-
1
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531–539, 2006. doi:10.1038/ng1777.
-
(2006)
Nat Genet
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
Samad, T.A.6
Campagna, J.A.7
Chung, R.T.8
Schneyer, A.L.9
Woolf, C.J.10
Rews, N.C.11
Lin, H.Y.12
-
2
-
-
80052655782
-
The molecular pathogenesis of hereditary hemochromatosis
-
Babitt JL, Lin HY. The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis 31: 280–292, 2011. doi:10.1055/s-0031-1286059.
-
(2011)
Semin Liver Dis
, vol.31
, pp. 280-292
-
-
Babitt, J.L.1
Lin, H.Y.2
-
3
-
-
0032427653
-
Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis
-
Bastin JM, Jones M, O’Callaghan CA, Schimanski L, Mason DY, Townsend AR. Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. Br J Haematol 103: 931–941, 1998. doi:10.1046/j.1365-2141.1998.01102.x.
-
(1998)
Br J Haematol
, vol.103
, pp. 931-941
-
-
Bastin, J.M.1
Jones, M.2
O’Callaghan, C.A.3
Schimanski, L.4
Mason, D.Y.5
Townsend, A.R.6
-
4
-
-
33748265283
-
Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
-
Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 131: 788–796, 2006. doi:10.1053/j.gastro.2006.07.007.
-
(2006)
Gastroenterology
, vol.131
, pp. 788-796
-
-
Bekri, S.1
Gual, P.2
Anty, R.3
Luciani, N.4
Dahman, M.5
Ramesh, B.6
Iannelli, A.7
Staccini-Myx, A.8
Casanova, D.9
Ben Amor, I.10
Saint-Paul, M.C.11
Huet, P.M.12
Sadoul, J.L.13
Gugenheim, J.14
Srai, S.K.15
Tran, A.16
Le Marchand-Brustel, Y.17
-
5
-
-
0034022636
-
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
-
Camaschella C, Roetto A, Calì A, De Gobbi M, Garozzo G, Carella M, Majorano N, Totaro A, Gasparini P. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet 25: 14–15, 2000. doi:10.1038/75534.
-
(2000)
Nat Genet
, vol.25
, pp. 14-15
-
-
Camaschella, C.1
Roetto, A.2
Calì, A.3
De Gobbi, M.4
Garozzo, G.5
Carella, M.6
Majorano, N.7
Totaro, A.8
Gasparini, P.9
-
6
-
-
85014966092
-
Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice
-
Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL. Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice. Blood 129: 405–414, 2017. doi:10.1182/blood-2016-06-721571.
-
(2017)
Blood
, vol.129
, pp. 405-414
-
-
Canali, S.1
Zumbrennen-Bullough, K.B.2
Core, A.B.3
Wang, C.Y.4
Nairz, M.5
Bouley, R.6
Swirski, F.K.7
Babitt, J.L.8
-
7
-
-
84978370086
-
Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera
-
Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood 128: 265–276, 2016. doi:10.1182/blood-2015-10-676742.
-
(2016)
Blood
, vol.128
, pp. 265-276
-
-
Casu, C.1
Oikonomidou, P.R.2
Chen, H.3
Nandi, V.4
Ginzburg, Y.5
Prasad, P.6
Fleming, R.E.7
Shah, Y.M.8
Valore, E.V.9
Nemeth, E.10
Ganz, T.11
Macdonald, B.12
Rivella, S.13
-
8
-
-
37549055467
-
HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions
-
Chen J, Chloupková M, Gao J, Chapman-Arvedson TL, Enns CA. HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions. J Biol Chem 282: 36862–36870, 2007. doi:10.1074/jbc.M706720200.
-
(2007)
J Biol Chem
, vol.282
, pp. 36862-36870
-
-
Chen, J.1
Chloupková, M.2
Gao, J.3
Chapman-Arvedson, T.L.4
Enns, C.A.5
-
9
-
-
79959437085
-
Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis
-
Chen W, Huang FW, de Renshaw TB, Andrews NC. Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. Blood 117: 6319–6325, 2011. doi:10.1182/blood-2010-12-327957.
-
(2011)
Blood
, vol.117
, pp. 6319-6325
-
-
Chen, W.1
Huang, F.W.2
De Renshaw, T.B.3
Rews, N.C.4
-
10
-
-
80052666748
-
Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe
-
Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE. Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology 141: 1907–1914, 2011. doi: 10.1053/j.gastro.2011.06.077.
