-
1
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy, J. and Allsop, D. (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12, 383-388
-
(1991)
Trends Pharmacol. Sci.
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
2
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy, J.A. and Higgins, G.A. (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
3
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
Selkoe, D.J. (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
4
-
-
0025863618
-
Neuropathological staging of Alzheimer-related changes
-
Braak, H. and Braak, E. (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82, 239-259
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
5
-
-
0032211830
-
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
-
Selkoe, D.J. (1998) The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8, 447-453
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
6
-
-
4043127719
-
Amyloid β-peptide: The inside story
-
Tseng, B.P., Kitazawa, M. and LaFerla, F.M. (2004) Amyloid β-peptide: the inside story. Curr. Alzheimer Res. 1, 231-239
-
(2004)
Curr. Alzheimer Res.
, vol.1
, pp. 231-239
-
-
Tseng, B.P.1
Kitazawa, M.2
LaFerla, F.M.3
-
7
-
-
7244236841
-
A modified β-amyloid hypothesis: Intraneuronal accumulation of the β-amyloid peptide: The first step of a fatal cascade
-
Wirths, O., Multhaup, G. and Bayer, T.A. (2004) A modified β-amyloid hypothesis: intraneuronal accumulation of the β-amyloid peptide: the first step of a fatal cascade. J. Neurochem. 91, 513-520
-
(2004)
J. Neurochem.
, vol.91
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
8
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe, D.J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
9
-
-
0035993237
-
Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets
-
Klein, W.L. (2002) Aβ toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem. Int. 41, 345-352
-
(2002)
Neurochem. Int.
, vol.41
, pp. 345-352
-
-
Klein, W.L.1
-
10
-
-
67049087108
-
Role of amyloid-β glycine 33 in oligomerization, toxicity, and neuronal plasticity
-
Harmeier, A., Wozny, C., Rost, B.R., Munter, L.M., Hua, H., Georgiev, O., Beyermann, M., Hildebrand, P.W., Weise, C., Schaffner, W. et al. (2009) Role of amyloid-β glycine 33 in oligomerization, toxicity, and neuronal plasticity. J. Neurosci. 29, 7582-7590
-
(2009)
J. Neurosci.
, vol.29
, pp. 7582-7590
-
-
Harmeier, A.1
Wozny, C.2
Rost, B.R.3
Munter, L.M.4
Hua, H.5
Georgiev, O.6
Beyermann, M.7
Hildebrand, P.W.8
Weise, C.9
Schaffner, W.10
-
11
-
-
0032590054
-
Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean, C.A., Cherny, R.A., Fraser, F.W., Fuller, S.J., Smith, M.J., Beyreuther, K., Bush, A.I. and Masters, C.L. (1999) Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46, 860-866
-
(1999)
Ann. Neurol.
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
12
-
-
0038117796
-
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
-
Naslund, J., Haroutunian, V., Mohs, R., Davis, K.L., Davies, P., Greengard, P. and Buxbaum, J.D. (2000) Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. JAMA, J. Am. Med. Assoc. 283, 1571-1577
-
(2000)
JAMA, J. Am. Med. Assoc.
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
Davis, K.L.4
Davies, P.5
Greengard, P.6
Buxbaum, J.D.7
-
13
-
-
0034609516
-
The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain
-
Walsh, D.M., Tseng, B.P., Rydel, R.E., Podlisny, M.B. and Selkoe, D.J. (2000) The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain. Biochemistry 39, 10831-10839
-
(2000)
Biochemistry
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
Podlisny, M.B.4
Selkoe, D.J.5
-
14
-
-
1842732209
-
Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain
-
Takahashi, R.H., Almeida, C.G., Kearney, P.F., Yu, F., Lin, M.T., Milner, T.A. and Gouras, G.K. (2004) Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain. J. Neurosci. 24, 3592-3599
-
(2004)
J. Neurosci.
, vol.24
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
Yu, F.4
Lin, M.T.5
Milner, T.A.6
Gouras, G.K.7
-
15
-
-
0035297712
-
Targeting small Aβ oligomers: The solution to an Alzheimer's disease conundrum?
-
Klein, W.L., Krafft, G.A. and Finch, C.E. (2001) Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci. 24, 219-224
-
(2001)
Trends Neurosci.
