The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis

Neurobiology of Aging

Volumn 61, Issue , 2018, Pages 112-123

  Hoeijmakers, Lianne ^a   Meerhoff, Gideon F ^a   de Vries, Janneke W ^a   Ruigrok, Silvie R ^a   van Dam, Anne Marie ^b   van Leuven, Fred ^c   Korosi, Aniko ^a   Lucassen, Paul J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU University Medical Center ^*  (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Aging; Alzheimer's disease; APP; Calretinin; Doublecortin; Neurogenesis; Neuroinflammation

Indexed keywords

AMYLOID; CALRETININ; CD68 ANTIGEN; DOUBLECORTIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DOUBLECORTIN PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE; PRESENILIN 1;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APP V717I MICE; ARTICLE; BRAIN ATROPHY; CELL ACTIVATION; CONTROLLED STUDY; CORRELATIONAL STUDY; EXPERIMENTAL MOUSE; HIPPOCAMPUS; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROPATHOLOGY; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE; ALZHEIMER DISEASE; ANIMAL; COGNITION; DISEASE MODEL; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; COGNITION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MICE, TRANSGENIC; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGENESIS; NEUROPEPTIDES; PRESENILIN-1;

EID: 85032857097     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2017.09.013     Document Type: Article

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