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Volumn 182, Issue 6, 2013, Pages 2332-2344

A phenotypic change but not proliferation underlies glial responses in Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE AMMONIA LIGASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 84878243515     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.02.031     Document Type: Article
Times cited : (129)

References (63)
  • 1
    • 0024824922 scopus 로고
    • Patterns of gliosis in Alzheimer's disease and aging cerebrum
    • T.G. Beach, R. Walker, and E.G. McGeer Patterns of gliosis in Alzheimer's disease and aging cerebrum Glia 2 1989 420 436
    • (1989) Glia , vol.2 , pp. 420-436
    • Beach, T.G.1    Walker, R.2    McGeer, E.G.3
  • 2
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • S. Itagaki, P.L. McGeer, H. Akiyama, S. Zhu, and D. Selkoe Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease J Neuroimmunol 24 1989 173 182
    • (1989) J Neuroimmunol , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 5
    • 0028123075 scopus 로고
    • Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro
    • E. Ulvestad, K. Williams, S. Mørk, J. Antel, and H. Nyland Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro J Neuropathol Exp Neurol 53 1994 492 501
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 492-501
    • Ulvestad, E.1    Williams, K.2    Mørk, S.3    Antel, J.4    Nyland, H.5
  • 6
    • 0023633015 scopus 로고
    • Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR
    • P.L. McGeer, S. Itagaki, H. Tago, and E.G. McGeer Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR Neurosci Lett 79 1987 195 200
    • (1987) Neurosci Lett , vol.79 , pp. 195-200
    • McGeer, P.L.1    Itagaki, S.2    Tago, H.3    McGeer, E.G.4
  • 7
    • 0025162755 scopus 로고
    • Brain microglia constitutively express beta-2 integrins
    • H. Akiyama, and P.L. McGeer Brain microglia constitutively express beta-2 integrins J Neuroimunol 30 1990 81 93
    • (1990) J Neuroimunol , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 13
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease
    • G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 14
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute of Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute of Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease Neurobiol Aging 18 4 Suppl 1997 S1 S2
    • (1997) Neurobiol Aging , vol.18 , Issue.4 SUPPL.
  • 15
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • J. Gerdes, H. Lemke, H. Baisch, H.H. Wacker, U. Schwab, and H. Stein Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67 J immunol 133 1984 1710 1715
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3    Wacker, H.H.4    Schwab, U.5    Stein, H.6
  • 16
    • 0027057589 scopus 로고
    • Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections
    • G. Cattoretti, M.H. Becker, G. Key, M. Duchrow, C. Schlüter, J. Galle, and J. Gerdes Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections J Pathol 168 1992 357 363
    • (1992) J Pathol , vol.168 , pp. 357-363
    • Cattoretti, G.1    Becker, M.H.2    Key, G.3    Duchrow, M.4    Schlüter, C.5    Galle, J.6    Gerdes, J.7
  • 18
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • P.V. Arriagada, J.H. Growdon, E.T. Hedley-Whyte, and B.T. Hyman Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Neurology 42 1992 631 639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 22
    • 0033963901 scopus 로고    scopus 로고
    • Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes
    • S.R. Robinson Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes Neurochem Int 36 2000 471 482
    • (2000) Neurochem Int , vol.36 , pp. 471-482
    • Robinson, S.R.1
  • 23
    • 0025339720 scopus 로고
    • Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors
    • L.A. Mattiace, P. Davis, and D.W. Dickson Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors Am J Pathol 136 1990 1101 1114
    • (1990) Am J Pathol , vol.136 , pp. 1101-1114
    • Mattiace, L.A.1    Davis, P.2    Dickson, D.W.3
  • 24
    • 0031831690 scopus 로고    scopus 로고
    • Microglial activation in Alzheimer disease: Association with APOE genotype
    • R. Egensperger, S. Kösel, U. von Eitzen, and M.B. Graeber Microglial activation in Alzheimer disease: association with APOE genotype Brain Pathol 8 1998 439 447
    • (1998) Brain Pathol , vol.8 , pp. 439-447
    • Egensperger, R.1    Kösel, S.2    Von Eitzen, U.3    Graeber, M.B.4
  • 27
    • 0031043049 scopus 로고    scopus 로고
    • Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions
    • Z. Nagy, M.M. Esiri, and A.D. Smith Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions Acta Neuropathol 93 1997 294 300
    • (1997) Acta Neuropathol , vol.93 , pp. 294-300
    • Nagy, Z.1    Esiri, M.M.2    Smith, A.D.3
  • 28
    • 20344384232 scopus 로고    scopus 로고
    • Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the aging human hippocampus increases with the burden of Alzheimer-type pathology
    • MRC Cognitive Function and Ageing Neuropathology Study Group
    • S.B. Wharton, G.H. Williams, K. Stoeber, C.H. Gelsthorpe, L. Baxter, A.L. Johnson, P.G. Ince MRC Cognitive Function and Ageing Neuropathology Study Group Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the aging human hippocampus increases with the burden of Alzheimer-type pathology Neurosci Lett 383 2005 33 38
    • (2005) Neurosci Lett , vol.383 , pp. 33-38
    • Wharton, S.B.1    Williams, G.H.2    Stoeber, K.3    Gelsthorpe, C.H.4    Baxter, L.5    Johnson, A.L.6    Ince, P.G.7
  • 29
    • 33748790666 scopus 로고    scopus 로고
    • Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    • K. Boekhoorn, M. Joels, and P.J. Lucassen Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus Neurobiol Dis 24 2006 1 14
    • (2006) Neurobiol Dis , vol.24 , pp. 1-14
    • Boekhoorn, K.1    Joels, M.2    Lucassen, P.J.3
  • 30
    • 0344444229 scopus 로고    scopus 로고
    • Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons
    • U. Gärtner, M.K. Brückner, S. Krug, S. Schmetsdorf, M. Staufenbiel, and T. Arendt Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons Acta Neuropathol 106 2003 535 544
    • (2003) Acta Neuropathol , vol.106 , pp. 535-544
    • Gärtner, U.1    Brückner, M.K.2    Krug, S.3    Schmetsdorf, S.4    Staufenbiel, M.5    Arendt, T.6
  • 32
    • 84855199741 scopus 로고    scopus 로고
    • Abeta plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: A study in APP mutant mice
    • I. Luccarini, C. Grossi, C. Traini, A. Fiorentini, T.E. Dami, and F. Casamenti Abeta plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: a study in APP mutant mice Neurosci Lett 506 2012 94 99
    • (2012) Neurosci Lett , vol.506 , pp. 94-99
    • Luccarini, I.1    Grossi, C.2    Traini, C.3    Fiorentini, A.4    Dami, T.E.5    Casamenti, F.6
  • 33
    • 84856715245 scopus 로고    scopus 로고
    • Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model
    • W. Kamphuis, M. Orre, L. Kooijman, M. Dahmen, and E.M. Hol Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model Glia 60 2012 615 629
    • (2012) Glia , vol.60 , pp. 615-629
    • Kamphuis, W.1    Orre, M.2    Kooijman, L.3    Dahmen, M.4    Hol, E.M.5
  • 34
    • 77049085956 scopus 로고    scopus 로고
    • Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
    • MRC Cognitive Function and Ageing Neuropathology Study Group
    • J.E. Simpson, P.G. Ince, G. Lace, G. Forster, P.J. Shaw, F. Matthews, G. Savva, C. Brayne, S.B. Wharton MRC Cognitive Function and Ageing Neuropathology Study Group Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain Neurobiol Aging 31 2010 578 590
    • (2010) Neurobiol Aging , vol.31 , pp. 578-590
    • Simpson, J.E.1    Ince, P.G.2    Lace, G.3    Forster, G.4    Shaw, P.J.5    Matthews, F.6    Savva, G.7    Brayne, C.8    Wharton, S.B.9
  • 36
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
    • T. Wyss-Coray Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12 2006 1005 1015
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 40
    • 61349096009 scopus 로고    scopus 로고
    • Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
    • K.V. Kuchibhotla, C.R. Lattarulo, B.T. Hyman, and B.J. Bacskai Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice Science 323 2009 1211 1215
    • (2009) Science , vol.323 , pp. 1211-1215
    • Kuchibhotla, K.V.1    Lattarulo, C.R.2    Hyman, B.T.3    Bacskai, B.J.4
  • 44
    • 0026687640 scopus 로고
    • Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain
    • M.B. Graeber, W.J. Streit, D. Büringer, L. Sparks, and G.W. Kreutzberg Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain J Neuropathol Exp Neurol 51 1992 303 311
    • (1992) J Neuropathol Exp Neurol , vol.51 , pp. 303-311
    • Graeber, M.B.1    Streit, W.J.2    Büringer, D.3    Sparks, L.4    Kreutzberg, G.W.5
  • 45
    • 0026470167 scopus 로고
    • MHC class II-positive microglia in human brain: Association with Alzheimer lesions
    • [Erratum appeared in J Neurosci Res 1993, 35:346]