, vol.24
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
16
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe, D.J. (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
17
-
-
20844458090
-
Synaptic targeting by Alzheimer's-related amyloid β oligomers
-
Lacor, P.N., Buniel, M.C., Chang, L., Fernandez, S.J., Gong, Y., Viola, K.L., Lambert, M.P., Velasco, P.T., Bigio, E.H., Finch, C.E. et al. (2004) Synaptic targeting by Alzheimer's-related amyloid β oligomers. J. Neurosci. 24, 10191-10200
-
(2004)
J. Neurosci.
, vol.24
, pp. 10191-10200
-
-
Lacor, P.N.1
Buniel, M.C.2
Chang, L.3
Fernandez, S.J.4
Gong, Y.5
Viola, K.L.6
Lambert, M.P.7
Velasco, P.T.8
Bigio, E.H.9
Finch, C.E.10
-
18
-
-
33846633336
-
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
DOI 10.1523/JNEUROSCI.3501-06.2007
-
Lacor, P.N., Buniel, M.C., Furlow, P.W., Sanz Clemente, A., Velasco, P.T., Wood, M., Viola, K.L. and Klein, W.L. (2007) Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 27, 796-807 (Pubitemid 46174498)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.4
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
19
-
-
11544279355
-
1-42 are potent central nervous system neurotoxins
-
1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. U.S.A. 95, 6448-6453
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
-
20
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
DOI 10.1038/416535a
-
Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, M.J. and Selkoe, D.J. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (Pubitemid 34288854)
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
21
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong, Y., Chang, L., Viola, K.L., Lacor, P.N., Lambert, M.P., Finch, C.E., Krafft, G.A. and Klein, W.L. (2003) Alzheimer's disease-affected brain: presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. U.S.A. 100, 10417-10422
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
Lacor, P.N.4
Lambert, M.P.5
Finch, C.E.6
Krafft, G.A.7
Klein, W.L.8
-
22
-
-
0032888131
-
Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue, L.F., Kuo, Y.M., Roher, A.E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J.H., Rydel, R.E. and Rogers, J. (1999) Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853-862
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
23
-
-
27644493692
-
Globular amyloid β-peptide oligomer: A homogenous and stable neuropathological protein in Alzheimer's disease
-
Barghorn, S., Nimmrich, V., Striebinger, A., Krantz, C., Keller, P., Janson, B., Bahr, M., Schmidt, M., Bitner, R.S., Harlan, J. et al. (2005) Globular amyloid β-peptide oligomer: a homogenous and stable neuropathological protein in Alzheimer's disease. J. Neurochem. 95, 834-847
-
(2005)
J. Neurochem.
, vol.95
, pp. 834-847
-
-
Barghorn, S.1
Nimmrich, V.2
Striebinger, A.3
Krantz, C.4
Keller, P.5
Janson, B.6
Bahr, M.7
Schmidt, M.8
Bitner, R.S.9
Harlan, J.10
-
24
-
-
38549141544
-
1-42) globulomer suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
-
1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J. Neurosci. 28, 788-797
-
(2008)
J. Neurosci.
, vol.28
, pp. 788-797
-
-
Nimmrich, V.1
Grimm, C.2
Draguhn, A.3
Barghorn, S.4
Lehmann, A.5
Schoemaker, H.6
Hillen, H.7
Gross, G.8
Ebert, U.9
Bruehl, C.10
-
25
-
-
33645038471
-
A specific amyloid-β protein assembly in the brain impairs memory
-
Lesne, S., Koh, M.T., Kotilinek, L., Kayed, R., Glabe, C.G., Yang, A., Gallagher, M. and Ashe, K.H. (2006) A specific amyloid-β protein assembly in the brain impairs memory. Nature 440, 352-357
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
26
-
-
70349295278
-
Structure-neurotoxicity relationships of amyloid β-protein oligomers
-
Ono, K., Condron, M.M. and Teplow, D.B. (2009) Structure-neurotoxicity relationships of amyloid β-protein oligomers. Proc. Natl. Acad. Sci. U.S.A. 106, 14745-14750
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 14745-14750
-
-
Ono, K.1
Condron, M.M.2
Teplow, D.B.3
-
27
-
-
49149124343
-
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar, G.M., Li, S., Mehta, T.H., Garcia-Munoz, A., Shepardson, N.E., Smith, I., Brett, F.M., Farrell, M.A., Rowan, M.J., Lemere, C.A. et al. (2008) Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 14, 837-842
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
-
28
-
-
16644379264
-
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
-
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J. and Ashe, K.H. (2005) Natural oligomers of the amyloid-β protein specifically disrupt cognitive function. Nat. Neurosci. 8, 79-84
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
Ashe, K.H.7
-
29
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
DOI 10.1523/JNEUROSCI.4970-06.2007
-
Shankar, G.M., Bloodgood, B.L., Townsend, M., Walsh, D.M., Selkoe, D.J. and Sabatini, B.L. (2007) Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27, 2866-2875 (Pubitemid 46438992)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.11
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
30
-
-
77950617631
-
A mouse model of amyloid β oligomers: Their contribution to synaptic alteration, abnormal Tau phosphorylation, glial activation, and neuronal loss in vivo
-
Tomiyama, T., Matsuyama, S., Iso, H., Umeda, T., Takuma, H., Ohnishi, K., Ishibashi, K., Teraoka, R., Sakama, N., Yamashita, T. et al. (2010) A mouse model of amyloid β oligomers: their contribution to synaptic alteration, abnormal Tau phosphorylation, glial activation, and neuronal loss in vivo. J. Neurosci. 30, 4845-4856
-
(2010)
