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Volumn 156, Issue 10, 2015, Pages 3610-3624

Impact of reduced ATGL-mediated adipocyte lipolysis on obesity-associated insulin resistance and inflammation in male mice

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL LIPASE; DIFFERENTIATION ANTIGEN; GLYCOPROTEIN P 15095; LIPID; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN; PNPLA2 PROTEIN, MOUSE;

EID: 84943641363     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1322     Document Type: Article
Times cited : (142)

References (50)
  • 1
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012;148:852-871.
    • (2012) Cell. , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 2
    • 79959216069 scopus 로고    scopus 로고
    • Adipose tissue macrophages: Phenotypic plasticity and diversity in lean and obese states
    • Morris DL, Singer K, Lumeng CN. Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care. 2011;14:341-346.
    • (2011) Curr Opin Clin Nutr Metab Care. , vol.14 , pp. 341-346
    • Morris, D.L.1    Singer, K.2    Lumeng, C.N.3
  • 3
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005;46:2347-2355.
    • (2005) J Lipid Res. , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3
  • 5
    • 77957838795 scopus 로고    scopus 로고
    • Weight loss and lipolysis promote a dynamicimmuneresponse in murine adipose tissue
    • Kosteli A, Sugaru E, Haemmerle G, et al. Weight loss and lipolysis promote a dynamicimmuneresponse in murine adipose tissue. J Clin Invest. 2010;120:3466-3479.
    • (2010) J Clin Invest. , vol.120 , pp. 3466-3479
    • Kosteli, A.1    Sugaru, E.2    Haemmerle, G.3
  • 6
    • 77954656874 scopus 로고    scopus 로고
    • β3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK
    • Mottillo EP, Shen XJ, Granneman JG. β3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK. Biochim Biophys Acta. 2010;1801: 1048-1055.
    • (2010) Biochim Biophys Acta. , vol.1801 , pp. 1048-1055
    • Mottillo, E.P.1    Shen, X.J.2    Granneman, J.G.3
  • 7
    • 8844226709 scopus 로고    scopus 로고
    • Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    • Zimmermann R, Strauss JG, Haemmerle G, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004;306:1383-1386.
    • (2004) Science. , vol.306 , pp. 1383-1386
    • Zimmermann, R.1    Strauss, J.G.2    Haemmerle, G.3
  • 8
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem. 2004;279:48968-48975.
    • (2004) J Biol Chem. , vol.279 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5    Gross, R.W.6
  • 9
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis
    • Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem. 2004;279: 47066-47075.
    • (2004) J Biol Chem. , vol.279 , pp. 47066-47075
    • Villena, J.A.1    Roy, S.2    Sarkadi-Nagy, E.3    Kim, K.H.4    Sul, H.S.5
  • 10
    • 33646462136 scopus 로고    scopus 로고
    • Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    • Haemmerle G, Lass A, Zimmermann R, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 2006;312:734-737.
    • (2006) Science. , vol.312 , pp. 734-737
    • Haemmerle, G.1    Lass, A.2    Zimmermann, R.3
  • 11
    • 71049114611 scopus 로고    scopus 로고
    • Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling
    • Kienesberger PC, Lee D, Pulinilkunnil T, et al. Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem. 2009;284:30218-30229.
    • (2009) J Biol Chem. , vol.284 , pp. 30218-30229
    • Kienesberger, P.C.1    Lee, D.2    Pulinilkunnil, T.3
  • 12
    • 84890123944 scopus 로고    scopus 로고
    • Proline oxidaseadipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation
    • Lettieri Barbato D, Aquilano K, Baldelli S, et al. Proline oxidaseadipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation. Cell Death Differ. 2014;21:113-123.
    • (2014) Cell Death Differ. , vol.21 , pp. 113-123
    • Lettieri Barbato, D.1    Aquilano, K.2    Baldelli, S.3
  • 13
    • 84899960796 scopus 로고    scopus 로고
    • Inhibition of age-related cytokines production by ATGL: A mechanism linked to the anti-inflammatory effect of resveratrol
    • Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo MR. Inhibition of age-related cytokines production by ATGL: a mechanism linked to the anti-inflammatory effect of resveratrol. Mediators Inflamm. 2014;2014:917698.
    • (2014) Mediators Inflamm. , vol.2014 , pp. 917698
    • Lettieri Barbato, D.1    Tatulli, G.2    Aquilano, K.3    Ciriolo, M.R.4
  • 14
    • 79958244231 scopus 로고    scopus 로고
    • PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
    • Varga T, Czimmerer Z, Nagy L. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta. 2011;1812:1007-1022.
