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Volumn 514, Issue 7523, 2014, Pages 513-517

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(26)  Ntziachristos, Panagiotis a,b   Tsirigos, Aristotelis a   Welstead, G Grant c,d,p   Trimarchi, Thomas a,b   Bakogianni, Sofia a,b   Xu, Luyao e   Loizou, Evangelia a,b   Holmfeldt, Linda f   Strikoudis, Alexandros a,b   King, Bryan a,b   Mullenders, Jasper a,b   Becksfort, Jared f   Nedjic, Jelena a,b   Paietta, Elisabeth g   Tallman, Martin S h   Rowe, Jacob M i,j   Tonon, Giovanni k   Satoh, Takashi l,m   Kruidenier, Laurens n   Prinjha, Rab n   more..


Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEMETHYLASE; JUMONJI D3 PROTEIN; MESSENGER RNA; NOTCH1 RECEPTOR; SHORT HAIRPIN RNA; TETRATRICOPEPTIDE REPEAT X LINKED PROTEIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; BENZAZEPINE DERIVATIVE; GSK-J4; HISTONE; KDM6B PROTEIN, MOUSE; LYSINE; PYRIMIDINE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN; UTX PROTEIN, MOUSE;

EID: 84907526739     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13605     Document Type: Article
Times cited : (318)

