-
1
-
-
84942910137
-
Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces
-
A precise quantitative method based on flow cytometry at single-cell (protoplast) resolution in Streptomyces was established for the identification of regulatory elements. A series of native or synthetic promoters and ribosomal binding sites has been characterized. Moreover, an insulator was demonstrated to eliminate element–element interference.
-
Bai, C., Zhang, Y., Zhao, X., Hu, Y., Xiang, S., Miao, J., Lou, C., Zhang, L., Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A 112 (2015), 12181–12186 A precise quantitative method based on flow cytometry at single-cell (protoplast) resolution in Streptomyces was established for the identification of regulatory elements. A series of native or synthetic promoters and ribosomal binding sites has been characterized. Moreover, an insulator was demonstrated to eliminate element–element interference.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 12181-12186
-
-
Bai, C.1
Zhang, Y.2
Zhao, X.3
Hu, Y.4
Xiang, S.5
Miao, J.6
Lou, C.7
Zhang, L.8
-
2
-
-
85030371899
-
Interrogation of Streptomyces avermitilis for efficient production of avermectins
-
Chen, J., Liu, M., Liu, X., Miao, J., Fu, C., Gao, H., Müller, R., Zhang, Q., Zhang, L., Interrogation of Streptomyces avermitilis for efficient production of avermectins. Synth Syst Biotechnol 1 (2016), 7–16.
-
(2016)
Synth Syst Biotechnol
, vol.1
, pp. 7-16
-
-
Chen, J.1
Liu, M.2
Liu, X.3
Miao, J.4
Fu, C.5
Gao, H.6
Müller, R.7
Zhang, Q.8
Zhang, L.9
-
3
-
-
84979524810
-
Avermectin, from winning the Nobel Prize to“innovation in China”
-
Chen, J., Liu, M., Zhang, L., Avermectin, from winning the Nobel Prize to“innovation in China”. Wei Sheng Wu Xue Bao=Acta Microbiol Sin 56 (2016), 543–558.
-
(2016)
Wei Sheng Wu Xue Bao=Acta Microbiol Sin
, vol.56
, pp. 543-558
-
-
Chen, J.1
Liu, M.2
Zhang, L.3
-
4
-
-
84895074462
-
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters
-
Ikeda, H., Shin-ya, K., Omura, S., Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters. J Ind Microbiol Biotechnol 41 (2014), 233–250.
-
(2014)
J Ind Microbiol Biotechnol
, vol.41
, pp. 233-250
-
-
Ikeda, H.1
Shin-ya, K.2
Omura, S.3
-
5
-
-
77954689110
-
Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains
-
Li, L., Guo, J., Wen, Y., Chen, Z., Song, Y., Li, J., Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. J Ind Microbiol Biotechnol 37 (2010), 673–679.
-
(2010)
J Ind Microbiol Biotechnol
, vol.37
, pp. 673-679
-
-
Li, L.1
Guo, J.2
Wen, Y.3
Chen, Z.4
Song, Y.5
Li, J.6
-
6
-
-
84874850153
-
Molecular regulation of antibiotic biosynthesis in Streptomyces
-
Liu, G., Chater, K.F., Chandra, G., Niu, G., Tan, H., Molecular regulation of antibiotic biosynthesis in Streptomyces. Microbiol Mol Biol Rev 77 (2013), 112–143.
-
(2013)
Microbiol Mol Biol Rev
, vol.77
, pp. 112-143
-
-
Liu, G.1
Chater, K.F.2
Chandra, G.3
Niu, G.4
Tan, H.5
-
7
-
-
84995563337
-
SAV742, a novel AraC-family regulator from Streptomyces avermitilis, controls avermectin biosynthesis, cell growth and development
-
Sun, D., Zhu, J., Chen, Z., Li, J., Wen, Y., SAV742, a novel AraC-family regulator from Streptomyces avermitilis, controls avermectin biosynthesis, cell growth and development. Sci Rep, 2016, 6.
-
(2016)
Sci Rep
, pp. 6
-
-
Sun, D.1
Zhu, J.2
Chen, Z.3
Li, J.4
Wen, Y.5
-
8
-
-
24944526167
-
Interdisciplinary research and education at the biology–engineering–computer science interface: a perspective
-
Tadmor, B., Tidor, B., Interdisciplinary research and education at the biology–engineering–computer science interface: a perspective. Drug Discov Today 10 (2005), 1183–1189.
-
(2005)
Drug Discov Today
, vol.10
, pp. 1183-1189
-
-
Tadmor, B.1
Tidor, B.2
-
9
-
-
84981297901
-
Sharing and community curation of mass spectrometry data with GNPS
-
Wang, M., Carver, J.J., Phelan, V.V., Sanchez, L.M., Garg, N., Peng, Y., Nguyen, D.D., Watrous, J., Kapono, C.A., Luzzatto-Knaan, T., Sharing and community curation of mass spectrometry data with GNPS. Nat Biotechnol, 34, 2016, 828.
