메뉴 건너뛰기




Volumn 2, Issue 4, 2017, Pages

Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 switch gene 2 expression

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85028916013     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.88735     Document Type: Article
Times cited : (25)

References (59)
  • 1
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science. 2011;332(6037):1519–1523.
    • (2011) Science , vol.332 , Issue.6037 , pp. 1519-1523
    • Cohen, JC1    Horton, JD2    Hobbs, HH.3
  • 2
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28(4):360–369.
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 360-369
    • Malhi, H1    Gores, GJ.2
  • 3
    • 84927671391 scopus 로고    scopus 로고
    • Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD
    • Fuchs CD, Claudel T, Trauner M. Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD. Trends Endocrinol Metab. 2014;25(11):576–585.
    • (2014) Trends Endocrinol Metab , vol.25 , Issue.11 , pp. 576-585
    • Fuchs, CD1    Claudel, T2    Trauner, M.3
  • 4
    • 19644394861 scopus 로고    scopus 로고
    • Hepatic triglyceride contents are genetically determined in mice: results of a strain survey
    • Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005;288(6):G1179–G1189.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288 , Issue.6 , pp. G1179-G1189
    • Lin, X1    Yue, P2    Chen, Z3    Schonfeld, G.4
  • 5
    • 69949189508 scopus 로고    scopus 로고
    • Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice
    • Guan HP, Goldstein JL, Brown MS, Liang G. Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. J Biol Chem. 2009;284(36):24644–24652.
    • (2009) J Biol Chem , vol.284 , Issue.36 , pp. 24644-24652
    • Guan, HP1    Goldstein, JL2    Brown, MS3    Liang, G.4
  • 6
    • 54949115804 scopus 로고    scopus 로고
    • The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet
    • Nishikawa S, Doi K, Nakayama H, Uetsuka K. The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet. Toxicol Pathol. 2008;36(6):850–857.
    • (2008) Toxicol Pathol , vol.36 , Issue.6 , pp. 850-857
    • Nishikawa, S1    Doi, K2    Nakayama, H3    Uetsuka, K.4
  • 7
    • 84867364913 scopus 로고    scopus 로고
    • G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase
    • Schweiger M, et al. G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J Lipid Res. 2012;53(11):2307–2317.
    • (2012) J Lipid Res , vol.53 , Issue.11 , pp. 2307-2317
    • Schweiger, M1
  • 8
    • 80054778472 scopus 로고    scopus 로고
    • The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively
    • Cornaciu I, et al. The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively. PLoS One. 2011;6(10):e26349.
    • (2011) PLoS One , vol.6 , Issue.10 , pp. e26349
    • Cornaciu, I1
  • 9
    • 84911412359 scopus 로고    scopus 로고
    • A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase
    • Cerk IK, et al. A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J Biol Chem. 2014;289(47):32559–32570.
    • (2014) J Biol Chem , vol.289 , Issue.47 , pp. 32559-32570
    • Cerk, IK1
  • 10
    • 77249118270 scopus 로고    scopus 로고
    • The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
    • Yang X, et al. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab. 2010;11(3):194–205.
    • (2010) Cell Metab , vol.11 , Issue.3 , pp. 194-205
    • Yang, X1
  • 11
    • 84859631366 scopus 로고    scopus 로고
    • Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models
    • Girousse A, Langin D. Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models. Int J Obes (Lond). 2012;36(4):581–594.
    • (2012) Int J Obes (Lond) , vol.36 , Issue.4 , pp. 581-594
    • Girousse, A1    Langin, D.2
  • 12
    • 84858020291 scopus 로고    scopus 로고
    • FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling
    • Zechner R, et al. FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15(3):279–291.
    • (2012) Cell Metab , vol.15 , Issue.3 , pp. 279-291
    • Zechner, R1
  • 13
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem. 2004;279(47):48968–48975.
    • (2004) J Biol Chem , vol.279 , Issue.47 , pp. 48968-48975
    • Jenkins, CM1    Mancuso, DJ2    Yan, W3    Sims, HF4    Gibson, B5    Gross, RW.6
  • 14
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    • Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem. 2004;279(45):47066–47075.
    • (2004) J Biol Chem , vol.279 , Issue.45 , pp. 47066-47075
    • Villena, JA1    Roy, S2    Sarkadi-Nagy, E3    Kim, KH4    Sul, HS.5
  • 15
    • 8844226709 scopus 로고    scopus 로고
    • Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    • Zimmermann R, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004;306(5700):1383–1386.
    • (2004) Science , vol.306 , Issue.5700 , pp. 1383-1386
    • Zimmermann, R1
  • 16
    • 63449127032 scopus 로고    scopus 로고
    • Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    • Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 2009;50(1):3–21.