References (47)
  • 1
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome: Biological and translational implications
    • Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome: biological and translational implications. Nature Rev. Cancer 11, 726-734 (2011)
    • (2011) Nature Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 2
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang, J. et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481, 157-163 (2012)
    • (2012) Nature , vol.481 , pp. 157-163
    • Zhang, J.1
  • 3
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX
    • Jankowska, A. M. et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 118, 3932-3941 (2011)
    • (2011) EZH2, and DNMT3A. Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1
  • 4
    • 84856747744 scopus 로고    scopus 로고
    • Genetic inactivation of the polycombrepressive complex 2 in T cell acute lymphoblastic leukemia
    • Ntziachristos, P. et al. Genetic inactivation of the polycombrepressive complex 2 in T cell acute lymphoblastic leukemia. Nature Med. 18, 298-303 (2012)
    • (2012) Nature Med. , vol.18 , pp. 298-303
    • Ntziachristos, P.1
  • 5
    • 84865120905 scopus 로고    scopus 로고
    • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
    • Kruidenier, L. et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408 (2012)
    • (2012) Nature , vol.488 , pp. 404-408
    • Kruidenier, L.1
  • 6
    • 84859295400 scopus 로고    scopus 로고
    • A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
    • Simon, C. et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev. 26, 651-656 (2012)
    • (2012) Genes Dev. , vol.26 , pp. 651-656
    • Simon, C.1
  • 7
    • 80052398939 scopus 로고    scopus 로고
    • Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation
    • Hubner, M. R. & Spector, D. L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb. Symp. Quant. Biol. 75, 43-49 (2010)
    • (2010) Cold Spring Harb. Symp. Quant. Biol. , vol.75 , pp. 43-49
    • Hubner, M.R.1    Spector, D.L.2
  • 8
    • 84860215207 scopus 로고    scopus 로고
    • Molecular mechanisms and potential functions of histone demethylases
    • Kooistra, S. M. & Helin, K. Molecular mechanisms and potential functions of histone demethylases. Nature Rev. Mol. Cell Biol. 13, 297-311 (2012)
    • (2012) Nature Rev. Mol. Cell Biol. , vol.13 , pp. 297-311
    • Kooistra, S.M.1    Helin, K.2
  • 9
    • 84875722648 scopus 로고    scopus 로고
    • Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells
    • Morales Torres, C., Laugesen, A. & Helin, K. Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS ONE 8, e60020 (2013)
    • (2013) PLoS ONE , vol.8 , pp. e60020
    • Morales Torres, C.1    Laugesen, A.2    Helin, K.3
  • 10
    • 84866530722 scopus 로고    scopus 로고
    • UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
    • Wang, C. et al. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc. Natl Acad. Sci. USA 109, 15324-15329 (2012)
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 15324-15329
    • Wang, C.1
  • 11
    • 84865112255 scopus 로고    scopus 로고
    • The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
    • Mansour, A. A. et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature 488, 409-413 (2012)
    • (2012) Nature , vol.488 , pp. 409-413
    • Mansour, A.A.1
  • 12
    • 34548644772 scopus 로고    scopus 로고
    • The histone H3lysine-27 demethylaseJmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
    • De Santa, F. et al. The histone H3lysine-27 demethylaseJmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130, 1083-1094 (2007)
    • (2007) Cell , vol.130 , pp. 1083-1094
    • De Santa, F.1
  • 13
    • 66149138053 scopus 로고    scopus 로고
    • The H3K27me3 demethylaseJMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
    • Agger, K. et al. The H3K27me3 demethylaseJMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 23, 1171-1176 (2009)
    • (2009) Genes Dev. , vol.23 , pp. 1171-1176
    • Agger, K.1
  • 14
    • 66149135288 scopus 로고    scopus 로고
    • HistonedemethylaseJMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
    • Barradas, M. et al. HistonedemethylaseJMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 23, 1177-1182 (2009)
    • (2009) Genes Dev. , vol.23 , pp. 1177-1182
    • Barradas, M.1
  • 15
    • 36248990248 scopus 로고    scopus 로고
    • SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
    • Jepsen, K. et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450, 415-419 (2007)
    • (2007) Nature , vol.450 , pp. 415-419
    • Jepsen, K.1
  • 16
    • 47549105128 scopus 로고    scopus 로고
    • Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
    • Sen, G. L., Webster, D. E., Barragan, D. I., Chang, H. Y. & Khavari, P. A. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev. 22, 1865-1870 (2008)
    • (2008) Genes Dev. , vol.22 , pp. 1865-1870
    • Sen, G.L.1    Webster, D.E.2    Barragan, D.I.3    Chang, H.Y.4    Khavari, P.A.5
  • 17
    • 84874789264 scopus 로고    scopus 로고
    • Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination
    • Zhao, W. et al. Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Cell 152, 1037-1050 (2013)
    • (2013) Cell , vol.152 , pp. 1037-1050
    • Zhao, W.1
  • 18
    • 76749139057 scopus 로고    scopus 로고
    • The histone demethylase UTX enables RB-dependent cell fate control
    • Wang, J. K. et al. The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev. 24, 327-332 (2010)
    • (2010) Genes Dev. , vol.24 , pp. 327-332
    • Wang, J.K.1
  • 19
    • 84876470605 scopus 로고    scopus 로고
    • The histone demethylase UTX regulates stem cell migration and hematopoiesis
    • Thieme, S. et al. The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood 121, 2462-2473 (2013)
    • (2013) Blood , vol.121 , pp. 2462-2473
    • Thieme, S.1
  • 20
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • van Haaften, G. et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genet. 41, 521-523 (2009)
    • (2009) Nature Genet. , vol.41 , pp. 521-523
    • Van Haaften, G.1
  • 21
    • 84864869260 scopus 로고    scopus 로고
    • Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia
    • Mar, B. G. et al. Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia. Leukemia 26, 1881-1883 (2012)
    • (2012) Leukemia , vol.26 , pp. 1881-1883
    • Mar, B.G.1
  • 22
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng, A. P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004)
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 23
    • 77956511912 scopus 로고    scopus 로고
    • The Notch/Hes1 pathway sustains NF-kB activation through CYLD repression in T cell leukemia
    • Espinosa, L. et al. The Notch/Hes1 pathway sustains NF-kB activation through CYLD repression in T cell leukemia. Cancer Cell 18, 268-281 (2010)
    • (2010) Cancer Cell , vol.18 , pp. 268-281
    • Espinosa, L.1
  • 24
    • 22344445528 scopus 로고    scopus 로고
    • New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
    • Dik, W. A. et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J. Exp. Med. 201, 1715-1723 (2005)
    • (2005) J. Exp. Med. , vol.201 , pp. 1715-1723
    • Dik, W.A.1
  • 25
    • 84855508998 scopus 로고    scopus 로고
    • ETV6 mutations in early immature human T cell leukemias
