The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins

Journal of Virology

Volumn 85, Issue 14, 2011, Pages 7048-7058

  Spesock, April ^a,d   Malur, Meghana ^b   Hossain, M Jaber ^a,d   Chen, Li Mei ^a   Njaa, Bradley L ^c   Davis, Charles T ^a   Lipatov, Aleksandr S ^a   York, Ian A ^a   Krug, Robert M ^b   Donis, Ruben O ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c OKLAHOMA STATE UNIVERSITY   (United States)

^d BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTRUCTURAL PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DISEASE SEVERITY; FEMALE; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; LETHALITY; LUNG DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALS; CELL LINE; DOGS; FEMALE; FLOW CYTOMETRY; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INTERFERON-BETA; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; RNA, MESSENGER; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 79960403406     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00417-11     Document Type: Article

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