    • (2011) Biochim Biophys Acta. , vol.1812 , pp. 1007-1022
    • Varga, T.1    Czimmerer, Z.2    Nagy, L.3
  • 15
    • 82255175222 scopus 로고    scopus 로고
    • Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis
    • Aflaki E, Balenga NA, Luschnig-Schratl P, et al. Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis. Cell Mol Life Sci. 2011;68:3933-3947.
    • (2011) Cell Mol Life Sci. , vol.68 , pp. 3933-3947
    • Aflaki, E.1    Balenga, N.A.2    Luschnig-Schratl, P.3
  • 16
    • 79953208051 scopus 로고    scopus 로고
    • Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages
    • Aflaki E, Radovic B, Chandak PG, et al. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem. 2011;286:7418-7428.
    • (2011) J Biol Chem. , vol.286 , pp. 7418-7428
    • Aflaki, E.1    Radovic, B.2    Chandak, P.G.3
  • 17
    • 77953774791 scopus 로고    scopus 로고
    • Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase
    • Chandak PG, Radovic B, Aflaki E, et al. Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J Biol Chem. 2010;285:20192-20201.
    • (2010) J Biol Chem. , vol.285 , pp. 20192-20201
    • Chandak, P.G.1    Radovic, B.2    Aflaki, E.3
  • 18
    • 79958047295 scopus 로고    scopus 로고
    • Desnutrin/ATGL is regulated byAMPKand is required for a brown adipose phenotype
    • Ahmadian M, Abbott MJ, Tang T, et al. Desnutrin/ATGL is regulated byAMPKand is required for a brown adipose phenotype. Cell Metab. 2011;13:739-748.
    • (2011) Cell Metab. , vol.13 , pp. 739-748
    • Ahmadian, M.1    Abbott, M.J.2    Tang, T.3
  • 19
    • 84860326574 scopus 로고    scopus 로고
    • Fasting energy homeostasis in mice with adipose deficiency of desnutrin/ adipose triglyceride lipase
    • Wu JW, Wang SP, Casavant S, Moreau A, Yang GS, Mitchell GA. Fasting energy homeostasis in mice with adipose deficiency of desnutrin/ adipose triglyceride lipase. Endocrinology. 2012;153:2198-2207.
    • (2012) Endocrinology , vol.153 , pp. 2198-2207
    • Wu, J.W.1    Wang, S.P.2    Casavant, S.3    Moreau, A.4    Yang, G.S.5    Mitchell, G.A.6
  • 20
    • 84874399589 scopus 로고    scopus 로고
    • Lessons on conditional gene targeting in mouse adipose tissue
    • Lee KY, Russell SJ, Ussar S, et al. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013;62:864-874.
    • (2013) Diabetes. , vol.62 , pp. 864-874
    • Lee, K.Y.1    Russell, S.J.2    Ussar, S.3
  • 21
    • 84921634958 scopus 로고    scopus 로고
    • Characterization of Cre recombinase models for the study of adipose tissue
    • Jeffery E, Berry R, Church CD, et al. Characterization of Cre recombinase models for the study of adipose tissue. Adipocyte. 2014; 3:206-211.
    • (2014) Adipocyte. , vol.3 , pp. 206-211
    • Jeffery, E.1    Berry, R.2    Church, C.D.3
  • 22
    • 84888130465 scopus 로고    scopus 로고
    • Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity
    • Sitnick MT, Basantani MK, Cai L, et al. Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes. 2013;62:3350-3361.
    • (2013) Diabetes. , vol.62 , pp. 3350-3361
    • Sitnick, M.T.1    Basantani, M.K.2    Cai, L.3
  • 23
    • 79952155359 scopus 로고    scopus 로고
    • Transcriptional control of adipose lipid handling by IRF4
    • Eguchi J, Wang X, Yu S, et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 2011;13:249-259.
    • (2011) Cell Metab. , vol.13 , pp. 249-259
    • Eguchi, J.1    Wang, X.2    Yu, S.3
  • 24
    • 78751489992 scopus 로고    scopus 로고
    • Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    • Basantani MK, Sitnick MT, Cai L, et al. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res. 2011;52:318-329.
    • (2011) J Lipid Res. , vol.52 , pp. 318-329
    • Basantani, M.K.1    Sitnick, M.T.2    Cai, L.3
  • 25
    • 84865460082 scopus 로고    scopus 로고
    • Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases inCD11cβcells in adipose tissue and liver
    • Stefanovic-Racic M, Yang X, Turner MS, et al. Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases inCD11cβcells in adipose tissue and liver. Diabetes. 2012;61:2330-2339.
