, L.; San Martín, R.; Quezada, C. Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling. Mol. Asp. Med. 2017, 55, 140-151.
    • (2017) Mol. Asp. Med , vol.55 , pp. 140-151
    • Uribe, D.1    Torres, Á.2    Rocha, J.D.3    Niechi, I.4    Oyarzún, C.5    Sobrevia, L.6    San Martín, R.7    Quezada, C.8
  • 161
  • 162
    • 84963819737 scopus 로고    scopus 로고
    • Distinctive properties of metastasis-initiating cells
    • Celià-Terrassa, T.; Kang, Y. Distinctive properties of metastasis-initiating cells. Genes Dev. 2016, 30, 892-908.
    • (2016) Genes Dev , vol.30 , pp. 892-908
    • Celià-Terrassa, T.1    Kang, Y.2
  • 165
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • Tam, W.L.; Weinberg, R.A. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 2013, 19, 1438-1449.
    • (2013) Nat. Med , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 168
    • 0026806148 scopus 로고
    • Prognostic Significance of Micrometastatic Tumour Cells in Bone Marrow of Colorectal Cancer Patients
    • Lindemann, F.; Schlimok, G.; Dirschedl, P.; Witte, J.; Riethmüller, G. Prognostic Significance of Micrometastatic Tumour Cells in Bone Marrow of Colorectal Cancer Patients. Lancet 1992, 340, 685-689.
    • (1992) Lancet , vol.340 , pp. 685-689
    • Lindemann, F.1    Schlimok, G.2    Dirschedl, P.3    Witte, J.4    Riethmüller, G.5
  • 169
    • 84890314061 scopus 로고    scopus 로고
    • The pre-metastatic niche: Finding common ground
    • Sceneay, J.; Smyth, M.J.; Möller, A. The pre-metastatic niche: Finding common ground. Cancer Metastasis Rev. 2013, 32, 449-464.
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 449-464
    • Sceneay, J.1    Smyth, M.J.2    Möller, A.3
  • 172
    • 84856528076 scopus 로고    scopus 로고
    • Transportomics: Screening for substrates of ABC transporters in body fluids using vesicular transport assays
    • Krumpochova, P.; Sapthu, S.; Brouwers, J.F.; de Haas, M.; de Vos, R.; Borst, P.; van de Wetering, K. Transportomics: Screening for substrates of ABC transporters in body fluids using vesicular transport assays. FASEB J. 2012, 26, 738-747.
    • (2012) FASEB J , vol.26 , pp. 738-747
    • Krumpochova, P.1    Sapthu, S.2    Brouwers, J.F.3    De Haas, M.4    De Vos, R.5    Borst, P.6    Van De Wetering, K.7
  • 173
    • 70350104791 scopus 로고    scopus 로고
    • Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo
    • Van de Wetering, K.; Feddema, W.; Helms, J.B.; Brouwers, J.F.; Borst, P. Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo. Gastroenterology 2009, 137, 1725-1735.
    • (2009) Gastroenterology , vol.137 , pp. 1725-1735
    • Van De Wetering, K.1    Feddema, W.2    Helms, J.B.3    Brouwers, J.F.4    Borst, P.5


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