-
1
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P. & Kivipelto, M. Alzheimer's disease: clinical trials and drug development. Lancet Neurol. 9, 702-716 (2010).
-
(2010)
Lancet Neurol.
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
-
2
-
-
84900808364
-
Investigational drugs in Alzheimer's disease: Current progress
-
Berk, C., Paul, G. & Sabbagh, M. Investigational drugs in Alzheimer's disease: current progress. Expert Opin. Investig. Drugs 23, 837-846 (2014).
-
(2014)
Expert Opin. Investig. Drugs
, vol.23
, pp. 837-846
-
-
Berk, C.1
Paul, G.2
Sabbagh, M.3
-
3
-
-
84963520567
-
The amyloid hypothesis of Alzheimer's disease at 25 years
-
Selkoe, D. J. & Hardy, J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8, 595-608 (2016).
-
(2016)
EMBO Mol. Med.
, vol.8
, pp. 595-608
-
-
Selkoe, D.J.1
Hardy, J.2
-
4
-
-
0026432318
-
Seminars in medicine of the Beth Israel Hospital, Boston. β-Amyloid and the pathogenesis of Alzheimer's disease
-
Yankner, B. A. & Mesulam, M. M. Seminars in medicine of the Beth Israel Hospital, Boston. β-Amyloid and the pathogenesis of Alzheimer's disease. N. Engl. J. Med. 325, 1849-1857 (1991).
-
(1991)
N. Engl. J. Med.
, vol.325
, pp. 1849-1857
-
-
Yankner, B.A.1
Mesulam, M.M.2
-
5
-
-
58049155245
-
Amyloid β peptides in human plasma and tissues and their significance for Alzheimer's disease
-
Roher, A. E. et al. Amyloid β peptides in human plasma and tissues and their significance for Alzheimer's disease. Alzheimers Dement. 5, 18-29 (2009).
-
(2009)
Alzheimers Dement.
, vol.5
, pp. 18-29
-
-
Roher, A.E.1
-
6
-
-
0032860931
-
The amyloid precursor protein of Alzheimer disease in human brain and blood
-
Li, Q. X., Fuller, S. J., Beyreuther, K. & Masters, C. L. The amyloid precursor protein of Alzheimer disease in human brain and blood. J. Leukoc. Biol. 66, 567-574 (1999).
-
(1999)
J. Leukoc. Biol.
, vol.66
, pp. 567-574
-
-
Li, Q.X.1
Fuller, S.J.2
Beyreuther, K.3
Masters, C.L.4
-
7
-
-
80054705807
-
Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI
-
Toledo, J. et al. Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI. Acta Neuropathol. 122, 401-413 (2011).
-
(2011)
Acta Neuropathol.
, vol.122
, pp. 401-413
-
-
Toledo, J.1
-
8
-
-
0035907123
-
Amyloid β protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
-
Mehta, P. D., Pirttila, T., Patrick, B. A., Barshatzky, M. & Mehta, S. P. Amyloid β protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci. Lett. 304, 102-106 (2001).
-
(2001)
Neurosci. Lett.
, vol.304
, pp. 102-106
-
-
Mehta, P.D.1
Pirttila, T.2
Patrick, B.A.3
Barshatzky, M.4
Mehta, S.P.5
-
9
-
-
84875271668
-
Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes
-
Delvaux, E., Bentley, K., Stubbs, V., Sabbagh, M. & Coleman, P. Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes. Neurobiol. Aging 34, 1680-1686 (2013).
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1680-1686
-
-
Delvaux, E.1
Bentley, K.2
Stubbs, V.3
Sabbagh, M.4
Coleman, P.5
-
10
-
-
0242267132
-
Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
-
Evin, G., Zhu, A., Holsinger, R. M., Masters, C. & Li, Q.-X. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets. J. Neurosci. Res. 74, 386-392 (2003).
-
(2003)
J. Neurosci. Res.
, vol.74
, pp. 386-392
-
-
Evin, G.1
Zhu, A.2
Holsinger, R.M.3
Masters, C.4
Li, Q.-X.5
-
11
-
-
16944364644
-
Amyloid β-peptide is transported on lipoproteins and albumin in human plasma
-
Biere, A. L. et al. Amyloid β-peptide is transported on lipoproteins and albumin in human plasma. J. Biol. Chem. 271, 32916-32922 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32916-32922
-
-
Biere, A.L.1
-
12
-
-
0034708137
-
Amyloid-β peptides interact with plasma proteins and erythrocytes: Implications for their quantitation in plasma
-
Kuo, Y. M. et al. Amyloid-β peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma. Biochem. Biophys. Res. Commun. 268, 750-756 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.268
, pp. 750-756
-
-
Kuo, Y.M.1
-
13
-
-
0024451476
-
Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease
-
Joachim, C. L., Mori, H. & Selkoe, D. J. Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease. Nature 341, 226-230 (1989).
-
(1989)
Nature
, vol.341
, pp. 226-230
-
-
Joachim, C.L.1
Mori, H.2
Selkoe, D.J.3
-
14
-
-
84860217982
-
Alzheimer's disease in the retina: Imaging retinal Aβ plaques for early diagnosis and therapy assessment
-
Koronyo, Y., Salumbides, B., Black, K. & Koronyo Hamaoui, M. Alzheimer's disease in the retina: imaging retinal Aβ plaques for early diagnosis and therapy assessment. Neurodegener. Dis. 10, 285-293 (2012).
-
(2012)
Neurodegener. Dis.
, vol.10
, pp. 285-293
-
-
Koronyo, Y.1
Salumbides, B.2
Black, K.3
Koronyo Hamaoui, M.4
-
15
-
-
84999873166
-
Aβ amyloid pathology affects the hearts of patients with Alzheimer's disease: Mind the heart
-
Troncone, L. et al. Aβ amyloid pathology affects the hearts of patients with Alzheimer's disease: mind the heart. J. Am. Coll. Cardiol. 68, 2395-2407 (2016).
-
(2016)
J. Am. Coll. Cardiol.
, vol.68
, pp. 2395-2407
-
-
Troncone, L.1
-
16
-
-
0038176528
-
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
-
Stine, W. B., Dahlgren, K., Krafft, G. & LaDu, M. In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis. J. Biol. Chem. 278, 11612-11622 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11612-11622
-
-
Stine, W.B.1
Dahlgren, K.2
Krafft, G.3
LaDu, M.4
-
17
-
-
70149102204
-
Amyloid β protein: Aβ40 inhibits Aβ42 oligomerization
-
Murray, M. et al. Amyloid β protein: Aβ40 inhibits Aβ42 oligomerization. J. Am. Chem. Soc. 131, 6316-6317 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 6316-6317
-
-
Murray, M.1
-
18
-
-
84938949776
-
Clearance systems in the brain - Implications for Alzheimer disease
-
Tarasoff-Conway, J. M. et al. Clearance systems in the brain - implications for Alzheimer disease. Nat. Rev. Neurol. 11, 457-470 (2015).
-
(2015)
Nat. Rev. Neurol.
, vol.11
, pp. 457-470
-
-
Tarasoff-Conway, J.M.1
-
19
-
-
84946500159
-
P75NTR ectodomain is a physiological neuroprotective molecule against amyloid-β toxicity in the brain of Alzheimer's disease
-
Yao, X. Q. et al. p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-β toxicity in the brain of Alzheimer's disease. Mol. Psychiatry 20, 1301-1310 (2015).
