Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis

Applied Microbiology and Biotechnology

Volumn 92, Issue 2, 2011, Pages 337-345

  Qiu, Jingfan ^a   Zhuo, Ying ^b   Zhu, Dongqing ^a   Zhou, Xiufen ^a   Zhang, Lixin ^b   Bai, Linquan ^a   Deng, Zixin ^a  

^a Shanghai Jiao Tong University   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

ABC transporter; Antibiotic overproduction; Avermectin; Drug efflux pump

Indexed keywords

ABC TRANSPORTER; AGAR PLATES; ANTIPARASITIC ACTIVITY; AVERMECTINS; BIOSYNTHETIC GENE; BIOSYNTHETIC GENE CLUSTER; DRUG EFFLUX PUMP; EXTRACELLULAR ACCUMULATIONS; FEEDBACK INHIBITION; INDUSTRIAL FERMENTATION; MACROCYCLICS; MULTIDRUG EFFLUX; OVER-EXPRESSION; P-GLYCOPROTEIN; POLYKETIDES; RT-PCR ANALYSIS; STREPTOMYCES AVERMITILIS; WILD TYPES;

ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; ENZYME ACTIVITY; FERMENTATION; GENE ENCODING; INTERNATIONAL TRADE; LIQUIDS; MAMMALS;

GENE EXPRESSION;

ABC TRANSPORTER; ABC TRANSPORTER AVTAB; AVERMECTIN; AVERMECTIN B1 A; MESSENGER RNA; OLIGOMYCIN; UNCLASSIFIED DRUG;

AGAR; ANTIBIOTICS; BACTERIUM; DRUG DEVELOPMENT; FEEDBACK MECHANISM; FERMENTATION; GENE EXPRESSION; GENETIC ENGINEERING; INDUSTRIAL PRODUCTION; MICROBIAL ACTIVITY; PLASMID; POLYMERASE CHAIN REACTION;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; DRUG DESIGN; DRUG MANUFACTURE; DRUG SYNTHESIS; EXTRACELLULAR SPACE; FEEDBACK SYSTEM; FERMENTATION MEDIUM; GENE EXPRESSION; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; INTRACELLULAR SPACE; LIQUID; NONHUMAN; OPERON; PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING; IVERMECTIN; STREPTOMYCES;

MAMMALIA; STREPTOMYCES AVERMITILIS;

EID: 82455167863     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3439-4     Document Type: Article

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