-
(2016)
Nat Biotechnol
, vol.34
, pp. 828
-
-
Wang, M.1
Carver, J.J.2
Phelan, V.V.3
Sanchez, L.M.4
Garg, N.5
Peng, Y.6
Nguyen, D.D.7
Watrous, J.8
Kapono, C.A.9
Luzzatto-Knaan, T.10
-
11
-
-
84897648007
-
Synthetic biology of avermectin for production improvement and structure diversification
-
Zhuo, Y., Zhang, T., Wang, Q., Cruz-Morales, P., Zhang, B., Liu, M., Barona-Gómez, F., Zhang, L., Synthetic biology of avermectin for production improvement and structure diversification. Biotechnol J 9 (2014), 316–325.
-
(2014)
Biotechnol J
, vol.9
, pp. 316-325
-
-
Zhuo, Y.1
Zhang, T.2
Wang, Q.3
Cruz-Morales, P.4
Zhang, B.5
Liu, M.6
Barona-Gómez, F.7
Zhang, L.8
-
12
-
-
79961061778
-
The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis
-
Miyamoto, K.T., Kitani, S., Komatsu, M., Ikeda, H., Nihira, T., The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. Microbiology 157 (2011), 2266–2275.
-
(2011)
Microbiology
, vol.157
, pp. 2266-2275
-
-
Miyamoto, K.T.1
Kitani, S.2
Komatsu, M.3
Ikeda, H.4
Nihira, T.5
-
13
-
-
84948388980
-
Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme
-
Yan, W., Song, H., Song, F., Guo, Y., Wu, C.-H., Her, A.S., Pu, Y., Wang, S., Naowarojna, N., Weitz, A., Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme. Nature 527 (2015), 539–543.
-
(2015)
Nature
, vol.527
, pp. 539-543
-
-
Yan, W.1
Song, H.2
Song, F.3
Guo, Y.4
Wu, C.-H.5
Her, A.S.6
Pu, Y.7
Wang, S.8
Naowarojna, N.9
Weitz, A.10
-
14
-
-
84899102437
-
Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation
-
Zhang, H.M., Dai, H., Hanson, P.J., Li, H., Guo, H., Ye, X., Hemida, M.G., Wang, L., Tong, Y., Qiu, Y., Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation. ACS Chem Biol 9 (2014), 1015–1024.
-
(2014)
ACS Chem Biol
, vol.9
, pp. 1015-1024
-
-
Zhang, H.M.1
Dai, H.2
Hanson, P.J.3
Li, H.4
Guo, H.5
Ye, X.6
Hemida, M.G.7
Wang, L.8
Tong, Y.9
Qiu, Y.10
-
15
-
-
84978712445
-
Development of a synthetic oxytetracycline-inducible expression system for Streptomycetes using de novo characterized genetic parts
-
To develop ideal inducible expression systems for streptomycetes, new genetic parts, oxytetracycline responsive repressor OtrR, operator otrO, and promoter otrBp from Streptomyces rimosus, were selected de novo and characterized in vivoand in vitro. Precise control of gene expression using exogenous factors is of great significance.
-
Wang, W., Yang, T., Li, Y., Li, S., Yin, S., Styles, K., Corre, C., Yang, K., Development of a synthetic oxytetracycline-inducible expression system for Streptomycetes using de novo characterized genetic parts. ACS Synth Biol 5 (2016), 765–773 To develop ideal inducible expression systems for streptomycetes, new genetic parts, oxytetracycline responsive repressor OtrR, operator otrO, and promoter otrBp from Streptomyces rimosus, were selected de novo and characterized in vivoand in vitro. Precise control of gene expression using exogenous factors is of great significance.
-
(2016)
ACS Synth Biol
, vol.5
, pp. 765-773
-
-
Wang, W.1
Yang, T.2
Li, Y.3
Li, S.4
Yin, S.5
Styles, K.6
Corre, C.7
Yang, K.8
-
16
-
-
85031720023
-
HTS and Drug Discovery from Microbial Natural Products
-
Higher Education Express ISBN: 978-7-04-032263-7
-
Zhang, L., Demain, A.L., HTS and Drug Discovery from Microbial Natural Products. 2017, Higher Education Express ISBN: 978-7-04-032263-7.
-
(2017)
-
-
Zhang, L.1
Demain, A.L.2
-
17
-
-
84872403188
-
Abyssomicins from the South China deep-sea sediment Verrucosispora sp.: natural thioether michael addition adducts as antitubercular prodrugs
-
Wang, Q., Song, F., Xiao, X., Huang, P., Li, L., Monte, A., Abdel-Mageed, W.M., Wang, J., Guo, H., He, W., et al. Abyssomicins from the South China deep-sea sediment Verrucosispora sp.: natural thioether michael addition adducts as antitubercular prodrugs. Angew Chem Int Ed 52 (2013), 1231–1234.