    • (2009) J Lipid Res , vol.50 , Issue.1 , pp. 3-21
    • Zechner, R1    Kienesberger, PC2    Haemmerle, G3    Zimmermann, R4    Lass, A.5
  • 17
    • 84894472160 scopus 로고    scopus 로고
    • Adipose triglyceride lipase and G0/G1 switch gene 2: approaching proof of concept
    • Nielsen TS, Møller N. Adipose triglyceride lipase and G0/G1 switch gene 2: approaching proof of concept. Diabetes. 2014;63(3):847–849.
    • (2014) Diabetes , vol.63 , Issue.3 , pp. 847-849
    • Nielsen, TS1    Møller, N.2
  • 18
    • 84944894356 scopus 로고    scopus 로고
    • G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis
    • Heier C, et al. G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem. 2015;290(43):26141–26150.
    • (2015) J Biol Chem , vol.290 , Issue.43 , pp. 26141-26150
    • Heier, C1
  • 19
    • 84916198082 scopus 로고    scopus 로고
    • The sparing use of fat: G0s2 controls lipolysis and fatty acid oxidation
    • Heier C, Zimmermann R. The sparing use of fat: G0s2 controls lipolysis and fatty acid oxidation. Diabetologia. 2015;58(1):7–9.
    • (2015) Diabetologia , vol.58 , Issue.1 , pp. 7-9
    • Heier, C1    Zimmermann, R.2
  • 20
    • 84894484467 scopus 로고    scopus 로고
    • Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis
    • Zhang X, Xie X, Heckmann BL, Saarinen AM, Czyzyk TA, Liu J. Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes. 2014;63(3):934–946.
    • (2014) Diabetes , vol.63 , Issue.3 , pp. 934-946
    • Zhang, X1    Xie, X2    Heckmann, BL3    Saarinen, AM4    Czyzyk, TA5    Liu, J.6
  • 21
    • 84916595427 scopus 로고    scopus 로고
    • Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice
    • El-Assaad W, et al. Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia. 2015;58(1):149–157.
    • (2015) Diabetologia , vol.58 , Issue.1 , pp. 149-157
    • El-Assaad, W1
  • 22
    • 84899884588 scopus 로고    scopus 로고
    • Mice lacking G0S2 are lean and cold-tolerant
    • Ma T, et al. Mice lacking G0S2 are lean and cold-tolerant. Cancer Biol Ther. 2014;15(5):643–650.
    • (2014) Cancer Biol Ther , vol.15 , Issue.5 , pp. 643-650
    • Ma, T1
  • 23
    • 84942829771 scopus 로고    scopus 로고
    • Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
    • Jaeger D, et al. Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. J Hepatol. 2015;63(2):437–445.
    • (2015) J Hepatol , vol.63 , Issue.2 , pp. 437-445
    • Jaeger, D1
  • 24
    • 84901937811 scopus 로고    scopus 로고
    • Liver X receptors in lipid metabolism: opportunities for drug discovery
    • Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014;13(6):433–444.
    • (2014) Nat Rev Drug Discov , vol.13 , Issue.6 , pp. 433-444
    • Hong, C1    Tontonoz, P.2
  • 25
    • 84884300669 scopus 로고    scopus 로고
    • The liver X receptor: a master regulator of the gut-liver axis and a target for non alcoholic fatty liver disease
    • Ducheix S, Montagner A, Theodorou V, Ferrier L, Guillou H. The liver X receptor: a master regulator of the gut-liver axis and a target for non alcoholic fatty liver disease. Biochem Pharmacol. 2013;86(1):96–105.
    • (2013) Biochem Pharmacol , vol.86 , Issue.1 , pp. 96-105
    • Ducheix, S1    Montagner, A2    Theodorou, V3    Ferrier, L4    Guillou, H.5
  • 26
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • Repa JJ, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14(22):2819–2830.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2819-2830
    • Repa, JJ1
  • 27
    • 0035047709 scopus 로고    scopus 로고
    • Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
    • Yoshikawa T, et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol. 2001;21(9):2991–3000.
    • (2001) Mol Cell Biol , vol.21 , Issue.9 , pp. 2991-3000
    • Yoshikawa, T1
  • 28
    • 0037192797 scopus 로고    scopus 로고
    • Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
    • Joseph SB, et al. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002;277(13):11019–11025.
    • (2002) J Biol Chem , vol.277 , Issue.13 , pp. 11019-11025
    • Joseph, SB1
  • 29
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest. 1997;99(5):846–854.
    • (1997) J Clin Invest , vol.99 , Issue.5 , pp. 846-854
    • Shimano, H1    Horton, JD2    Shimomura, I3    Hammer, RE4    Brown, MS5    Goldstein, JL.6
  • 30
    • 24144490445 scopus 로고    scopus 로고
    • LXRs regulate the balance between fat storage and oxidation
    • Kalaany NY, et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 2005;1(4):231–244.
