-
1
-
-
84896125494
-
Evolution of the cancer stem cell model
-
Kreso A, Dick JE. Evolution of the cancer stem cell model. Cell Stem Cell (2014) 14(3):275-91. doi:10.1016/j.stem.2014.02.006
-
(2014)
Cell Stem Cell
, vol.14
, Issue.3
, pp. 275-291
-
-
Kreso, A.1
Dick, J.E.2
-
2
-
-
79952370202
-
The cancer stem cell: premises, promises and challenges
-
Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med (2011) 17(3):313-9. doi:10.1038/nm.2304
-
(2011)
Nat Med
, vol.17
, Issue.3
, pp. 313-319
-
-
Clevers, H.1
-
3
-
-
84903768676
-
Tackling the cancer stem cells - what challenges do they pose
-
Pattabiraman DR, Weinberg RA. Tackling the cancer stem cells - what challenges do they pose Nat Rev Drug Discov (2014) 13(7):497-512. doi:10.1038/nrd4253
-
(2014)
Nat Rev Drug Discov
, vol.13
, Issue.7
, pp. 497-512
-
-
Pattabiraman, D.R.1
Weinberg, R.A.2
-
4
-
-
84856226651
-
Cancer stem cells: an evolving concept
-
Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 12(2):133-43. doi:10.1038/nrc3184
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.2
, pp. 133-143
-
-
Nguyen, L.V.1
Vanner, R.2
Dirks, P.3
Eaves, C.J.4
-
5
-
-
33846242910
-
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia
-
Cox CV, Martin HM, Kearns PR, Virgo P, Evely RS, Blair A. Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia. Blood (2007) 109(2):674-82. doi:10.1182/blood-2006-06-030445
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 674-682
-
-
Cox, C.V.1
Martin, H.M.2
Kearns, P.R.3
Virgo, P.4
Evely, R.S.5
Blair, A.6
-
6
-
-
80051782265
-
Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations
-
Gerby B, Clappier E, Armstrong F, Deswarte C, Calvo J, Poglio S, et al. Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations. Leukemia (2011) 25(8):1249-58. doi:10.1038/leu.2011.93
-
(2011)
Leukemia
, vol.25
, Issue.8
, pp. 1249-1258
-
-
Gerby, B.1
Clappier, E.2
Armstrong, F.3
Deswarte, C.4
Calvo, J.5
Poglio, S.6
-
7
-
-
78650068497
-
Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance
-
Chiu PP, Jiang H, Dick JE. Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. Blood (2010) 116(24):5268-79. doi:10.1182/blood-2010-06-292300
-
(2010)
Blood
, vol.116
, Issue.24
, pp. 5268-5279
-
-
Chiu, P.P.1
Jiang, H.2
Dick, J.E.3
-
8
-
-
77953079694
-
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes
-
Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, et al. Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev (2010) 24(11):1093-105. doi:10.1101/gad.1897910
-
(2010)
Genes Dev
, vol.24
, Issue.11
, pp. 1093-1105
-
-
Tremblay, M.1
Tremblay, C.S.2
Herblot, S.3
Aplan, P.D.4
Hébert, J.5
Perreault, C.6
-
9
-
-
80051640151
-
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL
-
Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood (2011) 118(6):1579-90. doi:10.1182/blood-2010-08-300343
-
(2011)
Blood
, vol.118
, Issue.6
, pp. 1579-1590
-
-
Tatarek, J.1
Cullion, K.2
Ashworth, T.3
Gerstein, R.4
Aster, J.C.5
Kelliher, M.A.6
-
10
-
-
2942579675
-
TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
-
O'Neil J, Shank J, Cusson N, Murre C, Kelliher M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell (2004) 5(6):587-96. doi:10.1016/j.ccr.2004.05.023
-
(2004)
Cancer Cell
, vol.5
, Issue.6
, pp. 587-596
-
-
O'Neil, J.1
Shank, J.2
Cusson, N.3
Murre, C.4
Kelliher, M.5
-
11
-
-
76749097260
-
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal
-
McCormack MP, Young LF, Vasudevan S, de Graaf CA, Codrington R, Rabbitts TH, et al. The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science (2010) 327(5967):879-83. doi:10.1126/science.1182378
-
(2010)
Science
, vol.327
, Issue.5967
, pp. 879-883
-
-
McCormack, M.P.1
Young, L.F.2
Vasudevan, S.3
de Graaf, C.A.4
Codrington, R.5
Rabbitts, T.H.6
-
12
-
-
84919683992
-
SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells
-
Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, et al. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet (2014) 10(12):e1004768. doi:10.1371/journal.pgen.1004768
-
(2014)
PLoS Genet
, vol.10
, Issue.12
-
-
Gerby, B.1
Tremblay, C.S.2
Tremblay, M.3
Rojas-Sutterlin, S.4
Herblot, S.5
Hébert, J.6
-
13
-
-
42649124306
-
Molecular pathogenesis of T-cell leukaemia and lymphoma
-
Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol (2008) 8(5):380-90. doi:10.1038/nri2304
-
(2008)
Nat Rev Immunol
, vol.8
, Issue.5
, pp. 380-390
-
-
Aifantis, I.1
Raetz, E.2
Buonamici, S.3
-
14
-
-
84979586915
-
The genetics and mechanisms of T cell acute lymphoblastic leukaemia
-
Belver L, Ferrando A. The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer (2016) 16(8):494-507. doi:10.1038/nrc.2016.63
-
(2016)
Nat Rev Cancer
, vol.16
, Issue.8
, pp. 494-507
-
-
Belver, L.1
Ferrando, A.2
-
15
-
-
85016232457
-
Genetic basis of acute lymphoblastic leukemia
-
Iacobucci I, Mullighan CG. Genetic basis of acute lymphoblastic leukemia. J Clin Oncol (2017) 35(9):975-83. doi:10.1200/JCO.2016.70.7836
-
(2017)
J Clin Oncol
, vol.35
, Issue.9
, pp. 975-983
-
-
Iacobucci, I.1
Mullighan, C.G.2
-
16
-
-
0030658039
-
Oncogenic transcription factors in the human acute leukemias
-
Look AT. Oncogenic transcription factors in the human acute leukemias. Science (1997) 278(5340):1059-64. doi:10.1126/science.278.5340.1059
-
(1997)
Science
, vol.278
, Issue.5340
, pp. 1059-1064
-
-
Look, A.T.1
-
17
-
-
84866446850
-
Thymus-autonomous T cell development in the absence of progenitor import
-
Martins VC, Ruggiero E, Schlenner SM, Madan V, Schmidt M, Fink PJ, et al. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med (2012) 209(8):1409-17. doi:10.1084/jem.20120846
-
(2012)
J Exp Med
, vol.209
, Issue.8
, pp. 1409-1417
-
-
Martins, V.C.1
