Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis

Applied Microbiology and Biotechnology

Volumn 98, Issue 1, 2014, Pages 399-409

  He, Fei ^a   Liu, Wenshuai ^a   Sun, Di ^a   Luo, Shuai ^a   Chen, Zhi ^a   Wen, Ying ^a   Li, Jilun ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Avermectin; SAV151; Streptomyces avermitilis; TetR family transcriptional regulator

Indexed keywords

AGRICULTURAL ROBOTS; BACTERIA; ENCODING (SYMBOLS);

AVERMECTINS; CHROMATIN IMMUNOPRECIPITATION; SAV151; STREPTOMYCES AVERMITILIS; TRANSCRIPTIONAL LEVELS; TRANSCRIPTIONAL REGULATOR; TRANSCRIPTIONAL UNITS; TRANSCRIPTOME ANALYSIS;

TRANSCRIPTION;

AVERMECTIN; BACTERIAL PROTEIN; PROTEIN SAV 151; TRANSCRIPTOME; UNCLASSIFIED DRUG;

COMMERCIAL ACTIVITY; ESTER; GENE EXPRESSION; GENETIC ENGINEERING; INDUSTRIAL PRODUCTION; PARASITE CONTROL; PROTEIN;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BINDING AFFINITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE CLUSTER; GENE DELETION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES AVERMITILIS;

STREPTOMYCES AVERMITILIS;

ANTIPARASITIC AGENTS; CHROMATIN IMMUNOPRECIPITATION; DNA, BACTERIAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; IVERMECTIN; METABOLIC ENGINEERING; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; STREPTOMYCES; TRANSCRIPTION FACTORS;

EID: 84891870326     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5348-1     Document Type: Article

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