메뉴 건너뛰기




Volumn 51, Issue 1, 2015, Pages 1-7

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

Author keywords

Adverse effects; Alzheimer s disease; Amyloid beta; Immunotherapy; Peripheral clearance

Indexed keywords

AMYLOID BETA PROTEIN;

EID: 84939891140     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8694-9     Document Type: Review
Times cited : (59)

References (60)
  • 1
    • 84876307732 scopus 로고    scopus 로고
    • Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer’s disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial
    • COI: 1:CAS:528:DC%2BC3sXitVGgurY%3D, PID: 23375965
    • Dodel R et al (2013) Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer’s disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial. Lancet Neurol 12:233–243. doi:10.1016/S1474-4422(13)70014-0
    • (2013) Lancet Neurol , vol.12 , pp. 233-243
    • Dodel, R.1
  • 2
    • 84892748542 scopus 로고    scopus 로고
    • Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXhs1Ggt70%3D, PID: 24450890
    • Doody RS et al (2014) Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease. N Engl J Med 370:311–321. doi:10.1056/NEJMoa1312889
    • (2014) N Engl J Med , vol.370 , pp. 311-321
    • Doody, R.S.1
  • 3
    • 84892710970 scopus 로고    scopus 로고
    • Antiamyloid therapy for Alzheimer’s disease—are we on the right road?
    • COI: 1:CAS:528:DC%2BC2cXhs1Ggtb4%3D, PID: 24450897
    • Karran E, Hardy J (2014) Antiamyloid therapy for Alzheimer’s disease—are we on the right road? N Engl J Med 370:377–378. doi:10.1056/NEJMe1313943
    • (2014) N Engl J Med , vol.370 , pp. 377-378
    • Karran, E.1    Hardy, J.2
  • 4
    • 84892695519 scopus 로고    scopus 로고
    • Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXhs1Ggt7o%3D, PID: 24450891
    • Salloway S et al (2014) Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease. N Engl J Med 370:322–333. doi:10.1056/NEJMoa1304839
    • (2014) N Engl J Med , vol.370 , pp. 322-333
    • Salloway, S.1
  • 5
    • 84898003901 scopus 로고    scopus 로고
    • Lessons from immunotherapy for Alzheimer disease
    • Wang YJ (2014) Lessons from immunotherapy for Alzheimer disease. Nat Rev Neurol 10:188–189. doi:10.1038/nrneurol.2014.44
    • (2014) Nat Rev Neurol , vol.10 , pp. 188-189
    • Wang, Y.J.1
  • 6
    • 78650507352 scopus 로고    scopus 로고
    • Modified immunotherapies against Alzheimer’s disease: toward safer and effective amyloid clearance
    • COI: 1:CAS:528:DC%2BC3cXhtlOhtr3P
    • Wang YJ, Zhou HD, Zhou XF (2010) Modified immunotherapies against Alzheimer’s disease: toward safer and effective amyloid clearance. J Alzheimer Dis 21:1065–1075
    • (2010) J Alzheimer Dis , vol.21 , pp. 1065-1075
    • Wang, Y.J.1    Zhou, H.D.2    Zhou, X.F.3
  • 7
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3MXls1Wiurk%3D, PID: 11438712
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A 98:8850–8855
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 8
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD38XitlGkt7g%3D, PID: 11910111
    • DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer’s disease. Science 295:2264–2267
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 9
    • 78650210590 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXhsFKms7s%3D
    • Morgan D (2011) Immunotherapy for Alzheimer’s disease. J Int Med 269:54–63. doi:10.1111/j.1365-2796.2010.02315.x
    • (2011) J Int Med , vol.269 , pp. 54-63
    • Morgan, D.1
  • 10
    • 84862777153 scopus 로고    scopus 로고
    • Amyloid-related imaging abnormalities in patients with Alzheimer’s disease treated with bapineuzumab: a retrospective analysis
    • COI: 1:CAS:528:DC%2BC38XislSqs74%3D, PID: 22305802
    • Sperling R et al (2012) Amyloid-related imaging abnormalities in patients with Alzheimer’s disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol 11:241–249. doi:10.1016/S1474-4422(12)70015-7
