NS1 protein mutation I64T affects interferon responses and virulence of circulating H3N2 human influenza A viruses

Journal of Virology

Volumn 90, Issue 21, 2016, Pages 9693-9711

  DeDiego, Marta L ^a   Nogales, Aitor ^a   Lambert Emo, Kris ^a   Martinez Sobrido, Luis ^a   Topham, David J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 30 PROTEIN; DOUBLE STRANDED RNA; INTERFERON; MEMBRANE PROTEIN; NONSTRUCTURAL PROTEIN 1; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CPSF30 PROTEIN, HUMAN; VIRAL PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLUENZA A VIRUS (H3N2); INNATE IMMUNITY; INTERFERON INDUCTION; MOLECULAR CLONING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; VIROGENESIS; VIRUS ATTENUATION; VIRUS PATHOGENESIS; VIRUS TITRATION; VIRUS VIRULENCE; A-549 CELL LINE; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; DRUG EFFECT; GENETICS; HEK293 CELL LINE; IMMUNE EVASION; INFLUENZA; INFLUENZA A VIRUS (H1N1); MONONUCLEAR CELL; MUTATION; PATHOGENICITY; TUMOR CELL LINE; VERO CELL LINE; VIROLOGY; VIRULENCE;

A549 CELLS; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; HEK293 CELLS; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; INTERFERONS; LEUKOCYTES, MONONUCLEAR; MUTATION; RNA, DOUBLE-STRANDED; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE;

EID: 84994013927     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01039-16     Document Type: Article

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