-
1
-
-
33846265834
-
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
-
Kobasa, D. et al. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445, 319-323 (2007).
-
(2007)
Nature
, vol.445
, pp. 319-323
-
-
Kobasa, D.1
-
2
-
-
51849103407
-
Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: Implications for pandemic influenza preparedness
-
Morens, D. M., Taubenberger, J. K. & Fauci, A. S. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J. Infect. Dis. 198, 962-970 (2008).
-
(2008)
J. Infect. Dis
, vol.198
, pp. 962-970
-
-
Morens, D.M.1
Taubenberger, J.K.2
Fauci, A.S.3
-
3
-
-
0030987210
-
-
Taubenberger, J. K., Reid, A. H., Krafft, A. E., Bijwaard, K. E. & Fanning, T. G. Initial genetic characterization of the 1918 ''Spanish'' influenza virus. Science 275, 1793-1796 (1997). This is an important paper that describes the deciphering of the genomic sequence of the 1918 pandemic influenza virus.
-
Taubenberger, J. K., Reid, A. H., Krafft, A. E., Bijwaard, K. E. & Fanning, T. G. Initial genetic characterization of the 1918 ''Spanish'' influenza virus. Science 275, 1793-1796 (1997). This is an important paper that describes the deciphering of the genomic sequence of the 1918 pandemic influenza virus.
-
-
-
-
4
-
-
0033574005
-
Origin and evolution of the 1918 ''Spanish'' influenza virus hemagglutinin gene
-
Reid, A. H., Fanning, T. G., Hultin, J. V. & Taubenberger, J. K. Origin and evolution of the 1918 ''Spanish'' influenza virus hemagglutinin gene. Proc. Natl Acad. Sci. USA 96, 1651-1656 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 1651-1656
-
-
Reid, A.H.1
Fanning, T.G.2
Hultin, J.V.3
Taubenberger, J.K.4
-
5
-
-
13044287344
-
Generation of influenza A viruses entirely from cloned cDNA
-
This paper describes the artificial generation of influenza viruses, a breakthrough technology that allows the molecular characterization of influenza viruses and the generation of influenza virus vaccines
-
Neumann, G. et al. Generation of influenza A viruses entirely from cloned cDNA. Proc. Natl Acad. Sci. USA 96, 9345-9350 (1999). This paper describes the artificial generation of influenza viruses, a breakthrough technology that allows the molecular characterization of influenza viruses and the generation of influenza virus vaccines.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 9345-9350
-
-
Neumann, G.1
-
6
-
-
26444490055
-
-
Characterization of the reconstructed Spanish influenza pandemic virus, 310, 77-80 , This is a pivotal paper that describes the re-creation of the pandemic influenza virus. 2005
-
Tumpey, T. M. et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310, 77-80 (2005). This is a pivotal paper that describes the re-creation of the 1918 pandemic influenza virus.
-
(1918)
Science
-
-
Tumpey, T.M.1
-
7
-
-
33749514992
-
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
-
Kash, J. C. et al. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443, 578-581 (2006).
-
(2006)
Nature
, vol.443
, pp. 578-581
-
-
Kash, J.C.1
-
8
-
-
33749511112
-
Fatal outcome of human influenza A(H5N1) is associated with high viral load and hypercytokinemia
-
This important paper describes high levels of cytokines in humans infected with highly pathogenic avian H5N1 viruses
-
de Jong, M. D. et al. Fatal outcome of human influenza A(H5N1) is associated with high viral load and hypercytokinemia. Nature Med. 12, 1203-1207 (2006). This important paper describes high levels of cytokines in humans infected with highly pathogenic avian H5N1 viruses.
-
(2006)
Nature Med
, vol.12
, pp. 1203-1207
-
-
de Jong, M.D.1
-
9
-
-
6044274640
-
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus
-
Kobasa, D. et al. Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature 431, 703-707 (2004).