-
(2015)
Mol. Psychiatry
, vol.20
, pp. 1301-1310
-
-
Yao, X.Q.1
-
20
-
-
78149255950
-
N-Terminal domain of myelin basic protein inhibits amyloid β-protein fibril assembly
-
Liao, M. C. et al. N-Terminal domain of myelin basic protein inhibits amyloid β-protein fibril assembly. J. Biol. Chem. 285, 35590-35598 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35590-35598
-
-
Liao, M.C.1
-
21
-
-
84893833082
-
Differences in amyloid-β clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modeling
-
Qosa, H. et al. Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology 79, 668-678 (2014).
-
(2014)
Neuropharmacology
, vol.79
, pp. 668-678
-
-
Qosa, H.1
-
22
-
-
84969262537
-
Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model
-
Yuede, C. M. et al. Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model. J. Exp. Med. 213, 677-685 (2016).
-
(2016)
J. Exp. Med.
, vol.213
, pp. 677-685
-
-
Yuede, C.M.1
-
23
-
-
84942365599
-
Physiological amyloid-β clearance in the periphery and its therapeutic potential for Alzheimer's disease
-
Xiang, Y. et al. Physiological amyloid-β clearance in the periphery and its therapeutic potential for Alzheimer's disease. Acta Neuropathol. 130, 487-499 (2015).
-
(2015)
Acta Neuropathol.
, vol.130
, pp. 487-499
-
-
Xiang, Y.1
-
24
-
-
84891706947
-
CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology
-
Bradshaw, E. M. et al. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat. Neurosci. 16, 848-850 (2013).
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 848-850
-
-
Bradshaw, E.M.1
-
25
-
-
84901341240
-
The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease
-
Kanekiyo, T. & Bu, G. The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease. Front. Aging Neurosci. 6, 93 (2014).
-
(2014)
Front. Aging Neurosci.
, vol.6
, pp. 93
-
-
Kanekiyo, T.1
Bu, G.2
-
26
-
-
8544240891
-
Systemic catabolism of Alzheimer's Aβ40 and Aβ42
-
Ghiso, J. et al. Systemic catabolism of Alzheimer's Aβ40 and Aβ42. J. Biol. Chem. 279, 45897-45908 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45897-45908
-
-
Ghiso, J.1
-
27
-
-
0030949335
-
Alzheimer's soluble amyloid β is a normal component of human urine
-
Ghiso, J. et al. Alzheimer's soluble amyloid β is a normal component of human urine. FEBS Lett. 408, 105-108 (1997).
-
(1997)
FEBS Lett.
, vol.408
, pp. 105-108
-
-
Ghiso, J.1
-
28
-
-
84859394857
-
Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: A role in Alzheimer's disease?
-
Liu, Z. et al. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease? J. Alzheimers Dis. 29, 329-340 (2012).
-
(2012)
J. Alzheimers Dis.
, vol.29
, pp. 329-340
-
-
Liu, Z.1
-
29
-
-
0032529151
-
Human blood-brain barrier receptors for Alzheimer's amyloid-β1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
-
Mackic, J. B. et al. Human blood-brain barrier receptors for Alzheimer's amyloid-β1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J. Clin. Invest. 102, 734-743 (1998).
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 734-743
-
-
Mackic, J.B.1
-
30
-
-
0038038284
-
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: A hypothesis
-
Silverberg, G. D., Mayo, M., Saul, T., Rubenstein, E. & McGuire, D. Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol. 2, 506-511 (2003).
-
(2003)
Lancet Neurol.
, vol.2
, pp. 506-511
-
-
Silverberg, G.D.1
Mayo, M.2
Saul, T.3
Rubenstein, E.4
McGuire, D.5
-
31
-
-
84942469639
-
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
-
Aspelund, A. et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J. Exp. Med. 212, 991-999 (2015).
-
(2015)
J. Exp. Med.
, vol.212
, pp. 991-999
-
-
Aspelund, A.1
-
32
-
-
84936871460
-
Structural and functional features of central nervous system lymphatic vessels
-
Louveau, A. et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337-341 (2015).
-
(2015)
Nature
, vol.523
, pp. 337-341
-
-
Louveau, A.1
-
33
-
-
84942410929
-
Implications of the discovery of brain lymphatic pathways
-
Iliff, J. J., Goldman, S. A. & Nedergaard, M. Implications of the discovery of brain lymphatic pathways. Lancet Neurol. 14, 977-979 (2015).
-
(2015)
Lancet Neurol.
, vol.14
, pp. 977-979
-
-
Iliff, J.J.1
Goldman, S.A.2
Nedergaard, M.3
-
34
-
-
78149392229
-
Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis
-
Eisele, Y. S. et al. Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis. Science 330, 980-982 (2010).
-
(2010)
Science
, vol.330
, pp. 980-982
-
-
Eisele, Y.S.1
-
35
-
-
84905053905
-
Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis
-
Eisele, Y. S. et al. Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis. J. Neurosci. 34, 10264-10273 (2014).
-
(2014)
J. Neurosci.
, vol.34
, pp. 10264-10273
-
-
Eisele, Y.S.1
-
36
-
-
85016129611
-
Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK
-
Ritchie, D. L. et al. Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK. Acta Neuropathol. 134, 221-240 (2017).
-
(2017)
Acta Neuropathol.
, vol.134
, pp. 221-240
-
-
Ritchie, D.L.1
-
37
-
-
84941198850
-
Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy
-
Jaunmuktane, Z. et al. Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy. Nature 525, 247-250 (2015).
-
(2015)
Nature
, vol.525
, pp. 247-250
-
-
Jaunmuktane, Z.1
-
38
-
-
0037703255
-
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
-
Deane, R. et al. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9, 907-913 (2003).
-
(2003)
Nat. Med.
, vol.9
, pp. 907-913
-
-
Deane, R.1
-
39
-
-
33749157416
-
RAGE, LRP-1, and amyloid-β protein in Alzheimer's disease
-
Donahue, J. E. et al. RAGE, LRP-1, and amyloid-β protein in Alzheimer's disease. Acta Neuropathol. 112, 405-415 (2006).
-
(2006)
Acta Neuropathol.
, vol.112
, pp. 405-415
-
-
Donahue, J.E.1
-
40
-
-
0013615899
-
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
-
Yan, S. D. et al. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691 (1996).
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
Yan, S.D.1
-
41
-
-
84939000054
-
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin
-
Zenaro, E. et al. Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. Nat. Med. 21, 880-886 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 880-886
-
-
Zenaro, E.1
-
42
-
-
84883361779
-
Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
-
Frenkel, D. et al. Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat. Commun. 4, 2030 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2030
-
-
Frenkel, D.1
-
43
-
-
84876006819
-
Functional impairment of microglia coincides with β-amyloid deposition in mice with Alzheimer-like pathology
-
Krabbe, G. et al. Functional impairment of microglia coincides with β-amyloid deposition in mice with Alzheimer-like pathology. PLoS ONE 8, e60921 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e60921
-
-
Krabbe, G.1
-
44
-
-
59249103997
-
Alzheimer disease macrophages shuttle amyloid-β from neurons to vessels, contributing to amyloid angiopathy
-
Zaghi, J. et al. Alzheimer disease macrophages shuttle amyloid-β from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol. 117, 111-124 (2009).
-
(2009)
Acta Neuropathol.
, vol.117
, pp. 111-124
-
-
Zaghi, J.1
-
45
-
-
84978176214
-
Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease
-
Gu, B. J. et al. Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease. Acta Neuropathol. 132, 377-389 (2016).