Ruggiero, E.2
Schlenner, S.M.3
Madan, V.4
Schmidt, M.5
Fink, P.J.6
-
18
-
-
84866463556
-
Thymocytes may persist and differentiate without any input from bone marrow progenitors
-
Peaudecerf L, Lemos S, Galgano A, Krenn G, Vasseur F, Di Santo JP, et al. Thymocytes may persist and differentiate without any input from bone marrow progenitors. J Exp Med (2012) 209(8):1401-8. doi:10.1084/jem.20120845
-
(2012)
J Exp Med
, vol.209
, Issue.8
, pp. 1401-1408
-
-
Peaudecerf, L.1
Lemos, S.2
Galgano, A.3
Krenn, G.4
Vasseur, F.5
Di Santo, J.P.6
-
19
-
-
40749150603
-
Acute lymphoblastic leukaemia
-
Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet (2008) 371(9617):1030-43. doi:10.1016/S0140-6736(08)60457-2
-
(2008)
Lancet
, vol.371
, Issue.9617
, pp. 1030-1043
-
-
Pui, C.H.1
Robison, L.L.2
Look, A.T.3
-
20
-
-
79952078495
-
Biology, risk stratification, and therapy of pediatric acute leukemias: an update
-
Pui CH, Carroll WL, Meshinchi S, Arceci RJ. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol (2011) 29(5):551-65. doi:10.1200/JCO.2010.30.7405
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 551-565
-
-
Pui, C.H.1
Carroll, W.L.2
Meshinchi, S.3
Arceci, R.J.4
-
21
-
-
79952095577
-
Modern therapy of acute lymphoblastic leukemia
-
Bassan R, Hoelzer D. Modern therapy of acute lymphoblastic leukemia. J Clin Oncol (2011) 29(5):532-43. doi:10.1200/JCO.2010.30.1382
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 532-543
-
-
Bassan, R.1
Hoelzer, D.2
-
22
-
-
57849138262
-
Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study
-
Nguyen K, Devidas M, Cheng SC, La M, Raetz EA, Carroll WL, et al. Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study. Leukemia (2008) 22(12):2142-50. doi:10.1038/leu.2008.251
-
(2008)
Leukemia
, vol.22
, Issue.12
, pp. 2142-2150
-
-
Nguyen, K.1
Devidas, M.2
Cheng, S.C.3
La, M.4
Raetz, E.A.5
Carroll, W.L.6
-
23
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence MS, Stojanov P, Mermel CH, Robinson JT, Garraway LA, Golub TR, et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature (2014) 505(7484):495-501. doi:10.1038/nature12912
-
(2014)
Nature
, vol.505
, Issue.7484
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
Robinson, J.T.4
Garraway, L.A.5
Golub, T.R.6
-
24
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature (2013) 500(7463):415-21. doi:10.1038/nature12477
-
(2013)
Nature
, vol.500
, Issue.7463
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.4
Behjati, S.5
Biankin, A.V.6
-
25
-
-
27244440324
-
Molecular genetics of acute lymphoblastic leukemia
-
Armstrong SA, Look AT. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol (2005) 23(26):6306-15. doi:10.1200/JCO.2005.05.047
-
(2005)
J Clin Oncol
, vol.23
, Issue.26
, pp. 6306-6315
-
-
Armstrong, S.A.1
Look, A.T.2
-
26
-
-
17144474314
-
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
-
Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell (2002) 1(1):75-87. doi:10.1016/S1535-6108(02)00018-1
-
(2002)
Cancer Cell
, vol.1
, Issue.1
, pp. 75-87
-
-
Ferrando, A.A.1
Neuberg, D.S.2
Staunton, J.3
Loh, M.L.4
Huard, C.5
Raimondi, S.C.6
-
27
-
-
85026366349
-
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
-
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, et al. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet (2017) 49(8):1211-8. doi:10.1038/ng.3909
-
(2017)
Nat Genet
, vol.49
, Issue.8
, pp. 1211-1218
-
-
Liu, Y.1
Easton, J.2
Shao, Y.3
Maciaszek, J.4
Wang, Z.5
Wilkinson, M.R.6
-
28
-
-
0032722671
-
Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding
-
Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development (1999) 126(20):4603-15.
-
(1999)
Development
, vol.126
, Issue.20
, pp. 4603-4615
-
-
Porcher, C.1
Liao, E.C.2
Fujiwara, Y.3
Zon, L.I.4
Orkin, S.H.5
-
29
-
-
0028858855
-
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
-
Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature (1995) 373(6513):432-4. doi:10.1038/373432a0
-
(1995)
Nature
, vol.373
, Issue.6513
, pp. 432-434
-
-
Shivdasani, R.A.1
Mayer, E.L.2
Orkin, S.H.3
-
30
-
-
0028278325
-
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
-
Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell (1994) 78(1):45-57. doi:10.1016/0092-8674(94)90571-1
-
(1994)
Cell
, vol.78
, Issue.1
, pp. 45-57
-
-
Warren, A.J.1
Colledge, W.H.2
Carlton, M.B.3
Evans, M.J.4
Smith, A.J.5
Rabbitts, T.H.6
-
31
-
-
33745079016
-
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation
-
Capron C, Lecluse Y, Kaushik AL, Foudi A, Lacout C, Sekkai D, et al. The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation. Blood (2006) 107(12):4678-86. doi:10.1182/blood-2005-08-3145
-
(2006)
Blood
, vol.107
, Issue.12
, pp. 4678-4686
-
-
Capron, C.1
Lecluse, Y.2
Kaushik, A.L.3
Foudi, A.4
Lacout, C.5
Sekkai, D.6
-
32
-
-
84942437038
-
LMO2 at 25 years: a paradigm of chromosomal translocation proteins
-
Chambers J, Rabbitts TH. LMO2 at 25 years: a paradigm of chromosomal translocation proteins. Open Biol (2015) 5(6):150062. doi:10.1098/rsob.150062
-
(2015)
Open Biol
, vol.5
, Issue.6
, pp. 150062
-
-
Chambers, J.1
Rabbitts, T.H.2
-
33
-
-
85018900318
-
SCL/TAL1: a multifaceted regulator from blood development to disease
-
Porcher C, Chagraoui H, Kristiansen MS. SCL/TAL1: a multifaceted regulator from blood development to disease. Blood (2017) 129(15):2051-60. doi:10.1182/blood-2016-12-754051
-
(2017)
Blood
, vol.129
, Issue.15
, pp. 2051-2060
-
-
Porcher, C.1
Chagraoui, H.2
Kristiansen, M.S.3
-
34
-
-
0029815976
-
Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha
-
Kelliher MA, Seldin DC, Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J (1996) 15(19):5160-6.
