Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins

Virology Journal

Volumn 8, Issue , 2011, Pages

  Thomas, Miranda ^a   Kranjec, Christian ^a   Nagasaka, Kazunori ^a,c   Matlashewski, Greg ^b,d   Banks, Lawrence ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF TOKYO   (Japan)

^d WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 1; PDZ PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; VIRULENCE FACTOR; VIRUS PROTEIN;

ARTICLE; CELL POLARITY; CELL STRAIN HEK293; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; SIGNAL TRANSDUCTION; BINDING SITE; CELL LINE; HOST PATHOGEN INTERACTION; METABOLISM; PATHOGENICITY; PROTEIN DOMAIN; PROTEIN MOTIF; WESTERN BLOTTING;

AVES; INFLUENZA A VIRUS;

AMINO ACID MOTIFS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL POLARITY; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS;

EID: 78651504041     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-25     Document Type: Article

References (31)

1. NS1 protein of influenza A virus down-regulates apoptosis. OP Zhirnov TE Konakova T Wolff TD Klenk, J Virol 2002 76 1617 1625 10.1128/JVI.76.4.1617-1625. 2002 11799156
2. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. C Ehrhardt T Wolff S Pleschka O Planz W Beermann JG Bode M Schmolke S Ludwig, J Virol 2007 81 3058 3067 10.1128/JVI.02082-06 17229704
3. SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. YK Shin Y Li Q Liu DH Anderson LA Babiuk Y Zhou, J Virol 2007 81 12730 12739 10.1128/JVI.01427-07 17881440
4. PI3K signalling during influenza A virus infections. BG Hale RE Randall, Biochem Soc Trans 2007 35 186 187 10.1042/BST0350186 17371234
5. Large-scale sequence analysis of avian influenza isolates. JC Obenauer J Denson PK Mehta X Su S Mukatira DB Finkelstein X Xu J Wang J Ma Y Fan KM Rakestraw RG Webster E Hoffmann S Krauss J Zheng Z Zhang CW Naeve, Science 2006 311 1576 1580 10.1126/science.1121586 16439620
6. DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. CP Ponting C Phillips, Trends Biochem Sci 1995 20 10210 10213
7. PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. AS Fanning JM Anderson, J Clin Invest 1999 103 767 772 10.1172/JCI6509 10079096
8. The NS1 gene contributes to the virulence of H5N1 avian influenza viruses. Z Li Y Jiang P Jiao A Wang F Zhao G Tian X Wang K Yu Z Bu H Chen, J Virol 2006 80 11115 11123 10.1128/JVI.00993-06 16971424
9. Amelioration of influenza virus pathogenesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene. AN Cauthen DE Swayne MJ Sekellick PI Marcus DL Suarez, J Virol 2007 81 1838 1847 10.1128/JVI.01667-06 17121796
10. Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence. SM Soubies C Volmer G Croville J Loupias B Peralta P Costes C Lacroux JL Guérin R Volmer, J Virol 2010 84 6733 6747 10.1128/JVI.02427-09 20410267
11. The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. H Liu L Golebiewski EC Dow RM Krug RT Javier AP Rice, J Virol 2010 84 11164 11174 10.1128/JVI.01278-10 20702615
12. Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. Y Zhang J Dasgupta RZ Ma L Banks M Thomas XJ Chen, J Virol 2007 81 3618 3626 10.1128/JVI.02044-06 17267502
13. Analysis of specificity determinants in the interactions of different HPV E6 proteins with their PDZ domain-containing substrates. M Thomas J Dasgupta Y Zhang XJ Chen L Banks, Virology 2008 376 371 378 10.1016/j.virol.2008.03.021 18452965
14. Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells. D Pim A Storey M Thomas P Massimi L Banks, Oncogene 1994 9 1869 1876 8208532
15. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. D Gardiol C Kühne B Glaunsinger SS Lee R Javier L Banks, Oncogene 1999 18 5487 5496 10.1038/sj.onc.1202920 10523825
16. Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins. D Pim M Thomas L Banks, Oncogene 2002 21 8140 8148 10.1038/sj.onc.1206026 12444549
17. Transformation of mammalian cells with genes from procaryotes and eucaryotes. M Wigler R Sweet GK Sim B Wold A Pellicer E Lacy T Maniatis S Silverstein R Axel, Cell 1979 16 777 785 10.1016/0092-8674(79)90093-X 222468
18. A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. D Jackson MJ Hossain D Hickman DR Perez RA Lamb, Proc Natl Acad Sci USA 2008 105 4381 4386 10.1073/pnas.0800482105 18334632
19. Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1. IY Dobrosotskaya, Biochem Biophys Res Commun 2001 283 969 975 10.1006/bbrc.2001.4880 11350080
20. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. BA Glaunsinger SS Lee M Thomas L Banks R Javier, Oncogene 2000 19 5270 5280 10.1038/sj.onc.1203906 11077444
21. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. SS Lee B Glaunsinger F Mantovani L Banks RT Javier, J Virol 2000 74 9680 9693 10.1128/JVI.74.20.9680-9693.2000 11000240
22. HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation. M Thomas B Glaunsinger D Pim R Javier L Banks, Oncogene 2001 20 5431 5439 10.1038/sj.onc.1204719 11571640
23. Mutational analysis of the discs large tumour suppressor identifies domains responsible for human papillomavirus type 18 E6-mediated degradation. D Gardiol S Galizzi L Banks, J Gen Virol 2002 83 283 289 11807220
24. The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. M Thomas P Massimi C Navarro JP Borg L Banks, Oncogene 2005 24 6222 6230 10.1038/sj.onc.1208757 16103886
25. Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. M Thomas R Laura K Hepner E Guccione C Sawyers L Lasky L Banks, Oncogene 2002 21 5088 5096 10.1038/sj.onc.1205668 12140759
26. The Scribble and Par complexes in polarity and migration: friends or foes? PO Humbert LE Dow SM Russell, Trends Cell Biol 2006 16 622 630 10.1016/j.tcb.2006.10.005 17067797
27. Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. PO Humbert NA Grzeschik AM Brumby R Galea I Elsum HE Richardson, Oncogene 2008 27 6888 6907 10.1038/onc.2008.341 19029932
28. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. EK Pauli M Schmolke T Wolff D Viemann J Roth JG Bode S Ludwig, PLoS Pathog 2008 11 10001964
29. Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells. SM Soubies C Volmer JL Guérin R Volmer, Avian Dis 2010 54 1 Suppl 527 531 10.1637/8707-031709- Reg.1 20521689
30. Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling. KM Wigerius M Johansson, Cell Microbiol 2008 10 696 712 10.1111/j.1462-5822.2007.01076.x 18042258
31. Virulence detereminants of avian H5N1 influenza A virus in mammalian and avian hosts: the role of the C-terminal ESEV motif in the viral NS1 protein. F Zielecki I Semmler D Kalthoff D Voss S Mauel AD Gruber M Beer T Wolff, J Virol 2010 84 10708 18 10.1128/JVI.00610-10 20686040