-
(2016)
Acta Neuropathol.
, vol.132
, pp. 377-389
-
-
Gu, B.J.1
-
46
-
-
84945936473
-
Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-β pathology in PSAPP mice
-
Darlington, D. et al. Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-β pathology in PSAPP mice. Cell Transplant. 24, 2237-22350 (2015).
-
(2015)
Cell Transplant.
, vol.24
, pp. 2237-22350
-
-
Darlington, D.1
-
47
-
-
84957431867
-
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease
-
Baruch, K. et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease. Nat. Med. 22, 135-137 (2016).
-
(2016)
Nat. Med.
, vol.22
, pp. 135-137
-
-
Baruch, K.1
-
48
-
-
84950248998
-
Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice
-
Prokop, S. et al. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. J. Exp. Med. 212, 1811-1818 (2015).
-
(2015)
J. Exp. Med.
, vol.212
, pp. 1811-1818
-
-
Prokop, S.1
-
49
-
-
79955484414
-
Common variants at ABCA7. MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
Hollingworth, P. et al. Common variants at ABCA7. MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 43, 429-435 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 429-435
-
-
Hollingworth, P.1
-
50
-
-
84872088087
-
Variant of TREM2 associated with the risk of Alzheimer's disease
-
Jonsson, T. et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N. Engl. J. Med. 368, 107-116 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 107-116
-
-
Jonsson, T.1
-
51
-
-
84924737031
-
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
-
Jay, T. R. et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J. Exp. Med. 212, 287-295 (2015).
-
(2015)
J. Exp. Med.
, vol.212
, pp. 287-295
-
-
Jay, T.R.1
-
52
-
-
84867142068
-
Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament
-
Bartos, A., Fialova, L., Svarcova, J. & Ripova, D. Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament. J. Neuroimmunol. 252, 100-105 (2012).
-
(2012)
J. Neuroimmunol.
, vol.252
, pp. 100-105
-
-
Bartos, A.1
Fialova, L.2
Svarcova, J.3
Ripova, D.4
-
53
-
-
84889086668
-
Immunity and Alzheimer's disease: Immunological perspectives on the development of novel therapies
-
Liu, Y. H. et al. Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies. Drug Discov. Today 18, 1212-1220 (2013).
-
(2013)
Drug Discov. Today
, vol.18
, pp. 1212-1220
-
-
Liu, Y.H.1
-
54
-
-
84959365890
-
Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin
-
Wang, T. et al. Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin. Neuropharmacology 105, 561-576 (2016).
-
(2016)
Neuropharmacology
, vol.105
, pp. 561-576
-
-
Wang, T.1
-
55
-
-
84966318506
-
Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood-based biomarkers
-
DeMarshall, C. A. et al. Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood-based biomarkers. Alzheimers Dement. (Amst.) 3, 51-62 (2016).
-
(2016)
Alzheimers Dement. (Amst.)
, vol.3
, pp. 51-62
-
-
DeMarshall, C.A.1
-
57
-
-
84985896386
-
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
-
Sevigny, J. et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature 537, 50-56 (2016).
-
(2016)
Nature
, vol.537
, pp. 50-56
-
-
Sevigny, J.1
-
58
-
-
84959432135
-
The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function
-
Marsh, S. E. et al. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc. Natl Acad. Sci. USA 113, E1316-E1325 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E1316-E1325
-
-
Marsh, S.E.1
-
59
-
-
84939490054
-
Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer's disease pathology
-
Baruch, K. et al. Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer's disease pathology. Nat. Commun. 6, 7967 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7967
-
-
Baruch, K.1
-
60
-
-
0031047350
-
Altered amyloid protein processing in platelets of patients with Alzheimer disease
-
Rosenberg, R. N. et al. Altered amyloid protein processing in platelets of patients with Alzheimer disease. Arch. Neurol. 54, 139-144 (1997).
-
(1997)
Arch. Neurol.
, vol.54
, pp. 139-144
-
-
Rosenberg, R.N.1
-
61
-
-
0029819924
-
Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome
-
Di Luca, M. et al. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome. Arch. Neurol. 53, 1162-1166 (1996).
-
(1996)
Arch. Neurol.
, vol.53
, pp. 1162-1166
-
-
Di Luca, M.1
-
62
-
-
84876689268
-
The platelet amyloid precursor protein ratio as a diagnostic marker for Alzheimer's disease in Thai patients
-
Srisawat, C. et al. The platelet amyloid precursor protein ratio as a diagnostic marker for Alzheimer's disease in Thai patients. J. Clin. Neurosci. 20, 644-648 (2013).
-
(2013)
J. Clin. Neurosci.
, vol.20
, pp. 644-648
-
-
Srisawat, C.1
-
63
-
-
84867339786
-
Blood-based protein biomarkers for diagnosis of Alzheimer disease
-
Doecke, J. D. et al. Blood-based protein biomarkers for diagnosis of Alzheimer disease. Arch. Neurol. 69, 1318-1325 (2012).
-
(2012)
Arch. Neurol.
, vol.69
, pp. 1318-1325
-
-
Doecke, J.D.1
-
64
-
-
33750031006
-
Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes
-
Rogers, J. et al. Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes. Neurobiol. Aging 27, 1733-1739 (2006).
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1733-1739
-
-
Rogers, J.1
-
65
-
-
85020476769
-
Altered peripheral profile of blood cells in Alzheimer disease: A hospital-based case-control study
-
Chen, S. H. et al. Altered peripheral profile of blood cells in Alzheimer disease: a hospital-based case-control study. Medicine (Baltimore) 96, e6843 (2017).
-
(2017)
Medicine (Baltimore)
, vol.96
, pp. e6843
-
-
Chen, S.H.1
-
66
-
-
84877687210
-
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
-
Loffredo, F. S. et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153, 828-839 (2013).
-
(2013)
Cell
, vol.153
, pp. 828-839
-
-
Loffredo, F.S.1
-
67
-
-
85018326953
-
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
-
Castellano, J. M. et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 544, 488-492 (2017).
-
(2017)
Nature
, vol.544
, pp. 488-492
-
-
Castellano, J.M.1
-
68
-
-
84902075251
-
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
-
Villeda, S. A. et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 20, 659-663 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 659-663
-
-
Villeda, S.A.1
-
69
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
Villeda, S. A. et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90-94 (2011).
-
(2011)
Nature
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
-
70
-
-
84900338737
-
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
-
Katsimpardi, L. et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 344, 630-634 (2014).
-
(2014)
Science
, vol.344
, pp. 630-634
-
-
Katsimpardi, L.1
-
71
-
-
84996957300
-
Preclinical assessment of young blood plasma for Alzheimer disease
-
Middeldorp, J. et al. Preclinical assessment of young blood plasma for Alzheimer disease. JAMA Neurol. 73, 1325-1333 (2016).
-
(2016)
JAMA Neurol.
, vol.73
, pp. 1325-1333
-
-
Middeldorp, J.1
-
72
-
-
84956583739
-
Meta-analysis of modifiable risk factors for Alzheimer's disease
-
Xu, W. et al. Meta-analysis of modifiable risk factors for Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 86, 1299-1306 (2015).
-
(2015)
J. Neurol. Neurosurg. Psychiatry
, vol.86
, pp. 1299-1306
-
-
Xu, W.1
-
73
-
-
74949127586
-
Risk of developing dementia in people with diabetes and mild cognitive impairment
-
Velayudhan, L. et al. Risk of developing dementia in people with diabetes and mild cognitive impairment. Br. J. Psychiatry 196, 36-40 (2010).
