Structure-guided functional annotation of the influenza A virus NS1 protein reveals dynamic evolution of the p85β-binding site during circulation in humans

Journal of Virology

Volumn 91, Issue 21, 2017, Pages

  Lopes, Antonio M ^a   Domingues, Patricia ^a   Zell, Roland ^b   Hale, Benjamin G ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Akt signaling; Evolution; Influenza virus; NS1; Protein structure function; Virulence

Indexed keywords

NONSTRUCTURAL PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN P85BETA; UNCLASSIFIED DRUG; INS1 PROTEIN, INFLUENZA VIRUS; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN BINDING; VIRAL PROTEIN;

ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; HUMAN; IMMUNOPRECIPITATION; IN VIVO STUDY; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H3N2); LIMIT OF QUANTITATION; LUNG ALVEOLUS EPITHELIUM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VIRUS ISOLATION; VIRUS STRAIN; VIRUS VIRULENCE; AMINO ACID SEQUENCE; BINDING SITE; BLOOD; CHEMISTRY; GENETICS; HEK293 CELL LINE; INFLUENZA; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR EVOLUTION; PATHOGENICITY; PROTEIN CONFORMATION; VIROLOGY; VIRULENCE; VIRUS REPLICATION;

AMINO ACID SEQUENCE; BINDING SITES; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; EVOLUTION, MOLECULAR; HEK293 CELLS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 85031095954     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01081-17     Document Type: Article

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