Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 9, 2012, Pages 3510-3515

  Sehgal, Neha ^a   Gupta, Alok ^a   Valli, Rupanagudi Khader ^a   Joshi, Shanker Datt ^a   Mills, Jessica T ^b   Hamel, Edith ^b   Khanna, Pankaj ^c   Jain, Subhash Chand ^c   Thakur, Suman S ^d   Ravindranath, Vijayalakshmi ^a,d  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF DELHI   (India)

^d INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Dementia; Herbal extract; Neurodegenerative disease

Indexed keywords

AMYLOID BETA PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; WITHANIA SOMNIFERA EXTRACT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; LIVER; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; THERAPY EFFECT; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE; WITHANIA SOMNIFERA;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; LIVER; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MICROGLIA; NEPRILYSIN; OLIGONUCLEOTIDES, ANTISENSE; ORGAN SPECIFICITY; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLAQUE, AMYLOID; PRESENILIN-1; UP-REGULATION; WITHANIA;

MUS; MUS MUSCULUS; WITHANIA SOMNIFERA;

EID: 84863393470     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112209109     Document Type: Article

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