-
(2010)
Br. J. Psychiatry
, vol.196
, pp. 36-40
-
-
Velayudhan, L.1
-
74
-
-
34748856161
-
Insulin facilitates the hepatic clearance of plasma amyloid β-peptide (1-40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes
-
Tamaki, C., Ohtsuki, S. & Terasaki, T. Insulin facilitates the hepatic clearance of plasma amyloid β-peptide (1-40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes. Mol. Pharmacol. 72, 850-855 (2007).
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 850-855
-
-
Tamaki, C.1
Ohtsuki, S.2
Terasaki, T.3
-
75
-
-
85016172501
-
Metabolism-centric overview of the pathogenesis of Alzheimer's disease
-
Kang, S., Lee, Y. H. & Lee, J. E. Metabolism-centric overview of the pathogenesis of Alzheimer's disease. Yonsei Med. J. 58, 479-488 (2017).
-
(2017)
Yonsei Med. J.
, vol.58
, pp. 479-488
-
-
Kang, S.1
Lee, Y.H.2
Lee, J.E.3
-
76
-
-
0035871641
-
Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling
-
Gasparini, L. et al. Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling. J. Neurosci. 21, 2561-2570 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 2561-2570
-
-
Gasparini, L.1
-
77
-
-
84995426808
-
Blood-brain barrier disruption and neurovascular unit dysfunction in diabetic mice: Protection with the mitochondrial carbonic anhydrase inhibitor topiramate
-
Salameh, T. S., Shah, G. N., Price, T. O., Hayden, M. R. & Banks, W. A. Blood-brain barrier disruption and neurovascular unit dysfunction in diabetic mice: protection with the mitochondrial carbonic anhydrase inhibitor topiramate. J. Pharmacol. Exp. Ther. 359, 452-459 (2016).
-
(2016)
J. Pharmacol. Exp. Ther.
, vol.359
, pp. 452-459
-
-
Salameh, T.S.1
Shah, G.N.2
Price, T.O.3
Hayden, M.R.4
Banks, W.A.5
-
78
-
-
84860198618
-
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid β formation
-
Leuner, K. et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid β formation. Antioxid. Redox Signal. 16, 1421-1433 (2012).
-
(2012)
Antioxid. Redox Signal.
, vol.16
, pp. 1421-1433
-
-
Leuner, K.1
-
79
-
-
85007605038
-
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
-
Moreno-Gonzalez, I. et al. Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding. Mol. Psychiatry 22, 1327-1334 (2017).
-
(2017)
Mol. Psychiatry
, vol.22
, pp. 1327-1334
-
-
Moreno-Gonzalez, I.1
-
80
-
-
84903220594
-
Brain changes underlying cognitive dysfunction in diabetes: What can we learn from MRI?
-
Biessels, G. J. & Reijmer, Y. D. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes 63, 2244-2252 (2014).
-
(2014)
Diabetes
, vol.63
, pp. 2244-2252
-
-
Biessels, G.J.1
Reijmer, Y.D.2
-
81
-
-
84860704421
-
Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama study
-
Lesser, G. T. Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama study. Neurology 78, 1280 (2012).
-
(2012)
Neurology
, vol.78
, pp. 1280
-
-
Lesser, G.T.1
-
82
-
-
84946570480
-
The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease
-
Sato, N. & Morishita, R. The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease. Front. Aging Neurosci. 7, 199 (2015).
-
(2015)
Front. Aging Neurosci.
, vol.7
, pp. 199
-
-
Sato, N.1
Morishita, R.2
-
83
-
-
84904678185
-
Apolipoprotein E in Alzheimer's disease: An update
-
Yu, J. T., Tan, L. & Hardy, J. Apolipoprotein E in Alzheimer's disease: an update. Annu. Rev. Neurosci. 37, 79-100 (2014).
-
(2014)
Annu. Rev. Neurosci.
, vol.37
, pp. 79-100
-
-
Yu, J.T.1
Tan, L.2
Hardy, J.3
-
84
-
-
84862911656
-
Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels
-
Lee, C. Y., Tse, W., Smith, J. D. & Landreth, G. E. Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. J. Biol. Chem. 287, 2032-2044 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 2032-2044
-
-
Lee, C.Y.1
Tse, W.2
Smith, J.D.3
Landreth, G.E.4
-
85
-
-
85014710654
-
Sex and race differences in the association between statin use and the incidence of Alzheimer disease
-
Zissimopoulos, J. M., Barthold, D., Brinton, R. D. & Joyce, G. Sex and race differences in the association between statin use and the incidence of Alzheimer disease. JAMA Neurol. 74, 225-232 (2016).
-
(2016)
JAMA Neurol.
, vol.74
, pp. 225-232
-
-
Zissimopoulos, J.M.1
Barthold, D.2
Brinton, R.D.3
Joyce, G.4
-
86
-
-
84893825608
-
Associations between serum cholesterol levels and cerebral amyloidosis
-
Reed, B. et al. Associations between serum cholesterol levels and cerebral amyloidosis. JAMA Neurol. 71, 195-200 (2014).
-
(2014)
JAMA Neurol.
, vol.71
, pp. 195-200
-
-
Reed, B.1
-
87
-
-
0023236375
-
Platelet membrane fluidity in Alzheimer's disease and major depression
-
Zubenko, G. S. et al. Platelet membrane fluidity in Alzheimer's disease and major depression. Am. J. Psychiatry 144, 860-868 (1987).
-
(1987)
Am. J. Psychiatry
, vol.144
, pp. 860-868
-
-
Zubenko, G.S.1
-
88
-
-
0025756520
-
Altered membrane anisotropy gradients of plasma membranes of living peripheral blood leukocytes in aging and Alzheimer's disease
-
Collins, J. M., Scott, R. B., McClish, D. K., Taylor, J. R. & Grogan, W. M. Altered membrane anisotropy gradients of plasma membranes of living peripheral blood leukocytes in aging and Alzheimer's disease. Mech. Ageing Dev. 59, 153-162 (1991).
-
(1991)
Mech. Ageing Dev.
, vol.59
, pp. 153-162
-
-
Collins, J.M.1
Scott, R.B.2
McClish, D.K.3
Taylor, J.R.4
Grogan, W.M.5
-
89
-
-
0024269363
-
Markedly increased platelet membrane fluidity in Down syndrome with a (14q, 21q) translocation
-
Zubenko, G. S. & Howland, R. Markedly increased platelet membrane fluidity in Down syndrome with a (14q, 21q) translocation. J. Geriatr. Psychiatry Neurol. 1, 218-219 (1988).
-
(1988)
J. Geriatr. Psychiatry Neurol.
, vol.1
, pp. 218-219
-
-
Zubenko, G.S.1
Howland, R.2
-
90
-
-
0028065465
-
Alzheimer's disease and Down syndrome: Leukocyte membrane fluidity alterations
-
Scott, R. B., Collins, J. M. & Hunt, P. A. Alzheimer's disease and Down syndrome: leukocyte membrane fluidity alterations. Mech. Ageing Dev. 75, 1-10 (1994).
-
(1994)
Mech. Ageing Dev.
, vol.75
, pp. 1-10
-
-
Scott, R.B.1
Collins, J.M.2
Hunt, P.A.3
-
91
-
-
84998706975
-
Association of serum docosahexaenoic acid with cerebral amyloidosis
-
Yassine, H. N. et al. Association of serum docosahexaenoic acid with cerebral amyloidosis. JAMA Neurol. 73, 1208-1216 (2016).
