An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

Nature Genetics

Volumn 46, Issue 4, 2014, Pages 364-370

  Knoechel, Birgit ^a,b,c,d   Roderick, Justine E ^e   Williamson, Kaylyn E ^a,b,f   Zhu, Jiang ^a,b,f   Lohr, Jens G ^b,c   Cotton, Matthew J ^a,b,f   Gillespie, Shawn M ^a,b,f   Fernandez, Daniel ^b,g   Ku, Manching ^a,b   Wang, Hongfang ^h   Piccioni, Federica ^b   Silver, Serena J ^b   Jain, Mohit ^a,b   Pearson, Daniel ^d,i   Kluk, Michael J ^h   Ott, Christopher J ^c   Shultz, Leonard D ^j   Brehm, Michael A ^e   Greiner, Dale L ^e   Gutierrez, Alejandro ^c,d   Stegmaier, Kimberly ^c,d   Kung, Andrew L ^c,d   Root, David E ^b   Bradner, James E ^b,c   Aster, Jon C ^h   Kelliher, Michelle A ^e   Bernstein, Bradley E ^a,b,f   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g HARVARD UNIVERSITY   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j JACKSON LABORATORY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (3,5 DIFLUOROPHENYL)ACETYLAMINO] N (5 METHYL 6 OXO 6,7 DIHYDRO 5H DIBENZ[B,D]AZEPIN 7 YL)PROPIONAMIDE; DOXORUBICIN; GAMMA SECRETASE INHIBITOR; JQ 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VORINOSTAT;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BCL2 GENE; BRD4 GENE; CANCER RESISTANCE; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG TOLERANCE; EPIGENETICS; GENE; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; MALE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; ONCOGENE C MYC; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AZEPINES; CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIGENESIS, GENETIC; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; INDOLES; MICE; NUCLEAR PROTEINS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRIAZOLES;

EID: 84898059073     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2913     Document Type: Article

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