-
(2013)
Angew Chem Int Ed
, vol.52
, pp. 1231-1234
-
-
Wang, Q.1
Song, F.2
Xiao, X.3
Huang, P.4
Li, L.5
Monte, A.6
Abdel-Mageed, W.M.7
Wang, J.8
Guo, H.9
He, W.10
-
18
-
-
84927561023
-
Mechanisms of antibiotic resistance
-
Lin, J., Nishino, K., Roberts, M.C., Tolmasky, M., Aminov, R.I., Zhang, L., Mechanisms of antibiotic resistance. Front Microbiol, 6, 2015, 34.
-
(2015)
Front Microbiol
, vol.6
, pp. 34
-
-
Lin, J.1
Nishino, K.2
Roberts, M.C.3
Tolmasky, M.4
Aminov, R.I.5
Zhang, L.6
-
19
-
-
84949790844
-
Targeting the osmotic stress response for strain improvement of an industrial producer of secondary metabolites
-
Godinez, O., Dyson, P., Del Sol, R., Barrios-Gonzalez, J., Millan-Pacheco, C., Mejia, A., Targeting the osmotic stress response for strain improvement of an industrial producer of secondary metabolites. J Microbiol Biotechnol 25 (2015), 1787–1795.
-
(2015)
J Microbiol Biotechnol
, vol.25
, pp. 1787-1795
-
-
Godinez, O.1
Dyson, P.2
Del Sol, R.3
Barrios-Gonzalez, J.4
Millan-Pacheco, C.5
Mejia, A.6
-
20
-
-
84864103526
-
Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor
-
Yu, Z., Zhu, H., Dang, F., Zhang, W., Qin, Z., Yang, S., Tan, H., Lu, Y., Jiang, W., Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. Mol Microbiol 85 (2012), 535–556.
-
(2012)
Mol Microbiol
, vol.85
, pp. 535-556
-
-
Yu, Z.1
Zhu, H.2
Dang, F.3
Zhang, W.4
Qin, Z.5
Yang, S.6
Tan, H.7
Lu, Y.8
Jiang, W.9
-
21
-
-
84980048141
-
Native and engineered promoters in natural product discovery
-
Myronovskyi, M., Luzhetskyy, A., Native and engineered promoters in natural product discovery. Nat Prod Rep 33 (2016), 1006–1019.
-
(2016)
Nat Prod Rep
, vol.33
, pp. 1006-1019
-
-
Myronovskyi, M.1
Luzhetskyy, A.2
-
22
-
-
85011658292
-
Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine
-
Van Voorhis, W.C., van Huijsduijnen, R.H., Wells, T.N., Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine. Proc Natl Acad Sci U S A 112 (2015), 15773–15776.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 15773-15776
-
-
Van Voorhis, W.C.1
van Huijsduijnen, R.H.2
Wells, T.N.3
-
23
-
-
84924068152
-
1,19-seco-avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain
-
Three new 1,19-seco-avermectin (AVE) analogues were isolated from the ΔaveCDE mutant Streptomyces avermectinius strain. In an in vitro assay these compounds displayed cytotoxicity against Saos-2, MG-63, and B16 cell lines.
-
Sun, P., Zhao, Q., Wu, Z., Zhang, W., Liu, W., 1,19-seco-avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain. J Nat Prod 78 (2015), 301–305 Three new 1,19-seco-avermectin (AVE) analogues were isolated from the ΔaveCDE mutant Streptomyces avermectinius strain. In an in vitro assay these compounds displayed cytotoxicity against Saos-2, MG-63, and B16 cell lines.
-
(2015)
J Nat Prod
, vol.78
, pp. 301-305
-
-
Sun, P.1
Zhao, Q.2
Wu, Z.3
Zhang, W.4
Liu, W.5
-
24
-
-
84873878536
-
Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC
-
Sun, P., Zhao, Q., Yu, F., Zhang, H., Wu, Z., Wang, Y., Wang, Y., Zhang, Q., Liu, W., Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. J Am Chem Soc 135 (2013), 1540–1548.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 1540-1548
-
-
Sun, P.1
Zhao, Q.2
Yu, F.3
Zhang, H.4
Wu, Z.5
Wang, Y.6
Wang, Y.7
Zhang, Q.8
Liu, W.9
-
25
-
-
84896388819
-
Effect of stereochemistry of avermectin-like 6, 6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius
-
Sun, P., Zhao, Q., Zhang, H., Wu, J., Liu, W., Effect of stereochemistry of avermectin-like 6, 6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. Chembiochem 15 (2014), 660–664.
-
(2014)
Chembiochem
, vol.15
, pp. 660-664
-
-
Sun, P.1
Zhao, Q.2
Zhang, H.3
Wu, J.4
Liu, W.5
-
26
-
-
34248361999
-
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections
-
Zhang, L., Yan, K., Zhang, Y., Huang, R., Bian, J., Zheng, C., Sun, H., Chen, Z., Sun, N., An, R., High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci U S A 104 (2007), 4606–4611.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4606-4611
-
-
Zhang, L.1
Yan, K.2
Zhang, Y.3
Huang, R.4
Bian, J.5
Zheng, C.6
Sun, H.7
Chen, Z.8
Sun, N.9
An, R.10
-
27
-
-
68749085165
-
Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway
-
Ci, X., Li, H., Yu, Q., Zhang, X., Yu, L., Chen, N., Song, Y., Deng, X., Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fund Clin Pharmacol 23 (2009), 449–455.
