Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease

JAMA Neurology

Volumn 74, Issue 5, 2017, Pages 557-566

  Mattsson, Niklas ^a,b   Andreasson, Ulf ^c,d   Zetterberg, Henrik ^c,d,e   Blennow, Kaj ^c,d   Weiner, Michael W ^f   Aisen, Paul ^g   Toga, Arthur W ^g   Petersen, Ronald ^h   Jack, Clifford R ^h   Jagust, William ⁱ   Trojanowki, John Q ^j   Shaw, Leslie M ^j   Beckett, Laurel ^k   Green, Robert C ^l   Saykin, Andrew J ^m   Morris, John C ⁿ   Khachaturian, Zaven ^cc   Sorensen, Greg ^o   Carrillo, Maria ^p   Kuller, Lew ^q   Raichle, Marc ⁿ   Holtzman, David ⁿ   Paul, Steven ^r   Davies, Peter ^s   Fillit, Howard ^t   Hefti, Franz ^u   Mesulam, M Marcel ^v   Potter, William ^w   Snyder, Peter ^x   Lilly, Eli ^cc   Schwartz, Adam ^cc   Montine, Tom ^y   Thomas, Ronald G ^z   Donohue, Michael ^z   Walter, Sarah ^z   Gessert, Devon ^z   Sather, Tamie ^z   Jiminez, Gus ^z   Balasubramanian, Archana B ^z   Mason, Jennifer ^z   Sim, Iris ^z   Harvey, Danielle ^k   Bernstein, Matthew ^h   Borowski, Bret ^h   Gunter, Jeff ^h   Senjem, Matt ^h   Vemuri, Prashanthi ^h   Jones, David ^h   Kantarci, Kejal ^h   Ward, Chad ^h   Fox, Nick ^aa   Thompson, Paul ^ab   Schuff, Norbert ^f   DeCarli, Charles ^k   Landau, Susan ⁱ   Koeppe, Robert A ^ac   Foster, Norm ^ad   Reiman, Eric M ^ae   Chen, Kewei ^ae   Mathis, Chet ^q   Cairns, Nigel J ⁿ   Franklin, Erin ⁿ   Taylor Reinwald, Lisa ⁿ   Lee, Virginia ^j   Korecka, Magdalena ^j   Figurski, Michal ^j   Crawford, Karen ^j   Neu, Scott ^j   Foroud, Tatiana M ^m   Shen, Li ^m   Faber, Kelley ^m   Kim, Sungeun ^m   Nho, Kwangsik ^m   Potkin, Steven ^af   Thal, Lean ^z   Albert, Marilyn ^ag   Frank, Richard ^ah   Hsiao, John ^ai   Kaye, Jeffrey ^aj   Quinn, Joseph ^aj   Silbert, Lisa ^aj   Lind, Betty ^aj   Carter, Raina ^aj   Dolen, Sara ^aj   Schneider, Lon S ^g   Pawluczyk, Sonia ^g   Becerra, Mauricio ^g   Teodoro, Liberty ^g   Spann, Bryan M ^g   Brewer, James ^z   Vanderswag, Helen ^z   Fleisher, Adam ^z,ae   Heidebrink, Judith L ^ac   Lord, Joanne L ^ac   Mason, Sara S ^h   Albers, Colleen S ^h   Knopman, David ^h   Johnson, Kris ^h   Doody, Rachelle S ^ak   Villanueva Meyer, Javier ^ak   Pavlik, Valory ^ak   Shibley, Victoria ^ak   Chowdhury, Munir ^ak   Rountree, Susan ^ak   Dang, Mimi ^ak   Stern, Yaakov ^al   Honig, Lawrence S ^al   Bell, Karen L ^al   Ances, Beau ⁿ   Carroll, Maria ⁿ   Creech, Mary L ⁿ   Mintun, Mark A ⁿ   Schneider, Stacy ⁿ   Oliver, Angela ⁿ   Marson, Daniel ^am   Geldmacher, David ^am   Love, Marissa Natelson ^am   Griffith, Randall ^am   Clark, David ^am   Brockington, John ^am   Roberson, Erik ^am   Grossman, Hillel ^an   Mitsis, Effie ^an   Shah, Raj C ^ao   De Toledo Morrell, Leyla ^ao   Duara, Ranjan ^ap   Greig Custo, Maria T ^ap   Barker, Warren ^ap   Onyike, Chiadi ^ag   D'Agostino, Daniel ^ag   Kielb, Stephanie ^ag   Sadowski, Martin ^aq   Sheikh, Mohammed O ^aq   Ulysse, Anaztasia ^aq   Gaikwad, Mrunalini ^aq   Doraiswamy, P Murali ^ar   Petrella, Jeffrey R ^ar   Borges Neto, Salvador ^ar   Wong, Terence Z ^ar   Coleman, Edward ^ar   Arnold, Steven E ^j   Karlawish, Jason H ^j   Wolk, David A ^j   Clark, Christopher M ^j   Smith, Charles D ^as   Jicha, Greg ^as   Hardy, Peter ^as   Sinha, Partha ^as   Oates, Elizabeth ^as   Conrad, Gary ^as   Lopez, Oscar L ^q   Oakley, Mary Ann ^q   Simpson, Donna M ^q   Porsteinsson, Anton P ^at   Goldstein, Bonnie S ^at   