-
(2016)
JAMA Neurol.
, vol.73
, pp. 1208-1216
-
-
Yassine, H.N.1
-
92
-
-
84963748890
-
Associations between serum omega-3 fatty acid levels and cognitive functions among community-dwelling octogenarians in Okinawa, Japan: The KOCOA study
-
Nishihira, J. et al. Associations between serum omega-3 fatty acid levels and cognitive functions among community-dwelling octogenarians in Okinawa, Japan: the KOCOA study. J. Alzheimers Dis. 51, 857-866 (2016).
-
(2016)
J. Alzheimers Dis.
, vol.51
, pp. 857-866
-
-
Nishihira, J.1
-
93
-
-
84919664241
-
Heart diseases and long-term risk of dementia and Alzheimer's disease: A population-based CAIDE study
-
Rusanen, M. et al. Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study. J. Alzheimers Dis. 42, 183-191 (2014).
-
(2014)
J. Alzheimers Dis.
, vol.42
, pp. 183-191
-
-
Rusanen, M.1
-
94
-
-
33646417625
-
Heart failure and risk of dementia and Alzheimer disease: A population-based cohort study
-
Qiu, C. et al. Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch. Intern. Med. 166, 1003-1008 (2006).
-
(2006)
Arch. Intern. Med.
, vol.166
, pp. 1003-1008
-
-
Qiu, C.1
-
95
-
-
84929305910
-
Low cardiac index is associated with incident dementia and Alzheimer disease: The Framingham Heart Study
-
Jefferson, A. L. et al. Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation 131, 1333-1339 (2015).
-
(2015)
Circulation
, vol.131
, pp. 1333-1339
-
-
Jefferson, A.L.1
-
96
-
-
23844522541
-
Aggregation of vascular risk factors and risk of incident Alzheimer disease
-
Luchsinger, J. A. et al. Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology 65, 545-551 (2005).
-
(2005)
Neurology
, vol.65
, pp. 545-551
-
-
Luchsinger, J.A.1
-
97
-
-
79955521915
-
Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease
-
Li, J. et al. Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 76, 1485-1491 (2011).
-
(2011)
Neurology
, vol.76
, pp. 1485-1491
-
-
Li, J.1
-
98
-
-
85020414600
-
Reduced cardiovascular functions in patients with Alzheimer's disease
-
Jin, W. S. et al. Reduced cardiovascular functions in patients with Alzheimer's disease. J. Alzheimers Dis. 58, 919-925 (2017).
-
(2017)
J. Alzheimers Dis.
, vol.58
, pp. 919-925
-
-
Jin, W.S.1
-
99
-
-
84857922274
-
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
-
Okamoto, Y. et al. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 123, 381-394 (2012).
-
(2012)
Acta Neuropathol.
, vol.123
, pp. 381-394
-
-
Okamoto, Y.1
-
100
-
-
83355176479
-
Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans
-
Zetterberg, H. et al. Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PLoS ONE 6, e28263 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e28263
-
-
Zetterberg, H.1
-
101
-
-
84978924191
-
Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice
-
Wang, L. et al. Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice. Exp. Neurol. 283, 353-364 (2016).
-
(2016)
Exp. Neurol.
, vol.283
, pp. 353-364
-
-
Wang, L.1
-
102
-
-
84925298330
-
Heart failure and Alzheimer's disease
-
Cermakova, P. et al. Heart failure and Alzheimer's disease. J. Intern. Med. 277, 406-425 (2015).
-
(2015)
J. Intern. Med.
, vol.277
, pp. 406-425
-
-
Cermakova, P.1
-
103
-
-
84899789357
-
Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment
-
Mattsson, N. et al. Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain 137, 1550-1561 (2014).
-
(2014)
Brain
, vol.137
, pp. 1550-1561
-
-
Mattsson, N.1
-
104
-
-
85005950971
-
Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease
-
Leeuwis, A. E. et al. Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease. Alzheimers Dement. 13, 531-540 (2017).
-
(2017)
Alzheimers Dement.
, vol.13
, pp. 531-540
-
-
Leeuwis, A.E.1
-
105
-
-
84974691661
-
Could better phenotyping small vessel disease provide new insights into Alzheimer disease and improve clinical trial outcomes?
-
Marnane, M. & Hsiung, G. Y. Could better phenotyping small vessel disease provide new insights into Alzheimer disease and improve clinical trial outcomes? Curr. Alzheimer Res. 13, 750-763 (2016).
-
(2016)
Curr. Alzheimer Res.
, vol.13
, pp. 750-763
-
-
Marnane, M.1
Hsiung, G.Y.2
-
106
-
-
84905497402
-
Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers
-
Kester, M. I. et al. Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers. JAMA Neurol. 71, 855-862 (2014).
-
(2014)
JAMA Neurol.
, vol.71
, pp. 855-862
-
-
Kester, M.I.1
-
107
-
-
0031961832
-
Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid-β peptide in aged squirrel monkey with cerebral amyloid angiopathy
-
Mackic, J. B. et al. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid-β peptide in aged squirrel monkey with cerebral amyloid angiopathy. J. Neurochem. 70, 210-215 (1998).
-
(1998)
J. Neurochem.
, vol.70
, pp. 210-215
-
-
Mackic, J.B.1
-
108
-
-
84960127682
-
Associations between hepatic functions and plasma amyloid-β levels.- Implications for the capacity of liver in peripheral amyloid-β clearance
-
Wang, Y. R. et al. Associations between hepatic functions and plasma amyloid-β levels.- implications for the capacity of liver in peripheral amyloid-β clearance. Mol. Neurobiol. 54, 2338-2344 (2017).
-
(2017)
Mol. Neurobiol.
, vol.54
, pp. 2338-2344
-
-
Wang, Y.R.1
-
109
-
-
84863393470
-
Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
-
Sehgal, N. et al. Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc. Natl Acad. Sci. USA 109, 3510-3515 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 3510-3515
-
-
Sehgal, N.1
-
110
-
-
0030035294
-
Fate of cerebrospinal fluid-borne amyloid β-peptide: Rapid clearance into blood and appreciable accumulation by cerebral arteries
-
Ghersi-Egea, J. F. et al. Fate of cerebrospinal fluid-borne amyloid β-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J. Neurochem. 67, 880-883 (1996).
-
(1996)
J. Neurochem.
, vol.67
, pp. 880-883
-
-
Ghersi-Egea, J.F.1
-
111
-
-
0036630803
-
Serum creatinine levels correlate with plasma amyloid β protein
-
Arvanitakis, Z., Lucas, J. A., Younkin, L. H., Younkin, S. G. & Graff-Radford, N. R. Serum creatinine levels correlate with plasma amyloid β protein. Alzheimer Dis. Assoc. Disord. 16, 187-190 (2002).
-
(2002)
Alzheimer Dis. Assoc. Disord.
, vol.16
, pp. 187-190
-
-
Arvanitakis, Z.1
Lucas, J.A.2
Younkin, L.H.3
Younkin, S.G.4
Graff-Radford, N.R.5
-
112
-
-
84937978484
-
Association between serum amyloid-β and renal functions: Implications for roles of kidney in amyloid-β clearance
-
Liu, Y. H. et al. Association between serum amyloid-β and renal functions: implications for roles of kidney in amyloid-β clearance. Mol. Neurobiol. 52, 115-119 (2015).