    • (2012) Lancet Neurol , vol.11 , pp. 241-249
    • Sperling, R.1
  • 11
    • 79960769590 scopus 로고    scopus 로고
    • Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer’s disease study cohorts from phase 3 trials of semagacestat and solanezumab
    • COI: 1:CAS:528:DC%2BC3MXpt1Oqtb8%3D
    • Carlson C et al (2011) Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer’s disease study cohorts from phase 3 trials of semagacestat and solanezumab. Alzheimer Dement 7:396–401. doi:10.1016/j.jalz.2011.05.2353
    • (2011) Alzheimer Dement , vol.7 , pp. 396-401
    • Carlson, C.1
  • 12
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • COI: 1:CAS:528:DC%2BD2MXjsVCjsbg%3D, PID: 15883316
    • Gilman S et al (2005) Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64:1553–1562
    • (2005) Neurology , vol.64 , pp. 1553-1562
    • Gilman, S.1
  • 13
    • 77950158093 scopus 로고    scopus 로고
    • Conformations and biological activities of amyloid beta peptide 25-35
    • COI: 1:CAS:528:DC%2BC3cXkt1ersrg%3D
    • Millucci L, Ghezzi L, Bernardini G, Santucci A (2010) Conformations and biological activities of amyloid beta peptide 25-35. Curr Protein Peptide Sci 11:54–67
    • (2010) Curr Protein Peptide Sci , vol.11 , pp. 54-67
    • Millucci, L.1    Ghezzi, L.2    Bernardini, G.3    Santucci, A.4
  • 14
    • 80054752317 scopus 로고    scopus 로고
    • Molecular basis for amyloid-beta polymorphism
    • COI: 1:CAS:528:DC%2BC3MXhtlGnurvK, PID: 21949245
    • Colletier JP et al (2011) Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A 108:16938–16943. doi:10.1073/pnas.1112600108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16938-16943
    • Colletier, J.P.1
  • 15
    • 84862286464 scopus 로고    scopus 로고
    • Traumatic brain injury, microglia, and Beta amyloid
    • Mannix RC, Whalen MJ (2012) Traumatic brain injury, microglia, and Beta amyloid. Int J Alzheimer Dis 2012:608732. doi:10.1155/2012/608732
    • (2012) Int J Alzheimer Dis , vol.2012 , pp. 608732
    • Mannix, R.C.1    Whalen, M.J.2
  • 16
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • COI: 1:CAS:528:DC%2BD1cXht1amsbrE, PID: 18495785
    • Dilger RN, Johnson RW (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84:932–939. doi:10.1189/jlb.0208108
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 17
    • 84883796681 scopus 로고    scopus 로고
    • PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases
    • COI: 1:CAS:528:DC%2BC3sXht1yltrjP, PID: 23955714
    • Pietri M et al (2013) PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases. Nat Med 19:1124–1131. doi:10.1038/nm.3302
    • (2013) Nat Med , vol.19 , pp. 1124-1131
    • Pietri, M.1
  • 18
    • 84871922036 scopus 로고    scopus 로고
    • Deciphering the mechanism underlying late-onset Alzheimer disease
    • PID: 23183882
    • Krstic D, Knuesel I (2012) Deciphering the mechanism underlying late-onset Alzheimer disease. Nat Rev Neurol 9:25–34. doi:10.1038/nrneurol.2012.236
    • (2012) Nat Rev Neurol , vol.9 , pp. 25-34
    • Krstic, D.1    Knuesel, I.2
  • 19
    • 84881476107 scopus 로고    scopus 로고
    • Integrative genomics identifies APOE epsilon4 effectors in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXht1SjtbjL, PID: 23883936
    • Rhinn H, Fujita R, Qiang L, Cheng R, Lee JH, Abeliovich A (2013) Integrative genomics identifies APOE epsilon4 effectors in Alzheimer’s disease. Nature 500:45–50. doi:10.1038/nature12415
    • (2013) Nature , vol.500 , pp. 45-50
    • Rhinn, H.1    Fujita, R.2    Qiang, L.3    Cheng, R.4    Lee, J.H.5    Abeliovich, A.6
  • 20
    • 78649446529 scopus 로고    scopus 로고
    • Autoantibodies recognizing native MOG are closely associated with active demyelination but not with neuroinflammation in chronic EAE
    • PID: 20573031
    • Ohtani S, Kohyama K, Matsumoto Y (2011) Autoantibodies recognizing native MOG are closely associated with active demyelination but not with neuroinflammation in chronic EAE. Neuropathology 31:101–111. doi:10.1111/j.1440-1789.2010.01131.x
