Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes

Enzyme and Microbial Technology

Volumn 50, Issue 1, 2012, Pages 5-9

  Wang, Tao ^a   Bai, Linquan ^a   Zhu, Dongqing ^a   Lei, Xuan ^a   Liu, Guang ^a   Deng, Zixin ^a   You, Delin ^a  

^a Shanghai Jiao Tong University   (China)

Author keywords

Avermectin; Candicidin; S adenosylmethionine synthetase; Streptomyces sp. FR 008; Transcriptional activator AdpA; Vitreoscilla hemoglobin

Indexed keywords

AVERMECTINS; CANDICIDIN; S-ADENOSYLMETHIONINE SYNTHETASE; STREPTOMYCES SP. FR-008; TRANSCRIPTIONAL ACTIVATORS; VITREOSCILLA HEMOGLOBIN;

AMINO ACIDS; ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; CLONING; DNA; ESCHERICHIA COLI; HEMOGLOBIN; METABOLITES;

GENES;

AMINO ACID; AVERMECTIN; BACTERIAL PROTEIN; HEMOGLOBIN; LEVORIN A2; MACROLIDE; METHIONINE ADENOSYLTRANSFERASE; PROTEIN ADPA; PROTEIN METK; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; CODON; ESCHERICHIA COLI; MOLECULAR CLONING; NONHUMAN; PLASMID; PROTEIN EXPRESSION; STREPTOMYCES; STREPTOMYCES AVERMITILIS; STREPTOMYCES COELICOLOR; VITREOSCILLA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DNA, BACTERIAL; GENE EXPRESSION; GENES, BACTERIAL; GENETIC ENGINEERING; MACROLIDES; METHIONINE ADENOSYLTRANSFERASE; MULTIGENE FAMILY; STREPTOMYCES; STREPTOMYCES COELICOLOR; TRANS-ACTIVATORS; TRUNCATED HEMOGLOBINS; VITREOSCILLA;

ESCHERICHIA COLI; STREPTOMYCES; STREPTOMYCES AVERMITILIS; STREPTOMYCES COELICOLOR; STREPTOMYCES SP. FR-008; VITREOSCILLA;

EID: 82455167849     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2011.09.014     Document Type: Article

References (40)

