Preclinical assessment of young blood plasma for Alzheimer disease

JAMA Neurology

Volumn 73, Issue 11, 2016, Pages 1325-1333

  Middeldorp, Jinte ^a   Lehallier, Benoit ^a   Villeda, Saul A ^b   Miedema, Suzanne S M ^a   Evans, Emily ^a   Czirr, Eva ^a   Zhang, Hui ^a   Luo, Jian ^a   Stan, Trisha ^a   Mosher, Kira I ^a   Masliah, Eliezer ^c,d   Wyss Coray, Tony ^a,e  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CALBINDIN; PROTEIN TYROSINE KINASE; SYNAPTOPHYSIN; APP PROTEIN, HUMAN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; APP GENE; ARTICLE; ASSOCIATIVE MEMORY; BEHAVIOR DISORDER; CIRCULATION; COGNITION; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE; GENE EXPRESSION; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL; NEUROPATHOLOGY; NONHUMAN; PARABIOSIS; PLASMA TRANSFUSION; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; WORKING MEMORY; AGE; ANIMAL; BLOOD COMPONENT THERAPY; C57BL MOUSE; CROSS CIRCULATION; METABOLISM; PROCEDURES; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOOD COMPONENT TRANSFUSION; CROSS CIRCULATION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 84996957300     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2016.3185     Document Type: Article

References (22)

1. Palop JJ, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci. 2010;13(7):812-818.
2. Masliah E, MalloryM, Alford M, et al. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology. 2001;56(1):127-129.
3. Mucke L, Masliah E, Yu GQ, et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000;20(11):4050-4058.
4. Palop JJ, Jones B, Kekonius L, et al. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A. 2003;100(16):9572-9577.
5. Rockenstein E, MalloryM, Mante M, Sisk A, Masliaha E. Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta (1-42). J Neurosci Res. 2001;66(4):573-582.
6. Villeda SA, Plambeck KE, Middeldorp J, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. 2014;20(6):659-663.
7. Villeda SA, Luo J, Mosher KI, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011;477(7362): 90-94.
8. Katsimpardi L, Litterman NK, Schein PA, et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014;344(6184):630-634.
9. Faizi M, Bader PL, Saw N, et al. Thy1-hAPP (Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain Behav. 2012;2 (2):142-154.
10. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4(2):249-264.
11. Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33(1):1-22.
12. Kolde R, Laur S, Adler P, Vilo J. Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics. 2012;28(4):573-580.
13. Luo J, Elwood F, Britschgi M, et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013;210(1):157-172.
14. Nagahara AH, Merrill DA, Coppola G, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009;15(3):331-337.
15. Pickford F, Masliah E, Britschgi M, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice. J Clin Invest. 2008; 118(6):2190-2199.
16. Alzheimer's Association. 2014 Alzheimer's disease facts and figures. Alzheimers Dement. 2014; 10(2):e47-e92.
17. He G, LuoW, Li P, et al. Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature. 2010;467(7311):95-98.
18. Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. FASEB J. 2011; 25(10):3594-3604.
19. Dineley KT,Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci. 2001;21(12): 4125-4133.
20. Webster B, Hansen L, Adame A, et al. Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. J Neuropathol Exp Neurol. 2006;65(2):142-151.
21. Perry G, Roder H, Nunomura A, et al. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport. 1999;10 (11):2411-2415.
22. Dineley KT,Weeber EJ, Atkins C, Adams JP, Anderson AE, Sweatt JD. Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination. J Neurochem. 2001; 77(4):961-971.