    • (2011) Neuropathology , vol.31 , pp. 101-111
    • Ohtani, S.1    Kohyama, K.2    Matsumoto, Y.3
  • 21
    • 33748767945 scopus 로고    scopus 로고
    • Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer’s disease patients: a biochemical analysis
    • COI: 1:CAS:528:DC%2BD28XpvFWqs7s%3D, PID: 16936277
    • Patton RL et al (2006) Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer’s disease patients: a biochemical analysis. Am J Pathol 169:1048–63
    • (2006) Am J Pathol , vol.169 , pp. 1048-1063
    • Patton, R.L.1
  • 22
    • 84862778010 scopus 로고    scopus 로고
    • Autoreactive-Abeta antibodies promote APP beta-secretase processing
    • COI: 1:CAS:528:DC%2BC38XksFCntrg%3D, PID: 22188568
    • Deng J et al (2012) Autoreactive-Abeta antibodies promote APP beta-secretase processing. J Neurochem 120:732–740. doi:10.1111/j.1471-4159.2011.07629.x
    • (2012) J Neurochem , vol.120 , pp. 732-740
    • Deng, J.1
  • 23
    • 79955758133 scopus 로고    scopus 로고
    • Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXltFGgtLw%3D, PID: 21490226
    • Dodel R et al (2011) Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer’s disease. J Neurosci 31:5847–5854. doi:10.1523/JNEUROSCI.4401-10.2011
    • (2011) J Neurosci , vol.31 , pp. 5847-5854
    • Dodel, R.1
  • 24
    • 84878407495 scopus 로고    scopus 로고
    • Anti-amyloid beta autoantibodies in cerebral amyloid angiopathy-related inflammation: implications for amyloid-modifying therapies
    • Piazza F et al (2013) Anti-amyloid beta autoantibodies in cerebral amyloid angiopathy-related inflammation: implications for amyloid-modifying therapies. Ann Neurol 73:449–458. doi:10.1002/ana.23857
    • (2013) Ann Neurol , vol.73 , pp. 449-458
    • Piazza, F.1
  • 25
    • 0038392473 scopus 로고    scopus 로고
    • Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys
    • COI: 1:CAS:528:DC%2BD38XptlGhsLY%3D, PID: 12471462
    • Bouras C, Riederer BM, Hof PR, Giannakopoulos P (2003) Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys. Acta Neuropathol 105:58–64. doi:10.1007/s00401-002-0617-6
    • (2003) Acta Neuropathol , vol.105 , pp. 58-64
    • Bouras, C.1    Riederer, B.M.2    Hof, P.R.3    Giannakopoulos, P.4
  • 26
    • 84863221661 scopus 로고    scopus 로고
    • Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XosVKhtb8%3D, PID: 22672770
    • Farlow M et al (2012) Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease. Alzheimers Dement 8:261–271. doi:10.1016/j.jalz.2011.09.224
    • (2012) Alzheimers Dement , vol.8 , pp. 261-271
    • Farlow, M.1
  • 27
    • 84891706947 scopus 로고    scopus 로고
    • CD33 Alzheimer’s disease locus: altered monocyte function and amyloid biology
    • COI: 1:CAS:528:DC%2BC3sXot1Cisrc%3D, PID: 23708142
    • Bradshaw EM et al (2013) CD33 Alzheimer’s disease locus: altered monocyte function and amyloid biology. Nat Neurosci 16:848–850. doi:10.1038/nn.3435
    • (2013) Nat Neurosci , vol.16 , pp. 848-850
    • Bradshaw, E.M.1
  • 28
    • 84866538826 scopus 로고    scopus 로고
    • Sustained levels of antibodies against Abeta in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice
    • COI: 1:CAS:528:DC%2BC38XhtlWksLjK, PID: 22892246
    • Bard F et al (2012) Sustained levels of antibodies against Abeta in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice. Exp Neurol 238:38–43. doi:10.1016/j.expneurol.2012.07.022
    • (2012) Exp Neurol , vol.238 , pp. 38-43
    • Bard, F.1
  • 29
    • 77957233161 scopus 로고    scopus 로고
    • Intramuscular delivery of a single chain antibody gene prevents brain Abeta deposition and cognitive impairment in a mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXht1ertLrL, PID: 20595065
    • Wang YJ et al (2010) Intramuscular delivery of a single chain antibody gene prevents brain Abeta deposition and cognitive impairment in a mouse model of Alzheimer’s disease. Brain Behav Immun 24:1281–1293. doi:10.1016/j.bbi.2010.05.010