-
(2004)
Nature
, vol.431
, pp. 703-707
-
-
Kobasa, D.1
-
10
-
-
0037109078
-
Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus
-
Tumpey, T. M. et al. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc. Natl Acad. Sci. USA 99, 13849-13854 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 13849-13854
-
-
Tumpey, T.M.1
-
11
-
-
1542267799
-
Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
-
Tumpey, T. M. et al. Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. Proc. Natl Acad. Sci. USA 101, 3166-3171 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3166-3171
-
-
Tumpey, T.M.1
-
12
-
-
58849167264
-
Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets
-
Watanabe, T. et al. Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc. Natl Acad. Sci. USA 106, 588-592 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 588-592
-
-
Watanabe, T.1
-
13
-
-
62549148694
-
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
-
Van Hoeven, N. et al. Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc. Natl Acad. Sci. USA 106, 3366-3371 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3366-3371
-
-
Van Hoeven, N.1
-
14
-
-
0036678864
-
Cellular transcriptional profiling in influenzaAvirus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
-
Geiss, G. K. et al. Cellular transcriptional profiling in influenzaAvirus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc. Natl Acad. Sci. USA 99, 10736-10741 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 10736-10741
-
-
Geiss, G.K.1
-
15
-
-
34848926238
-
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
-
McAuley, J. L. et al. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2, 240-249 (2007).
-
(2007)
Cell Host Microbe
, vol.2
, pp. 240-249
-
-
McAuley, J.L.1
-
16
-
-
0018149877
-
-
Nakajima, K., Desselberger, U. & Palese, P. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature 274, 334-339 (1978). This paper established that the Russian influenza in 1977 was genetically closely related to viruses circulating in humans in the 1950s.
-
Nakajima, K., Desselberger, U. & Palese, P. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature 274, 334-339 (1978). This paper established that the Russian influenza in 1977 was genetically closely related to viruses circulating in humans in the 1950s.
-
-
-
-
17
-
-
14444284599
-
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
-
Subbarao, K. et al. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393-396 (1998).
-
(1998)
Science
, vol.279
, pp. 393-396
-
-
Subbarao, K.1
-
18
-
-
0032515638
-
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
-
Claas, E. C. et al. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351, 472-477 (1998).
-
(1998)
Lancet
, vol.351
, pp. 472-477
-
-
Claas, E.C.1
-
19
-
-
33750946430
-
Emergence and predominance of an H5N1 influenza variant in China
-
Smith, G. J. et al. Emergence and predominance of an H5N1 influenza variant in China. Proc. Natl Acad. Sci. USA 103, 16936-16941 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16936-16941
-
-
Smith, G.J.1
-
20
-
-
33644526903
-
Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
-
Chen, H. et al. Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control. Proc. Natl. Acad. Sci. USA 103, 2845-2850 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2845-2850
-
-
Chen, H.1
-
21
-
-
0037173048
-
Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR
-
Guan, Y. et al. Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc. Natl Acad. Sci. USA 99, 8950-8955 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 8950-8955
-
-
Guan, Y.1
-
22
-
-
3142579867
-
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
-
This paper describes the frequent reassortment events of highly pathogenic avian H5N1 viruses that led to the emergence of the dominant 'genotype Z
-
Li, K. S. et al. Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430, 209-213 (2004). This paper describes the frequent reassortment events of highly pathogenic avian H5N1 viruses that led to the emergence of the dominant 'genotype Z'.
-
(2004)
Nature
, vol.430
, pp. 209-213
-
-
Li, K.S.1
-
23
-
-
33746007172
-
Avian flu: Multiple introductions of H5N1 in Nigeria
-
Ducatez, M. F. et al. Avian flu: multiple introductions of H5N1 in Nigeria. Nature 442, 37 (2006).
-
(2006)
Nature
, vol.442
, pp. 37
-
-
Ducatez, M.F.1
-
24
-
-
12144287234
-
Avian influenza A (H5N1) in 10 patients in Vietnam
-
Tran, T. H. et al. Avian influenza A (H5N1) in 10 patients in Vietnam. N. Engl. J. Med. 350, 1179-1188 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 1179-1188
-
-
Tran, T.H.1
-
25
-
-
25444432780
-
Consultation on Human Influenza A/H5. Avian influenzaA(H5N1) infection in humans
-
The Writing Committee of the World Health Organization WHO
-
The Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5. Avian influenzaA(H5N1) infection in humans. N. Engl. J. Med. 353, 1374-1385 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 1374-1385
-
-
-
26
-
-
13744249272
-
Human disease from influenza A (H5N1), Thailand, 2004
-
Chotpitayasunondh, T. et al. Human disease from influenza A (H5N1), Thailand, 2004. Emerg. Infect. Dis. 11, 201-209 (2005).