-
(2009)
Fund Clin Pharmacol
, vol.23
, pp. 449-455
-
-
Ci, X.1
Li, H.2
Yu, Q.3
Zhang, X.4
Yu, L.5
Chen, N.6
Song, Y.7
Deng, X.8
-
28
-
-
84872842061
-
Anthelmintic avermectins kill M. tuberculosis, including multidrug resistant clinical strains
-
Lim, L.E., Vilchèze, C., Ng, C., Jacobs, W.R., Ramón-García, S., Thompson, C.J., Anthelmintic avermectins kill M. tuberculosis, including multidrug resistant clinical strains. Antimicrob Agents Chemother 57 (2013), 1040–1046.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 1040-1046
-
-
Lim, L.E.1
Vilchèze, C.2
Ng, C.3
Jacobs, W.R.4
Ramón-García, S.5
Thompson, C.J.6
-
29
-
-
84928795316
-
In-vitro activity of avermectins against Mycobacterium ulcerans
-
Omansen, T.F., Porter, J.L., Johnson, P.D., van der Werf, T.S., Stienstra, Y., Stinear, T.P., In-vitro activity of avermectins against Mycobacterium ulcerans. PLoS Negl Trop Dis, 9, 2015, e0003549.
-
(2015)
PLoS Negl Trop Dis
, vol.9
, pp. e0003549
-
-
Omansen, T.F.1
Porter, J.L.2
Johnson, P.D.3
van der Werf, T.S.4
Stienstra, Y.5
Stinear, T.P.6
-
30
-
-
78049253546
-
Bioprospecting for antituberculosis leads from microbial metabolites
-
Ashforth, E.J., Fu, C., Liu, X., Dai, H., Song, F., Guo, H., Zhang, L., Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep 27 (2010), 1709–1719.
-
(2010)
Nat Prod Rep
, vol.27
, pp. 1709-1719
-
-
Ashforth, E.J.1
Fu, C.2
Liu, X.3
Dai, H.4
Song, F.5
Guo, H.6
Zhang, L.7
-
31
-
-
85027930731
-
Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin
-
Guo, H., Ren, B., Dai, H., Dai, S., Zhang, Y., Liu, Y., Cao, B., Zhang, L., Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. Int J Antimicrob Agents 44 (2014), 274–276.
-
(2014)
Int J Antimicrob Agents
, vol.44
, pp. 274-276
-
-
Guo, H.1
Ren, B.2
Dai, H.3
Dai, S.4
Zhang, Y.5
Liu, Y.6
Cao, B.7
Zhang, L.8
-
32
-
-
84947019500
-
Genome-wide identification and evaluation of constitutive promoters in streptomycetes
-
Li, S., Wang, J., Li, X., Yin, S., Wang, W., Yang, K., Genome-wide identification and evaluation of constitutive promoters in streptomycetes. Microb Cell Fact, 14, 2015, 172.
-
(2015)
Microb Cell Fact
, vol.14
, pp. 172
-
-
Li, S.1
Wang, J.2
Li, X.3
Yin, S.4
Wang, W.5
Yang, K.6
-
33
-
-
85006867023
-
A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays
-
Li, S., Zhou, L., Yao, Y., Fan, K., Li, Z., Zhang, L., Wang, W., Yang, K., A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. Chem Commun 53 (2017), 99–102.
-
(2017)
Chem Commun
, vol.53
, pp. 99-102
-
-
Li, S.1
Zhou, L.2
Yao, Y.3
Fan, K.4
Li, Z.5
Zhang, L.6
Wang, W.7
Yang, K.8
-
34
-
-
85021705092
-
Avermectin biosynthesis: stable functional expression of branched chain α-keto acid dehydrogenase complex from Streptomyces avermitilis in Escherichia coli by selectively regulating individual subunit gene expression
-
Cui, Q., Zhou, F., Liu, W., Tao, Y., Avermectin biosynthesis: stable functional expression of branched chain α-keto acid dehydrogenase complex from Streptomyces avermitilis in Escherichia coli by selectively regulating individual subunit gene expression. Biotechnol Lett, 2017, 1–8.
-
(2017)
Biotechnol Lett
, pp. 1-8
-
-
Cui, Q.1
Zhou, F.2
Liu, W.3
Tao, Y.4
-
35
-
-
85018362587
-
An alternative σ factor, σ8, controls avermectin production and multiple stress responses in Streptomyces avermitilis
-
Sun, D., Wang, Q., Chen, Z., Li, J., Wen, Y., An alternative σ factor, σ8, controls avermectin production and multiple stress responses in Streptomyces avermitilis. Front Microbiol, 8, 2017, 736.
