A single amino acid substitution in the novel H7N9 influenza a virus NS1 protein increases CPSF30 binding and virulence

Journal of Virology

Volumn 88, Issue 20, 2014, Pages 12146-12151

  Ayllon, Juan ^a   Domingues, Patricia ^b   Rajsbaum, Ricardo ^a   Miorin, Lisa ^a   Schmolke, Mirco ^a   Hale, Benjamin G ^b   García Sastre, Adolfo ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MRC UNIVERSITY OF GLASGOW CENTRE FOR VIRUS RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CPSF30 PROTEIN; NONSTRUCTURAL PROTEIN 1; UNCLASSIFIED DRUG; INS1 PROTEIN, INFLUENZA VIRUS; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A H7N9; MOUSE; NONHUMAN; PATHOGENICITY; PROTEIN BINDING; SENDAI VIRUS; SEQUENCE ANALYSIS; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; CHICKEN; GENETICS; METABOLISM; PHYSIOLOGY; VIRULENCE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; CHICKENS; GENE EXPRESSION; HUMANS; INFLUENZA A VIRUS, H7N9 SUBTYPE; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS; VIRULENCE;

EID: 84907915259     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01567-14     Document Type: Article

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