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Volumn 34, Issue 6, 2013, Pages 1680-1686

Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes

Author keywords

Alzheimer's disease; Amyloid precursor protein; APP; Brain; Differential processing; Peripheral blood leukocytes

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; BETA SECRETASE 2; NICASTRIN; PRESENILIN 1;

EID: 84875271668     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.12.004     Document Type: Article
Times cited : (16)

References (40)
  • 1
    • 71849117051 scopus 로고    scopus 로고
    • Blood cell markers in Alzheimer disease: amyloid precursor protein form ratio in platelets
    • Borroni B., Agosti C., Marcello E., Di Luca M., Padovani A. Blood cell markers in Alzheimer disease: amyloid precursor protein form ratio in platelets. Exp. Gerontol. 2010, 45:53-56.
    • (2010) Exp. Gerontol. , vol.45 , pp. 53-56
    • Borroni, B.1    Agosti, C.2    Marcello, E.3    Di Luca, M.4    Padovani, A.5
  • 2
    • 77955270739 scopus 로고    scopus 로고
    • Beta-amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain
    • Buoso E., Lanni C., Schettini G., Govoni S., Racchi M. Beta-amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain. Pharmacol. Res. 2010, 62:308-317.
    • (2010) Pharmacol. Res. , vol.62 , pp. 308-317
    • Buoso, E.1    Lanni, C.2    Schettini, G.3    Govoni, S.4    Racchi, M.5
  • 3
  • 4
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    • [erratum in 2001;293:1436]
    • Cao X., Sudhof T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120. [erratum in 2001;293:1436].
    • (2001) Science , vol.293 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 5
    • 2642582435 scopus 로고    scopus 로고
    • Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
    • Cao X., Sudhof T.C. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 2004, 279:24601-24611.
    • (2004) J. Biol. Chem. , vol.279 , pp. 24601-24611
    • Cao, X.1    Sudhof, T.C.2
  • 7
    • 25144501662 scopus 로고    scopus 로고
    • Intraneuronal abeta accumulation and origin of plaques in Alzheimer's disease
    • Gouras G.K., Almeida C.G., Takahashi R.H. Intraneuronal abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol. Aging 2005, 26:1235-1244.
    • (2005) Neurobiol. Aging , vol.26 , pp. 1235-1244
    • Gouras, G.K.1    Almeida, C.G.2    Takahashi, R.H.3
  • 8
  • 9
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 2007, 8:101-112.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 11
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 12
    • 80955151917 scopus 로고    scopus 로고
    • CSF biomarkers for Alzheimer's disease: current utility and potential future use
    • Holtzman D.M. CSF biomarkers for Alzheimer's disease: current utility and potential future use. Neurobiol. Aging 2011, 32:S4-S9.
    • (2011) Neurobiol. Aging , vol.32
    • Holtzman, D.M.1
  • 13
    • 0034844610 scopus 로고    scopus 로고
    • 17-β-Estradiol alters Jurkat lymphocyte cell cycling and induces apoptosis through suppression of Bcl-2 and cyclin A
    • Jenkins J.K., Suwannaroj S., Elbourne K.B., Ndebele K., McMurray R.W. 17-β-Estradiol alters Jurkat lymphocyte cell cycling and induces apoptosis through suppression of Bcl-2 and cyclin A. Int. Immunopharm. 2001, 1:1897-1911.
    • (2001) Int. Immunopharm. , vol.1 , pp. 1897-1911
    • Jenkins, J.K.1    Suwannaroj, S.2    Elbourne, K.B.3    Ndebele, K.4    McMurray, R.W.5
  • 15
    • 0033133456 scopus 로고    scopus 로고
    • β-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease
    • Jung S.S., Gauthier S., Cashman N.R. β-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease. Neurobiol. Aging 1999, 20:249-257.
    • (1999) Neurobiol. Aging , vol.20 , pp. 249-257
    • Jung, S.S.1    Gauthier, S.2    Cashman, N.R.3
  • 16
    • 0035955693 scopus 로고    scopus 로고
    • The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
    • Kimberly W.T., Zheng J.B., Guenette S.Y., Selkoe D.J. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J. Biol. Chem. 2001, 276:40288-40292.
    • (2001) J. Biol. Chem. , vol.276 , pp. 40288-40292
