Implications of the discovery of brain lymphatic pathways

The Lancet Neurology

Volumn 14, Issue 10, 2015, Pages 977-979

  Iliff, Jeffrey J ^a,b   Goldman, Steven A ^b,c   Nedergaard, Maiken ^b,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID PROTEIN; MACROMOLECULE;

BRAIN; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CRANIAL SINUS; HUMAN; LYMPH NODE; LYMPHATIC SYSTEM; NOTE; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; T LYMPHOCYTE; ANIMAL; EXTRACELLULAR FLUID; MACROMOLECULE; METABOLISM;

ANIMALS; BRAIN; CEREBROSPINAL FLUID; EXTRACELLULAR FLUID; LYMPH NODES; LYMPHATIC SYSTEM; MACROMOLECULAR SUBSTANCES;

EID: 84942410929     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(15)00221-5     Document Type: Note

References (10)

1. Davson H, Segal MB Physiology of the CSF and blood-brain barriers 1996, CRC Press, Boca Raton.
2. Cserr HF Role of secretion and bulk flow of brain interstitial fluid in brain volume regulation. Ann N Y Acad Sci 1988, 529:9-20.
3. Weed LH Studies on cerebro-spinal fluid. No. III: the pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J Med Res 1914, 31:51-91.
4. Butler A Correlated physiologic and structural studies of CSF absorption. Hydrocephalus 1984, 41-57. Raven Press, New York. K. Shapiro, A. Marmarou, H. Portnoy (Eds.).
5. Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature 2015, 523:337-341.
6. Aspelund A, Antila S, Proulx ST, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 2015, 212:991-999.
7. Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012, 4:147ra11.
8. Iliff JJ, Lee H, Yu M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 2013, 123:1299-1309.
9. Iliff JJ, Chen MJ, Plog BA, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci 2014, 34:16180-16193.
10. Kress BT, Iliff JJ, Xia M, et al. Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 2014, 76:845-861.