-
(2015)
Mol. Neurobiol.
, vol.52
, pp. 115-119
-
-
Liu, Y.H.1
-
113
-
-
84930168297
-
Factors responsible for plasma β-amyloid accumulation in chronic kidney disease
-
Gronewold, J. et al. Factors responsible for plasma β-amyloid accumulation in chronic kidney disease. Mol. Neurobiol. 53, 3136-3145 (2016).
-
(2016)
Mol. Neurobiol.
, vol.53
, pp. 3136-3145
-
-
Gronewold, J.1
-
114
-
-
85009152018
-
Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies
-
Deckers, K. et al. Dementia risk in renal dysfunction: a systematic review and meta-analysis of prospective studies. Neurology 88, 198-208 (2017).
-
(2017)
Neurology
, vol.88
, pp. 198-208
-
-
Deckers, K.1
-
115
-
-
84964868702
-
Patients that have undergone hemodialysis exhibit lower amyloid deposition in the brain: Evidence supporting a therapeutic strategy for Alzheimer's disease by removal of blood amyloid
-
Sakai, K. et al. Patients that have undergone hemodialysis exhibit lower amyloid deposition in the brain: evidence supporting a therapeutic strategy for Alzheimer's disease by removal of blood amyloid. J. Alzheimers Dis. 51, 997-1002 (2016).
-
(2016)
J. Alzheimers Dis.
, vol.51
, pp. 997-1002
-
-
Sakai, K.1
-
116
-
-
84974625597
-
The association between obstructive sleep apnea and Alzheimer's disease: A meta-analysis perspective
-
Emamian, F. et al. The association between obstructive sleep apnea and Alzheimer's disease: a meta-analysis perspective. Front. Aging Neurosci. 8, 78 (2016).
-
(2016)
Front. Aging Neurosci.
, vol.8
, pp. 78
-
-
Emamian, F.1
-
117
-
-
62849083860
-
Cause of death in patients with dementia disorders
-
Brunnstrom, H. R. & Englund, E. M. Cause of death in patients with dementia disorders. Eur. J. Neurol. 16, 488-492 (2009).
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 488-492
-
-
Brunnstrom, H.R.1
Englund, E.M.2
-
118
-
-
84910075230
-
Can sleep apnea cause Alzheimer's disease?
-
Pan, W. & Kastin, A. J. Can sleep apnea cause Alzheimer's disease? Neurosci. Biobehav. Rev. 47, 656-669 (2014).
-
(2014)
Neurosci. Biobehav. Rev.
, vol.47
, pp. 656-669
-
-
Pan, W.1
Kastin, A.J.2
-
119
-
-
80051571901
-
Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
-
Yaffe, K. et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306, 613-619 (2011).
-
(2011)
JAMA
, vol.306
, pp. 613-619
-
-
Yaffe, K.1
-
120
-
-
84929207791
-
Sleep-disordered breathing advances cognitive decline in the elderly
-
Osorio, R. S. et al. Sleep-disordered breathing advances cognitive decline in the elderly. Neurology 84, 1964-1971 (2015).
-
(2015)
Neurology
, vol.84
, pp. 1964-1971
-
-
Osorio, R.S.1
-
121
-
-
84941365323
-
Serum amyloid-β levels are increased in patients with obstructive sleep apnea syndrome
-
Bu, X. L. et al. Serum amyloid-β levels are increased in patients with obstructive sleep apnea syndrome. Sci. Rep. 5, 13917 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 13917
-
-
Bu, X.L.1
-
122
-
-
84942991055
-
Serum amyloid-β levels are increased in patients with chronic obstructive pulmonary disease
-
Bu, X. L. et al. Serum amyloid-β levels are increased in patients with chronic obstructive pulmonary disease. Neurotox. Res. 28, 346-351 (2015).
-
(2015)
Neurotox. Res.
, vol.28
, pp. 346-351
-
-
Bu, X.L.1
-
123
-
-
84903364735
-
Interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals
-
Osorio, R. S. et al. Interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals. Neurobiol. Aging 35, 1318-1324 (2014).
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 1318-1324
-
-
Osorio, R.S.1
-
124
-
-
84929032104
-
Sleep apnoea and the brain: A complex relationship
-
Rosenzweig, I. et al. Sleep apnoea and the brain: a complex relationship. Lancet Respir. Med. 3, 404-414 (2015).
-
(2015)
Lancet Respir. Med.
, vol.3
, pp. 404-414
-
-
Rosenzweig, I.1
-
125
-
-
84997447805
-
Mechanisms linking circadian clocks, sleep, and neurodegeneration
-
Musiek, E. S. & Holtzman, D. M. Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science 354, 1004-1008 (2016).
-
(2016)
Science
, vol.354
, pp. 1004-1008
-
-
Musiek, E.S.1
Holtzman, D.M.2
-
126
-
-
84961136218
-
Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease
-
Cedernaes, J. et al. Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease. Sleep Med. Rev. 31, 102-111 (2017).
-
(2017)
Sleep Med. Rev.
, vol.31
, pp. 102-111
-
-
Cedernaes, J.1
-
127
-
-
84909606798
-
Microbiota-gut-brain axis and cognitive function
-
Gareau, M. Microbiota-gut-brain axis and cognitive function. Adv. Exp. Med. Biol. 817, 357-371 (2014).
-
(2014)
Adv. Exp. Med. Biol.
, vol.817
, pp. 357-371
-
-
Gareau, M.1
-
128
-
-
84999863217
-
Gram-negative bacterial molecules associate with Alzheimer disease pathology
-
Zhan, X. et al. Gram-negative bacterial molecules associate with Alzheimer disease pathology. Neurology 87, 2324-2332 (2016).
-
(2016)
Neurology
, vol.87
, pp. 2324-2332
-
-
Zhan, X.1
-
129
-
-
85006265680
-
Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: A randomized, double-blind and controlled trial
-
Akbari, E. et al. Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: a randomized, double-blind and controlled trial. Front. Aging Neurosci. 8, 256 (2016).
-
(2016)
Front. Aging Neurosci.
, vol.8
, pp. 256
-
-
Akbari, E.1
-
130
-
-
84946743622
-
A study on the association between infectious burden and Alzheimer's disease
-
Bu, X. L. et al. A study on the association between infectious burden and Alzheimer's disease. Eur. J. Neurol. 22, 1519-1525 (2015).
-
(2015)
Eur. J. Neurol.
, vol.22
, pp. 1519-1525
-
-
Bu, X.L.1
-
131
-
-
84941266767
-
Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease
-
Harris, S. A. & Harris, E. A. Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease. J. Alzheimers Dis. 48, 319-353 (2015).
-
(2015)
J. Alzheimers Dis.
, vol.48
, pp. 319-353
-
-
Harris, S.A.1
Harris, E.A.2
-
132
-
-
84933036744
-
Association between periodontitis and Alzheimer's disease
-
Abbayya, K., Puthanakar, N. Y., Naduwinmani, S. & Chidambar, Y. S. Association between periodontitis and Alzheimer's disease. N. Am. J. Med. Sci. 7, 241-246 (2015).
-
(2015)
N. Am. J. Med. Sci.
, vol.7
, pp. 241-246
-
-
Abbayya, K.1
Puthanakar, N.Y.2
Naduwinmani, S.3
Chidambar, Y.S.4
-
133
-
-
84865585052
-
Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: A population-based study
-
Wallin, K. et al. Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study. J. Alzheimers Dis. 31, 669-676 (2012).