-
(2005)
Emerg. Infect. Dis
, vol.11
, pp. 201-209
-
-
Chotpitayasunondh, T.1
-
27
-
-
10744231351
-
-
Peiris, J. S. et al. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 363, 617-619 (2004). This paper describes the re-emergence of human infections with highly pathogenic avian H5N1 viruses in 2003, and also emphasises the high concentrations of cytokines found in infected individuals.
-
Peiris, J. S. et al. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 363, 617-619 (2004). This paper describes the re-emergence of human infections with highly pathogenic avian H5N1 viruses in 2003, and also emphasises the high concentrations of cytokines found in infected individuals.
-
-
-
-
28
-
-
0035140519
-
Pathology of fatal human infection associated with avian influenza A H5N1 virus
-
To, K. F. et al. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J. Med. Virol. 63, 242-246 (2001).
-
(2001)
J. Med. Virol
, vol.63
, pp. 242-246
-
-
To, K.F.1
-
29
-
-
28044445881
-
Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
-
Chan, M. C. et al. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 6, 135 (2005).
-
(2005)
Respir. Res
, vol.6
, pp. 135
-
-
Chan, M.C.1
-
30
-
-
0037038866
-
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease?
-
Cheung, C. Y. et al. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 360, 1831-1837 (2002).
-
(2002)
Lancet
, vol.360
, pp. 1831-1837
-
-
Cheung, C.Y.1
-
31
-
-
67249138142
-
Pandemic potential of a strain of influenza A (H1N1): Early findings
-
doi: 10.1126/science.1176062 in the press
-
Fraser, C. et al. Pandemic potential of a strain of influenza A (H1N1): early findings. Science doi: 10.1126/science.1176062 (in the press).
-
Science
-
-
Fraser, C.1
-
32
-
-
67449110743
-
-
Novel Swine-Origin InfluenzaA(H1N1) Investigation Team.. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J Med. doi: 10.1056/ NEJMoa0903810 (in the press). This highly important paper presents the first summary of epidemiological and virological data on the new swine-origin H1N1 viruses.
-
Novel Swine-Origin InfluenzaA(H1N1) Investigation Team.. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J Med. doi: 10.1056/ NEJMoa0903810 (in the press). This highly important paper presents the first summary of epidemiological and virological data on the new swine-origin H1N1 viruses.
-
-
-
-
33
-
-
0020520729
-
Receptor determinants of human and animal influenza virus isolates: Differences in receptor specificity of the H3 hemagglutinin based on species of origin
-
This paper establishes differences between human and avian influenza viruses in receptor-binding specificity
-
Rogers, G. N. & Paulson, J. C. Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 127, 361-373 (1983). This paper establishes differences between human and avian influenza viruses in receptor-binding specificity.
-
(1983)
Virology
, vol.127
, pp. 361-373
-
-
Rogers, G.N.1
Paulson, J.C.2
-
34
-
-
0031820637
-
Molecular basis for the generation in pigs of influenza A viruses with pandemic potential
-
Ito, T. et al. Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J. Virol. 72, 7367-7373 (1998).
-
(1998)
J. Virol
, vol.72
, pp. 7367-7373
-
-
Ito, T.1
-
35
-
-
0032927194
-
The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties
-
Matrosovich, M., Zhou, N., Kawaoka, Y. & Webster, R. The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties. J. Virol. 73, 1146-1155 (1999).
-
(1999)
J. Virol
, vol.73
, pp. 1146-1155
-
-
Matrosovich, M.1
Zhou, N.2
Kawaoka, Y.3
Webster, R.4
-
36
-
-
33645278326
-
Avian flu: Influenza virus receptors in the human airway
-
Shinya, K. et al. Avian flu: influenza virus receptors in the human airway. Nature 440, 435-436 (2006).
-
(2006)
Nature
, vol.440
, pp. 435-436
-
-
Shinya, K.1
-
37
-
-
33645972581
-
H5N1 virus attachment to lower respiratory tract
-
van Riel, D. et al. H5N1 virus attachment to lower respiratory tract. Science 312, 399 (2006).
-
(2006)
Science
, vol.312
, pp. 399
-
-
van Riel, D.1
-
38
-
-
33846995616
-
Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
-
Nicholls, J. M. et al. Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nature Med. 13, 147-149 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 147-149
-
-
Nicholls, J.M.1
-
39
-
-
1642352884
-
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus
-
Stevens, J. et al. Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science 303, 1866-1870 (2004).