    • (2010) Brain Behav Immun , vol.24 , pp. 1281-1293
    • Wang, Y.J.1
  • 30
    • 58549116371 scopus 로고    scopus 로고
    • Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer’s disease
    • PID: 17686552
    • Wang YJ et al (2009) Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer’s disease. Neurobiol Aging 30:364–376. doi:10.1016/j.neurobiolaging.2007.06.013
    • (2009) Neurobiol Aging , vol.30 , pp. 364-376
    • Wang, Y.J.1
  • 31
    • 0037073670 scopus 로고    scopus 로고
    • Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels
    • COI: 1:CAS:528:DC%2BD38Xptlegt7w%3D, PID: 12384498
    • Fukumoto H, Deng A, Irizarry MC, Fitzgerald ML, Rebeck GW (2002) Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J Biol Chem 277:48508–48513. doi:10.1074/jbc.M209085200
    • (2002) J Biol Chem , vol.277 , pp. 48508-48513
    • Fukumoto, H.1    Deng, A.2    Irizarry, M.C.3    Fitzgerald, M.L.4    Rebeck, G.W.5
  • 32
    • 42249103252 scopus 로고    scopus 로고
    • Fatty acids, lipid metabolism and Alzheimer pathology
    • COI: 1:CAS:528:DC%2BD1cXls1Sjsrs%3D, PID: 18378224
    • Hooijmans CR, Kiliaan AJ (2008) Fatty acids, lipid metabolism and Alzheimer pathology. Eur J Pharmacol 585:176–196. doi:10.1016/j.ejphar.2007.11.081
    • (2008) Eur J Pharmacol , vol.585 , pp. 176-196
    • Hooijmans, C.R.1    Kiliaan, A.J.2
  • 33
    • 84860704421 scopus 로고    scopus 로고
    • Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study
    • PID: 22508850
    • Lesser GT (2012) Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study. Neurology 78:1280. doi:10.1212/WNL.0b013e318254f6ad
    • (2012) Neurology , vol.78 , pp. 1280
    • Lesser, G.T.1
  • 34
    • 0024299370 scopus 로고
    • Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    • COI: 1:CAS:528:DyaL1cXitFOrtr8%3D, PID: 3283935
    • Mahley RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622–630
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 35
    • 20444374712 scopus 로고    scopus 로고
    • LRP and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2MXlvVGhsLg%3D, PID: 15959937
    • Zerbinatti CV, Bu G (2005) LRP and Alzheimer’s disease. Rev Neurosci 16:123–135
    • (2005) Rev Neurosci , vol.16 , pp. 123-135
    • Zerbinatti, C.V.1    Bu, G.2
  • 36
    • 0033762062 scopus 로고    scopus 로고
    • Modulation of amyloid beta-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor-related protein pathway
    • COI: 1:CAS:528:DC%2BD3cXnvFyqur0%3D, PID: 11067868
    • Kang DE et al (2000) Modulation of amyloid beta-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest 106:1159–1166. doi:10.1172/JCI11013
    • (2000) J Clin Invest , vol.106 , pp. 1159-1166
    • Kang, D.E.1
  • 37
    • 7644225312 scopus 로고    scopus 로고
    • RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier
    • COI: 1:CAS:528:DC%2BD2cXovVCgtLY%3D, PID: 15459432
    • Deane R, Wu Z, Zlokovic BV (2004) RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 35:2628–2631
    • (2004) Stroke , vol.35 , pp. 2628-2631
    • Deane, R.1    Wu, Z.2    Zlokovic, B.V.3
  • 38
    • 30044438463 scopus 로고    scopus 로고
    • Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
    • COI: 1:CAS:528:DC%2BD2MXhtlCmsb3K, PID: 16207713
    • Koldamova R, Staufenbiel M, Lefterov I (2005) Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice. J Biol Chem 280:43224–43235. doi:10.1074/jbc.M504513200
    • (2005) J Biol Chem , vol.280 , pp. 43224-43235
    • Koldamova, R.1    Staufenbiel, M.2    Lefterov, I.3
  • 39
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    • COI: 1:CAS:528:DC%2BD3sXislGrurg%3D, PID: 12547833
    • Koldamova RP et al (2003) 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem 278:13244–13256. doi:10.1074/jbc.M300044200
    • (2003) J Biol Chem , vol.278 , pp. 13244-13256
    • Koldamova, R.P.1
  • 40
