Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5359-5363

  Li, Meng ^a   Chen, Zhi ^a   Lin, Xiuping ^a   Zhang, Xuan ^a   Song, Yuan ^a   Wen, Ying ^a   Li, Jilun ^a  

^a College of Biological Sciences   (China)

Author keywords

aveC; Avermectin; Combinatorial biosynthesis; Ivermectin; Polyketide synthase; Streptomyces avermitilis

Indexed keywords

AVERMECTIN; IVERMECTIN; POLYKETIDE SYNTHASE;

ARTICLE; AVEC GENE; BACTERIAL GENE; BACTERIAL STRAIN; GENE CLUSTER; GENE OVEREXPRESSION; GENE SYNTHESIS; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; NONHUMAN; PROTEIN DOMAIN; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

AMINO ACID SEQUENCE; ANTIPARASITIC AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; GENETIC ENGINEERING; IVERMECTIN; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NUCLEOTIDES; STREPTOMYCES;

STREPTOMYCES AVERMITILIS;

EID: 53349162137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.061     Document Type: Article

References (17)

1. Burg R.W., Miller B.M., Baker E.E., Birnbaum J., Currie S.A., Hartman R., Kong Y.L., Monaghan R.L., Olson G., Putter I., Tunac J.B., Wallick H., Stapley E.O., Oiwa R., and Omura S. Antimicrob. Agents Chemother. 15 (1979) 361
2. Aziz M.A., Diallo S., Diop I.M., Lariviere M., and Porta M. Lancet 2 (1982) 171
3. Campbell W.C. Ivermectin and Abamectin (1989), Springer-Verlag, New York 60-323
4. Chabala J.C., Mrozik H., Tolman R.L., Eskola P., Lusi A., Peterson L.H., Woods M.F., Fisher M.H., Campbell W.C., Egerton J.R., and Ostlind D.A. J. Med. Chem. 23 (1980) 1134
5. Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., and Omura S. Nat. Biotechnol. 21 (2003) 526
6. Ikeda H., Nonomiya T., Usami M., Ohta T., and Omura S. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 9509
7. Zhang X., Chen Z., Li M., Wen Y., Song Y., and Li J. Appl. Microbiol. Biotechnol. 72 (2006) 986
8. Gaisser S., Kellenberger L., Kaja A.L., Weston A.J., Lill R.E., Wirtz G., Kendrew S.G., Low L., Sheridan R.M., Wilkinson B., Galloway I.S., Stutzman-Engwall K., McArthur H.A., Staunton J., and Leadlay P.F. Org. Biomol. Chem. 1 (2003) 2840
9. Pinna L.A., Lorini M., Moret V., and Siliprandi N. Biochim. Biophys. Acta 143 (1967) 18
10. Zhang X., Chen Z., Zhao J., Song Y., Wen Y., and Li J. Chin. Sci. Bull. 49 (2004) 350
11. Ikeda H., Wang L.R., Ohta T., Inokoshi J., and Omura S. Gene 206 (1998) 175
12. Chen Z., Wen Y., Song Y., and Li J. Acta Microbiol. Sin. 42 (2002) 534
13. Tang L., Fu H., and McDaniel R. Chem. Biol. 7 (2000) 77
14. Yadav G., Gokhale R.S., and Mohanty D. Nucleic Acids Res. 31 (2003) 3654
15. Watanabe K., Wang C.C., Boddy C.N., Cane D.E., and Khosla C. J. Biol. Chem. 278 (2003) 42020
16. Stutzman-Engwall K., Conlon S., Fedechko R., Kaczmarek F., McArthur H., Krebber A., Chen Y., Minshull J., Raillard S.A., and Gustafsson C. Biotechnol. Bioeng. 82 3 (2003) 359
17. Stutzman-Engwall K., Conlon S., Fedechko R., McArthur H., Pekrun K., Chen Y., Jenne S., La C., Trinh N., Kim S., Zhang Y.X., Fox R., Gustafsson C., and Krebber A. Metab. Eng. 7 1 (2005) 27