Martin, Kim ^at   Makino, Kelly M ^at   Ismail, M Saleem ^at   Brand, Connie ^at   Preda, Adrian ^af   Nguyen, Dana ^af   Womack, Kyle ^au   Mathews, Dana ^au   Quiceno, Mary ^au   Levey, Allan I ^av   Lah, James J ^av   Cellar, Janet S ^av   Burns, Jeffrey M ^aw   Swerdlow, Russell H ^aw   Brooks, William M ^aw   Apostolova, Liana ^ax   Tingus, Kathleen ^ax   Woo, Ellen ^ax   Silverman, Daniel H S ^ax   Lu, Po H ^ax   Bartzokis, George ^ax   Graff Radford, Neill R ^ay   Parfitt, Francine ^ay   Poki Walker, Kim ^ay   Farlow, Martin R ^m   Hake, Ann Marie ^m   Matthews, Brandy R ^m   Brosch, Jared R ^m   Herring, Scott ^m   Van Dyck, Christopher H ^az   Carson, Richard E ^az   MacAvoy, Martha G ^az   Varma, Pradeep ^az   Chertkow, Howard ^ba   Bergman, Howard ^ba   Hosein, Chris ^ba   Black, Sandra ^bb   Stefanovic, Bojana ^bb   Caldwell, Curtis ^bb   Hsiung, Ging Yuek Robin ^bc   Mudge, Benita ^bc   Sossi, Vesna ^bc   Feldman, Howard ^bc   Assaly, Michele ^bc   Finger, Elizabeth ^bd,by   Pasternack, Stephen ^bd   Rachisky, Irina ^bd   Trost, Dick ^bd   Kertesz, Andrew ^bd,by   Bernick, Charles ^be   Munic, Donna ^be   Rogalski, Emily ^v   Lipowski, Kristine ^v   Weintraub, Sandra ^v   Bonakdarpour, Borna ^v   Kerwin, Diana ^v   Wu, Chuang Kuo ^v   Johnson, Nancy ^v   Sadowsky, Carl ^bf   Villena, Teresa ^bf   Turner, Raymond Scott ^bg   Johnson, Kathleen ^bg   Reynolds, Brigid ^bg   Sperling, Reisa A ^l   Marshall, Gad ^l   Yesavage, Jerome ^bh   Taylor, Joy L ^bh   Lane, Barton ^bh   Rosen, Allyson ^bh   Tinklenberg, Jared ^bh   Sabbagh, Marwan N ^bi   Belden, Christine M ^bi   Jacobson, Sandra A ^bi   Sirrel, Sherye A ^bi   Kowall, Neil ^bj   Killiany, Ronald ^bj   Budson, Andrew E ^bj   Norbash, Alexander ^bj   Johnson, Patricia Lynn ^bj   Obisesan, Thomas O ^bk   Wolday, Saba ^bk   Allard, Joanne ^bk   Lerner, Alan ^bl   Ogrocki, Paula ^bl   Tatsuoka, Curtis ^bl   Fatica, Parianne ^bl   Fletcher, Evan ^k   Maillard, Pauline ^k   Olichney, John ^k   Carmichael, Owen ^k   Kittur, Smita ^bm   Borrie, Michael ^bn   Lee, T Y ^bn   Bartha, Rob ^bn   Johnson, Sterling ^bo   Asthana, Sanjay ^bo   Carlsson, Cynthia M ^bo   Tariot, Pierre ^ae   Burke, Anna ^ae   Milliken, Ann Marie ^ae   Trncic, Nadira ^ae   Reeder, Stephanie ^ae   Bates, Vernice ^bp   Capote, Horacio ^bp   Rainka, Michelle ^bp   Scharre, Douglas W ^bq   Kataki, Maria ^bq   Kelley, Brendan ^bq   Zimmerman, Earl A ^br   Celmins, Dzintra ^br   Brown, Alice D ^br   Pearlson, Godfrey D ^bs   Blank, Karen ^bs   Anderson, Karen ^bs   Flashman, Laura A ^bt   Seltzer, Marc ^bt   Hynes, Mary L ^bt   Santulli, Robert B ^bt   Sink, Kaycee M ^bu   Gordineer, Leslie ^bu   Williamson, Jeff D ^bu   Garg, Pradeep ^bu   Watkins, Franklin ^bu   Ott, Brian R ^bv   Tremont, Geoffrey ^bv   Daiello, Lori A ^bv   Salloway, Stephen ^bw   Malloy, Paul ^bw   Correia, Stephen ^bw   Rosen, Howard J ^f   Miller, Bruce L ^f   Perry, David ^f   Mintzer, Jacobo ^bx   Spicer, Kenneth ^bx   Bachman, David ^bx   Pasternak, Stephen ^by   Rachinsky, Irina ^by   Rogers, John ^by   Drost, Dick ^by   Pomara, Nunzio ^bz   Hernando, Raymundo ^bz   Sarrael, Antero ^bz   Schultz, Susan K ^ca   Smith, Karen Ekstam ^ca   Koleva, Hristina ^ca   Nam, Ki Won ^ca   Shim, Hyungsub ^ca   Relkin, Norman ^r   Chiang, Gloria ^r   Lin, Michael ^r   Ravdin, Lisa ^r   Smith, Amanda ^cb   Raj, Balebail Ashok ^cb   Fargher, Kristin ^cb   more..