    • 70350728321 scopus 로고    scopus 로고
    • Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease
    • COI: 1:CAS:528:DC%2BD1MXmtlyhsLo%3D, PID: 19471248
    • Liu Y et al (2009) Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Mol Ther 17:1381–1386. doi:10.1038/mt.2009.115
    • (2009) Mol Ther , vol.17 , pp. 1381-1386
    • Liu, Y.1
  • 41
    • 33745778440 scopus 로고    scopus 로고
    • Membrane proteins and phospholipids as effectors of reverse cholesterol transport
    • COI: 1:STN:280:DC%2BD28zovFWltw%3D%3D, PID: 16805382
    • Torkhovskaia TI, Ipatova OM, Medvedeva NV, Zakharova TS, Khalilov EM (2006) Membrane proteins and phospholipids as effectors of reverse cholesterol transport. Biomed Khim 52:113–123
    • (2006) Biomed Khim , vol.52 , pp. 113-123
    • Torkhovskaia, T.I.1    Ipatova, O.M.2    Medvedeva, N.V.3    Zakharova, T.S.4    Khalilov, E.M.5
  • 42
    • 33846689559 scopus 로고    scopus 로고
    • ABCA1, from pathology to membrane function
    • COI: 1:CAS:528:DC%2BD2sXhtFWjtrg%3D, PID: 16858612
    • Zarubica A, Trompier D, Chimini G (2007) ABCA1, from pathology to membrane function. Pflugers Arch 453:569–579. doi:10.1007/s00424-006-0108-z
    • (2007) Pflugers Arch , vol.453 , pp. 569-579
    • Zarubica, A.1    Trompier, D.2    Chimini, G.3
  • 43
    • 34147173784 scopus 로고    scopus 로고
    • Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver
    • COI: 1:CAS:528:DC%2BD2sXksVWkt7g%3D, PID: 17430242
    • Sparks DL (2007) Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver. Curr Alzheimer Res 4:165–169
    • (2007) Curr Alzheimer Res , vol.4 , pp. 165-169
    • Sparks, D.L.1
  • 44
    • 34748856161 scopus 로고    scopus 로고
    • Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes
    • COI: 1:CAS:528:DC%2BD2sXhtFaiu77L, PID: 17609417
    • Tamaki C, Ohtsuki S, Terasaki T (2007) Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes. Mol Pharmacol 72:850–855. doi:10.1124/mol.107.036913
    • (2007) Mol Pharmacol , vol.72 , pp. 850-855
    • Tamaki, C.1    Ohtsuki, S.2    Terasaki, T.3
  • 45
    • 3042677631 scopus 로고    scopus 로고
    • Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study
    • PID: 15213280
    • Seliger SL et al (2004) Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol 15:1904–1911
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1904-1911
    • Seliger, S.L.1
  • 46
    • 79955521915 scopus 로고    scopus 로고
    • Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease
    • COI: 1:STN:280:DC%2BC3MrpsVWhug%3D%3D, PID: 21490316
    • Li J et al (2011) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 76:1485–1491. doi:10.1212/WNL.0b013e318217e7a4
    • (2011) Neurology , vol.76 , pp. 1485-1491
    • Li, J.1
  • 47
    • 77954476781 scopus 로고    scopus 로고
    • Vascular risk aggravates the progression of Alzheimer’s disease in a Chinese cohort
    • PID: 20164563
    • Li J et al (2010) Vascular risk aggravates the progression of Alzheimer’s disease in a Chinese cohort. J Alzheimers Dis 20:491–500. doi:10.3233/JAD-2010-1383
    • (2010) J Alzheimers Dis , vol.20 , pp. 491-500
    • Li, J.1
  • 49
    • 84865007775 scopus 로고    scopus 로고
    • Human serum albumin can regulate amyloid-beta peptide fiber growth in the brain interstitium: implications for Alzheimer disease
    • COI: 1:CAS:528:DC%2BC38XhtFOktr7F, PID: 22718756
    • Stanyon HF, Viles JH (2012) Human serum albumin can regulate amyloid-beta peptide fiber growth in the brain interstitium: implications for Alzheimer disease. J Biol Chem 287:28163–28168. doi:10.1074/jbc.C112.360800
    • (2012) J Biol Chem , vol.287 , pp. 28163-28168
    • Stanyon, H.F.1    Viles, J.H.2
  • 50
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXktFahtrk%3D, PID: 21460841
    • Naj AC et al (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease. Nat Genet 43:436–441. doi:10.1038/ng.801
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1