-
(2004)
Science
, vol.303
, pp. 1866-1870
-
-
Stevens, J.1
-
40
-
-
33846820412
-
A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
-
Tumpey, T. M. et al. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 315, 655-659 (2007).
-
(2007)
Science
, vol.315
, pp. 655-659
-
-
Tumpey, T.M.1
-
41
-
-
30044433592
-
Evolution of the receptor binding phenotype of influenza A (H5) viruses
-
Gambaryan, A. et al. Evolution of the receptor binding phenotype of influenza A (H5) viruses. Virology 344, 432-438 (2006).
-
(2006)
Virology
, vol.344
, pp. 432-438
-
-
Gambaryan, A.1
-
42
-
-
33751083554
-
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
-
Yamada, S. et al. Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444, 378-382 (2006).
-
(2006)
Nature
, vol.444
, pp. 378-382
-
-
Yamada, S.1
-
43
-
-
35348895001
-
An avian influenza H5N1 virus that binds to a human-type receptor
-
Auewarakul, P. et al. An avian influenza H5N1 virus that binds to a human-type receptor. J. Virol. 81, 9950-9955 (2007).
-
(2007)
J. Virol
, vol.81
, pp. 9950-9955
-
-
Auewarakul, P.1
-
44
-
-
33645981586
-
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
-
Stevens, J. et al. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312, 404-410 (2006).
-
(2006)
Science
, vol.312
, pp. 404-410
-
-
Stevens, J.1
-
45
-
-
0023736676
-
Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells
-
Kawaoka, Y. & Webster, R. G. Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells. Proc. Natl Acad. Sci. USA 85, 324-328 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 324-328
-
-
Kawaoka, Y.1
Webster, R.G.2
-
46
-
-
0027468737
-
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range
-
Subbarao, E. K., London, W. & Murphy, B. R. A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J. Virol. 67, 1761-1764 (1993).
-
(1993)
J. Virol
, vol.67
, pp. 1761-1764
-
-
Subbarao, E.K.1
London, W.2
Murphy, B.R.3
-
47
-
-
0035823083
-
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
-
Hatta, M., Gao, P., Halfmann, P. & Kawaoka, Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293, 1840-1842 (2001).
-
(2001)
Science
, vol.293
, pp. 1840-1842
-
-
Hatta, M.1
Gao, P.2
Halfmann, P.3
Kawaoka, Y.4
-
48
-
-
48649085166
-
An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase
-
Mehle, A. & Doudna, J. A. An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host Microbe 4, 111-122 (2008).
-
(2008)
Cell Host Microbe
, vol.4
, pp. 111-122
-
-
Mehle, A.1
Doudna, J.A.2
-
49
-
-
59749097063
-
Avian influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection
-
Rameix-Welti, M. A., Tomoiu, A., Dos Santos Afonso, E., van der Werf, S. & Naffakh, N. Avian influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection. J. Virol. 83, 1320-1331 (2009).
-
(2009)
J. Virol
, vol.83
, pp. 1320-1331
-
-
Rameix-Welti, M.A.1
Tomoiu, A.2
Dos Santos Afonso, E.3
van der Werf, S.4
Naffakh, N.5
-
50
-
-
36049011840
-
Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice
-
Hatta, M. et al. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog. 3, e133 (2007).
-
(2007)
PLoS Pathog
, vol.3
-
-
Hatta, M.1
-
51
-
-
0035026051
-
Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses
-
Massin, P., van der Werf, S. & Naffakh, N. Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J. Virol. 75, 5398-5404 (2001).
-
(2001)
J. Virol
, vol.75
, pp. 5398-5404
-
-
Massin, P.1
van der Werf, S.2
Naffakh, N.3
-
52
-
-
59249096926
-
-
Steel, J., Lowen, A. C., Mubareka, S. & Palese, P. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 5, e1000252 (2009).
-
Steel, J., Lowen, A. C., Mubareka, S. & Palese, P. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 5, e1000252 (2009).
-
-
-
-
53
-
-
24644484686
-
Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model
-
Li, Z. et al. Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J. Virol. 79, 12058-12064 (2005).
-
(2005)
J. Virol
, vol.79
, pp. 12058-12064
-
-
Li, Z.1
-
54
-
-
34548169547
-
Differential polymerase activity in avian and mammalian cells determines host range of influenza virus
-
Gabriel, G. et al. Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J. Virol. 81, 9601-9604 (2007).