-
(2017)
Front Microbiol
, vol.8
, pp. 736
-
-
Sun, D.1
Wang, Q.2
Chen, Z.3
Li, J.4
Wen, Y.5
-
36
-
-
85011422156
-
Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis
-
Kim, M.-S., Cho, W.-J., Song, M.C., Park, S.-W., Kim, K., Kim, E., Lee, N., Nam, S.-J., Oh, K.-H., Yoon, Y.J., Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis. Microb Cell Fact, 16, 2017, 9.
-
(2017)
Microb Cell Fact
, vol.16
, pp. 9
-
-
Kim, M.-S.1
Cho, W.-J.2
Song, M.C.3
Park, S.-W.4
Kim, K.5
Kim, E.6
Lee, N.7
Nam, S.-J.8
Oh, K.-H.9
Yoon, Y.J.10
-
37
-
-
85006276111
-
Direct involvement of the master nitrogen metabolism regulator GlnR in antibiotic biosynthesis in Streptomyces
-
He, J.-M., Zhu, H., Zheng, G.-S., Liu, P.-P., Wang, J., Zhao, G.-P., Zhu, G.-Q., Jiang, W.-H., Lu, Y.-H., Direct involvement of the master nitrogen metabolism regulator GlnR in antibiotic biosynthesis in Streptomyces. J Biol Chem 291 (2016), 26443–26454.
-
(2016)
J Biol Chem
, vol.291
, pp. 26443-26454
-
-
He, J.-M.1
Zhu, H.2
Zheng, G.-S.3
Liu, P.-P.4
Wang, J.5
Zhao, G.-P.6
Zhu, G.-Q.7
Jiang, W.-H.8
Lu, Y.-H.9
-
38
-
-
84982245086
-
Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis
-
Sultan, S.P., Kitani, S., Miyamoto, K.T., Iguchi, H., Atago, T., Ikeda, H., Nihira, T., Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis. Appl Microbiol Biotechnol 100 (2016), 9581–9591.
-
(2016)
Appl Microbiol Biotechnol
, vol.100
, pp. 9581-9591
-
-
Sultan, S.P.1
Kitani, S.2
Miyamoto, K.T.3
Iguchi, H.4
Atago, T.5
Ikeda, H.6
Nihira, T.7
-
39
-
-
84991451184
-
Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis
-
Meng, L., Xiong, Z., Chu, J., Wang, Y., Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis. Lett Appl Microbiol 63 (2016), 384–390.
-
(2016)
Lett Appl Microbiol
, vol.63
, pp. 384-390
-
-
Meng, L.1
Xiong, Z.2
Chu, J.3
Wang, Y.4
-
40
-
-
84960079330
-
Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase
-
Zhang, J., Yan, Y.-J., An, J., Huang, S.-X., Wang, X.-J., Xiang, W.-S., Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. Microb Cell Fact, 14, 2015, 152.
-
(2015)
Microb Cell Fact
, vol.14
, pp. 152
-
-
Zhang, J.1
Yan, Y.-J.2
An, J.3
Huang, S.-X.4
Wang, X.-J.5
Xiang, W.-S.6
-
41
-
-
84936972379
-
Increasing avermectin production in Streptomyces avermitilis by manipulating the expression of a novel TetR-family regulator and its target gene product
-
Liu, W., Zhang, Q., Guo, J., Chen, Z., Li, J., Wen, Y., Increasing avermectin production in Streptomyces avermitilis by manipulating the expression of a novel TetR-family regulator and its target gene product. Appl Environ Microbiol 81 (2015), 5157–5173.
-
(2015)
Appl Environ Microbiol
, vol.81
, pp. 5157-5173
-
-
Liu, W.1
Zhang, Q.2
Guo, J.3
Chen, Z.4
Li, J.5
Wen, Y.6
-
42
-
-
84872287714
-
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites
-
Komatsu, M., Komatsu, K., Koiwai, H., Yamada, Y., Kozone, I., Izumikawa, M., Hashimoto, J., Takagi, M., Omura, S., Shin-ya, K., Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol 2 (2013), 384–396.
-
(2013)
ACS Synth Biol
, vol.2
, pp. 384-396
-
-
Komatsu, M.1
Komatsu, K.2
Koiwai, H.3
Yamada, Y.4
Kozone, I.5
Izumikawa, M.6
Hashimoto, J.7
Takagi, M.8
Omura, S.9
Shin-ya, K.10
-
43
-
-
84872016805
-
Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production
-
Yin, P., Li, Y.-Y., Zhou, J., Wang, Y.-H., Zhang, S.-L., Ye, B.-C., Ge, W.-F., Xia, Y.-L., Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. J Proteom 79 (2013), 1–12.
-
(2013)
J Proteom
, vol.79
, pp. 1-12
-
-
Yin, P.1
Li, Y.-Y.2
Zhou, J.3
Wang, Y.-H.4
Zhang, S.-L.5
Ye, B.-C.6
Ge, W.-F.7
Xia, Y.-L.8
-
44
-
-
84863435278
-
Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis
-
Zhang, X., Chen, W., Zhang, Y., Jiang, L., Chen, Z., Wen, Y., Li, J., Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. J Ind Microbiol Biotechnol 39 (2012), 917–925.