  • 51
    • 84869208877 scopus 로고    scopus 로고
    • Amyloid beta levels in human red blood cells
    • COI: 1:CAS:528:DC%2BC38XhvVSiu73E, PID: 23166730
    • Kiko T et al (2012) Amyloid beta levels in human red blood cells. PloS one 7:e49620. doi:10.1371/journal.pone.0049620
    • (2012) PloS one , vol.7 , pp. e49620
    • Kiko, T.1
  • 52
    • 84867517853 scopus 로고    scopus 로고
    • Considering the vascular hypothesis of Alzheimer’s disease: effect of copper associated amyloid on red blood cells
    • COI: 1:CAS:528:DC%2BC3sXntVOqtL0%3D, PID: 22879025
    • Lucas HR, Rifkind JM (2013) Considering the vascular hypothesis of Alzheimer’s disease: effect of copper associated amyloid on red blood cells. Adv Exp Med Biol 765:131–138. doi:10.1007/978-1-4614-4989-8_19
    • (2013) Adv Exp Med Biol , vol.765 , pp. 131-138
    • Lucas, H.R.1    Rifkind, J.M.2
  • 53
    • 33750031006 scopus 로고    scopus 로고
    • Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes
    • COI: 1:CAS:528:DC%2BD28XhtFSlu7zJ, PID: 16290270
    • Rogers J et al (2006) Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes. Neurobiol Aging 27:1733–1739
    • (2006) Neurobiol Aging , vol.27 , pp. 1733-1739
    • Rogers, J.1
  • 54
    • 70350551950 scopus 로고    scopus 로고
    • Amyloid-targeted therapeutics in Alzheimer’s disease: use of human albumin in plasma exchange as a novel approach for Abeta mobilization
    • COI: 1:CAS:528:DC%2BD1MXhtlOrsb7J, PID: 19771322
    • Boada M et al (2009) Amyloid-targeted therapeutics in Alzheimer’s disease: use of human albumin in plasma exchange as a novel approach for Abeta mobilization. Drug News Perspect 22:325–339. doi:10.1358/dnp.2009.22.6.1395256
    • (2009) Drug News Perspect , vol.22 , pp. 325-339
    • Boada, M.1
  • 55
    • 84863393470 scopus 로고    scopus 로고
    • Withania somnifera reverses Alzheimer’s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
    • COI: 1:CAS:528:DC%2BC38XksVyhtbY%3D, PID: 22308347
    • Sehgal N et al (2012) Withania somnifera reverses Alzheimer’s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc Natl Acad Sci U S A 109:3510–3515. doi:10.1073/pnas.1112209109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3510-3515
    • Sehgal, N.1
  • 56
    • 65549114145 scopus 로고    scopus 로고
    • Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer’s disease
    • Guan H et al (2008) Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer’s disease. J Neurosci Res. doi:10.1002/jnr.21944
    • (2008) J Neurosci Res
    • Guan, H.1
  • 58
    • 84893860052 scopus 로고    scopus 로고
    • Sustained peripheral depletion of amyloid-beta with a novel form of neprilysin does not affect central levels of amyloid-beta
    • PID: 24259408
    • Henderson SJ et al (2013) Sustained peripheral depletion of amyloid-beta with a novel form of neprilysin does not affect central levels of amyloid-beta. Brain. doi:10.1093/brain/awt308
    • (2013) Brain
    • Henderson, S.J.1
  • 59
    • 84873314921 scopus 로고    scopus 로고
    • Enhanced proteolytic clearance of plasma Abeta by peripherally administered neprilysin does not result in reduced levels of brain Abeta in mice
    • COI: 1:CAS:528:DC%2BC3sXhtlOjsrjP, PID: 23392674
    • Walker JR et al (2013) Enhanced proteolytic clearance of plasma Abeta by peripherally administered neprilysin does not result in reduced levels of brain Abeta in mice. J Neurosci 33:2457–2464. doi:10.1523/JNEUROSCI.3407-12.2013
    • (2013) J Neurosci , vol.33 , pp. 2457-2464
    • Walker, J.R.1
  • 60
    • 36148979336 scopus 로고    scopus 로고
    • In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes
    • COI: 1:CAS:528:DC%2BD2sXhtlCqsrvE, PID: 17988763
    • Liu Y et al (2007) In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides 28:2348–2355. doi:10.1016/j.peptides.2007.09.015
    • (2007) Peptides , vol.28 , pp. 2348-2355
    • Liu, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.