    • Kimberly, W.T.1    Zheng, J.B.2    Guenette, S.Y.3    Selkoe, D.J.4
  • 17
    • 0026670809 scopus 로고
    • Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells
    • Konig G., Monning U., Czech C., Prior R., Banati R., Schreiter-Gasser U., Bauer J., Masters C.L., Beyreuther K. Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells. J. Biol. Chem. 1992, 267:10804-10809.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10804-10809
    • Konig, G.1    Monning, U.2    Czech, C.3    Prior, R.4    Banati, R.5    Schreiter-Gasser, U.6    Bauer, J.7    Masters, C.L.8    Beyreuther, K.9
  • 18
    • 0032860931 scopus 로고    scopus 로고
    • The amyloid precursor protein of Alzheimer disease in human brain and blood
    • Li Q.X., Fuller S.J., Beyreuther K., Masters C.L. The amyloid precursor protein of Alzheimer disease in human brain and blood. J. Leukocyte Biol. 1999, 66:567-574.
    • (1999) J. Leukocyte Biol. , vol.66 , pp. 567-574
    • Li, Q.X.1    Fuller, S.J.2    Beyreuther, K.3    Masters, C.L.4
  • 19
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 20
    • 75649133191 scopus 로고    scopus 로고
    • Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's disease
    • Lublin A.L., Gandy S. Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's disease. Mt. Sinai J. Med. 2010, 77:43-49.
    • (2010) Mt. Sinai J. Med. , vol.77 , pp. 43-49
    • Lublin, A.L.1    Gandy, S.2
  • 21
    • 80955137863 scopus 로고    scopus 로고
    • Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants
    • Mayeux R., Schupf N. Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants. Neurobiol. Aging 2011, 32:S10-S19.
    • (2011) Neurobiol. Aging , vol.32
    • Mayeux, R.1    Schupf, N.2
  • 23
    • 84860518949 scopus 로고    scopus 로고
    • Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study
    • Mukaetova-Ladinska E.B., Abdel-All Z., Dodds S., Andrade J., Alves da Silva J., Kalaria R.N., O'Brien J.T. Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study. Age Ageing 2012, 41:408-412.
    • (2012) Age Ageing , vol.41 , pp. 408-412
    • Mukaetova-Ladinska, E.B.1    Abdel-All, Z.2    Dodds, S.3    Andrade, J.4    Alves da Silva, J.5    Kalaria, R.N.6    O'Brien, J.T.7
  • 24
    • 48349085043 scopus 로고    scopus 로고
    • The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
    • Muller T., Meyer H.E., Egensperger R., Marcus K. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog. Neurobiol. 2008, 85:393-406.
    • (2008) Prog. Neurobiol. , vol.85 , pp. 393-406
    • Muller, T.1    Meyer, H.E.2    Egensperger, R.3    Marcus, K.4
  • 25
    • 1542359477 scopus 로고    scopus 로고
    • A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment
    • Muresan Z., Muresan V. A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. Hum. Mol. Genet. 2004, 13:475-488.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 475-488
    • Muresan, Z.1    Muresan, V.2
  • 26
    • 79952004107 scopus 로고    scopus 로고
    • The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis
    • Ohkawara T., Nagase H., Koh C.S., Nakayama K. The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis. Gene 2011, 475:1-9.
    • (2011) Gene , vol.475 , pp. 1-9
    • Ohkawara, T.1    Nagase, H.2    Koh, C.S.3    Nakayama, K.4
  • 27
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
    • Palop J.J., Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat. Neurosci. 2010, 13:812-818.
    • (2010) Nat. Neurosci. , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 28
    • 32644474993 scopus 로고    scopus 로고
    • Regulation of IRF7 through cell type-specific protein stability
    • Prakash A., Levy D.E. Regulation of IRF7 through cell type-specific protein stability. Biochem. Biophys. Res. Commun. 2006, 342:50-56.
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 50-56
    • Prakash, A.1    Levy, D.E.2
  • 30
    • 0028174106 scopus 로고
    • Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons
    • Sandbrink R., Masters C.L., Beyreuther K. Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. J. Biol. Chem. 1994, 269:1510-1517.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1510-1517