-
(2012)
J Ind Microbiol Biotechnol
, vol.39
, pp. 917-925
-
-
Zhang, X.1
Chen, W.2
Zhang, Y.3
Jiang, L.4
Chen, Z.5
Wen, Y.6
Li, J.7
-
45
-
-
82455167849
-
Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes
-
The largest increase in avermectin production was achieved by the plasmid containing all three genes introduced in Streptomyces sp, including adpA, a global regulator from Streptomyces coelicolor, metK, encoding S-adenosylmethionine synthetase from S. coelicolor, and, VHbS, hemoglobin from Vitreoscilla.
-
Wang, T., Bai, L., Zhu, D., Lei, X., Liu, G., Deng, Z., You, D., Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes. Enzyme Microb Technol 50 (2012), 5–9 The largest increase in avermectin production was achieved by the plasmid containing all three genes introduced in Streptomyces sp, including adpA, a global regulator from Streptomyces coelicolor, metK, encoding S-adenosylmethionine synthetase from S. coelicolor, and, VHbS, hemoglobin from Vitreoscilla.
-
(2012)
Enzyme Microb Technol
, vol.50
, pp. 5-9
-
-
Wang, T.1
Bai, L.2
Zhu, D.3
Lei, X.4
Liu, G.5
Deng, Z.6
You, D.7
-
46
-
-
80055053258
-
Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation
-
To verify the biological significance of some of the transcriptomics-guided targets, five putative regulatory genes were individually cloned under the strong promoter and constitutive promoter of the Streptomyces expression vector pSE34, followed by the transformation into the low producer S. avermitilis ATCC 31267.
-
Liu, M., Gao, H., Shang, P., Zhou, X., Ashforth, E., Zhuo, Y., Chen, D., Ren, B., Liu, Z., Zhang, L., Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. PLoS One, 6, 2011, e24697 To verify the biological significance of some of the transcriptomics-guided targets, five putative regulatory genes were individually cloned under the strong promoter and constitutive promoter of the Streptomyces expression vector pSE34, followed by the transformation into the low producer S. avermitilis ATCC 31267.
-
(2011)
PLoS One
, vol.6
, pp. e24697
-
-
Liu, M.1
Gao, H.2
Shang, P.3
Zhou, X.4
Ashforth, E.5
Zhuo, Y.6
Chen, D.7
Ren, B.8
Liu, Z.9
Zhang, L.10
-
47
-
-
82455167863
-
Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis
-
Upstream of the avermectin biosynthetic gene cluster, there is the avtAB operon encoding the ABC transporter AvtAB, highly homologous to P-glycoprotein. Inactivation of avtAB had no effect, but increasing the concentration of avtAB mRNA 30–500-fold could enhance avermectin production.
-
Qiu, J., Zhuo, Y., Zhu, D., Zhou, X., Zhang, L., Bai, L., Deng, Z., Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol 92 (2011), 337–345 Upstream of the avermectin biosynthetic gene cluster, there is the avtAB operon encoding the ABC transporter AvtAB, highly homologous to P-glycoprotein. Inactivation of avtAB had no effect, but increasing the concentration of avtAB mRNA 30–500-fold could enhance avermectin production.
-
(2011)
Appl Microbiol Biotechnol
, vol.92
, pp. 337-345
-
-
Qiu, J.1
Zhuo, Y.2
Zhu, D.3
Zhou, X.4
Zhang, L.5
Bai, L.6
Deng, Z.7
-
48
-
-
80052811904
-
Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis
-
Jiang, L., Liu, Y., Wang, P., Wen, Y., Song, Y., Chen, Z., Li, J., Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. Biotechnol Lett 33 (2011), 1955–1961.
-
(2011)
Biotechnol Lett
, vol.33
, pp. 1955-1961
-
-
Jiang, L.1
Liu, Y.2
Wang, P.3
Wen, Y.4
Song, Y.5
Chen, Z.6
Li, J.7
-
49
-
-
79956077665
-
Production of doramectin by rational engineering of the avermectin biosynthetic pathway
-
Wang, J.-B., Pan, H.-X., Tang, G.-L., Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett 21 (2011), 3320–3323.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 3320-3323
-
-
Wang, J.-B.1
Pan, H.-X.2
Tang, G.-L.3
-
50
-
-
77955657404
-
Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis
-
Li, M., Chen, Z., Zhang, X., Song, Y., Wen, Y., Li, J., Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. Bioresour Technol 101 (2010), 9228–9235.
-
(2010)
Bioresour Technol
, vol.101
, pp. 9228-9235
-
-
Li, M.1
Chen, Z.2
Zhang, X.3
Song, Y.4
Wen, Y.5
Li, J.6
-
51
-
-
84964599801
-
Different fates of avermectin and artemisinin in China
-
Chen, J., Miao, J., Liu, M., Liu, X., Bao, L., Jiang, Y., Wang, D., Zhang, Q., Zhang, L., Different fates of avermectin and artemisinin in China. Sci China Life Sci 59 (2016), 634–636.