-
(2011)
Gastroenterology
, vol.141
, pp. 1907-1914
-
-
Corradini, E.1
Rozier, M.2
Meynard, D.3
Odhiambo, A.4
Lin, H.Y.5
Feng, Q.6
Migas, M.C.7
Britton, R.S.8
Babitt, J.L.9
Fleming, R.E.10
-
11
-
-
78049463632
-
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
-
Corradini E, Schmidt PJ, Meynard D, Garuti C, Montosi G, Chen S, Vukicevic S, Pietrangelo A, Lin HY, Babitt JL. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology 139: 1721–1729, 2010. doi:10.1053/j.gastro.2010.07.044.
-
(2010)
Gastroenterology
, vol.139
, pp. 1721-1729
-
-
Corradini, E.1
Schmidt, P.J.2
Meynard, D.3
Garuti, C.4
Montosi, G.5
Chen, S.6
Vukicevic, S.7
Pietrangelo, A.8
Lin, H.Y.9
Babitt, J.L.10
-
12
-
-
84867578495
-
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation
-
D’Alessio F, Hentze MW, Muckenthaler MU. The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol 57: 1052–1060, 2012. doi: 10.1016/j.jhep.2012.06.015.
-
(2012)
J Hepatol
, vol.57
, pp. 1052-1060
-
-
D’Alessio, F.1
Hentze, M.W.2
Muckenthaler, M.U.3
-
13
-
-
33846164453
-
Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3
-
Drake SF, Morgan EH, Herbison CE, Delima R, Graham RM, Chua AC, Leedman PJ, Fleming RE, Bacon BR, Olynyk JK, Trinder D. Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. Am J Physiol Gastrointest Liver Physiol 292: G323–G328, 2007. doi:10.1152/ajpgi.00278.2006.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.292
, pp. G323-G328
-
-
Drake, S.F.1
Morgan, E.H.2
Herbison, C.E.3
Delima, R.4
Graham, R.M.5
Chua, A.C.6
Leedman, P.J.7
Fleming, R.E.8
Bacon, B.R.9
Olynyk, J.K.10
Trinder, D.11
-
14
-
-
44449177930
-
The serine protease TMPRSS6 is required to sense iron deficiency
-
Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, Khovananth K, Mudd S, Mann N, Moresco EM, Beutler E, Beutler B. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088–1092, 2008. doi:10.1126/science.1157121.
-
(2008)
Science
, vol.320
, pp. 1088-1092
-
-
Du, X.1
She, E.2
Gelbart, T.3
Truksa, J.4
Lee, P.5
Xia, Y.6
Khovananth, K.7
Mudd, S.8
Mann, N.9
Moresco, E.M.10
Beutler, E.11
Beutler, B.12
-
15
-
-
84875649042
-
Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway
-
Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One 8: e60534, 2013. doi:10.1371/journal.pone.0060534.
-
(2013)
Plos One
, vol.8
-
-
Enns, C.A.1
Ahmed, R.2
Wang, J.3
Ueno, A.4
Worthen, C.5
Tsukamoto, H.6
Zhang, A.S.7
-
16
-
-
84867411483
-
Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage
-
Enns CA, Ahmed R, Zhang AS. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage. J Biol Chem 287: 35104–35117, 2012. doi:10.1074/jbc.M112.363937.
-
(2012)
J Biol Chem
, vol.287
, pp. 35104-35117
-
-
Enns, C.A.1
Ahmed, R.2
Zhang, A.S.3
-
17
-
-
9344224529
-
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
-
Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13: 399–408, 1996. doi:10.1038/ng0896-399.
-
(1996)
Nat Genet
, vol.13
, pp. 399-408
-
-
Feder, J.N.1
Gnirke, A.2
Thomas, W.3
Tsuchihashi, Z.4
Ruddy, D.A.5
Basava, A.6
Dormishian, F.7
Domingo, R.8
Ellis, M.C.9
Fullan, A.10
Hinton, L.M.11
Jones, N.L.12
Kimmel, B.E.13
Kronmal, G.S.14
Lauer, P.15
Lee, V.K.16
Loeb, D.B.17
Mapa, F.A.18
McClelland, E.19
Meyer, N.C.20
Mintier, G.A.21
Moeller, N.22
Moore, T.23
Morikang, E.24
Prass, C.E.25
Quintana, L.26
Starnes, S.M.27
Schatzman, R.C.28
Brunke, K.J.29
Drayna, D.T.30
Risch, N.J.31
Bacon, B.R.32
Wolff, R.K.33
more..
-
18
-
-
13144282684
-
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
-
Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95: 1472–1477, 1998. doi:10.1073/pnas.95.4.1472.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1472-1477
-
-
Feder, J.N.1
Penny, D.M.2
Irrinki, A.3
Lee, V.K.4
Lebrón, J.A.5
Watson, N.6
Tsuchihashi, Z.7
Sigal, E.8
Bjorkman, P.J.9
Schatzman, R.C.10
-
19
-
-
17644434333
-
The hemochromatosis founder mutation in HLA-H disrupts β
-
2-microglobulin interaction and cell surface expression. J Biol Chem 272: 14025–14028, 1997. doi:10.1074/jbc.272.22.14025.