J. Neurosci.
, vol.30
, pp. 4845-4856
-
-
Tomiyama, T.1
Matsuyama, S.2
Iso, H.3
Umeda, T.4
Takuma, H.5
Ohnishi, K.6
Ishibashi, K.7
Teraoka, R.8
Sakama, N.9
Yamashita, T.10
-
31
-
-
77955290621
-
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers
-
Gandy, S., Simon, A.J., Steele, J.W., Lublin, A.L., Lah, J.J., Walker, L.C., Levey, A.I., Krafft, G.A., Levy, E., Checler, F. et al. (2010) Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers. Ann. Neurol. 68, 220-230
-
(2010)
Ann. Neurol.
, vol.68
, pp. 220-230
-
-
Gandy, S.1
Simon, A.J.2
Steele, J.W.3
Lublin, A.L.4
Lah, J.J.5
Walker, L.C.6
Levey, A.I.7
Krafft, G.A.8
Levy, E.9
Checler, F.10
-
32
-
-
58849112704
-
Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice
-
Lord, A., Englund, H., Soderberg, L., Tucker, S., Clausen, F., Hillered, L., Gordon, M., Morgan, D., Lannfelt, L., Pettersson, F.E. and Nilsson, L.N. (2009) Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice. FEBS J. 276, 995-1006
-
(2009)
FEBS J.
, vol.276
, pp. 995-1006
-
-
Lord, A.1
Englund, H.2
Soderberg, L.3
Tucker, S.4
Clausen, F.5
Hillered, L.6
Gordon, M.7
Morgan, D.8
Lannfelt, L.9
Pettersson, F.E.10
Nilsson, L.N.11
-
33
-
-
27744512118
-
The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic miceNeurobiol
-
Lord, A., Kalimo, H., Eckman, C., Zhang, X.Q., Lannfelt, L. and Nilsson, L.N. (2006) The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic miceNeurobiol. Aging 27, 67-77
-
(2006)
Aging
, vol.27
, pp. 67-77
-
-
Lord, A.1
Kalimo, H.2
Eckman, C.3
Zhang, X.Q.4
Lannfelt, L.5
Nilsson, L.N.6
-
34
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters, C.L., Simms, G., Weinman, N.A., Multhaup, G., McDonald, B.L. and Beyreuther, K. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. U.S.A. 82, 4245-4249
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
35
-
-
0022654027
-
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease
-
Selkoe, D.J., Abraham, C.R., Podlisny, M.B. and Duffy, L.K. (1986) Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J. Neurochem. 46, 1820-1834 (Pubitemid 16095489)
-
(1986)
Journal of Neurochemistry
, vol.46
, Issue.6
, pp. 1820-1834
-
-
Selkoe, D.J.1
Abraham, C.R.2
Podlisny, M.B.3
Duffy, L.K.4
-
36
-
-
0023037536
-
Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: Immunohistological studies
-
Gorevic, P.D., Goni, F., Pons-Estel, B., Alvarez, F., Peress, N.S. and Frangione, B. (1986) Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies. J. Neuropathol. Exp. Neurol. 45, 647-664
-
(1986)