    • L.S. Perlmutter, S.A. Scott, E. Barrón, and H.C. Chui MHC class II-positive microglia in human brain: association with Alzheimer lesions [Erratum appeared in J Neurosci Res 1993, 35:346] J Neurosci Res 33 1992 549 558
    • (1992) J Neurosci Res , vol.33 , pp. 549-558
    • Perlmutter, L.S.1    Scott, S.A.2    Barrón, E.3    Chui, H.C.4
  • 46
    • 11844255779 scopus 로고    scopus 로고
    • Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
    • T.M. Malm, M. Koistinaho, M. Pärepalo, T. Vatanen, A. Ooka, S. Karlsson, and J. Koistinaho Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice Neurobiol Dis 18 2005 134 142
    • (2005) Neurobiol Dis , vol.18 , pp. 134-142
    • Malm, T.M.1    Koistinaho, M.2    Pärepalo, M.3    Vatanen, T.4    Ooka, A.5    Karlsson, S.6    Koistinaho, J.7
  • 48
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia plays a critical role in restricting senile plaque formation in Alzheimer's disease
    • A.R. Simard, D. Soulet, G. Gowing, J.P. Julien, and S. Rivest Bone marrow-derived microglia plays a critical role in restricting senile plaque formation in Alzheimer's disease Neuron 49 2006 489 502
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 50
    • 0020348267 scopus 로고
    • Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT)
    • H.M. Wisniewski, and P.B. Kozlowski Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT) Ann N Y Acad Sci 396 1982 119 129
    • (1982) Ann N y Acad Sci , vol.396 , pp. 119-129
    • Wisniewski, H.M.1    Kozlowski, P.B.2
  • 52
    • 82455162480 scopus 로고    scopus 로고
    • Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort
    • A.P. Viggars, S.B. Wharton, J.E. Simpson, F.E. Matthews, C. Brayne, G.M. Savva, C. Garwood, D. Drew, P.J. Shaw, and P.G. Ince Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort Neurosci Lett 505 2011 25 30
    • (2011) Neurosci Lett , vol.505 , pp. 25-30
    • Viggars, A.P.1    Wharton, S.B.2    Simpson, J.E.3    Matthews, F.E.4    Brayne, C.5    Savva, G.M.6    Garwood, C.7    Drew, D.8    Shaw, P.J.9    Ince, P.G.10
  • 53
    • 0031922362 scopus 로고    scopus 로고
    • A population study on blood-brain barrier function in 85-year-olds: Relation to Alzheimer's disease and vascular dementia
    • I. Skoog, A. Wallin, P. Fredman, C. Hesse, O. Aevarsson, I. Karlsson, C.G. Gottfries, and K. Blennow A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia Neurology 50 1998 966 971
    • (1998) Neurology , vol.50 , pp. 966-971
    • Skoog, I.1    Wallin, A.2    Fredman, P.3    Hesse, C.4    Aevarsson, O.5    Karlsson, I.6    Gottfries, C.G.7    Blennow, K.8
  • 54
    • 34248645424 scopus 로고    scopus 로고
    • The integrity of the blood-brain barrier in Alzheimer's disease
    • A. Algotsson, and B. Winblad The integrity of the blood-brain barrier in Alzheimer's disease Acta Neurol Scand 115 2007 403 408
    • (2007) Acta Neurol Scand , vol.115 , pp. 403-408
    • Algotsson, A.1    Winblad, B.2
  • 55
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • G.L. Bowman, J.A. Kaye, M. Moore, D. Waichunas, N.E. Carlson, and J.F. Quinn Blood-brain barrier impairment in Alzheimer disease: stability and functional significance Neurology 68 2007 1809 1814
    • (2007) Neurology , vol.68 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 56
  • 57
    • 67649104088 scopus 로고    scopus 로고
    • APOE genotype-specific differences in the innate immune response
    • M.P. Vitek, C.M. Brown, and C.A. Colton APOE genotype-specific differences in the innate immune response Neurobiol Aging 30 2009 1350 1360
    • (2009) Neurobiol Aging , vol.30 , pp. 1350-1360
    • Vitek, M.P.1    Brown, C.M.2    Colton, C.A.3
  • 61
    • 84869187974 scopus 로고    scopus 로고
    • Molecular imaging of microglia/macrophages in the brain
    • S. Venneti, B.J. Lopresti, and C.A. Wiley Molecular imaging of microglia/macrophages in the brain Glia 61 2012 10 23
    • (2012) Glia , vol.61 , pp. 10-23
    • Venneti, S.1    Lopresti, B.J.2    Wiley, C.A.3
  • 62
    • 58449115240 scopus 로고    scopus 로고
    • Carbon 11-labeled Pittsburgh compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    • C.A. Wiley, B.J. Lopresti, S. Venetti, J. Price, W.E. Klunk, S.T. DeKosky, and C.A. Mathis Carbon 11-labeled Pittsburgh compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease Arch Neurol 66 2009 60 67
    • (2009) Arch Neurol , vol.66 , pp. 60-67
    • Wiley, C.A.1    Lopresti, B.J.2    Venetti, S.3    Price, J.4    Klunk, W.E.5    Dekosky, S.T.6    Mathis, C.A.7


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