1. Nielsen J. Metabolic engineering. Appl Microbiol Biotechnol 2001, 55:263-283.
2. Koffas M., Roberge C., Lee K., Stephanopoulos G. Metabolic engineering. Annu Rev Biomed Eng 1999, 1:535-557.
3. Bibb M.J. Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 2005, 8:208-215.
4. Martin J.F., Liras P. Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. Curr Opin Microbiol 2010, 13:263-273.
5. Ohnishi Y., Yamazaki H., Kato J.Y., Tomono A., Horinouchi S. AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Biosci Biotechnol Biochem 2005, 69:431-439.
6. Yamazaki H., Tomono A., Ohnishi Y., Horinouchi S. DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. Mol Microbiol 2004, 53:555-572.
7. Tomono A., Tsai Y., Yamazaki H., Ohnishi Y., Horinouchi S. Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol 2005, 187:5595-5604.
8. Ohnishi Y., Kameyama S., Onaka H., Horinouchi S. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 1999, 34:102-111.
9. Chiang P.K., Gordon R.K., Tal J., Zeng G.C., Doctor B.P., Pardhasaradhi K., et al. S-Adenosylmethionine and methylation. FASEB J 1996, 10:471-480.
10. Okamoto S., Lezhava A., Hosaka T., Okamoto-Hosoya Y., Ochi K. Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). J Bacteriol 2003, 185:601-609.
11. Kim D.J., Huh J.H., Yang Y.Y., Kang C.M., Lee I.H., Hyun C.G., et al. Accumulation of S-adenosyl-l-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23. J Bacteriol 2003, 185:592-600.
12. Zhang X., Fen M., Shi X., Bai L., Zhou P. Overexpression of yeast S-adenosylmethionine synthetase metK in Streptomyces actuosus leads to increased production of nosiheptide. Appl Microbiol Biotechnol 2008, 78:991-995.
13. Yoon K.K., Kanga G.S., Suh H.W., Kim J.W., Ryu Y.S.Y.W. Characterization of S-adenosylmethionine synthetase from Streptomyces avermitilis NRRL8165 and its effect on antibiotic production. Enzyme Microb Technol 2006, 39:466-473.
14. Wakabayashi S., Matsubara H., Webster D.A. Primary sequence of a dimeric bacterial haemoglobin from Vitreoscilla. Nature 1986, 322:481-483.
15. Minas W., Brunker P., Kallio P.T., Bailey J.E. Improved erythromycin production in a genetically engineered industrial strain of Saccharopolyspora erythraea. Biotechnol Prog 1998, 14:561-566.
16. Holmberg N., Lilius G., Bailey J.E., Bulow L. Transgenic tobacco expressing Vitreoscilla hemoglobin exhibits enhanced growth and altered metabolite production. Nat Biotechnol 1997, 15:244-247.
17. Meng C., Ye Q., Shi X., Qiu L., Song S., Guo Y. Cloning and expression of Vitreoscilla hemoglobin in Streptomyces aureofaciens. Wei Sheng Wu Xue Bao 2002, 42:305-310.
18. Wen Y., Song Y., Li J.L. The effects of Vitreoscilla hemoglobin expression on growth and antibiotic production in Streptomyces cinnamonensis. Sheng Wu Gong Cheng Xue Bao 2001, 17:24-28.
19. Chen S., Huang X., Zhou X., Bai L., He J., Jeong K.J., et al. Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. Chem Biol 2003, 10:1065-1076.
20. Zhou Y., Li J., Zhu J., Chen S., Bai L., Zhou X., et al. Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. Chem Biol 2008, 15:629-638.
21. Yong J.H., Byeon W.H. Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. J Microbiol 2005, 43:277-284.
22. Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol 2003, 21:526-531.
23. Mazodier P., Petter R., Thompson C. Intergeneric conjugation between Escherichia coli and Streptomyces species. J Bacteriol 1989, 171:3583-3585.
24. Wilkinson C.J., Hughes-Thomas Z.A., Martin C.J., Bohm I., Mironenko T., Deacon M., et al. Increasing the efficiency of heterologous promoters in actinomycetes. J Mol Microbiol Biotechnol 2002, 4:417-426.
25. Zhao X.Q., Gust B., Heide L. S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces. Arch Microbiol 2010, 192:289-297.
26. Huh J.H., Kim D.J., Zhao X.Q., Li M., Jo Y.Y., Yoon T.M., et al. Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in streptomycetes. FEMS Microbiol Lett 2004, 238:439-447.
27. Staunton J., Wilkinson B. Biosynthesis of erythromycin and rapamycin. Chem Rev 1997, 97:2611-2630.
28. Thibaut D., Bisch D., Ratet N., Maton L., Couder M., Debussche L., et al. Purification of peptide synthetases involved in pristinamycin I biosynthesis. J Bacteriol 1997, 179:697-704.
29. Chiba Y., Sakurai R., Yoshino M., Ominato K., Ishikawa M., Onouchi H., et al. S-adenosyl-l-methionine is an effector in the posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis. Proc Natl Acad Sci U S A 2003, 100:10225-10230.
30. Shin S.K., Xu D., Kwon H.J., Suh J.W. S-adenosylmethionine activates adpA transcription and promotes streptomycin biosynthesis in Streptomyces griseus. FEMS Microbiol Lett 2006, 259:53-59.
31. Magnolo S.K., Leenutaphong D.L., DeModena J.A., Curtis J.E., Bailey J.E., Galazzo J.L., et al. Actinorhodin production by Streptomyces coelicolor and growth of Streptomyces lividans are improved by the expression of a bacterial hemoglobin. Biotechnology (NY) 1991, 9:473-476.
32. Ho C.S., Ju L.K., Baddour R.F. Enhancing penicillin fermentations by increased oxygen solubility through the addition of n-hexadecane. Biotechnol Bioeng 1990, 36:1110-1118.
33. Elibol M., Mavituna F. Effect of perfluorodecalin as an oxygen carrier on actinorhodin production by Streptomyces coelicolor A3(2). Appl Microbiol Biotechnol 1995, 43:206-210.
34. Brunker P., Minas W., Kallio P.T., Bailey J.E. Genetic engineering of an industrial strain of Saccharopolyspora erythraea for stable expression of the Vitreoscilla haemoglobin gene (vhb). Microbiology 1998, 144(Pt 9):2441-2448.
35. Isarankura-Na-Ayudhya C., Panpumthong P., Tangkosakul T., Boonpangrak S., Prachayasittikul V. Shedding light on the role of Vitreoscilla hemoglobin on cellular catabolic regulation by proteomic analysis. Int J Biol Sci 2008, 4:71-80.
36. Leskiw B.K., Lawlor E.J., Fernandez-Abalos J.M., Chater K.F. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc Natl Acad Sci U S A 1991, 88:2461-2465.
37. Egerton J.R., Ostlind D.A., Blair L.S., Eary C.H., Suhayda D., Cifelli S., et al. Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component. Antimicrob Agents Chemother 1979, 15:372-378.
38. Zhao J.L., Wen Y., Chen Z., Song Y., Li J.L. An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis. Chin Sci Bull 2007, 52:623-630.
39. Wen Y., Li J. Expression of Vitreoscilla hemoglobin gene in Streptomyces avermitilis. Wei Sheng Wu Xue Bao 2000, 40:50-56.
40. Combes P., Till R., Bee S., Smith M.C. The Streptomyces genome contains multiple pseudo-attB sites for the (phi)C31-encoded site-specific recombination system. J Bacteriol 2002, 184:5746-5752.