-
(1996)
EMBO J
, vol.15
, Issue.19
, pp. 5160-5166
-
-
Kelliher, M.A.1
Seldin, D.C.2
Leder, P.3
-
35
-
-
0030921503
-
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
-
Aplan PD, Jones CA, Chervinsky DS, Zhao X, Ellsworth M, Wu C, et al. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J (1997) 16(9):2408-19. doi:10.1093/emboj/16.9.2408
-
(1997)
EMBO J
, vol.16
, Issue.9
, pp. 2408-2419
-
-
Aplan, P.D.1
Jones, C.A.2
Chervinsky, D.S.3
Zhao, X.4
Ellsworth, M.5
Wu, C.6
-
36
-
-
0004328021
-
Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript
-
Begley CG, Aplan PD, Davey MP, Nakahara K, Tchorz K, Kurtzberg J, et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci U S A (1989) 86(6):2031-5. doi:10.1073/pnas.86.6.2031
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, Issue.6
, pp. 2031-2035
-
-
Begley, C.G.1
Aplan, P.D.2
Davey, M.P.3
Nakahara, K.4
Tchorz, K.5
Kurtzberg, J.6
-
37
-
-
0027447707
-
Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes
-
Breit TM, Mol EJ, Wolvers-Tettero IL, Ludwig WD, van Wering ER, van Dongen JJ. Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes. J Exp Med (1993) 177(4):965-77. doi:10.1084/jem.177.4.965
-
(1993)
J Exp Med
, vol.177
, Issue.4
, pp. 965-977
-
-
Breit, T.M.1
Mol, E.J.2
Wolvers-Tettero, I.L.3
Ludwig, W.D.4
van Wering, E.R.5
van Dongen, J.J.6
-
38
-
-
84917710235
-
Oncogene regulation
-
Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, et al. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science (2014) 346(6215):1373-7. doi:10.1126/science.1259037
-
(2014)
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science
, vol.346
, Issue.6215
, pp. 1373-1377
-
-
Mansour, M.R.1
Abraham, B.J.2
Anders, L.3
Berezovskaya, A.4
Gutierrez, A.5
Durbin, A.D.6
-
39
-
-
0028335821
-
Hox11 controls the genesis of the spleen
-
Roberts CW, Shutter JR, Korsmeyer SJ. Hox11 controls the genesis of the spleen. Nature (1994) 368(6473):747-9. doi:10.1038/368747a0
-
(1994)
Nature
, vol.368
, Issue.6473
, pp. 747-749
-
-
Roberts, C.W.1
Shutter, J.R.2
Korsmeyer, S.J.3
-
40
-
-
78149348102
-
The TLX1 oncogene drives aneuploidy in T cell transformation
-
De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, et al. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med (2010) 16(11):1321-7. doi:10.1038/nm.2246
-
(2010)
Nat Med
, vol.16
, Issue.11
, pp. 1321-1327
-
-
De Keersmaecker, K.1
Real, P.J.2
Gatta, G.D.3
Palomero, T.4
Sulis, M.L.5
Tosello, V.6
-
41
-
-
84877587301
-
The role of HOX genes in normal hematopoiesis and acute leukemia
-
Alharbi RA, Pettengell R, Pandha HS, Morgan R. The role of HOX genes in normal hematopoiesis and acute leukemia. Leukemia (2013) 27(5):1000-8. doi:10.1038/leu.2012.356
-
(2013)
Leukemia
, vol.27
, Issue.5
, pp. 1000-1008
-
-
Alharbi, R.A.1
Pettengell, R.2
Pandha, H.S.3
Morgan, R.4
-
42
-
-
27644484043
-
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes
-
Dik WA, Brahim W, Braun C, Asnafi V, Dastugue N, Bernard OA, et al. CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes. Leukemia (2005) 19(11):1948-57. doi:10.1038/sj.leu.2403891
-
(2005)
Leukemia
, vol.19
, Issue.11
, pp. 1948-1957
-
-
Dik, W.A.1
Brahim, W.2
Braun, C.3
Asnafi, V.4
Dastugue, N.5
Bernard, O.A.6
-
43
-
-
58749095816
-
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
-
Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol (2009) 10(2):147-56. doi:10.1016/S1470-2045(08)70314-0
-
(2009)
Lancet Oncol
, vol.10
, Issue.2
, pp. 147-156
-
-
Coustan-Smith, E.1
Mullighan, C.G.2
Onciu, M.3
Behm, F.G.4
Raimondi, S.C.5
Pei, D.6
-
44
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 306(5694):269-71. doi:10.1126/science.1102160
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
-
45
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 66(4):649-61. doi:10.1016/0092-8674(91)90111-B
-
(1991)
Cell
, vol.66
, Issue.4
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
Soreng, A.L.4
Reynolds, T.C.5
Smith, S.D.6
-
46
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
-
O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 204(8):1813-24. doi:10.1084/jem.20070876
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1813-1824
-
-
O'Neil, J.1
Grim, J.2
Strack, P.3
Rao, S.4
Tibbitts, D.5
Winter, C.6
-
47
-
-
34547820257
-
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
-
Thompson BJ, Buonamici S, Sulis ML, Palomero T, Vilimas T, Basso G, et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med (2007) 204(8):1825-35. doi:10.1084/jem.20070872
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1825-1835
-
-
Thompson, B.J.1
Buonamici, S.2
Sulis, M.L.3
Palomero, T.4
Vilimas, T.5
Basso, G.6
-
48
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med (1996) 183(5):2283-91. doi:10.1084/jem.183.5.2283
-
(1996)
J Exp Med
, vol.183
, Issue.5
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
Hasserjian, R.P.4
Soffer, B.5
Sklar, J.6
-
49
-
-
33845306813
-
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
-
Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 103(48):18261-6. doi:10.1073/pnas.0606108103
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.48
, pp. 18261-18266
-
-
Palomero, T.1
Lim, W.K.2