-
(2012)
J. Alzheimers Dis.
, vol.31
, pp. 669-676
-
-
Wallin, K.1
-
134
-
-
66449130960
-
Regulation of innate immune responses in the brain
-
Rivest, S. Regulation of innate immune responses in the brain. Nat. Rev. Immunol. 9, 429-439 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 429-439
-
-
Rivest, S.1
-
135
-
-
47749126515
-
Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
-
Gao, H. M. & Hong, J. S. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol. 29, 357-365 (2008).
-
(2008)
Trends Immunol.
, vol.29
, pp. 357-365
-
-
Gao, H.M.1
Hong, J.S.2
-
136
-
-
84921531052
-
Anti-inflammatory drugs and risk of Alzheimer's disease: An updated systematic review and meta-analysis
-
Wang, J. et al. Anti-inflammatory drugs and risk of Alzheimer's disease: an updated systematic review and meta-analysis. J. Alzheimers Dis. 44, 385-396 (2015).
-
(2015)
J. Alzheimers Dis.
, vol.44
, pp. 385-396
-
-
Wang, J.1
-
137
-
-
85008611356
-
Plasma concentrations of free amyloid-β cannot predict the development of Alzheimer's disease
-
Lövheim, H. et al. Plasma concentrations of free amyloid-β cannot predict the development of Alzheimer's disease. Alzheimers Dement. 13, 778-782 (2017).
-
(2017)
Alzheimers Dement.
, vol.13
, pp. 778-782
-
-
Lövheim, H.1
-
138
-
-
84992386036
-
Plasma tau in Alzheimer disease
-
Mattsson, N. et al. Plasma tau in Alzheimer disease. Neurology 87, 1827-1835 (2016).
-
(2016)
Neurology
, vol.87
, pp. 1827-1835
-
-
Mattsson, N.1
-
139
-
-
84991035124
-
Alzheimer disease: Biomarkers of AD risk - The end of the road for plasma amyloid-β?
-
Wood, H. Alzheimer disease: biomarkers of AD risk - the end of the road for plasma amyloid-β? Nat. Rev. Neurol. 12, 613 (2016).
-
(2016)
Nat. Rev. Neurol.
, vol.12
, pp. 613
-
-
Wood, H.1
-
140
-
-
84879755951
-
Luminex assay detects amyloid β oligomers in Alzheimer's disease cerebrospinal fluid
-
Herskovits, A. Z., Locascio, J. J., Peskind, E. R., Li, G. & Hyman, B. T. A. Luminex assay detects amyloid β oligomers in Alzheimer's disease cerebrospinal fluid. PLoS ONE 8, e67898 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e67898
-
-
Herskovits, A.Z.1
Locascio, J.J.2
Peskind, E.R.3
Li, G.4
Hyman, B.T.A.5
-
141
-
-
85019234204
-
Tau oligomers in cerebrospinal fluid in Alzheimer's disease
-
Sengupta, U. et al. Tau oligomers in cerebrospinal fluid in Alzheimer's disease. Ann. Clin. Transl Neurol. 4, 226-235 (2017).
-
(2017)
Ann. Clin. Transl Neurol.
, vol.4
, pp. 226-235
-
-
Sengupta, U.1
-
142
-
-
85016194944
-
Increased plasma β-secretase 1 may predict conversion to Alzheimer's disease dementia in individuals with mild cognitive impairment
-
Shen, Y. et al. Increased plasma β-secretase 1 may predict conversion to Alzheimer's disease dementia in individuals with mild cognitive impairment. Biol. Psychiatry http://dx.doi.org/10.1016/j.biopsych.2017.02.007 (2017).
-
(2017)
Biol. Psychiatry
-
-
Shen, Y.1
-
143
-
-
85032580289
-
One target, one treatment? Not for Alzheimer's disease
-
Brooks, M. One target, one treatment? Not for Alzheimer's disease. Medscape http://www.medscape. com/viewarticle/848322 (2015).
-
(2015)
Medscape
-
-
Brooks, M.1
-
144
-
-
84898003901
-
Alzheimer disease: Lessons from immunotherapy for Alzheimer disease
-
Wang, Y. J. Alzheimer disease: lessons from immunotherapy for Alzheimer disease. Nat. Rev. Neurol. 10, 188-189 (2014).
-
(2014)
Nat. Rev. Neurol.
, vol.10
, pp. 188-189
-
-
Wang, Y.J.1
-
145
-
-
84889817038
-
New insights into the dementia epidemic
-
Larson, E. B., Yaffe, K. & Langa, K. M. New insights into the dementia epidemic. N. Engl. J. Med. 369, 2275-2277 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 2275-2277
-
-
Larson, E.B.1
Yaffe, K.2
Langa, K.M.3
-
146
-
-
84965189418
-
Dementia in western Europe: Epidemiological evidence and implications for policy making
-
Wu, Y. T. et al. Dementia in western Europe: epidemiological evidence and implications for policy making. Lancet Neurol. 15, 116-124 (2016).
-
(2016)
Lancet Neurol.
, vol.15
, pp. 116-124
-
-
Wu, Y.T.1
-
147
-
-
84959314283
-
Incidence of dementia over three decades in the Framingham heart study
-
Satizabal, C. L. et al. Incidence of dementia over three decades in the Framingham heart study. N. Engl. J. Med. 374, 523-532 (2016).
-
(2016)
N. Engl. J. Med.
, vol.374
, pp. 523-532
-
-
Satizabal, C.L.1
-
148
-
-
85011278265
-
A comparison of the prevalence of dementia in the United States in 2000 and 2012
-
Langa, K. M. et al. A comparison of the prevalence of dementia in the United States in 2000 and 2012. JAMA Intern. Med. 177, 51-58 (2017).
-
(2017)
JAMA Intern. Med.
, vol.177
, pp. 51-58
-
-
Langa, K.M.1
-
149
-
-
58249089520
-
Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam study
-
Haag, M. D., Hofman, A., Koudstaal, P. J., Stricker, B. H. & Breteler, M. M. Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J. Neurol. Neurosurg. Psychiatry 80, 13-17 (2009).
-
(2009)
J. Neurol. Neurosurg. Psychiatry
, vol.80
, pp. 13-17
-
-
Haag, M.D.1
Hofman, A.2
Koudstaal, P.J.3
Stricker, B.H.4
Breteler, M.M.5
-
150
-
-
84885189956
-
Selective benefits of simvastatin in bitransgenic APPSwe, Ind/TGF-β1 mice
-
Papadopoulos, P., Tong, X. K. & Hamel, E. Selective benefits of simvastatin in bitransgenic APPSwe, Ind/TGF-β1 mice. Neurobiol. Aging 35, 203-212 (2014).
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 203-212
-
-
Papadopoulos, P.1
Tong, X.K.2
Hamel, E.3
-
151
-
-
84888265005
-
Statins and cognitive function: A systematic review
-
Richardson, K. et al. Statins and cognitive function: a systematic review. Ann. Intern. Med. 159, 688-697 (2013).
-
(2013)
Ann. Intern. Med.
, vol.159
, pp. 688-697
-
-
Richardson, K.1
-
152
-
-
55349089930
-
Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: A randomized controlled study
-
Ancoli-Israel, S. et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J. Am. Geriatr. Soc. 56, 2076-2081 (2008).