    • (2005) Cell Metab , vol.1 , Issue.4 , pp. 231-244
    • Kalaany, NY1
  • 31
    • 79959578732 scopus 로고    scopus 로고
    • Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
    • Korach-André M, et al. Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice. Am J Physiol Endocrinol Metab. 2011;301(1):E210–E222.
    • (2011) Am J Physiol Endocrinol Metab , vol.301 , Issue.1 , pp. E210-E222
    • Korach-André, M1
  • 32
    • 54449094904 scopus 로고    scopus 로고
    • Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice
    • Oosterveer MH, et al. Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice. J Biol Chem. 2008;283(37):25437–25445.
    • (2008) J Biol Chem , vol.283 , Issue.37 , pp. 25437-25445
    • Oosterveer, MH1
  • 33
    • 84860548049 scopus 로고    scopus 로고
    • Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice
    • Zhang Y, et al. Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest. 2012;122(5):1688–1699.
    • (2012) J Clin Invest , vol.122 , Issue.5 , pp. 1688-1699
    • Zhang, Y1
  • 34
    • 77951063806 scopus 로고    scopus 로고
    • Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
    • Bischoff ED, et al. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res. 2010;51(5):900–906.
    • (2010) J Lipid Res , vol.51 , Issue.5 , pp. 900-906
    • Bischoff, ED1
  • 35
    • 33748951579 scopus 로고    scopus 로고
    • Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting
    • Quinet EM, et al. Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. Mol Pharmacol. 2006;70(4):1340–1349.
    • (2006) Mol Pharmacol , vol.70 , Issue.4 , pp. 1340-1349
    • Quinet, EM1
  • 36
    • 84943641363 scopus 로고    scopus 로고
    • Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice
    • Schoiswohl G, et al. Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology. 2015;156(10):3610–3624.
    • (2015) Endocrinology , vol.156 , Issue.10 , pp. 3610-3624
    • Schoiswohl, G1
  • 37
    • 29144451332 scopus 로고    scopus 로고
    • The G0/G1 switch gene 2 is a novel PPAR target gene
    • (Pt 2)
    • Zandbergen F, et al. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J. 2005;392(Pt 2):313–324.
    • (2005) Biochem J , vol.392 , pp. 313-324
    • Zandbergen, F1
  • 38
    • 84954497061 scopus 로고    scopus 로고
    • Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation
    • Sun X, et al. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016;291(3):1115–1122.
    • (2016) J Biol Chem , vol.291 , Issue.3 , pp. 1115-1122
    • Sun, X1
  • 39
    • 84901937811 scopus 로고    scopus 로고
    • Liver X receptors in lipid metabolism: opportunities for drug discovery
    • Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014;13(6):433–444.
    • (2014) Nat Rev Drug Discov , vol.13 , Issue.6 , pp. 433-444
    • Hong, C1    Tontonoz, P.2
  • 40
    • 4043140077 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain
    • Lengqvist J, et al. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics. 2004;3(7):692–703.
    • (2004) Mol Cell Proteomics , vol.3 , Issue.7 , pp. 692-703
    • Lengqvist, J1
  • 41
    • 84892144705 scopus 로고    scopus 로고
    • Regulation of energy metabolism by long-chain fatty acids
    • Nakamura MT, Yudell BE, Loor JJ. Regulation of energy metabolism by long-chain fatty acids. Prog Lipid Res. 2014;53:124–144.
    • (2014) Prog Lipid Res , vol.53 , pp. 124-144
    • Nakamura, MT1    Yudell, BE2    Loor, JJ.3
  • 42
    • 0031965780 scopus 로고    scopus 로고
    • Gene transcription of the retinoid X receptor alpha (RXRalpha) is regulated by fatty acids and hormones in rat hepatic cells
    • Steineger HH, Arntsen BM, Spydevold O, Sørensen HN. Gene transcription of the retinoid X receptor alpha (RXRalpha) is regulated by fatty acids and hormones in rat hepatic cells. J Lipid Res. 1998;39(4):744–754.
    • (1998) J Lipid Res , vol.39 , Issue.4 , pp. 744-754
    • Steineger, HH1    Arntsen, BM2    Spydevold, O3    Sørensen, HN.4
  • 43
    • 0141590658 scopus 로고    scopus 로고
    • Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes
    • Fan YY, Spencer TE, Wang N, Moyer MP, Chapkin RS. Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. Carcinogenesis. 2003;24(9):1541–1548.