-
(2007)
J. Virol
, vol.81
, pp. 9601-9604
-
-
Gabriel, G.1
-
55
-
-
40349113426
-
Interaction of polymerase subunit PB2 and NP with importin a1 is a determinant of host range of influenza A virus
-
Gabriel, G., Herwig, A. & Klenk, H. D. Interaction of polymerase subunit PB2 and NP with importin a1 is a determinant of host range of influenza A virus. PLoS Pathog. 4, e11 (2008).
-
(2008)
PLoS Pathog
, vol.4
-
-
Gabriel, G.1
Herwig, A.2
Klenk, H.D.3
-
56
-
-
33645058912
-
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
-
Salomon, R. et al. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J. Exp. Med. 203, 689-697 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 689-697
-
-
Salomon, R.1
-
57
-
-
50849137828
-
-
Tarendeau, F. et al. Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog. 4, e1000136 (2008).
-
Tarendeau, F. et al. Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog. 4, e1000136 (2008).
-
-
-
-
58
-
-
65449163086
-
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue
-
Kuzuhara, T. et al. Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue. J. Biol. Chem. 284, 6855-6860 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 6855-6860
-
-
Kuzuhara, T.1
-
59
-
-
0035864298
-
Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses
-
Garcia-Sastre, A. Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology 279, 375-384 (2001).
-
(2001)
Virology
, vol.279
, pp. 375-384
-
-
Garcia-Sastre, A.1
-
60
-
-
0345004816
-
-
Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems, 252, 324-330 , This paper establishes the NS1 protein as an interferon antagonist
-
Garcia-Sastre, A. et al. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252, 324-330 (1998). This paper establishes the NS1 protein as an interferon antagonist.
-
(1998)
Virology
-
-
Garcia-Sastre, A.1
-
61
-
-
33750984771
-
RIG-I-mediated antiviral responses to single-stranded RNA bearing 59-phosphates
-
Pichlmair, A. et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 59-phosphates. Science 314, 997-1001 (2006).
-
(2006)
Science
, vol.314
, pp. 997-1001
-
-
Pichlmair, A.1
-
62
-
-
1542317550
-
-
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
-
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
-
-
-
-
63
-
-
1842631428
-
Recognition of single-stranded RNA viruses by Toll-like receptor 7
-
Lund, J. M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl Acad. Sci. USA 101, 5598-5603 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 5598-5603
-
-
Lund, J.M.1
-
64
-
-
41949087380
-
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
-
Imai, Y. et al. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133, 235-249 (2008).
-
(2008)
Cell
, vol.133
, pp. 235-249
-
-
Imai, Y.1
-
65
-
-
0036734038
-
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
-
Seo, S., Hoffmann, E. & Webster, R. G. Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nature Med. 8, 950-954 (2002).
-
(2002)
Nature Med
, vol.8
, pp. 950-954
-
-
Seo, S.1
Hoffmann, E.2
Webster, R.G.3
-
66
-
-
2542640122
-
H5N1 influenza: A protean pandemic threat
-
Guan, Y. et al. H5N1 influenza: a protean pandemic threat. Proc. Natl Acad. Sci. USA 101, 8156-8161 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 8156-8161
-
-
Guan, Y.1
-
67
-
-
38349180176
-
A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice
-
Jiao, P. et al. A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J. Virol. 82, 1146-1154 (2008).
-
(2008)
J. Virol
, vol.82
, pp. 1146-1154
-
-
Jiao, P.1
-
68
-
-
33750719489
-
The NS1 gene contributes to the virulence of H5N1 avian influenza viruses
-
Li, Z. et al. The NS1 gene contributes to the virulence of H5N1 avian influenza viruses. J. Virol. 80, 11115-11123 (2006).
-
(2006)
J. Virol
, vol.80
, pp. 11115-11123
-
-
Li, Z.1
-
69
-
-
33645067624
-
Large-scale sequence analysis of avian influenza isolates
-
Obenauer, J. C. et al. Large-scale sequence analysis of avian influenza isolates. Science 311, 1576-1580 (2006).
-
(2006)
Science
, vol.311
, pp. 1576-1580
-
-
Obenauer, J.C.1
-
70
-
-
41949123710
-
A.A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity
-
Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R.&Lamb, R. A.A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc. Natl Acad. Sci. USA 105, 4381-4386 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 4381-4386
-
-
Jackson, D.1
Hossain, M.J.2
Hickman, D.3
Perez, D.R.4
Lamb, R.5
-
71
-
-
0035658084
-
A novel influenza A virus mitochondrial protein that induces cell death
-
Chen, W. et al. A novel influenza A virus mitochondrial protein that induces cell death. Nature Med. 7, 1306-1312 (2001).
