NS1 protein amino acid changes D189N and V194I affect interferon responses, thermosensitivity, and virulence of circulating H3N2 human influenza A viruses

Journal of Virology

Volumn 91, Issue 5, 2017, Pages

  Nogales, Aitor ^a   Martinez Sobrido, Luis ^a   Topham, David J ^a   DeDiego, Marta L ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Antiviral response; Influenza virus; Innate immunity; NS1 protein; Pathogenesis; Virus host interactions

Indexed keywords

INTERFERON; NONSTRUCTURAL PROTEIN 1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CPSF30 PROTEIN, HUMAN; INS1 PROTEIN, INFLUENZA VIRUS; PROTEIN BINDING; VIRAL PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; HEAT SENSITIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPRECIPITATION; IMMUNOSURVEILLANCE; INFLUENZA A (H3N2); INFLUENZA A VIRUS (H3N2); INNATE IMMUNITY; MOUSE; MUTATION; NONHUMAN; PATHOGENICITY; PHENOTYPE; POLYADENYLATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIRUS TITRATION; VIRUS VIRULENCE; A-549 CELL LINE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHLOROCEBUS AETHIOPS; DOG; FEMALE; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; INFLUENZA; MDCK CELL LINE; METABOLISM; MICROBIAL VIABILITY; PHYSIOLOGY; PROTEIN SYNTHESIS; VERO CELL LINE; VIROLOGY; VIRULENCE; VIRUS REPLICATION;

A549 CELLS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; DOGS; FEMALE; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; INTERFERONS; MADIN DARBY CANINE KIDNEY CELLS; MICE, INBRED C57BL; MICROBIAL VIABILITY; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 85013870083     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01930-16     Document Type: Article

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