-
(2016)
Sci China Life Sci
, vol.59
, pp. 634-636
-
-
Chen, J.1
Miao, J.2
Liu, M.3
Liu, X.4
Bao, L.5
Jiang, Y.6
Wang, D.7
Zhang, Q.8
Zhang, L.9
-
52
-
-
74549114344
-
Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis
-
Zhao, X., Wang, Y., Wang, S., Chen, Z., Wen, Y., Song, Y., Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis. Can J Microbiol 55 (2009), 1355–1363.
-
(2009)
Can J Microbiol
, vol.55
, pp. 1355-1363
-
-
Zhao, X.1
Wang, Y.2
Wang, S.3
Chen, Z.4
Wen, Y.5
Song, Y.6
-
53
-
-
75649122638
-
The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis
-
Guo, J., Zhao, J., Li, L., Chen, Z., Wen, Y., Li, J., The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol Genet Genom 283 (2010), 123–133.
-
(2010)
Mol Genet Genom
, vol.283
, pp. 123-133
-
-
Guo, J.1
Zhao, J.2
Li, L.3
Chen, Z.4
Wen, Y.5
Li, J.6
-
54
-
-
64549152096
-
Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species
-
Duong, C., Lee, H.-N., Choi, S.-S., Lee, S.Y., Kim, E.-S., Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. J Microbiol Biotechnol 19 (2009), 136–139.
-
(2009)
J Microbiol Biotechnol
, vol.19
, pp. 136-139
-
-
Duong, C.1
Lee, H.-N.2
Choi, S.-S.3
Lee, S.Y.4
Kim, E.-S.5
-
55
-
-
63949083799
-
Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis
-
Kitani, S., Ikeda, H., Sakamoto, T., Noguchi, S., Nihira, T., Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. Appl Microbiol Biotechnol, 82, 2009, 1089.
-
(2009)
Appl Microbiol Biotechnol
, vol.82
, pp. 1089
-
-
Kitani, S.1
Ikeda, H.2
Sakamoto, T.3
Noguchi, S.4
Nihira, T.5
-
56
-
-
53349162137
-
Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis
-
Li, M., Chen, Z., Lin, X., Zhang, X., Song, Y., Wen, Y., Li, J., Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. Bioorg Med Chem Lett 18 (2008), 5359–5363.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 5359-5363
-
-
Li, M.1
Chen, Z.2
Lin, X.3
Zhang, X.4
Song, Y.5
Wen, Y.6
Li, J.7
-
57
-
-
42249095952
-
Isolation of soluble proteins from an industrial strain Streptomyces avermitilis in complex culture medium for two-dimensional gel electrophoresis
-
Yin, P., Wang, Y.-H., Zhang, S.-L., Chu, J., Zhuang, Y.-P., Wang, M.-L., Zhou, J., Isolation of soluble proteins from an industrial strain Streptomyces avermitilis in complex culture medium for two-dimensional gel electrophoresis. J Microbiol Methods 73 (2008), 105–110.
-
(2008)
J Microbiol Methods
, vol.73
, pp. 105-110
-
-
Yin, P.1
Wang, Y.-H.2
Zhang, S.-L.3
Chu, J.4
Zhuang, Y.-P.5
Wang, M.-L.6
Zhou, J.7
-
58
-
-
35348871395
-
Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis
-
Rajkarnikar, A., Kwon, H., Ryu, Y., Suh, J., Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. J Microbiol Biotechnol, 17, 2007, 1563.
-
(2007)
J Microbiol Biotechnol
, vol.17
, pp. 1563
-
-
Rajkarnikar, A.1
Kwon, H.2
Ryu, Y.3
Suh, J.4
-
59
-
-
34247486612
-
Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis
-
Řezanka, T., Sobotka, M., Prell, A., Sigler, K., Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis. Folia Microbiol (Praha), 52, 2007, 26.
-
(2007)
Folia Microbiol (Praha)
, vol.52
, pp. 26
-
-
Řezanka, T.1
Sobotka, M.2
Prell, A.3
Sigler, K.4
-
60
-
-
48349084339
-
Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165
-
Chen, L., Lu, Y., Chen, J., Zhang, W., Shu, D., Qin, Z., Yang, S., Jiang, W., Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Appl Microbiol Biotechnol, 80, 2008, 277.
-
(2008)
Appl Microbiol Biotechnol
, vol.80
, pp. 277
-
-
Chen, L.1
Lu, Y.2
Chen, J.3
Zhang, W.4
Shu, D.5
Qin, Z.6
Yang, S.7
Jiang, W.8
-
61
-
-
80053620569
-
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
-
Kitani, S., Miyamoto, K.T., Takamatsu, S., Herawati, E., Iguchi, H., Nishitomi, K., Uchida, M., Nagamitsu, T., Omura, S., Ikeda, H., Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci U S A 108 (2011), 16410–16415.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 16410-16415
-
-
Kitani, S.1
Miyamoto, K.T.2
Takamatsu, S.3
Herawati, E.4
Iguchi, H.5
Nishitomi, K.6
Uchida, M.7
Nagamitsu, T.8
Omura, S.9
Ikeda, H.10
-
62
-
-
84891870326
-
Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis
-
He, F., Liu, W., Sun, D., Luo, S., Chen, Z., Wen, Y., Li, J., Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol 98 (2014), 399–409.