    • Sandbrink, R.1    Masters, C.L.2    Beyreuther, K.3
  • 31
    • 0029970325 scopus 로고    scopus 로고
    • APP gene family. Alternative splicing generates functionally related isoforms
    • Sandbrink R., Masters C.L., Beyreuther K. APP gene family. Alternative splicing generates functionally related isoforms. Ann. N. Y. Acad. Sci. 1996, 777:281-287.
    • (1996) Ann. N. Y. Acad. Sci. , vol.777 , pp. 281-287
    • Sandbrink, R.1    Masters, C.L.2    Beyreuther, K.3
  • 32
    • 0001067847 scopus 로고
    • β-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane associated proteins in neural and nonneural tissues
    • Selkoe D.J., Podlisny M.B., Joachim C.L., Vickers E.A., Lee G., Fritz L.C., Oltersdorf T. β-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane associated proteins in neural and nonneural tissues. Proc. Natl. Acad. Sci. U. S. A 1988, 85:7341-7345.
    • (1988) Proc. Natl. Acad. Sci. U. S. A , vol.85 , pp. 7341-7345
    • Selkoe, D.J.1    Podlisny, M.B.2    Joachim, C.L.3    Vickers, E.A.4    Lee, G.5    Fritz, L.C.6    Oltersdorf, T.7
  • 33
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • Shankar G.M., Bloodgood B.L., Townsend M., Walsh D.M., Selkoe D.J., Sabatini B.L. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 2007, 27:2866-2875.
    • (2007) J. Neurosci. , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 34
    • 80051579129 scopus 로고    scopus 로고
    • Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein
    • Shimada H., Ataka S., Tomiyama T., Takechi H., Mori H., Miki T. Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein. Dement. Geriatr. Cogn. Disord. 2011, 32:45-54.
    • (2011) Dement. Geriatr. Cogn. Disord. , vol.32 , pp. 45-54
    • Shimada, H.1    Ataka, S.2    Tomiyama, T.3    Takechi, H.4    Mori, H.5    Miki, T.6
  • 35
    • 82755191611 scopus 로고    scopus 로고
    • Multivariate analysis of differential lymphocyte cell cycle activity in Alzheimer's disease
    • Stieler J., Grimes R., Weber D., Gartner W., Sabbagh M., Arendt T. Multivariate analysis of differential lymphocyte cell cycle activity in Alzheimer's disease. Neurobiol. Aging 2012, 33:234-241.
    • (2012) Neurobiol. Aging , vol.33 , pp. 234-241
    • Stieler, J.1    Grimes, R.2    Weber, D.3    Gartner, W.4    Sabbagh, M.5    Arendt, T.6
  • 36
    • 79955658979 scopus 로고    scopus 로고
    • Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder
    • Sultana R., Mecocci P., Mangialasche F., Cecchetti R., Baglioni M., Butterfield D.A. Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder. J. Alzheimers Dis. 2011, 24:77-84.
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 77-84
    • Sultana, R.1    Mecocci, P.2    Mangialasche, F.3    Cecchetti, R.4    Baglioni, M.5    Butterfield, D.A.6
  • 37
    • 77956529805 scopus 로고    scopus 로고
    • Plasma beta-amyloid as potential biomarker of Alzheimer disease: possibility of diagnostic tool for Alzheimer disease
    • Takeda S., Sato N., Rakugi H., Morishita R. Plasma beta-amyloid as potential biomarker of Alzheimer disease: possibility of diagnostic tool for Alzheimer disease. Mol. Biosyst. 2010, 6:1760-1766.
    • (2010) Mol. Biosyst. , vol.6 , pp. 1760-1766
    • Takeda, S.1    Sato, N.2    Rakugi, H.3    Morishita, R.4
  • 38
    • 5444275067 scopus 로고    scopus 로고
    • The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
    • von Rotz R.C., Kohli B.M., Bosset J., Meier M., Suzuki T., Nitsch R.M., Konietzko U. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J. Cell Sci. 2004, 117:4435-4448.
    • (2004) J. Cell Sci. , vol.117 , pp. 4435-4448
    • von Rotz, R.C.1    Kohli, B.M.2    Bosset, J.3    Meier, M.4    Suzuki, T.5    Nitsch, R.M.6    Konietzko, U.7
  • 40
    • 0347479366 scopus 로고    scopus 로고
    • Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease
    • Zhao M., Su J., Head E., Cotman C. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol. Dis. 2003, 14:391-403.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 391-403
    • Zhao, M.1    Su, J.2    Head, E.3    Cotman, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.