Odom, D.T.3
Sulis, M.L.4
Real, P.J.5
Margolin, A.6
-
50
-
-
78649363017
-
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
-
Wendorff AA, Koch U, Wunderlich FT, Wirth S, Dubey C, Brüning JC, et al. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 33(5):671-84. doi:10.1016/j.immuni.2010.11.014
-
(2010)
Immunity
, vol.33
, Issue.5
, pp. 671-684
-
-
Wendorff, A.A.1
Koch, U.2
Wunderlich, F.T.3
Wirth, S.4
Dubey, C.5
Brüning, J.C.6
-
51
-
-
33750317437
-
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc
-
Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol (2006) 26(21):8022-31. doi:10.1128/MCB.01091-06
-
(2006)
Mol Cell Biol
, vol.26
, Issue.21
, pp. 8022-8031
-
-
Sharma, V.M.1
Calvo, J.A.2
Draheim, K.M.3
Cunningham, L.A.4
Hermance, N.5
Beverly, L.6
-
52
-
-
33746546368
-
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 20(15):2096-109. doi:10.1101/gad.1450406
-
(2006)
Genes Dev
, vol.20
, Issue.15
, pp. 2096-2109
-
-
Weng, A.P.1
Millholland, J.M.2
Yashiro-Ohtani, Y.3
Arcangeli, M.L.4
Lau, A.5
Wai, C.6
-
53
-
-
77950356588
-
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia
-
Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, et al. Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood (2010) 115(9):1735-45. doi:10.1182/blood-2009-07-235143
-
(2010)
Blood
, vol.115
, Issue.9
, pp. 1735-1745
-
-
Sanda, T.1
Li, X.2
Gutierrez, A.3
Ahn, Y.4
Neuberg, D.S.5
O'Neil, J.6
-
54
-
-
84856747744
-
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
-
Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Flaherty MS, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med (2012) 18(2):298-301. doi:10.1038/nm.2651
-
(2012)
Nat Med
, vol.18
, Issue.2
, pp. 298-301
-
-
Ntziachristos, P.1
Tsirigos, A.2
Van Vlierberghe, P.3
Nedjic, J.4
Trimarchi, T.5
Flaherty, M.S.6
-
55
-
-
84907526739
-
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
-
Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L, et al. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature (2014) 514(7523):513-7. doi:10.1038/nature13605
-
(2014)
Nature
, vol.514
, Issue.7523
, pp. 513-517
-
-
Ntziachristos, P.1
Tsirigos, A.2
Welstead, G.G.3
Trimarchi, T.4
Bakogianni, S.5
Xu, L.6
-
56
-
-
84920580721
-
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
-
Van der Meulen J, Sanghvi V, Mavrakis K, Durinck K, Fang F, Matthijssens F, et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. Blood (2015) 125(1):13-21. doi:10.1182/blood-2014-05-577270
-
(2015)
Blood
, vol.125
, Issue.1
, pp. 13-21
-
-
Van der Meulen, J.1
Sanghvi, V.2
Mavrakis, K.3
Durinck, K.4
Fang, F.5
Matthijssens, F.6
-
57
-
-
84959520560
-
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia
-
Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, et al. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. Genes Dev (2016) 30(5):508-21. doi:10.1101/gad.276790.115
-
(2016)
Genes Dev
, vol.30
, Issue.5
, pp. 508-521
-
-
Benyoucef, A.1
Palii, C.G.2
Wang, C.3
Porter, C.J.4
Chu, A.5
Dai, F.6
-
58
-
-
85026345400
-
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
-
Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, et al. Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet (2017) 49(8):1274-81. doi:10.1038/ng.3900
-
(2017)
Nat Genet
, vol.49
, Issue.8
, pp. 1274-1281
-
-
Seki, M.1
Kimura, S.2
Isobe, T.3
Yoshida, K.4
Ueno, H.5
Nakajima-Takagi, Y.6
-
59
-
-
33750313208
-
Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells
-
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 66(19):9339-44. doi:10.1158/0008-5472.CAN-06-3126
-
(2006)
Cancer Res
, vol.66
, Issue.19
, pp. 9339-9344
-
-
Clarke, M.F.1
Dick, J.E.2
Dirks, P.B.3
Eaves, C.J.4
Jamieson, C.H.5
Jones, D.L.6
-
60
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 367(6464):645-8. doi:10.1038/367645a0
-
(1994)
Nature
, vol.367
, Issue.6464
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
-
61
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 3(7):730-7. doi:10.1038/nm0797-730
-
(1997)
Nat Med
, vol.3
, Issue.7
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
62
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 100(7):3983-8. doi:10.1073/pnas.0530291100
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.7
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
63
-
-
78751676408
-
Cells of origin in cancer
-
Visvader JE. Cells of origin in cancer. Nature (2011) 469(7330):314-22. doi:10.1038/nature09781
-
(2011)
Nature
, vol.469
, Issue.7330
, pp. 314-322
-
-
Visvader, J.E.1
-
64
-
-
78650950098
-
Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R?c-deficient mice
-
Sarry JE, Murphy K, Perry R, Sanchez PV, Secreto A, Keefer C, et al. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R?c-deficient mice. J Clin Invest (2011) 121(1):384-95. doi:10.1172/JCI41495
-
(2011)
J Clin Invest
, vol.121
, Issue.1
, pp. 384-395
-
-
Sarry, J.E.1
Murphy, K.2
Perry, R.3
Sanchez, P.V.4
Secreto, A.5
Keefer, C.6
-
65
-
-
34547113747
-
Tumor growth need not be driven by rare cancer stem cells
-
Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A. Tumor growth need not be driven by rare cancer stem cells. Science (2007) 317(5836):337. doi:10.1126/science.1142596
