Production of doramectin by rational engineering of the avermectin biosynthetic pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3320-3323

  Wang, Jian Bo ^a   Pan, Hai Xue ^a   Tang, Gong Li ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Avermectin; Cyclohexanecarboxylic acid; Doramectin; Loading module swap; Polyketide synthase

Indexed keywords

AVERMECTIN; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; DORAMECTIN; PHOSLACTOMYCIN DERIVATIVE; POLYKETIDE SYNTHASE;

ARTICLE; BIOSYNTHESIS; GENE CASSETTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; NONHUMAN; PHARMACEUTICAL ENGINEERING; POLYMERASE CHAIN REACTION; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

ANTHELMINTICS; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING; IVERMECTIN; RECOMBINANT PROTEINS; STREPTOMYCES;

STREPTOMYCES AVERMITILIS;

EID: 79956077665     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.008     Document Type: Article

References (23)

1. R.W. Burg, B.M. Miller, E.E. Baker, J. Birnbaum, S.A. Currie, R. Hartman, Y.-L. Kong, R.L. Monaghan, G. Olson, I. Putter, J.B. Tunac, H. Wallick, E.O. Stapley, R. Oiwa, and S. mura Antimicrob. Agents Chemother. 15 1979 361
2. J.R. Egerton, D.A. Ostlind, L.S. Blair, C.H. Eary, D. Suhayda, S. Cifelli, R.F. Riek, and W.C. Campbell Antimicrob. Agents Chemother. 15 1979 372
3. H. Ikeda, and S. mura Chem. Rev. 97 1997 2591
4. H. Ikeda, T. Nonomiya, M. Usami, T. Ohta, and S. mura Proc. Natl. Acad. Sci. U.S.A. 96 1999 9509
5. Y.J. Yoon, E.-S. Kim, Y.-S. Hwang, and C.-Y. Choi Appl. Microbiol. Biotechnol. 63 2004 626
6. S. Kitani, H. Ikeda, T. Sakamoto, S. Noguchi, and T. Nihira Appl. Microbiol. Biotechnol. 82 2009 1089
7. McArthur, H. A. I. Developments in Industrial Microbiology-BMP 97. Hutchinson, C. R., McAlpine, J., Eds.; Society for Industrial Microbiology: Fairfax, VA, 1998; pp 43-48.
8. C.J. Dutton, S.P. Gibson, A.C. Goudie, K.S. Holdom, M.S. Pacey, J.C. Ruddock, J.D. Bu'Lock, and M.K. Richards J. Antibiot. 44 1991 357
9. K. Stutzman-Engwall, S. Conlon, R. Fedechko, F. Kaczmarek, H. McArthur, A. Krebber, Y. Chen, J. Minshull, S.A. Raillard, and C. Gustafsson Biotechnol. Bioeng. 82 2003 359
10. K. Stutzman-Engwall, S. Conlon, R. Fedechko, H. McArthur, K. Pekrun, Y. Chen, S. Jenne, C. La, N. Trinh, S. Kim, Y.-X. Zhang, R. Fox, C. Gustafsson, and A. Krebber Metab. Eng. 7 2005 27
11. K.J. Weissman, and P.L. Leadlay Nat. Rev. Microbiol. 3 2005 925
12. H.G. Floss J. Biotechnol. 124 2006 242
13. R.H. Baltz Nat. Biotechnol. 24 2006 1533
14. F.A. Marsden, B. Wilkinson, J. Cortés, N.J. Dunster, J. Staunton, and P.F. Leadlay Science 279 1998 199
15. L.S. Sheehan, R.E. Lill, B. Wilkinson, R.M. Sheridan, W.A. Vousden, A.L. Kaja, G.D. Crouse, J. Gifford, P.R. Graupner, L. Karr, P. Lewer, T.C. Sparks, P.F. Leadlay, C. Waldron, and C.J. Martin J. Nat. Prod. 69 2006 1702
16. N. Palaniappan, B.S. Kim, Y. Sekiyama, H. Osada, and K.A. Reynolds J. Biol. Chem. 278 2003 35552
17. M. Ghatge, N. Palaniappan, S.D. Choudhuri, and K.A. Reynolds J. Ind. Microbiol. Biotechnol. 33 2006 589
18. H.G. Menzella, R. Reid, J.R. Carney, S.S. Chandran, S.J. Reisinger, K.G. Patel, D.A. Hopwood, and D.V. Santi Nat. Biotechnol. 23 2005 1171
19. Y. Tang, C.-Y. Kim, I.I. Mathews, D.E. Cane, and C. Khosla Proc. Natl. Acad. Sci. U.S.A. 103 2006 11124
20. S. Chen, D. van Bamberg, V. Hale, M. Breuer, B. Hardt, R. Müller, H.G. Floss, K.A. Reynolds, and E. Leistner Eur. J. Biochem. 261 1999 98
21. T. Ashton Cropp, D.J. Wilson, and K.A. Reynolds Nat. Biotechnol. 18 2000 980
22. Ohtsu, M. M.; Takatsuki, T. K.; Ibaraki, S. A.; Takatsuki, N. A.; Suita, T. K.; Yokohama, H. H. U.S. Patent, 5021406, 1991.
23. Sugimura, Y.; Shibata, T.; Tamaki, K.; Kurihara, S.; Kohama, T.; Shiraishi, A.; Kobayashi, T.; Sasagawa, K.; Shimazaki, N. U.S. Patent, 5409912, 1995.