A single point mutation (Y89F) within the non-structural protein 1 of influenza A viruses limits epithelial cell tropism and virulence in mice

American Journal of Pathology

Volumn 180, Issue 6, 2012, Pages 2361-2374

  Hrincius, Eike R ^a   Hennecke, Ann Katrin ^a   Gensler, Lisa ^a   Nordhoff, Carolin ^a   Anhlan, Darisuren ^a   Vogel, Peter ^b   McCullers, Jonathan A ^b   Ludwig, Stephan ^a   Ehrhardt, Christina ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 1; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EPITHELIUM CELL; HISTOLOGY; IN VIVO STUDY; INFLAMMATION; INFLUENZA VIRUS A; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TROPISM; VIRUS REPLICATION; VIRUS VIRULENCE; WEIGHT REDUCTION;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; CYTOKINES; EPITHELIAL CELLS; INFLUENZA A VIRUS; LUNG; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; POINT MUTATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; SRC HOMOLOGY DOMAINS; VIRAL NONSTRUCTURAL PROTEINS; VIRAL TROPISM; VIRULENCE; VIRUS REPLICATION; WEIGHT LOSS;

EID: 84861650834     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.02.029     Document Type: Article

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