-
(2007)
Science
, vol.317
, Issue.5836
, pp. 337
-
-
Kelly, P.N.1
Dakic, A.2
Adams, J.M.3
Nutt, S.L.4
Strasser, A.5
-
66
-
-
7244223336
-
Characterization of acute lymphoblastic leukemia progenitor cells
-
Cox CV, Evely RS, Oakhill A, Pamphilon DH, Goulden NJ, Blair A. Characterization of acute lymphoblastic leukemia progenitor cells. Blood (2004) 104(9):2919-25. doi:10.1182/blood-2004-03-0901
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2919-2925
-
-
Cox, C.V.1
Evely, R.S.2
Oakhill, A.3
Pamphilon, D.H.4
Goulden, N.J.5
Blair, A.6
-
67
-
-
65149100417
-
Expression of CD133 on leukemia-initiating cells in childhood ALL
-
Cox CV, Diamanti P, Evely RS, Kearns PR, Blair A. Expression of CD133 on leukemia-initiating cells in childhood ALL. Blood (2009) 113(14):3287-96. doi:10.1182/blood-2008-04-154187
-
(2009)
Blood
, vol.113
, Issue.14
, pp. 3287-3296
-
-
Cox, C.V.1
Diamanti, P.2
Evely, R.S.3
Kearns, P.R.4
Blair, A.5
-
68
-
-
20944434753
-
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
-
Castor A, Nilsson L, Astrand-Grundström I, Buitenhuis M, Ramirez C, Anderson K, et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med (2005) 11(6):630-7. doi:10.1038/nm1253
-
(2005)
Nat Med
, vol.11
, Issue.6
, pp. 630-637
-
-
Castor, A.1
Nilsson, L.2
Astrand-Grundström, I.3
Buitenhuis, M.4
Ramirez, C.5
Anderson, K.6
-
69
-
-
84920704603
-
Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement
-
Bardini M, Woll PS, Corral L, Luc S, Wittmann L, Ma Z, et al. Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement. Leukemia (2015) 29(1):38-50. doi:10.1038/leu.2014.154
-
(2015)
Leukemia
, vol.29
, Issue.1
, pp. 38-50
-
-
Bardini, M.1
Woll, P.S.2
Corral, L.3
Luc, S.4
Wittmann, L.5
Ma, Z.6
-
70
-
-
30444436343
-
Activating Notch1 mutations in mouse models of T-ALL
-
O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, et al. Activating Notch1 mutations in mouse models of T-ALL. Blood (2006) 107(2):781-5. doi:10.1182/blood-2005-06-2553
-
(2006)
Blood
, vol.107
, Issue.2
, pp. 781-785
-
-
O'Neil, J.1
Calvo, J.2
McKenna, K.3
Krishnamoorthy, V.4
Aster, J.C.5
Bassing, C.H.6
-
71
-
-
84947344019
-
Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL
-
Cui Y, Onozawa M, Garber HR, Samsel L, Wang Z, McCoy JP, et al. Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL. Blood (2015) 125(19):2958-67. doi:10.1182/blood-2014-10-609271
-
(2015)
Blood
, vol.125
, Issue.19
, pp. 2958-2967
-
-
Cui, Y.1
Onozawa, M.2
Garber, H.R.3
Samsel, L.4
Wang, Z.5
McCoy, J.P.6
-
72
-
-
84873578601
-
Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
-
Chiang MY, Shestova O, Xu L, Aster JC, Pear WS. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood (2013) 121(6):905-17. doi:10.1182/blood-2012-03-416503
-
(2013)
Blood
, vol.121
, Issue.6
, pp. 905-917
-
-
Chiang, M.Y.1
Shestova, O.2
Xu, L.3
Aster, J.C.4
Pear, W.S.5
-
73
-
-
44349088690
-
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
-
Guo W, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, et al. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature (2008) 453(7194):529-33. doi:10.1038/nature06933
-
(2008)
Nature
, vol.453
, Issue.7194
, pp. 529-533
-
-
Guo, W.1
Lasky, J.L.2
Chang, C.J.3
Mosessian, S.4
Lewis, X.5
Xiao, Y.6
-
74
-
-
84916917855
-
Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia
-
Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner J, et al. Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia. Cancer Res (2014) 74(23):7048-59. doi:10.1158/0008-5472.CAN-14-1470
-
(2014)
Cancer Res
, vol.74
, Issue.23
, pp. 7048-7059
-
-
Schubbert, S.1
Cardenas, A.2
Chen, H.3
Garcia, C.4
Guo, W.5
Bradner, J.6
-
75
-
-
17844403755
-
Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
-
Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2005) 102(17):6068-73. doi:10.1073/pnas.0408708102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.17
, pp. 6068-6073
-
-
Langenau, D.M.1
Feng, H.2
Berghmans, S.3
Kanki, J.P.4
Kutok, J.L.5
Look, A.T.6
-
76
-
-
77951443642
-
High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia
-
Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, et al. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood (2010) 115(16):3296-303. doi:10.1182/blood-2009-10-246488
-
(2010)
Blood
, vol.115
, Issue.16
, pp. 3296-3303
-
-
Smith, A.C.1
Raimondi, A.R.2
Salthouse, C.D.3
Ignatius, M.S.4
Blackburn, J.S.5
Mizgirev, I.V.6
-
77
-
-
84896070368
-
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation
-
Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, et al. Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell (2014) 25(3):366-78. doi:10.1016/j.ccr.2014.01.032
-
(2014)
Cancer Cell
, vol.25
, Issue.3
, pp. 366-378
-
-
Blackburn, J.S.1
Liu, S.2
Wilder, J.L.3
Dobrinski, K.P.4
Lobbardi, R.5
Moore, F.E.6
-
78
-
-
84897132895
-
Nice neighborhood: emerging concepts of the stem cell niche
-
Scadden DT. Nice neighborhood: emerging concepts of the stem cell niche. Cell (2014) 157(1):41-50. doi:10.1016/j.cell.2014.02.013
-
(2014)
Cell
, vol.157
, Issue.1
, pp. 41-50
-
-
Scadden, D.T.1
-
79
-
-
84892610064
-
The bone marrow niche for haematopoietic stem cells
-
Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature (2014) 505(7483):327-34. doi:10.1038/nature12984
-
(2014)
Nature
, vol.505
, Issue.7483
, pp. 327-334
-
-
Morrison, S.J.1
Scadden, D.T.2
-
80
-
-
78650949272
-
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
-
Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW, Druker BJ. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest (2011) 121(1):396-409. doi:10.1172/JCI35721
-
(2011)
J Clin Invest
, vol.121
, Issue.1
, pp. 396-409
-
-
Corbin, A.S.1
Agarwal, A.2
Loriaux, M.3
Cortes, J.4
Deininger, M.W.5
Druker, B.J.6
-
81
-
-
74049121331
-
Contribution of bone microenvironment to leukemogenesis and leukemia progression
-
Ayala F, Dewar R, Kieran M, Kalluri R. Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia (2009) 23(12):2233-41. doi:10.1038/leu.2009.175
-
(2009)
Leukemia
, vol.23
, Issue.12
, pp. 2233-2241
-
-
Ayala, F.1
Dewar, R.2
Kieran, M.3
Kalluri, R.4
-
82
-
-
84930583383
-
CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance
-
Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, et al. CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance. Cancer Cell (2015) 27(6):755-68. doi:10.1016/j.ccell.2015.05.002
-
(2015)
Cancer Cell
, vol.27
, Issue.6
, pp. 755-768
-
-
Pitt, L.A.1
Tikhonova, A.N.2
Hu, H.3
Trimarchi, T.4
King, B.5
Gong, Y.6
-
83
-
-
84930587531
-
CXCR4 is required for leukemia-initiating cell activity in T cell acute lymphoblastic leukemia
-
Passaro D, Irigoyen M, Catherinet C, Gachet S, Da Costa De Jesus C, Lasgi C, et al. CXCR4 is required for leukemia-initiating cell activity in T cell acute lymphoblastic leukemia. Cancer Cell (2015) 27(6):769-79. doi:10.1016/j.ccell.2015.05.003
-
(2015)
Cancer Cell
, vol.27
, Issue.6
, pp. 769-779
-
-
Passaro, D.1
Irigoyen, M.2
Catherinet, C.3
Gachet, S.4
Da Costa De Jesus, C.5
Lasgi, C.6
-
84
-
-
84866445717
-
Self-renewal of thymocytes in the absence of competitive precursor replenishment
-
Boehm T. Self-renewal of thymocytes in the absence of competitive precursor replenishment. J Exp Med (2012) 209(8):1397-400. doi:10.1084/jem.20121412
-
(2012)
J Exp Med
, vol.209
, Issue.8
, pp. 1397-1400
-
-
Boehm, T.1
-
85
-
-
84901246854
-
Cell competition is a tumour suppressor mechanism in the thymus
-
Martins VC, Busch K, Juraeva D, Blum C, Ludwig C, Rasche V, et al. Cell competition is a tumour suppressor mechanism in the thymus. Nature (2014) 509(7501):465-70. doi:10.1038/nature13317
-
(2014)
Nature
, vol.509
, Issue.7501
, pp. 465-470
-
-
Martins, V.C.1
Busch, K.2
Juraeva, D.3
Blum, C.4
Ludwig, C.5
Rasche, V.6
-
86
-
-
84856738988
-
Hematopoiesis: a human perspective
-
Doulatov S, Notta F, Laurenti E, Dick JE. Hematopoiesis: a human perspective. Cell Stem Cell (2012) 10(2):120-36. doi:10.1016/j.stem.2012.01.006
-
(2012)
Cell Stem Cell
, vol.10
, Issue.2
, pp. 120-136
-
-
Doulatov, S.1
Notta, F.2
Laurenti, E.3
Dick, J.E.4
-
87
-
-
78651486442
-
Densely interconnected transcriptional circuits control cell states in human hematopoiesis
-
Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell (2011) 144(2):296-309. doi:10.1016/j.cell.2011.01.004
-
(2011)
Cell
, vol.144
, Issue.2
, pp. 296-309
-
-
Novershtern, N.1
Subramanian, A.2
Lawton, L.N.3
Mak, R.H.4
Haining, W.N.5
McConkey, M.E.6
-
88
-
-
84934442657
-
Transcriptional regulation of haematopoietic stem cells
-
Wilkinson AC, Gottgens B. Transcriptional regulation of haematopoietic stem cells. Adv Exp Med Biol (2013) 786:187-212. doi:10.1007/978-94-007-6621-1_11
-
(2013)
Adv Exp Med Biol
, vol.786
, pp. 187-212
-
-
Wilkinson, A.C.1
Gottgens, B.2
-
90
-
-
0030999645
-
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
-
Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 16(11):3145-57. doi:10.1093/emboj/16.11.3145
-
(1997)
EMBO J
, vol.16
, Issue.11
, pp. 3145-3157
-
-
Wadman, I.A.1
Osada, H.2
Grutz, G.G.3
Agulnick, A.D.4
Westphal, H.5
Forster, A.6
-
91
-
-
77957348625
-
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
-
Wilson NK, Foster SD, Wang X, Knezevic K, Schutte J, Kaimakis P, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 7(4):532-44. doi:10.1016/j.stem.2010.07.016
-
(2010)
Cell Stem Cell
, vol.7
, Issue.4
, pp. 532-544
-
-
Wilson, N.K.1
Foster, S.D.2
Wang, X.3
Knezevic, K.4
Schutte, J.5
Kaimakis, P.6
-
92
-
-
84886240466
-
Transcriptional hierarchies regulating early blood cell development
-
Moignard V, Woodhouse S, Fisher J, Gottgens B. Transcriptional hierarchies regulating early blood cell development. Blood Cells Mol Dis (2013) 51(4):239-47. doi:10.1016/j.bcmd.2013.07.007
-
(2013)
Blood Cells Mol Dis
, vol.51
, Issue.4
, pp. 239-247
-
-
Moignard, V.1
Woodhouse, S.2
Fisher, J.3
Gottgens, B.4
-
93
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells
-
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 122(6):947-56. doi:10.1016/j.cell.2005.08.020
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
Johnstone, S.E.4
Levine, S.S.5
Zucker, J.P.6
-
94
-
-
33745456986
-
Core transcriptional regulatory circuitry in human hepatocytes
-
Odom DT, Dowell RD, Jacobsen ES, Nekludova L, Rolfe PA, Danford TW, et al. Core transcriptional regulatory circuitry in human hepatocytes. Mol Syst Biol (2006) 2(2006):0017. doi:10.1038/msb4100059
