Abyssomicins from the South China Sea deep-sea sediment verrucosispora sp.: Natural thioether michael addition adducts as antitubercular prodrugs

Angewandte Chemie - International Edition

Volumn 52, Issue 4, 2013, Pages 1231-1234

  Wang, Qian ^a,c   Song, Fuhang ^a   Xiao, Xue ^b   Huang, Pei ^a,c   Li, Li ^d   Monte, Aaron ^e   Abdel Mageed, Wael M ^a,f   Wang, Jian ^a   Guo, Hui ^a,c   He, Wenni ^a   Xie, Feng ^a   Dai, Huanqin ^a   Liu, Miaomiao ^a,c   Chen, Caixia ^a   Xu, Hao ^g   Liu, Mei ^a   Piggott, Andrew M ^b   Liu, Xueting ^a   Capon, Robert J ^b   Zhang, Lixin ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d PEKING UNION MEDICAL COLLEGE   (China)

^e UNIVERSITY OF WISCONSIN LA CROSSE   (United States)

^f Assiut University   (Egypt)

^g GEORGIA STATE UNIVERSITY   (United States)

Author keywords

natural products; polyketides; prodrugs; structure elucidation; tuberculosis

Indexed keywords

NATURAL PRODUCTS; POLYKETIDES; PRODRUGS; STRUCTURE ELUCIDATION; TUBERCULOSIS;

BIOCHEMISTRY; BIOMIMETICS;

ADDITION REACTIONS;

ABYSSOMICIN J; ABYSSOMICIN K; ABYSSOMICIN L; FUSED HETEROCYCLIC RINGS; PRODRUG; SULFIDE; TUBERCULOSTATIC AGENT;

ARTICLE; CHEMISTRY; CHINA; DRUG EFFECT; ISOLATION AND PURIFICATION; MICROBIOLOGY; MICROMONOSPORACEAE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; OXIDATION REDUCTION REACTION; SEDIMENT;

ANTITUBERCULAR AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CHINA; GEOLOGIC SEDIMENTS; MICROMONOSPORACEAE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; PRODRUGS; SULFIDES;

EID: 84872403188     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201208801     Document Type: Article

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