J. Neuropathol. Exp. Neurol.
, vol.45
, pp. 647-664
-
-
Gorevic, P.D.1
Goni, F.2
Pons-Estel, B.3
Alvarez, F.4
Peress, N.S.5
Frangione, B.6
-
37
-
-
0026794746
-
Mass spectrometry of purified amyloid β protein in Alzheimer's disease
-
Mori, H., Takio, K., Ogawara, M. and Selkoe, D.J. (1992) Mass spectrometry of purified amyloid β protein in Alzheimer's disease. J. Biol. Chem. 267, 17082-17086
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 17082-17086
-
-
Mori, H.1
Takio, K.2
Ogawara, M.3
Selkoe, D.J.4
-
38
-
-
0028855851
-
N3(pE), in senile plaques
-
N3(pE), in senile plaques. Neuron 14, 457-466
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
40
-
-
47249117092
-
Amyloidogenic processing of amyloid precursor protein: Evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-β
-
Cynis, H., Scheel, E., Saido, T.C., Schilling, S. and Demuth, H.U. (2008) Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-β. Biochemistry 47, 7405-7413
-
(2008)
Biochemistry
, vol.47
, pp. 7405-7413
-
-
Cynis, H.1
Scheel, E.2
Saido, T.C.3
Schilling, S.4
Demuth, H.U.5
-
41
-
-
53549099647
-
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology
-
Schilling, S., Zeitschel, U., Hoffmann, T., Heiser, U., Francke, M., Kehlen, A., Holzer, M., Hutter-Paier, B., Prokesch, M., Windisch, M. et al. (2008) Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology. Nat. Med. 14, 1106-1111
-
(2008)
Nat. Med.
, vol.14
, pp. 1106-1111
-
-
Schilling, S.1
Zeitschel, U.2
Hoffmann, T.3
Heiser, U.4
Francke, M.5
Kehlen, A.6
Holzer, M.7
Hutter-Paier, B.8
Prokesch, M.9
Windisch, M.10
-
42
-
-
78650637437
-
Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: A novel tool for therapy and diagnosis
-
Wirths, O., Erck, C., Martens, H., Harmeier, A., Geumann, C., Jawhar, S., Kumar, S., Multhaup, G., Walter, J., Ingelsson, M. et al. (2010) Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J. Biol. Chem. 285, 41517-41524
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 41517-41524
-
-
Wirths, O.1
Erck, C.2
Martens, H.3
Harmeier, A.4
Geumann, C.5
Jawhar, S.6
Kumar, S.7
Multhaup, G.8
Walter, J.9
Ingelsson, M.10
-
43
-
-
0037452779
-
Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology
-
Bard, F., Barbour, R., Cannon, C., Carretto, R., Fox, M., Games, D., Guido, T., Hoenow, K., Hu, K., Johnson-Wood, K. et al. (2003) Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc. Natl. Acad. Sci. U.S.A. 100, 2023-2028
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 2023-2028
-
-
Bard, F.1
Barbour, R.2
Cannon, C.3
Carretto, R.4
Fox, M.5
Games, D.6
Guido, T.7
Hoenow, K.8
Hu, K.9
Johnson-Wood, K.10
-
44
-
-
27144511230
-
β-Amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease
-
Buttini, M., Masliah, E., Barbour, R., Grajeda, H., Motter, R., Johnson-Wood, K., Khan, K., Seubert, P., Freedman, S., Schenk, D. and Games, D. (2005) β-Amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J. Neurosci. 25, 9096-9101
-
(2005)
J. Neurosci.
, vol.25
, pp. 9096-9101
-
-
Buttini, M.1
Masliah, E.2
Barbour, R.3
Grajeda, H.4
Motter, R.5
Johnson-Wood, K.6
Khan, K.7
Seubert, P.8
Freedman, S.9
Schenk, D.10
Games, D.11
-
45
-
-
47949132196
-
Active and passive immunotherapy for neurodegenerative disorders
-
Brody, D.L. and Holtzman, D.M. (2008) Active and passive immunotherapy for neurodegenerative disorders. Annu. Rev. Neurosci. 31, 175-193
-
(2008)
Annu. Rev. Neurosci.
, vol.31
, pp. 175-193
-
-
Brody, D.L.1
Holtzman, D.M.2
|