-
(2008)
J. Am. Geriatr. Soc.
, vol.56
, pp. 2076-2081
-
-
Ancoli-Israel, S.1
-
153
-
-
70349092222
-
Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: A preliminary study
-
Cooke, J. R. et al. Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: a preliminary study. J. Clin. Sleep Med. 5, 305-309 (2009).
-
(2009)
J. Clin. Sleep Med.
, vol.5
, pp. 305-309
-
-
Cooke, J.R.1
-
154
-
-
70350551950
-
Amyloid-targeted therapeutics in Alzheimer's disease: Use of human albumin in plasma exchange as a novel approach for Aβ mobilization
-
Boada, M. et al. Amyloid-targeted therapeutics in Alzheimer's disease: use of human albumin in plasma exchange as a novel approach for Aβ mobilization. Drug News Perspect. 22, 325-339 (2009).
-
(2009)
Drug News Perspect.
, vol.22
, pp. 325-339
-
-
Boada, M.1
-
155
-
-
85018790640
-
Peritoneal dialysis reduces amyloid-β plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model
-
Jin, W. S. et al. Peritoneal dialysis reduces amyloid-β plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta Neuropathol. 134, 207-220 (2017).
-
(2017)
Acta Neuropathol.
, vol.134
, pp. 207-220
-
-
Jin, W.S.1
-
156
-
-
70350728321
-
Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease
-
Liu, Y. et al. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Mol. Ther. 17, 1381-1386 (2009).
-
(2009)
Mol. Ther.
, vol.17
, pp. 1381-1386
-
-
Liu, Y.1
-
157
-
-
84939891140
-
Clearance of amyloid-β in Alzheimer's disease: Shifting the action site from center to periphery
-
Liu, Y. H. et al. Clearance of amyloid-β in Alzheimer's disease: shifting the action site from center to periphery. Mol. Neurobiol. 51, 1-7 (2015).
-
(2015)
Mol. Neurobiol.
, vol.51
, pp. 1-7
-
-
Liu, Y.H.1
-
158
-
-
84975514611
-
Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile
-
Winston, C. N. et al. Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimers Dement. (Amst.) 3, 63-72 (2016).
-
(2016)
Alzheimers Dement. (Amst.)
, vol.3
, pp. 63-72
-
-
Winston, C.N.1
-
159
-
-
84996590165
-
Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease
-
Goetzl, E. J. et al. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. FASEB J. 30, 3853-3859 (2016).
-
(2016)
FASEB J.
, vol.30
, pp. 3853-3859
-
-
Goetzl, E.J.1
-
160
-
-
84922002985
-
A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype
-
Veitinger, M. et al. A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype. Acta Neuropathol. 128, 665-677 (2014).
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 665-677
-
-
Veitinger, M.1
-
161
-
-
84897108729
-
A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: Results from the AIBL study
-
Burnham, S. C. et al. A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: results from the AIBL study. Mol. Psychiatry 19, 519-526 (2014).
-
(2014)
Mol. Psychiatry
, vol.19
, pp. 519-526
-
-
Burnham, S.C.1
-
162
-
-
85018870200
-
Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease
-
Alzheimer's Disease Neuroimaging Initiative
-
Mattsson, N., Andreasson, U., Zetterberg, H., Blennow, K. & Alzheimer's Disease Neuroimaging Initiative. Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease. JAMA Neurol. 74, 557-566 (2017).
-
(2017)
JAMA Neurol.
, vol.74
, pp. 557-566
-
-
Mattsson, N.1
Andreasson, U.2
Zetterberg, H.3
Blennow, K.4
-
163
-
-
77649330263
-
Serum levels of S100B and NSE proteins in Alzheimer's disease patients
-
Chaves, M. L. et al. Serum levels of S100B and NSE proteins in Alzheimer's disease patients. J. Neuroinflammation 7, 6 (2010).
-
(2010)
J. Neuroinflammation
, vol.7
, pp. 6
-
-
Chaves, M.L.1
-
164
-
-
79955733045
-
Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases
-
Teunissen, C. E. et al. Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases. Eur. J. Neurol. 18, 865-871 (2011).
-
(2011)
Eur. J. Neurol.
, vol.18
, pp. 865-871
-
-
Teunissen, C.E.1
-
165
-
-
84875369325
-
Systemic immune system alterations in early stages of Alzheimer's disease
-
Zhang, R. et al. Systemic immune system alterations in early stages of Alzheimer's disease. J. Neuroimmunol. 256, 38-42 (2013).
-
(2013)
J. Neuroimmunol.
, vol.256
, pp. 38-42
-
-
Zhang, R.1
-
166
-
-
85032260519
-
Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis
-
Kayano, M. et al. Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis. Biomark. Res. 4, 22 (2016).
-
(2016)
Biomark. Res.
, vol.4
, pp. 22
-
-
Kayano, M.1
-
167
-
-
85031939761
-
Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer's disease and mild cognitive impairment
-
Lu, R. et al. Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer's disease and mild cognitive impairment. Mol. Psychiatry http://dx.doi.org/10.1038/mp.2017.136 (2017).
-
(2017)
Mol. Psychiatry
-
-
Lu, R.1
-
168
-
-
85019595961
-
Biochemically-defined pools of amyloid-β in sporadic Alzheimer's disease: Correlation with amyloid PET
-
Roberts, B. R. et al. Biochemically-defined pools of amyloid-β in sporadic Alzheimer's disease: correlation with amyloid PET. Brain 140, 1486-1498 (2017).
-
(2017)
Brain
, vol.140
, pp. 1486-1498
-
-
Roberts, B.R.1
-
169
-
-
0025171335
-
The amyloid precursor protein of Alzheimer's disease is released by human platelets
-
Bush, A. I. et al. The amyloid precursor protein of Alzheimer's disease is released by human platelets. J. Biol. Chem. 265, 15977-15983 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 15977-15983
-
-
Bush, A.I.1
-
170
-
-
0031959497
-
Secretion of Alzheimer's disease Aβ amyloid peptide by activated human platelets
-
Li, Q. X. et al. Secretion of Alzheimer's disease Aβ amyloid peptide by activated human platelets. Lab. Invest. 78, 461-469 (1998).
-
(1998)
Lab. Invest.
, vol.78
, pp. 461-469
-
-
Li, Q.X.1
-
171
-
-
0028099612
-
Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation
-
Citron, M. et al. Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proc. Natl Acad. Sci. USA 91, 11993-11997 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 11993-11997
-
-
Citron, M.1
-
172
-
-
84893590433
-
Amyloid β peptide is elevated in osteoporotic bone tissues and enhances osteoclast function
-
Li, S., Liu, B., Zhang, L. & Rong, L. Amyloid β peptide is elevated in osteoporotic bone tissues and enhances osteoclast function. Bone 61, 164-175 (2014).
-
(2014)
Bone
, vol.61
, pp. 164-175
-
-
Li, S.1
Liu, B.2
Zhang, L.3
Rong, L.4
-
173
-
-
0033622195
-
Elevated Aβ42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AβPP metabolism
-
Kuo, Y. M. et al. Elevated Aβ42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AβPP metabolism. Am. J. Pathol. 156, 797-805 (2000).
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 797-805
-
-
Kuo, Y.M.1
-
174
-
-
34249727115
-
Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation
-
Zhang, X. et al. Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation. J. Biol. Chem. 282, 10873-10880 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10873-10880
-
-
Zhang, X.1
-
175
-
-
33845505233
-
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
-
Sun, X. et al. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc. Natl Acad. Sci. USA 103, 18727-18732 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18727-18732
-
-
Sun, X.1
|