-
(2001)
Nature Med
, vol.7
, pp. 1306-1312
-
-
Chen, W.1
-
72
-
-
77951059450
-
Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1
-
Zamarin, D., Garcia-Sastre, A., Xiao, X., Wang, R. & Palese, P. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog. 1, e4 (2005).
-
(2005)
PLoS Pathog
, vol.1
-
-
Zamarin, D.1
Garcia-Sastre, A.2
Xiao, X.3
Wang, R.4
Palese, P.5
-
73
-
-
42149098369
-
The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein
-
Mazur, I. et al. The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell. Microbiol. 10, 1140-1152 (2008).
-
(2008)
Cell. Microbiol
, vol.10
, pp. 1140-1152
-
-
Mazur, I.1
-
74
-
-
36049034216
-
A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenzaAviruses contributes to increased virulence
-
Conenello, G. M., Zamarin, D., Perrone, L. A., Tumpey, T. & Palese, P. A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenzaAviruses contributes to increased virulence. PLoS Pathog. 3, e141 (2007).
-
(2007)
PLoS Pathog
, vol.3
-
-
Conenello, G.M.1
Zamarin, D.2
Perrone, L.A.3
Tumpey, T.4
Palese, P.5
-
75
-
-
4444369826
-
Resistant influenza A viruses in children treated with oseltamivir: Descriptive study
-
Kiso, M. et al. Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet 364, 759-765 (2004).
-
(2004)
Lancet
, vol.364
, pp. 759-765
-
-
Kiso, M.1
-
76
-
-
65549113423
-
Influenza virus resistance to antiviral agents: A plea for rational use
-
Poland, G. A., Jacobson, R. M. & Ovsyannikova, I. G. Influenza virus resistance to antiviral agents: a plea for rational use. Clin. Infect. Dis. 48, 1254-1256 (2009).
-
(2009)
Clin. Infect. Dis
, vol.48
, pp. 1254-1256
-
-
Poland, G.A.1
Jacobson, R.M.2
Ovsyannikova, I.G.3
-
77
-
-
27144468290
-
Avian flu: Isolation of drug-resistant H5N1 virus
-
Le, Q. M. et al. Avian flu: isolation of drug-resistant H5N1 virus. Nature 437, 1108 (2005).
-
(2005)
Nature
, vol.437
, pp. 1108
-
-
Le, Q.M.1
-
78
-
-
29144528757
-
Oseltamivir resistance during treatment of influenzaA(H5N1) infection
-
de Jong, M. D. et al. Oseltamivir resistance during treatment of influenzaA(H5N1) infection. N. Engl. J. Med. 353, 2667-2672 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 2667-2672
-
-
de Jong, M.D.1
-
79
-
-
0037468417
-
Prolonged shedding of multidrug-resistant influenza A virus in an immunocompromised patient
-
Weinstock, D. M., Gubareva, L. V. & Zuccotti, G. Prolonged shedding of multidrug-resistant influenza A virus in an immunocompromised patient. N. Engl. J. Med. 348, 867-868 (2003).
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 867-868
-
-
Weinstock, D.M.1
Gubareva, L.V.2
Zuccotti, G.3
-
80
-
-
33845455661
-
Characterization of multidrugresistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child
-
Baz, M., Abed, Y., McDonald, J. & Boivin, G. Characterization of multidrugresistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child. Clin. Infect. Dis. 43, 1555-1561 (2006).
-
(2006)
Clin. Infect. Dis
, vol.43
, pp. 1555-1561
-
-
Baz, M.1
Abed, Y.2
McDonald, J.3
Boivin, G.4
-
81
-
-
33644879977
-
Recovery of drug-resistant influenza virus from immunocompromised patients: A case series
-
Ison, M. G., Gubareva, L. V., Atmar, R. L., Treanor, J. & Hayden, F. G. Recovery of drug-resistant influenza virus from immunocompromised patients: a case series. J. Infect. Dis. 193, 760-764 (2006).
-
(2006)
J. Infect. Dis
, vol.193
, pp. 760-764
-
-
Ison, M.G.1
Gubareva, L.V.2
Atmar, R.L.3
Treanor, J.4
Hayden, F.G.5
-
82
-
-
46249111790
-
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
-
Collins, P. J. et al. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature 453, 1258-1261 (2008).
