Fibrillar amyloid plaque formation precedes microglial activation

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Jung, Christian K E ^a   Keppler, Kevin ^a   Steinbach, Sonja ^a   Blazquez Llorca, Lidia ^a   Herms, Jochen ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b Germany 3 Munich Cluster for Systems Neurology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHEMOKINE RECEPTOR CX3CR1; PRESENILIN 1; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL ACTIVATION; CONTROLLED STUDY; HIPPOCAMPUS; IN VIVO STUDY; MICROGLIA; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PRIMARY MOTOR CORTEX; SOMATOSENSORY CORTEX; TRANSGENIC MOUSE; ANIMAL; BRAIN; CELL CULTURE; COMPLICATION; DISEASE MODEL; ENZYME IMMUNOASSAY; FEMALE; HUMAN; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PLAQUE, AMYLOID;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MICE; MICE, TRANSGENIC; MICROGLIA; PLAQUE, AMYLOID; PRESENILIN-1; RECEPTORS, CHEMOKINE;

EID: 84925799248     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119768     Document Type: Article

References (24)

1. Sheng JG, Mrak RE, Griffin WS. Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages. J Neuropathol Exp Neurol. 1997; 56: 285-290. PMID: 9056542
2. Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH. Alzheimer's disease. A doublelabeling immunohistochemical study of senile plaques. Am J Pathol. 1988; 132: 86-101. PMID: 2456021
3. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989; 24: 173-182. PMID: 2808689
4. Burgold S, Bittner T, Dorostkar MM, Kieser D, Fuhrmann M, Mitteregger G, et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta Neuropathol. 2011; 121: 327-335. doi: 10.1007/s00401-010-0787-6 PMID: 21136067
5. Bittner T, Burgold S, Dorostkar MM, Fuhrmann M, Wegenast-Braun BM, Schmidt B, et al. Amyloid plaque formation precedes dendritic spine loss. Acta Neuropathol. 2012; 124: 797-807. doi: 10.1007/ s00401-012-1047-8 PMID: 22993126
6. Trojanowski JQ, Shin RW, Schmidt ML, Lee VM. Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease. Neurobiol Aging 1995; 16: 335-340; discussion 341-335. PMID: 7566343
7. Tsai J, Grutzendler J, Duff K, Gan WB. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci. 2004; 7: 1181-1183. PMID: 15475950
8. Shah P, Lal N, Leung E, Traul DE, Gonzalo-Ruiz A, Geula C. Neuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex. Am J Pathol. 2010; 177: 325-333. doi: 10.2353/ajpath.2010.090937 PMID: 20489158
9. Cunningham C. Microglia and neurodegeneration: the role of systemic inflammation. Glia 2013; 61: 71-90. doi: 10.1002/glia.22350 PMID: 22674585
10. Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem. 2007; 14: 1189-1197. PMID: 17504139
11. Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 2001; 33: 256-266. PMID: 11241743
12. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004; 13: 159-170. PMID: 14645205
13. Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. 2000; 20: 4106-4114. PMID: 10805752
14. Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000; 28: 41-51. PMID: 11086982
15. Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002; 61: 797-805. PMID: 12230326
16. Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol. 2010; 177: 2549-2562. doi: 10.2353/ajpath.2010.100265 PMID: 20864679
17. Liu Z, Condello C, Schain A, Harb R, Grutzendler J. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis. J Neurosci. 2010; 30: 17091-17101. doi: 10.1523/JNEUROSCI.4403-10.2010 PMID: 21159979
18. Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid betaprotein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia 1999; 25: 324-331. PMID: 10028915
19. Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, et al. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci. 2010; 13: 411-413. doi: 10.1038/nn.2511 PMID: 20305648
20. Wyss-Coray T. Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's. Curr Alzheimer Res. 2006; 3: 191-195. PMID: 16842094
21. Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, et al. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 2008; 451: 720-724. doi: 10.1038/nature06616 PMID: 18256671
22. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008; 9: 857-865. doi: 10.1038/ni.1636 PMID: 18604209
23. Griffin WS, Sheng JG, Roberts GW, Mrak RE. Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol. 1995; Exp Neurol 54: 276-281. PMID: 7876895
24. Xiang Z, Haroutunian V, Ho L, Purohit D, Pasinetti GM. Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia. Dis Markers 2006; 22: 95-102. PMID: 16410654