    • (2012) Diabetes. , vol.61 , pp. 2330-2339
    • Stefanovic-Racic, M.1    Yang, X.2    Turner, M.S.3
  • 26
    • 40949132523 scopus 로고    scopus 로고
    • Characterization of transplanted green fluorescent proteinβ bone marrow cells into adipose tissue
    • Tomiyama K, Murase N, Stolz DB, et al. Characterization of transplanted green fluorescent proteinβ bone marrow cells into adipose tissue. Stem Cell. 2008;26:330-338.
    • (2008) Stem Cell. , vol.26 , pp. 330-338
    • Tomiyama, K.1    Murase, N.2    Stolz, D.B.3
  • 27
    • 84857769995 scopus 로고    scopus 로고
    • The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene
    • Reilich P, Horvath R, Krause S, et al. The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene. J Neurol. 2011;258:1987-1997.
    • (2011) J Neurol. , vol.258 , pp. 1987-1997
    • Reilich, P.1    Horvath, R.2    Krause, S.3
  • 28
    • 84883697425 scopus 로고    scopus 로고
    • Metabolic consequences of adipose triglyceride lipase deficiency in humans: An in vivo study in patients with neutral lipid storage disease with myopathy
    • Natali A, Gastaldelli A, Camastra S, et al. Metabolic consequences of adipose triglyceride lipase deficiency in humans: an in vivo study in patients with neutral lipid storage disease with myopathy. J Clin Endocrinol Metab. 2013;98:E1540-E1548.
    • (2013) J Clin Endocrinol Metab. , vol.98 , pp. E1540-E1548
    • Natali, A.1    Gastaldelli, A.2    Camastra, S.3
  • 29
    • 84965185580 scopus 로고    scopus 로고
    • Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation
    • Mottillo EP, Balasubramanian P, Lee YH, Weng C, Kershaw EE, Granneman JG. Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation. J Lipid Res. 2014;55:2276-2286.
    • (2014) J Lipid Res. , vol.55 , pp. 2276-2286
    • Mottillo, E.P.1    Balasubramanian, P.2    Lee, Y.H.3    Weng, C.4    Kershaw, E.E.5    Granneman, J.G.6
  • 30
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-β
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-β. J Clin Invest. 1994;94: 1543-1549.
    • (1994) J Clin Invest. , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 31
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W, Metlakunta A, Dedousis N, et al. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes. 2010;59:347-357.
    • (2010) Diabetes. , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3
  • 32
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARβ regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, et al. Adipocyte-derived Th2 cytokines and myeloid PPARβ regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008;7:485-495.
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3
  • 33
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARβ ameliorates obesity-induced insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, et al. Alternative M2 activation of Kupffer cells by PPARβ ameliorates obesity-induced insulin resistance. Cell Metab. 2008;7:496-507.
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Red Eagle, A.3
  • 34
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor β knockout causes insulin resistance in fat and liver but not in muscle
    • He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferator-activated receptor β knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA. 2003;100: 15712-15717.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3
  • 35
    • 84922709227 scopus 로고    scopus 로고
    • Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
    • Perry RJ, Camporez JP, Kursawe R, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015;160:745-758.
    • (2015) Cell. , vol.160 , pp. 745-758
    • Perry, R.J.1    Camporez, J.P.2    Kursawe, R.3
  • 36
    • 64649096897 scopus 로고    scopus 로고
    • Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity
    • Ahmadian M, Duncan RE, Varady KA, et al. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes. 2009;58:855-866.
    • (2009) Diabetes. , vol.58 , pp. 855-866
    • Ahmadian, M.1    Duncan, R.E.2    Varady, K.A.3
  • 37
    • 84871901684 scopus 로고    scopus 로고
    • Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
    • Ong KT, Mashek MT, Bu SY, Mashek DG. Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation. FASEB J. 2013;27:313-321.
    • (2013) FASEB J. , vol.27 , pp. 313-321
    • Ong, K.T.1    Mashek, M.T.2    Bu, S.Y.3    Mashek, D.G.4
  • 38
    • 79959550724 scopus 로고    scopus 로고
    • Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
    • Wu JW, Wang SP, Alvarez F, et al. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology. 2011;54:122-132.
    • (2011) Hepatology. , vol.54 , pp. 122-132
    • Wu, J.W.1    Wang, S.P.2    Alvarez, F.3
  • 39
    • 79953787445 scopus 로고    scopus 로고
    • Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
    • Turpin SM, Hoy AJ, Brown RD, et al. Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia. 2011;54:146-156.
