Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression

Acta Pharmacologica Sinica

Volumn 37, Issue 4, 2016, Pages 519-529

  Zhou, Yan ^a   Zhao, Rui Hua ^b   Tseng, Kuo Fu ^d   Li, Kun Peng ^a   Lu, Zhi Gang ^c   Liu, Yuan ^c   Han, Kun ^a   Gan, Zhi Hua ^a   Lin, Shu Chen ^a   Hu, Hai Yan ^a   Min, Da Liu ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

ABCB1; chemosensitivity; doxorubicin; gemcitabine; methotrexate; miR 34b; Osteosarcoma; PAK1; sirolimus

Indexed keywords

DOXORUBICIN; GEMCITABINE; METHOTREXATE; MICRORNA; MICRORNA 34B; MULTIDRUG RESISTANCE PROTEIN 1; P21 ACTIVATED KINASE 1; RAPAMYCIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; MIRN34 MICRORNA, HUMAN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IN VITRO STUDY; MULTIDRUG RESISTANCE; OSTEOSARCOMA CELL; PROGNOSIS; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; BONE NEOPLASMS; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; GENETICS; HEK293 CELL LINE; METABOLISM; OSTEOSARCOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE NEOPLASMS; DEOXYCYTIDINE; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; HEK293 CELLS; HUMANS; METHOTREXATE; MICRORNAS; OSTEOSARCOMA; SIROLIMUS;

EID: 84962839081     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2015.153     Document Type: Article

References (37)

1. Jaffe N. Osteosarcoma: review of the past, impact on the future. The American experience. Cancer Treat Res 2009; 152: 239-62.
2. Milosevic Z, Pesic M, Stankovic T, Dinic J, Milovanovic Z, Stojsic J, et al. Targeting RAS-MAPK-ERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma. Transl Res 2014; 164: 411-23.
3. Zhang H, Cohen AL, Krishnakumar S, Wapnir IL, Veeriah S, Deng G, et al. Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition. Breast Cancer Res 2014; 16: R36.
4. Utomo WK, Narayanan V, Biermann K, van Eijck CH, Bruno MJ. mTOR is a promising therapeutical target in a subpopulation of pancreatic adenocarcinoma. Cancer Lett 2014; 346: 309-17.
5. Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, et al. Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Cancer Res 2014; 74: 543-51.
6. Arceci RJ, Stieglitz K, Bierer BE. Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood 1992; 80: 1528-36.
7. Wang Y, Hu Z, Liu Z, Chen R, Peng H, Guo J, et al. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy 2013; 9: 2069-86.
8. Zhao S, Lu N, Chai Y, Yu X. Rapamycin inhibits tumor growth of human osteosarcomas. J BUON 2015; 20: 588-94.
9. Ajabnoor GM, Crook T, Coley HM. Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis 2012; 3: e260.
10. McCarty MF. mTORC1 activity as a determinant of cancer risk-rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets. Med Hypotheses 2011; 77: 642-8.
11. Paoloni MC, Mazcko C, Fox E, Fan T, Lana S, Kisseberth W, et al. Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs. PLoS One 2010; 5: e11013.
12. Navarro F, Lieberman J. miR-34 and p53: new insights into a complex functional relationship. PLoS One 2015; 10: e0132767.
13. Li W, Han W, Ma Y, Cui L, Tian Y, Zhou Z, et al. P53-dependent miRNAs mediate nitric oxide-induced apoptosis in colonic carcinogenesis. Free Radic Biol Med 2015; 85: 105-13.
14. Rokavec M, Li H, Jiang L, Hermeking H. The p53/miR-34 axis in development and disease. J Mol Cell Biol 2014; 6: 214-30.
15. Siemens H, Jackstadt R, Kaller M, Hermeking H. Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 2013; 4: 1399-415.
16. Bao B, Li Y, Ahmad A, Azmi AS, Bao G, Ali S, et al. Targeting CSCrelated miRNAs for cancer therapy by natural agents. Curr Drug Targets 2012; 13: 1858-68.
17. Kim CH, Kim HK, Rettig RL, Kim J, Lee ET, Aprelikova O, et al. miRNA signature associated with outcome of gastric cancer patients following chemotherapy. BMC Med Genomics 2011; 4: 79.
18. Wang L, Yu J, Xu J, Zheng C, Li X, Du J. The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissues. Gene 2014; 554: 1-8.
19. Zhao J, Lammers P, Torrance CJ, Bader AG . TP53-independent function of miR-34a via HDAC1 and p21 (CIP1/WAF1). Mol Ther 2013; 21: 1678-86.
20. Wang LG, Ni Y, Su BH, Mu XR, Shen HC, Du JJ. MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met. Int J Oncol 2013; 42: 957-62.
21. Cannell IG, Bushell M. Regulation of Myc by miR-34c: A mechanism to prevent genomic instability? Cell Cycle 2010; 9: 2726-30.
22. Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, et al. Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells. Oncol Rep 2013; 29: 2169-74.
23. Anderson ME. Update on survival in osteosarcoma. Orthop Clin North Am 2016; 47: 283-92.
24. Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal 2014; 7: 121.
25. Liesveld JL, O'Dwyer K, Walker A, Becker MW, Ifthikharuddin JJ, Mulford D, et al. A phase I study of decitabine and rapamycin in relapsed/refractory AML. Leuk Res 2013; 37: 1622-7.
26. Moroney J, Fu S, Moulder S, Falchook G, Helgason T, Levenback C, et al. Phase I study of the antiangiogenic antibody bevacizumab and the mTOR/hypoxia-inducible factor inhibitor temsirolimus combined with liposomal doxorubicin: tolerance and biological activity. Clin Cancer Res 2012; 18: 5796-805.
27. Pop IV, Pop LM, Ghetie MA, Vitetta ES. Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines. Leuk Lymphoma 2009; 50: 1155-62.
28. Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, et al. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 2004; 10: 1013-23.
29. Ramaiah MJ, Pushpavalli SN, Lavanya A, Bhadra K, Haritha V, Patel N, et al. Novel anthranilamide-pyrazolo [1,5-a] pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis. Bioorg Med Chem Lett 2013; 23: 5699-706.
30. Brabletz T. MiR-34 and SNAI L: another double-negative feedback loop controlling cellular plasticity/EMT governed by p53. Cell Cycle 2012; 11: 215-6.
31. Jin K, Xiang Y, Tang J, Wu G, Li J, Xiao H, et al. miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells. Tumour Biol 2014; 35: 1503-10.
32. Ishida H, Li K, Yi M, Lemon SM. p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells. J Biol Chem 2007; 282: 11836-48.
33. Hammer A, Diakonova M. Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion. Adv Exp Med Biol 2015; 846: 97-137.
34. Qing H, Gong W, Che Y, Wang X, Peng L, Liang Y, et al. PAK1-dependent MAPK pathway activation is required for colorectal cancer cellproliferation. Tumour Biol 2012; 33: 985-94.
35. Maroof H, Salajegheh A, Smith RA, Lam AK. Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis. Exp Mol Pathol 2014; 97: 298-304.
36. Balca-Silva J, Sousa Neves S, Goncalves AC, Abrantes AM, Casalta-Lopes J, Botelho MF, et al. Effect of miR-34b overexpression on the radiosensitivity of non-small cell lung cancer cell lines. Anticancer Res 2012; 32: 1603-9.
37. Ye Z, Fang J, Dai S, Wang Y, Fu Z, Feng W, et al. MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background. Cancer Lett 2016; 370: 216-21.