-
(2008)
Nature
, vol.453
, pp. 1258-1261
-
-
Collins, P.J.1
-
83
-
-
0031724750
-
Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus
-
Gubareva, L. V., Matrosovich, M. N., Brenner, M. K., Bethell, R. C. & Webster, R. G. Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus. J. Infect. Dis. 178, 1257-1262 (1998).
-
(1998)
J. Infect. Dis
, vol.178
, pp. 1257-1262
-
-
Gubareva, L.V.1
Matrosovich, M.N.2
Brenner, M.K.3
Bethell, R.C.4
Webster, R.G.5
-
84
-
-
0034699492
-
BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structurebased drug design
-
Babu, Y. S. et al. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structurebased drug design. J. Med. Chem. 43, 3482-3486 (2000).
-
(2000)
J. Med. Chem
, vol.43
, pp. 3482-3486
-
-
Babu, Y.S.1
-
85
-
-
59749091876
-
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity
-
Yamashita, M. et al. CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob. Agents Chemother. 53, 186-192 (2009).
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 186-192
-
-
Yamashita, M.1
-
86
-
-
0036211719
-
In vitro and in vivo activities of anti-influenza virus compound T-705
-
Furuta, Y. et al. In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob. Agents Chemother. 46, 977-981 (2002).
-
(2002)
Antimicrob. Agents Chemother
, vol.46
, pp. 977-981
-
-
Furuta, Y.1
-
87
-
-
62049083943
-
Structural and functional bases for broad-spectrum neutralization of avian and human influenza Aviruses
-
Sui, J. et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza Aviruses. Nature Struct. Mol. Biol. 16, 265-273 (2009).
-
(2009)
Nature Struct. Mol. Biol
, vol.16
, pp. 265-273
-
-
Sui, J.1
-
88
-
-
33846995457
-
Live attenuated versus inactivated influenza vaccine in infants and young children
-
Belshe, R. B. et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N. Engl. J. Med. 356, 685-696 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 685-696
-
-
Belshe, R.B.1
-
89
-
-
33645399959
-
Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine
-
Treanor, J. J., Campbell, J. D., Zangwill, K. M., Rowe, T. & Wolff, M. Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N. Engl. J. Med. 354, 1343-1351 (2006).
-
(2006)
N. Engl. J. Med
, vol.354
, pp. 1343-1351
-
-
Treanor, J.J.1
Campbell, J.D.2
Zangwill, K.M.3
Rowe, T.4
Wolff, M.5
-
90
-
-
33646549355
-
Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: Phase I randomised trial
-
Bresson, J. L. et al. Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I randomised trial. Lancet 367, 1657-1664 (2006).
-
(2006)
Lancet
, vol.367
, pp. 1657-1664
-
-
Bresson, J.L.1
-
91
-
-
33748447102
-
Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: A phase I randomised controlled trial
-
Lin, J. et al. Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase I randomised controlled trial. Lancet 368, 991-997 (2006).
-
(2006)
Lancet
, vol.368
, pp. 991-997
-
-
Lin, J.1
-
92
-
-
40549088240
-
Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults
-
Bernstein, D. I. et al. Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. J. Infect. Dis. 197, 667-675 (2008).
-
(2008)
J. Infect. Dis
, vol.197
, pp. 667-675
-
-
Bernstein, D.I.1
-
93
-
-
53749098101
-
Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1
-
Stephenson, I. et al. Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1. N. Engl. J. Med. 359, 1631-1633 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1631-1633
-
-
Stephenson, I.1
-
94
-
-
50949104571
-
An adjuvanted, low-dose, pandemic influenza A (H5N1) vaccine candidate is safe, immunogenic, and induces cross-reactive immune responses in healthy adults
-
Levie, K. et al. An adjuvanted, low-dose, pandemic influenza A (H5N1) vaccine candidate is safe, immunogenic, and induces cross-reactive immune responses in healthy adults. J. Infect. Dis. 198, 642-649 (2008).
-
(2008)
J. Infect. Dis
, vol.198
, pp. 642-649
-
-
Levie, K.1
-
95
-
-
67649250180
-
-
Suguitan, A. L. Jr et al. Live, attenua
-
Suguitan, A. L. Jr et al. Live, attenua
-
-
-
|