    • (2011) Diabetologia. , vol.54 , pp. 146-156
    • Turpin, S.M.1    Hoy, A.J.2    Brown, R.D.3
  • 40
    • 84896695345 scopus 로고    scopus 로고
    • Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia
    • Jha P, Claudel T, Baghdasaryan A, et al. Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia. Hepatology. 2014;59: 858-869.
    • (2014) Hepatology. , vol.59 , pp. 858-869
    • Jha, P.1    Claudel, T.2    Baghdasaryan, A.3
  • 41
    • 36148929034 scopus 로고    scopus 로고
    • Role of hormone-sensitive lipase in β-adrenergic remodeling of white adipose tissue
    • Mottillo EP, Shen XJ, Granneman JG. Role of hormone-sensitive lipase in β-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab. 2007;293:E1188-E1197.
    • (2007) Am J Physiol Endocrinol Metab. , vol.293 , pp. E1188-E1197
    • Mottillo, E.P.1    Shen, X.J.2    Granneman, J.G.3
  • 42
    • 25144489034 scopus 로고    scopus 로고
    • Metabolic and cellular plasticity in white adipose tissue I: Effects ofβ3-adrenergic receptor activation
    • Granneman JG, Li P, Zhu Z, Lu Y. Metabolic and cellular plasticity in white adipose tissue I: effects ofβ3-adrenergic receptor activation. Am J Physiol Endocrinol Metab. 2005;289:E608-E616.
    • (2005) Am J Physiol Endocrinol Metab. , vol.289 , pp. E608-E616
    • Granneman, J.G.1    Li, P.2    Zhu, Z.3    Lu, Y.4
  • 43
    • 84883467905 scopus 로고    scopus 로고
    • Identification of an adipogenic niche for adipose tissue remodeling and restoration
    • Lee YH, Petkova AP, Granneman JG. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 2013;18:355-367.
    • (2013) Cell Metab. , vol.18 , pp. 355-367
    • Lee, Y.H.1    Petkova, A.P.2    Granneman, J.G.3
  • 44
    • 33745833415 scopus 로고    scopus 로고
    • Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model
    • Hansson O, Ström K, Güner N, et al. Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model. J Proteome Res. 2006;5:1701-1710.
    • (2006) J Proteome Res. , vol.5 , pp. 1701-1710
    • Hansson, O.1    Ström, K.2    Güner, N.3
  • 45
    • 84902159389 scopus 로고    scopus 로고
    • Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes
    • Albert JS, Yerges-Armstrong LM, Horenstein RB, et al. Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes. N Engl J Med. 2014;370:2307-2315.
    • (2014) N Engl J Med. , vol.370 , pp. 2307-2315
    • Albert, J.S.1    Yerges-Armstrong, L.M.2    Horenstein, R.B.3
  • 46
    • 36849012057 scopus 로고    scopus 로고
    • Adipocyte death, adipose tissue remodeling, and obesity complications
    • Strissel KJ, Stancheva Z, Miyoshi H, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007;56: 2910-2918.
    • (2007) Diabetes. , vol.56 , pp. 2910-2918
    • Strissel, K.J.1    Stancheva, Z.2    Miyoshi, H.3
  • 47
    • 84901336929 scopus 로고    scopus 로고
    • Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation
    • Tynan GA, Hearnden CH, Oleszycka E, et al. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Diabetes. 2014;63:2037-2050.
    • (2014) Diabetes. , vol.63 , pp. 2037-2050
    • Tynan, G.A.1    Hearnden, C.H.2    Oleszycka, E.3
  • 48
    • 80052454265 scopus 로고    scopus 로고
    • ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
    • Haemmerle G, Moustafa T, Woelkart G, et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med. 2011;17:1076-1085.
    • (2011) Nat Med. , vol.17 , pp. 1076-1085
    • Haemmerle, G.1    Moustafa, T.2    Woelkart, G.3
  • 49
    • 69449087522 scopus 로고    scopus 로고
    • Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity
    • Sapiro JM, Mashek MT, Greenberg AS, Mashek DG. Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity. J Lipid Res. 2009;50:1621-1629.
    • (2009) J Lipid Res. , vol.50 , pp. 1621-1629
    • Sapiro, J.M.1    Mashek, M.T.2    Greenberg, A.S.3    Mashek, D.G.4
  • 50
    • 84864098852 scopus 로고    scopus 로고
    • Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ inbrownadipocytes to match fatty acid oxidation with supply
    • Mottillo EP, Bloch AE, Leff T, Granneman JG. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ inbrownadipocytes to match fatty acid oxidation with supply. J Biol Chem. 2012;287:25038-25048.
    • (2012) J Biol Chem. , vol.287 , pp. 25038-25048
    • Mottillo, E.P.1    Bloch, A.E.2    Leff, T.3    Granneman, J.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.