-
(2006)
Mol Syst Biol
, vol.2
, Issue.2006
, pp. 0017
-
-
Odom, D.T.1
Dowell, R.D.2
Jacobsen, E.S.3
Nekludova, L.4
Rolfe, P.A.5
Danford, T.W.6
-
95
-
-
84960349182
-
Models of human core transcriptional regulatory circuitries
-
Saint-Andre V, Federation AJ, Lin CY, Abraham BJ, Reddy J, Lee TI, et al. Models of human core transcriptional regulatory circuitries. Genome Res (2016) 26(3):385-96. doi:10.1101/gr.197590.115
-
(2016)
Genome Res
, vol.26
, Issue.3
, pp. 385-396
-
-
Saint-Andre, V.1
Federation, A.J.2
Lin, C.Y.3
Abraham, B.J.4
Reddy, J.5
Lee, T.I.6
-
96
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 126(4):663-76. doi:10.1016/j.cell.2006.07.024
-
(2006)
Cell
, vol.126
, Issue.4
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
97
-
-
84915791031
-
Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells
-
Batta K, Florkowska M, Kouskoff V, Lacaud G. Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Rep (2014) 9(5):1871-84. doi:10.1016/j.celrep.2014.11.002
-
(2014)
Cell Rep
, vol.9
, Issue.5
, pp. 1871-1884
-
-
Batta, K.1
Florkowska, M.2
Kouskoff, V.3
Lacaud, G.4
-
98
-
-
84904966072
-
Developmental gene networks: a triathlon on the course to T cell identity
-
Yui MA, Rothenberg EV. Developmental gene networks: a triathlon on the course to T cell identity. Nat Rev Immunol (2014) 14(8):529-45. doi:10.1038/nri3702
-
(2014)
Nat Rev Immunol
, vol.14
, Issue.8
, pp. 529-545
-
-
Yui, M.A.1
Rothenberg, E.V.2
-
99
-
-
61349152914
-
E and ID proteins branch out
-
Kee BL. E and ID proteins branch out. Nat Rev Immunol (2009) 9(3):175-84. doi:10.1038/nri2507
-
(2009)
Nat Rev Immunol
, vol.9
, Issue.3
, pp. 175-184
-
-
Kee, B.L.1
-
100
-
-
27544442994
-
Helix-loop-helix proteins and lymphocyte development
-
Murre C. Helix-loop-helix proteins and lymphocyte development. Nat Immunol (2005) 6(11):1079-86. doi:10.1038/ni1260
-
(2005)
Nat Immunol
, vol.6
, Issue.11
, pp. 1079-1086
-
-
Murre, C.1
-
101
-
-
85012054721
-
Small genomic insertions form enhancers that misregulate oncogenes
-
Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, et al. Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun (2017) 8:14385. doi:10.1038/ncomms14385
-
(2017)
Nat Commun
, vol.8
, pp. 14385
-
-
Abraham, B.J.1
Hnisz, D.2
Weintraub, A.S.3
Kwiatkowski, N.4
Li, C.H.5
Li, Z.6
-
102
-
-
85016122906
-
APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL
-
Li Z, Abraham BJ, Berezovskaya A, Farah N, Liu Y, Leon T, et al. APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia (2017). doi:10.1038/leu.2017.75
-
(2017)
Leukemia
-
-
Li, Z.1
Abraham, B.J.2
Berezovskaya, A.3
Farah, N.4
Liu, Y.5
Leon, T.6
-
103
-
-
0032541488
-
The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
-
Grutz GG, Bucher K, Lavenir I, Larson T, Larson R, Rabbitts TH. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J (1998) 17(16):4594-605. doi:10.1093/emboj/17.16.4594
-
(1998)
EMBO J
, vol.17
, Issue.16
, pp. 4594-4605
-
-
Grutz, G.G.1
Bucher, K.2
Lavenir, I.3
Larson, T.4
Larson, R.5
Rabbitts, T.H.6
-
104
-
-
0028348648
-
Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells
-
Hsu HL, Wadman I, Baer R. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci U S A (1994) 91(8):3181-5. doi:10.1073/pnas.91.8.3181
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.8
, pp. 3181-3185
-
-
Hsu, H.L.1
Wadman, I.2
Baer, R.3
-
105
-
-
84865109759
-
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
-
Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell (2012) 22(2):209-21. doi:10.1016/j.ccr.2012.06.007
-
(2012)
Cancer Cell
, vol.22
, Issue.2
, pp. 209-221
-
-
Sanda, T.1
Lawton, L.N.2
Barrasa, M.I.3
Fan, Z.P.4
Kohlhammer, H.5
Gutierrez, A.6
-
106
-
-
0030752361
-
E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas
-
Bain G, Engel I, Robanus Maandag EC, te Riele HP, Voland JR, Sharp LL, et al. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol (1997) 17(8):4782-91. doi:10.1128/MCB.17.8.4782
-
(1997)
Mol Cell Biol
, vol.17
, Issue.8
, pp. 4782-4791
-
-
Bain, G.1
Engel, I.2
Robanus Maandag, E.C.3
te Riele, H.P.4
Voland, J.R.5
Sharp, L.L.6
-
107
-
-
85023173192
-
TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia
-
Sanda T, Leong WZ. TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia. Exp Hematol (2017) 53:7-15. doi:10.1016/j.exphem.2017.06.001
-
(2017)
Exp Hematol
, vol.53
, pp. 7-15
-
-
Sanda, T.1
Leong, W.Z.2
-
108
-
-
85010904429
-
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia
-
Liau WS, Tan SH, Ngoc PC, Wang CQ, Tergaonkar V, Feng H, et al. Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia (2017) 31(8):1798-807. doi:10.1038/leu.2016.392
-
(2017)
Leukemia
, vol.31
, Issue.8
, pp. 1798-1807
-
-
Liau, W.S.1
Tan, S.H.2
Ngoc, P.C.3
Wang, C.Q.4
Tergaonkar, V.5
Feng, H.6
-
109
-
-
33846645383
-
The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins
-
Nitta T, Takahama Y. The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends Immunol (2007) 28(2):58-65. doi:10.1016/j.it.2006.12.002
-
(2007)
Trends Immunol
, vol.28
, Issue.2
, pp. 58-65
-
-
Nitta, T.1
Takahama, Y.2
-
110
-
-
0036566240
-
Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells
-
Cambot M, Aresta S, Kahn-Perles B, de Gunzburg J, Romeo PH. Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells. Blood (2002) 99(9):3293-301. doi:10.1182/blood.V99.9.3293
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3293-3301
-
-
Cambot, M.1
Aresta, S.2
Kahn-Perles, B.3
de Gunzburg, J.4
Romeo, P.H.5
-
111
-
-
84953329815
-
GIMAP1 is essential for the survival of naive and activated B cells in vivo
-
Webb LM, Datta P, Bell SE, Kitamura D, Turner M, Butcher GW. GIMAP1 is essential for the survival of naive and activated B cells in vivo. J Immunol (2016) 196(1):207-16. doi:10.4049/jimmunol.1501582
-
(2016)
J Immunol
, vol.196
, Issue.1
, pp. 207-216
-
-
Webb, L.M.1
Datta, P.2
Bell, S.E.3
Kitamura, D.4
Turner, M.5
Butcher, G.W.6
-
112
-
-
84893530167
-
Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse
-
Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, et al. Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol (2014) 44(2):561-72. doi:10.1002/eji.201343750
-
(2014)
Eur J Immunol
, vol.44
, Issue.2
, pp. 561-572
-
-
Yano, K.1
Carter, C.2
Yoshida, N.3
Abe, T.4
Yamada, A.5
Nitta, T.6
-
113
-
-
79956105663
-
Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells
-
Chen Y, Yu M, Dai X, Zogg M, Wen R, Weiler H, et al. Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J Exp Med (2011) 208(5):923-35. doi:10.1084/jem.20101192
-
(2011)
J Exp Med
, vol.208
, Issue.5
, pp. 923-935
-
-
Chen, Y.1
Yu, M.2
Dai, X.3
Zogg, M.4
Wen, R.5
Weiler, H.6
-
114
-
-
77956871809
-
Notch protection against apoptosis in T-ALL cells mediated by GIMAP5
-
Chadwick N, Zeef L, Portillo V, Boros J, Hoyle S, van Doesburg JC, et al. Notch protection against apoptosis in T-ALL cells mediated by GIMAP5. Blood Cells Mol Dis (2010) 45(3):201-9. doi:10.1016/j.bcmd.2010.07.006
-
(2010)
Blood Cells Mol Dis
, vol.45
, Issue.3
, pp. 201-209
-
-
Chadwick, N.1
Zeef, L.2
Portillo, V.3
Boros, J.4
Hoyle, S.5
van Doesburg, J.C.6
-
115
-
-
80052569569
-
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells
-
Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, et al. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2011) 108(36):14908-13. doi:10.1073/pnas.1109023108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.36
, pp. 14908-14913
-
-
Wang, H.1
Zou, J.2
Zhao, B.3
Johannsen, E.4
Ashworth, T.5
Wong, H.6
-
116
-
-
0031724589
-
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
-
Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol (1998) 18(12):6939-50. doi:10.1128/MCB.18.12.6939
-
(1998)
Mol Cell Biol
, vol.18
, Issue.12
, pp. 6939-6950
-
-
Ono, Y.1
Fukuhara, N.2
Yoshie, O.3
-
117
-
-
34250732230
-
Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
-
Cheung AM, Wan TS, Leung JC, Chan LY, Huang H, Kwong YL, et al. Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential. Leukemia (2007) 21(7):1423-30. doi:10.1038/sj.leu.2404721
-
(2007)
Leukemia
, vol.21
, Issue.7
, pp. 1423-1430
-
-
Cheung, A.M.1
Wan, T.S.2
Leung, J.C.3
Chan, L.Y.4
Huang, H.5
Kwong, Y.L.6
-
118
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 1(5):555-67. doi:10.1016/j.stem.2007.08.014
-
(2007)
Cell Stem Cell
, vol.1
, Issue.5
, pp. 555-567
-
-
Ginestier, C.1
Hur, M.H.2
Charafe-Jauffret, E.3
Monville, F.4
Dutcher, J.5
Brown, M.6
-
119
-
-
79955593909
-
Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform
-
Marcato P, Dean CA, Giacomantonio CA, Lee PW. Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform. Cell Cycle (2011) 10(9):1378-84. doi:10.4161/cc.10.9.15486
-
(2011)
Cell Cycle
, vol.10
, Issue.9
, pp. 1378-1384
-
-
Marcato, P.1
Dean, C.A.2
Giacomantonio, C.A.3
Lee, P.W.4
-
120
-
-
66349096574
-
Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia
-
Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, et al. Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Res (2009) 69(11):4784-90. doi:10.1158/0008-5472.CAN-08-4774
-
(2009)
Cancer Res
, vol.69
, Issue.11
, pp. 4784-4790
-
-
Appert, A.1
Nam, C.H.2
Lobato, N.3
Priego, E.4
Miguel, R.N.5
Blundell, T.6
-
121
-
-
79952798245
-
Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain
-
Tanaka T, Sewell H, Waters S, Phillips SE, Rabbitts TH. Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain. J Biol Chem (2011) 286(5):3707-16. doi:10.1074/jbc.M110.188193
-
(2011)
J Biol Chem
, vol.286
, Issue.5
, pp. 3707-3716
-
-
Tanaka, T.1
Sewell, H.2
Waters, S.3
Phillips, S.E.4
Rabbitts, T.H.5
-
122
-
-
84904963991
-
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
-
Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature (2014) 511(7511):616-20. doi:10.1038/nature13393
-
(2014)
Nature
, vol.511
, Issue.7511
, pp. 616-620
-
-
Kwiatkowski, N.1
Zhang, T.2
Rahl, P.B.3
Abraham, B.J.4
Reddy, J.5
Ficarro, S.B.6
-
123
-
-
84898059073
-
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
-
Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, et al. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet (2014) 46(4):364-70. doi:10.1038/ng.2913
-
(2014)
Nat Genet
, vol.46
, Issue.4
, pp. 364-370
-
-
Knoechel, B.1
Roderick, J.E.2
Williamson, K.E.3
Zhu, J.4
Lohr, J.G.5
Cotton, M.J.6
|