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h MAYO CLINIC   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l HARVARD MEDICAL SCHOOL   (United States)

^m INDIANA UNIVERSITY   (United States)

ⁿ WASHINGTON UNIVERSITY   (United States)

^o SIEMENS AG   (Germany)

^p ALZHEIMER'S ASSOCIATION   (United States)

^q UNIVERSITY OF PITTSBURGH   (United States)

^r Cornell University ^*  (United States)

^s ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^t AD Drug Discovery Foundation   (United States)

^u Acumen Pharmaceuticals   (United States)

^v NORTHWESTERN UNIVERSITY   (United States)

^w NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^x BROWN UNIVERSITY   (United States)

^y UNIVERSITY OF WASHINGTON   (United States)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa UNIVERSITY OF LONDON   (United Kingdom)

^ab UNIVERSITY OF CALIFORNIA   (United States)

^ac UNIVERSITY OF MICHIGAN   (United States)

^ad UNIVERSITY OF UTAH   (United States)

^ae BANNER ALZHEIMER S INSTITUTE   (United States)

^af UNIVERSITY OF CALIFORNIA   (United States)

^ag JOHNS HOPKINS UNIVERSITY   (United States)

^ah Richard Frank Consulting   (United States)

^ai NATIONAL INSTITUTE ON AGING   (United States)

^aj OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^ak BAYLOR COLLEGE OF MEDICINE   (United States)

^al Department of Medicine   (United States)

^am UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^an MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ao RUSH UNIVERSITY MEDICAL CENTER   (United States)

^ap Wien Center   (United States)

^aq NEW YORK UNIVERSITY   (United States)

^ar DUKE UNIVERSITY MEDICAL CENTER   (United States)

^as UNIVERSITY OF KENTUCKY   (United States)

^at UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^au UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^av EMORY UNIVERSITY   (United States)

^aw UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^ax UNIVERSITY OF CALIFORNIA   (United States)

^ay MAYO CLINIC   (United States)

^az YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ba MCGILL UNIVERSITY   (Canada)

^bb SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^bc UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^bd Cognitive Neurology St Joseph's ^*  (Canada)

^be LERNER RESEARCH INSTITUTE   (United States)

^bf Premiere Research Institute (Palm Beach Neurology)   (United States)

^bg GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^bh STANFORD UNIVERSITY   (United States)

^bi SUN HEALTH RESEARCH INSTITUTE   (United States)

^bj BOSTON UNIVERSITY   (United States)

^bk HOWARD UNIVERSITY   (United States)

^bl CASE WESTERN RESERVE UNIVERSITY   (United States)

^bm Neurological Care of CNY   (United States)

^bn Parkwood Hospital   (United States)

^bo UNIVERSITY OF WISCONSIN   (United States)

^bp New York Dent Neurologic Institute   (United States)

^bq OHIO STATE UNIVERSITY   (United States)

^br ALBANY MEDICAL COLLEGE   (United States)

^bs HARTFORD HOSPITAL   (United States)

^bt DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^bu WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^bv RHODE ISLAND HOSPITAL   (United States)

^bw BUTLER HOSPITAL   (United States)

^bx Medical University South Carolina   (United States)

^by St Joseph's Health Care   (United States)

^bz Nathan Kline Institute   (United States)

^ca UNIVERSITY OF IOWA   (United States)

^cb UNIVERSITY OF SOUTH FLORIDA   (United States)

^cc USF Health Byrd Alzheimer's Institute ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; NEUROFILAMENT LIGHT; NEUROFILAMENT PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; NEUROFILAMENT PROTEIN L;

ADULT; AGED; ALZHEIMER DISEASE; AREA UNDER THE CURVE; ARTICLE; BRAIN ATROPHY; BRAIN HYPOMETABOLISM; BRAIN METABOLISM; CASE CONTROL STUDY; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; NERVE DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; RECEIVER OPERATING CHARACTERISTIC; ATROPHY; BLOOD; COGNITIVE DEFECT; DIAGNOSTIC IMAGING; DISEASE COURSE; LONGITUDINAL STUDY; MIDDLE AGED; PATHOPHYSIOLOGY; REGISTER; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ATROPHY; BIOMARKERS; CASE-CONTROL STUDIES; COGNITIVE DYSFUNCTION; DISEASE PROGRESSION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEUROFILAMENT PROTEINS; REGISTRIES;

EID: 85018870200     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2016.6117     Document Type: Article

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