    • (2003) Carcinogenesis , vol.24 , Issue.9 , pp. 1541-1548
    • Fan, YY1    Spencer, TE2    Wang, N3    Moyer, MP4    Chapkin, RS.5
  • 44
    • 59449098993 scopus 로고    scopus 로고
    • Transcriptome profiling of the feeding-to-fasting transition in chicken liver
    • Désert C, et al. Transcriptome profiling of the feeding-to-fasting transition in chicken liver. BMC Genomics. 2008;9:611.
    • (2008) BMC Genomics , vol.9 , pp. 611
    • Désert, C1
  • 45
    • 0034453225 scopus 로고    scopus 로고
    • Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha
    • Tobin KA, et al. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol Endocrinol. 2000;14(5):741–752.
    • (2000) Mol Endocrinol , vol.14 , Issue.5 , pp. 741-752
    • Tobin, KA1
  • 46
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem. 2000;275(37):28918–28928.
    • (2000) J Biol Chem , vol.275 , Issue.37 , pp. 28918-28928
    • Hashimoto, T1    Cook, WS2    Qi, C3    Yeldandi, AV4    Reddy, JK5    Rao, MS.6
  • 47
    • 0037155935 scopus 로고    scopus 로고
    • Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis
    • Tobin KA, et al. Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem. 2002;277(12):10691–10697.
    • (2002) J Biol Chem , vol.277 , Issue.12 , pp. 10691-10697
    • Tobin, KA1
  • 48
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci USA. 2004;101(31):11245–11250.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.31 , pp. 11245-11250
    • Chen, G1    Liang, G2    Ou, J3    Goldstein, JL4    Brown, MS.5
  • 49
    • 76249092371 scopus 로고    scopus 로고
    • Nuclear receptor liver X receptor is O-GlcNAcmodified in response to glucose
    • Anthonisen EH, Berven L, Holm S, Nygård M, Nebb HI, Grønning-Wang LM. Nuclear receptor liver X receptor is O-GlcNAcmodified in response to glucose. J Biol Chem. 2010;285(3):1607–1615.
    • (2010) J Biol Chem , vol.285 , Issue.3 , pp. 1607-1615
    • Anthonisen, EH1    Berven, L2    Holm, S3    Nygård, M4    Nebb, HI5    Grønning-Wang, LM.6
  • 50
    • 77950605567 scopus 로고    scopus 로고
    • Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model
    • Briand F, et al. Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model. J Lipid Res. 2010;51(4):763–770.
    • (2010) J Lipid Res , vol.51 , Issue.4 , pp. 763-770
    • Briand, F1
  • 51
    • 84891862000 scopus 로고    scopus 로고
    • LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression
    • Kannisto K, et al. LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression. Lipids. 2014;49(1):71–83.
    • (2014) Lipids , vol.49 , Issue.1 , pp. 71-83
    • Kannisto, K1
  • 52
    • 43149089601 scopus 로고    scopus 로고
    • Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression
    • Ou X, et al. Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression. Sci China, C, Life Sci. 2008;51(5):418–429.
    • (2008) Sci China, C, Life Sci , vol.51 , Issue.5 , pp. 418-429
    • Ou, X1
  • 53
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plōsch T, et al. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem. 2002;277(37):33870–33877.
    • (2002) J Biol Chem , vol.277 , Issue.37 , pp. 33870-33877
    • Plōsch, T1
  • 54
    • 77950911589 scopus 로고    scopus 로고
    • Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo
    • Yasuda T, et al. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010;30(4):781–786.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.4 , pp. 781-786
    • Yasuda, T1
  • 55
    • 50049130053 scopus 로고    scopus 로고
    • The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential
    • Zanotti I, et al. The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential. J Lipid Res. 2008;49(5):954–960.
    • (2008) J Lipid Res , vol.49 , Issue.5 , pp. 954-960
    • Zanotti, I1
  • 56
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282(1):743–751.
    • (2007) J Biol Chem , vol.282 , Issue.1 , pp. 743-751
    • Cha, JY1    Repa, JJ.2
  • 57
    • 33646462136 scopus 로고    scopus 로고
    • Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    • Haemmerle G, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 2006;312(5774):734–737.
    • (2006) Science , vol.312 , Issue.5774 , pp. 734-737
    • Haemmerle, G1
  • 58
    • 0034693047 scopus 로고    scopus 로고
    • A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides
    • Chen Z, Fitzgerald RL, Averna MR, Schonfeld G. A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides. J Biol Chem. 2000;275(42):32807–32815.
    • (2000) J Biol Chem , vol.275 , Issue.42 , pp. 32807-32815
    • Chen, Z1    Fitzgerald, RL2    Averna, MR3    Schonfeld, G.4
  • 59
    • 84856777771 scopus 로고    scopus 로고
    • Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites
    • Boergesen M, et al. Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol. 2012;32(4):852–867.
    • (2012) Mol Cell Biol , vol.32 , Issue.4 , pp. 852-867
    • Boergesen, M1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.