The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

Oncogene

Volumn 30, Issue 2, 2011, Pages 142-152

  Pieiro R ^a   Maffucci, T ^a   Falasca, M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

ABC transporters; G protein coupled receptor; GPR55; lysophosphatidylinositol; phospholipase A2; prostate cancer

Indexed keywords

ABC TRANSPORTER; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CYTOSOLIC PHOSPHOLIPASE A2; G PROTEIN COUPLED RECEPTOR 55; LYSOPHOSPHOLIPID LYSOPHOSPHATIDYLINOSITOL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CALCIUM MOBILIZATION; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; DOWN REGULATION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER;

AUTOCRINE COMMUNICATION; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; LYSOPHOSPHOLIPIDS; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OVARIAN NEOPLASMS; PHOSPHOLIPASES A2; PIPERIDINES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; TUMOR MARKERS, BIOLOGICAL;

EID: 78651383853     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.417     Document Type: Article

References (31)

1. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D et al. (1999). Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 59: 2551-2556.
2. Falasca M, Corda D. (1994). Elevated levels and mitogenic activity of lysophosphatidylinositol in k-ras-transformed epithelial cells. Eur J Biochem 221: 383-389.
3. Falasca M, Iurisci C, Carvelli A, Sacchetti A, Corda D. (1998). Release of the mitogen lysophosphatidylinositol from H-Ras-transformed fibroblasts; a possible mechanism of autocrine control of cell proliferation. Oncogene 16: 2357-2365.
4. Falasca M, Silletta MG, Carvelli A, Di Francesco AL, Fusco A, Ramakrishna V et al. (1995). Signalling pathways involved in the mitogenic action of lysophosphatidylinositol. Oncogene 10: 2113-2124.
5. Ford LA, Roelofs AJ, Anavi-Goffer S, Mowat L, Simpson DG, Irving AJ et al. (2010). A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. Br J Pharmacol 160: 762-771.
6. 2+ signaling and NFAT activation. FASEB J 23: 183-193.
7. Hoffmann U, Kroemer HK. (2004). The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance. Drug Metab Rev 36: 669-701.
8. Kapur A, Zhao P, Sharir H, Bai Y, Caron MG, Barak LS et al. (2009). Atypical responsiveness of the orphan receptor GPR55 to canna-binoid ligands. J Biol Chem 284: 29817-29827.
9. Kreitzer FR, Stella N. (2009). The therapeutic potential of novel cannabinoid receptors. Pharmacol Ther 122: 83-96.
10. Lauckner JE, Jensen JB, Chen HY, Lu HC, Hille B, Mackie K. (2008). GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci USA 105: 2699-2704.
11. Mitra P, Oskeritzian CA, Payne SG, Beaven MA, Milstien S, Spiegel S. (2006). Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci USA 103: 16394-16399.
12. 0kyi V, Pourtier A, Vanden Abeele F, Bidaux G et al. (2009). Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta 1793: 528-539.
13. Nevalainen T, Irving AJ. (2010). GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity? Curr Top Med Chem 10: 799-813.
14. Oka S, Kimura S, Toshida T, Ota R, Yamashita A, Sugiura T. (2010). Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells. J Biochem 147: 671-678.
15. Oka S, Nakajima K, Yamashita A, Kishimoto S, Sugiura T. (2007). Identification of GPR55 as a lysophosphatidylinositol receptor. Biochem Biophys Res Commun 362: 928-934.
16. Patel MI, Singh J, Niknami M, Kurek C, Yao M, Lu S et al. (2008). Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer. Clin Cancer Res 14: 8070-8079.
17. Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC et al. (2004). Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem 279: 11320-11326.
18. Ross RA. (2009). The enigmatic pharmacology of GPR55. Trends Pharmacol Sci 30: 156-163.
19. Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J et al. (2007). The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152: 1092-1101.
20. Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH et al. (1999). Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. Brain Res Mol Brain Res 64: 193-198.
21. Sharir H, Abood ME. (2010). Pharmacological characterization of GPR55, a putative cannabinoid receptor. Pharmacol Ther 126: 301-313.
22. Soga T, Ohishi T, Matsui T, Saito T, Matsumoto M, Takasaki J et al. (2005). Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun 326: 744-751.
23. Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes JP et al. (2008). The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 139: 225-236.
24. SulliVan GF, Amenta PS, Villanueva JD, Alvarez CJ, Yang JM, Hait WN. (1998). The expression of drug resistance gene products during the progression of human prostate cancer. Clin Cancer Res 4: 1393-1403.
25. SulliVan GF, Yang JM, Vassil A, Yang J, Bash-Babula J, Hait WN. (2000). Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells. J Clin Invest 105: 1261-1267.
26. Sutphen R, Xu Y, Wilbanks GD, Fiorica J, Grendys Jr EC, LaPolla JP et al. (2004). Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers Prev 13: 1185-1191.
27. Waldeck-Weiermair M, Zoratti C, Osibow K, Balenga N, Goessnitzer E, Waldhoer M et al. (2008). Integrin clustering enables ananda-mide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. J Cell Sci 121: 1704-1717.
28. Whyte LS, Ryberg E, Sims NA, Ridge SA, Mackie K, Greasley PJ et al. (2009). The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci USA 106: 16511-16516.
29. Xiao Y, Chen Y, Kennedy AW, Belinson J, Xu Y. (2000). Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses. Ann N Y Acad Sci 905: 242-259.
30. Xiao YJ, Schwartz B, Washington M, Kennedy A, Webster K, Belinson J et al. (2001). Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids. Anal Biochem 290: 302-313.
31. Yin H, Chu A, Li W, Wang B, Shelton F, Otero F et al. (2009). Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem 284: 12328-12338.