Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids

Journal of Hepatology

Volumn 63, Issue 2, 2015, Pages 437-445

  Jaeger, Doris ^a   Schoiswohl, Gabriele ^b   Hofer, Peter ^a   Schreiber, Renate ^a   Schweiger, Martina ^a   Eichmann, Thomas O ^a   Pollak, Nina M ^a   Poecher, Nadja ^a   Grabner, Gernot F ^a   Zierler, Kathrin A ^a   Eder, Sandra ^a   Kolb, Dagmar ^c   Radner, Franz P W ^a   Preiss Landl, Karina ^a   Lass, Achim ^a   Zechner, Rudolf ^a   Kershaw, Erin E ^b   Haemmerle, Guenter ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

ATGL; CGI 58; CREBH; Fibroblast growth factor 21; G0 G1 switch gene 2; Hepatic steatosis; Lipolysis; Obesity; PPARa

Indexed keywords

ACYL COENZYME A OXIDASE; FATTY ACID; FIBROBLAST GROWTH FACTOR 21; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; FIBROBLAST GROWTH FACTOR; RNA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENDOPLASMIC RETICULUM STRESS; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID BLOOD LEVEL; G0 G1 SWITCH GENE 2; GENE; GENE EXPRESSION REGULATION; IN VIVO STUDY; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID DIET; LIPOLYSIS; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; ELECTRON MICROSCOPY; FATTY LIVER; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FASTING; FATTY ACIDS; FATTY LIVER; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GENES, SWITCH; LIVER; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; REAL-TIME POLYMERASE CHAIN REACTION; RNA;

EID: 84942829771     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.02.035     Document Type: Article

References (33)

1. Zechner R, Zimmermann R, Eichmann TO, Kohlwein SD, Haemmerle G, Lass A, et al. FAT SIGNALS - Lipases and lipolysis in lipid metabolism and signaling. Cell Metab 2012;15:279-291.
2. Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 2006;3:309-319.
3. Schweiger M, Lass A, Zimmermann R, Eichmann TO, Zechner R. Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab 2009;297:E289-E296.
4. Ong KT, Mashek MT, Bu SY, Greenberg AS, Mashek DG. Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology 2011;53:116-126.
5. Gauthier N, Abed L, Wu JW, Wang SP, Alvarez F, Soni KG, et al. Deficiency of liver adipose triglyceride lipase in mice. Hepatology 2011:122-132.
6. Guo F, Ma Y, Kadegowda AKG, Xie P, Liu G, Liu X, et al. Deficiency of liver comparative gene identification-58 (CGI-58) causes steatohepatitis and fibrosis in mice. J Lipid Res 2013;54:2109-2120.
7. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005;115: 1343-1351.
8. Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, et al. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 2005;1:309-322.
9. Zierler KA, Jaeger D, Pollak NM, Eder S, Rechberger GN, Radner FPW, et al. Functional cardiac lipolysis in mice critically depends on comparative gene identification-58. J Biol Chem 2013;288:9892-9904.
10. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001;409:729-733.
11. Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, et al. Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes 2013;62:3350-3361.
12. Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med 2011;17:1076-1085.
13. Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol 2013;9:785-787.
14. Yang X, Lu X, Lombès M, Rha GB, Chi Y-I, Guerin TM, et al. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 2010;11:194-205.
15. Ahmadian M, Abbott MJ, Tang T, Hudak CSS, Kim Y, Bruss M, et al. Desnutrin/ ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 2011;13:739-748.
16. Wu JW, Wang SP, Casavant S, Moreau A, Yang GS, Mitchell GA. Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase. Endocrinology 2012;153:2198-2207.
17. Zandbergen F, Mandard S, Escher P, Tan NS, Patsouris D, JATkoe T, et al. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 2005;392:313-324.
18. Jump DB, Tripathy S, Depner CM. Fatty acid-regulated transcription factors in the liver. Annu Rev Nutr 2013;33:249-269.
19. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007;5:415-425.
20. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, et al. Regulation of hepatic fasting response by PPAR c coactivator-1 a (PGC-1): Requirement for hepatocyte nuclear factor 4 a in gluconeogenesis. Proc Natl Acad Sci U S A 2003;100:4012-4017.
21. Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, et al. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 2011;17:812-815.
22. Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, et al. Endoplasmic reticulum-tethered transcription factor cAMP responsive element- binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 2012;55:1070-1082.
23. Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 2006;124:587-599.
24. Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, et al. The PPARa-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metab 2014;20:512-525.
25. Chakrabarti P, Kandror KV. FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J Biol Chem 2009;284:13296-13300.
26. Zhang X, Xie X, Heckmann BL, Saarinen AM, Czyzyk TA, Liu J. Target Disruption of G0/G1 Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High Fat Diet-Induced Liver Steatosis. Diabetes 2013;63:934-946.
27. Heckmann BL, Zhang X, Xie X, Saarinen A, Lu X, Yang X, et al. Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 Switch Gene 2. J Biol Chem 2013;289:1905-1916.
28. Wang Y, Zhang Y, Qian H, Lu J, Zhang Z, Min X, et al. The g0/g1 switch gene 2 is an important regulator of hepatic triglyceride metabolism. PLoS One 2013;8:e72315.
29. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulinregulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003;423:550-555.
30. Gallego-Escuredo JM, Gómez-Ambrosi J, Catalan V, Domingo P, Giralt M, Frühbeck G, et al. Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients. Int J Obes (Lond) 2014;39:121-129.
31. Kim HB, Mendez R, Zheng Z, Chang L, Cai J, Zhang R, et al. Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor a to regulate metabolic hormone FGF21. Endocrinology 2014;155:en20131490.
32. Lee A-H. The role of CREB-H transcription factor in triglyceride metabolism. Curr Opin Lipidol 2012;23:141-146.
33. Huang Y, Cohen JC, Hobbs HH. Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. J Biol Chem 2011;286:37085-37093.