    • Van Vlierberghe, P. et al. ETV6 mutations in early immature human T cell leukemias. J. Exp. Med. 208, 2571-2579 (2011)
    • (2011) J. Exp. Med. , vol.208 , pp. 2571-2579
    • Van Vlierberghe, P.1
  • 26
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk, P. J. et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N. Engl. J. Med. 350, 1617-1628 (2004)
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1617-1628
    • Valk, P.J.1
  • 27
    • 80052569569 scopus 로고    scopus 로고
    • Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in humanandmurine T-lymphoblastic leukemia cells
    • Wang, H. et al. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in humanandmurine T-lymphoblastic leukemia cells. Proc. Natl Acad. Sci. USA 108, 14908-14913 (2011)
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14908-14913
    • Wang, H.1
  • 28
    • 84864663969 scopus 로고    scopus 로고
    • X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
    • Welstead, G. G. et al. X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc. Natl Acad. Sci. USA 109, 13004-13009 (2012)
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 13004-13009
    • Welstead, G.G.1
  • 29
    • 77956954197 scopus 로고    scopus 로고
    • TheJmjd3-Irf4axis regulatesM2macrophage polarization and host responses against helminth infection
    • Satoh, T. et al.TheJmjd3-Irf4axis regulatesM2macrophage polarization and host responses against helminth infection. Nature Immunol. 11, 936-944 (2010)
    • (2010) Nature Immunol. , vol.11 , pp. 936-944
    • Satoh, T.1
  • 30
    • 33745203104 scopus 로고    scopus 로고
    • CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to c-secretase inhibitors
    • Palomero, T. et al. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to c-secretase inhibitors. Leukemia 20, 1279-1287 (2006)
    • (2006) Leukemia , vol.20 , pp. 1279-1287
    • Palomero, T.1
  • 31
    • 33750317437 scopus 로고    scopus 로고
    • Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc
    • Sharma, V. M. et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol. Cell. Biol. 26, 8022-8031 (2006)
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 8022-8031
    • Sharma, V.M.1
  • 32
    • 84879364450 scopus 로고    scopus 로고
    • The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
    • King, B. et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153, 1552-1566 (2013)
    • (2013) Cell , vol.153 , pp. 1552-1566
    • King, B.1
  • 33
    • 61849100923 scopus 로고    scopus 로고
    • NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
    • Armstrong, F. et al. NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity. Blood 113, 1730-1740 (2009)
    • (2009) Blood , vol.113 , pp. 1730-1740
    • Armstrong, F.1
  • 34
    • 27644582893 scopus 로고    scopus 로고
    • Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
    • Dickins, R. A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nature Genet. 37, 1289-1295 (2005)
    • (2005) Nature Genet. , vol.37 , pp. 1289-1295
    • Dickins, R.A.1
  • 35
    • 79961230772 scopus 로고    scopus 로고
    • High-throughput Illumina strand-specific RNA sequencing library preparation
    • 2011
    • Zhong, S. et al. High-throughput Illumina strand-specific RNA sequencing library preparation. Cold Spring Harb. Protoc. 2011, 940-949 (2011)
    • (2011) Cold Spring Harb. Protoc. , pp. 940-949
    • Zhong, S.1
  • 36
    • 79960061227 scopus 로고    scopus 로고
    • Single nucleotide polymorphism microarray analysis of genetic alterations in cancer
    • Mullighan, C. G. Single nucleotide polymorphism microarray analysis of genetic alterations in cancer. Methods Mol. Biol. 730, 235-258 (2011)
    • (2011) Methods Mol. Biol. , vol.730 , pp. 235-258
    • Mullighan, C.G.1
  • 37
    • 79952381408 scopus 로고    scopus 로고
    • CREBBP mutations in relapsed acute lymphoblastic leukaemia
    • Mullighan, C. G. et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 471, 235-239 (2011)
    • (2011) Nature , vol.471 , pp. 235-239
    • Mullighan, C.G.1
  • 38
    • 34548084253 scopus 로고    scopus 로고
    • SNPdetector: A software tool for sensitive and accurate SNP detection
    • Zhang, J. et al. SNPdetector: a software tool for sensitive and accurate SNP detection. PLOS Comput. Biol. 1, e53 (2005)
    • (2005) PLOS Comput. Biol. , vol.1 , pp. e53
    • Zhang, J.1
  • 39
    • 34248170222 scopus 로고    scopus 로고
    • PolyScan: An automatic indel and SNP detection approach to the analysis of human resequencing data
    • Chen, K. et al. PolyScan: an automatic indel and SNP detection approach to the analysis of human resequencing data. Genome Res. 17, 659-666 (2007)
    • (2007) Genome Res. , vol.17 , pp. 659-666
    • Chen, K.1
  • 40
    • 73949110789 scopus 로고    scopus 로고
    • T-cell acute lymphoblastic leukemia in adults: Clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)
    • Marks, D. I. et al. T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993). Blood 114, 5136-5145 (2009)
    • (2009) Blood , vol.114 , pp. 5136-5145
    • Marks, D.I.1
  • 41
    • 58149240152 scopus 로고    scopus 로고
    • Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
    • Verhaak, R. G. et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica 94, 131-134 (2009)
    • (2009) Haematologica , vol.94 , pp. 131-134
    • Verhaak, R.G.1
  • 42
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005)
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 43
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast andmemory-efficient alignment of short DNA sequences to the human genome
    • Langmead, B., Trapnell, C., Pop, M.&Salzberg, S. L. Ultrafast andmemory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009)
    • (2009) Genome Biol. , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 44
    • 75249095274 scopus 로고    scopus 로고
    • DEGseq: An R package for identifying differentially expressed genes from RNA-seq data
    • Wang, L., Feng, Z., Wang, X., Wang, X. & Zhang, X. DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics 26, 136-138 (2010)
    • (2010) Bioinformatics , vol.26 , pp. 136-138
    • Wang, L.1    Feng, Z.2    Wang, X.3    Wang, X.4    Zhang, X.5
  • 45
    • 53849146020 scopus 로고    scopus 로고
    • Model-based analysis of ChIP-Seq (MACS)
    • Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008)
    • (2008) Genome Biol. , vol.9 , pp. R137
    • Zhang, Y.1
  • 46
    • 79955564639 scopus 로고    scopus 로고
    • Measuring reproducibility of highthroughput experiments
    • Li, Q., Brown, J. B., Huang, H. & Bickel, P. J. Measuring reproducibility of highthroughput experiments. Ann. Appl. Stat. 5, 1752-1779 (2011)
    • (2011) Ann. Appl. Stat. , vol.5 , pp. 1752-1779
    • Li, Q.1    Brown, J.B.2    Huang, H.3    Bickel, P.J.4
  • 47
    • 84856106400 scopus 로고    scopus 로고
    • GenomicTools: A computational platform for developing high-throughput analytics in genomics
    • Tsirigos, A., Haiminen, N., Bilal, E. & Utro, F. GenomicTools: a computational platform for developing high-throughput analytics in genomics. Bioinformatics 28, 282-283 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 282-283
    • Tsirigos, A.1    Haiminen, N.2    Bilal, E.3    Utro, F.4


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