-
(2014)
Appl Microbiol Biotechnol
, vol.98
, pp. 399-409
-
-
He, F.1
Liu, W.2
Sun, D.3
Luo, S.4
Chen, Z.5
Wen, Y.6
Li, J.7
-
63
-
-
84928116281
-
Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase
-
Wang, F., Wang, Y., Ji, J., Zhou, Z., Yu, J., Zhu, H., Su, Z., Zhang, L., Zheng, J., Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. ACS Chem Biol 10 (2015), 1017–1025.
-
(2015)
ACS Chem Biol
, vol.10
, pp. 1017-1025
-
-
Wang, F.1
Wang, Y.2
Ji, J.3
Zhou, Z.4
Yu, J.5
Zhu, H.6
Su, Z.7
Zhang, L.8
Zheng, J.9
-
64
-
-
85015273083
-
Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis
-
Liu, X., Cheng, Y., Lyu, M., Wen, Y., Song, Y., Chen, Z., Li, J., Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. Sci Rep, 2017, 7.
-
(2017)
Sci Rep
, pp. 7
-
-
Liu, X.1
Cheng, Y.2
Lyu, M.3
Wen, Y.4
Song, Y.5
Chen, Z.6
Li, J.7
-
65
-
-
67349125363
-
Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology
-
Gao, H., Liu, M., Liu, J., Dai, H., Zhou, X., Liu, X., Zhuo, Y., Zhang, W., Zhang, L., Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology. Bioresour Technol 100 (2009), 4012–4016.
-
(2009)
Bioresour Technol
, vol.100
, pp. 4012-4016
-
-
Gao, H.1
Liu, M.2
Liu, J.3
Dai, H.4
Zhou, X.5
Liu, X.6
Zhuo, Y.7
Zhang, W.8
Zhang, L.9
-
66
-
-
76649128997
-
Identification of avermectin-high-producing strains by high-throughput screening methods
-
Gao, H., Liu, M., Zhou, X., Liu, J., Zhuo, Y., Gou, Z., Xu, B., Zhang, W., Liu, X., Luo, A., Identification of avermectin-high-producing strains by high-throughput screening methods. Appl Microbiol Biotechnol 85 (2010), 1219–1225.
-
(2010)
Appl Microbiol Biotechnol
, vol.85
, pp. 1219-1225
-
-
Gao, H.1
Liu, M.2
Zhou, X.3
Liu, J.4
Zhuo, Y.5
Gou, Z.6
Xu, B.7
Zhang, W.8
Liu, X.9
Luo, A.10
-
67
-
-
77954911807
-
Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis
-
hrdB in vitro.
-
hrdB in vitro.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 11250-11254
-
-
Zhuo, Y.1
Zhang, W.2
Chen, D.3
Gao, H.4
Tao, J.5
Liu, M.6
Gou, Z.7
Zhou, X.8
Ye, B.-C.9
Zhang, Q.10
-
68
-
-
85006371354
-
Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine
-
Tian, P., Cao, P., Hu, D., Wang, D., Zhang, J., Wang, L., Zhu, Y., Gao, Q., Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine. J Ind Microbiol Biotechnol 44 (2017), 595–604.
-
(2017)
J Ind Microbiol Biotechnol
, vol.44
, pp. 595-604
-
-
Tian, P.1
Cao, P.2
Hu, D.3
Wang, D.4
Zhang, J.5
Wang, L.6
Zhu, Y.7
Gao, Q.8
-
69
-
-
85031735053
-
Enhanced avermectin production by rational feeding strategies based on comparative metabolomics
-
Cao, P., Hu, D., Zhang, J., Zhang, B., Gao, Q., Enhanced avermectin production by rational feeding strategies based on comparative metabolomics. Acta Microbiol Sin 57 (2017), 281–292.
-
(2017)
Acta Microbiol Sin
, vol.57
, pp. 281-292
-
-
Cao, P.1
Hu, D.2
Zhang, J.3
Zhang, B.4
Gao, Q.5
-
70
-
-
84879833139
-
An engineered strong promoter for streptomycetes
-
The kasOP promoter (renamed kasOP*) developed in this study exhibited the highest activity and was further analysed in Streptomyces.
-
Wang, W., Li, X., Wang, J., Xiang, S., Feng, X., Yang, K., An engineered strong promoter for streptomycetes. Appl Environ Microbiol 79 (2013), 4484–4492 The kasOP promoter (renamed kasOP*) developed in this study exhibited the highest activity and was further analysed in Streptomyces.
-
(2013)
Appl Environ Microbiol
, vol.79
, pp. 4484-4492
-
-
Wang, W.1
Li, X.2
Wang, J.3
Xiang, S.4
Feng, X.5
Yang, K.6
|