-
(1997)
J Biol Chem
, vol.272
, pp. 14025-14028
-
-
Feder, J.N.1
Tsuchihashi, Z.2
Irrinki, A.3
Lee, V.K.4
Mapa, F.A.5
Morikang, E.6
Prass, C.E.7
Starnes, S.M.8
Wolff, R.K.9
Parkkila, S.10
Sly, W.S.11
Schatzman, R.C.12
-
20
-
-
84862531062
-
Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice
-
Feng Q, Migas MC, Waheed A, Britton RS, Fleming RE. Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. Am J Physiol Gastrointest Liver Physiol 302: G1397–G1404, 2012. doi:10.1152/ajpgi.00020.2012.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
, pp. G1397-G1404
-
-
Feng, Q.1
Migas, M.C.2
Waheed, A.3
Britton, R.S.4
Fleming, R.E.5
-
21
-
-
42649118442
-
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
-
Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 40: 569–571, 2008. doi:10.1038/ng.130.
-
(2008)
Nat Genet
, vol.40
, pp. 569-571
-
-
Finberg, K.E.1
Heeney, M.M.2
Campagna, D.R.3
Aydinok, Y.4
Pearson, H.A.5
Hartman, K.R.6
Mayo, M.M.7
Samuel, S.M.8
Strouse, J.J.9
Markianos, K.10
Rews, N.C.11
Fleming, M.D.12
-
22
-
-
0036678091
-
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
-
Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, Kawabata H, Britton RS, Bacon BR, Sly WS. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci USA 99: 10653–10658, 2002. doi:10.1073/pnas.162360699.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10653-10658
-
-
Fleming, R.E.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Koeffler, H.P.5
Kawabata, H.6
Britton, R.S.7
Bacon, B.R.8
Sly, W.S.9
-
23
-
-
0034007995
-
Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
-
Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S, Bacon BR, Sly WS. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA 97: 2214–2219, 2000. doi:10.1073/pnas.040548097.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2214-2219
-
-
Fleming, R.E.1
Migas, M.C.2
Holden, C.C.3
Waheed, A.4
Britton, R.S.5
Tomatsu, S.6
Bacon, B.R.7
Sly, W.S.8
-
24
-
-
54349096688
-
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
-
Folgueras AR, de Lara FM, Pendás AM, Garabaya C, Rodríguez F, Astudillo A, Bernal T, Cabanillas R, López-Otín C, Velasco G. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112: 2539–2545, 2008. doi:10.1182/blood-2008-04-149773.
-
(2008)
Blood
, vol.112
, pp. 2539-2545
-
-
Folgueras, A.R.1
De Lara, F.M.2
Pendás, A.M.3
Garabaya, C.4
Rodríguez, F.5
Astudillo, A.6
Bernal, T.7
Cabanillas, R.8
López-Otín, C.9
Velasco, G.10
-
25
-
-
60649103774
-
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
-
Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9: 217–227, 2009. doi:10.1016/j.cmet.2009.01.010.
-
(2009)
Cell Metab
, vol.9
, pp. 217-227
-
-
Gao, J.1
Chen, J.2
Kramer, M.3
Tsukamoto, H.4
Zhang, A.S.5
Enns, C.A.6
-
27
-
-
0031783567
-
Large-scale sequencing of two regions in human chromosome 7q22: Analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes
-
Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. Genome Res 8: 1060–1073, 1998. doi:10.1101/gr.8.10.1060.
-
(1998)
Genome Res
, vol.8
, pp. 1060-1073
-
-
Glöckner, G.1
Scherer, S.2
Schattevoy, R.3
Boright, A.4
Weber, J.5
Tsui, L.C.6
Rosenthal, A.7
-
28
-
-
84874544637
-
Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells
-
Gnana-Prakasam JP, Veeranan-Karmegam R, Coothankandaswamy V, Reddy SK, Martin PM, Thangaraju M, Smith SB, Ganapathy V. Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 54: 63–71, 2013. doi:10.1167/iovs.12-10312.
-
(2013)
Invest Ophthalmol Vis Sci
, vol.54
, pp. 63-71
-
-
Gnana-Prakasam, J.P.1
Veeranan-Karmegam, R.2
Coothankandaswamy, V.3
Reddy, S.K.4
Martin, P.M.5
Thangaraju, M.6
Smith, S.B.7
Ganapathy, V.8
-
29
-
-
33749393565
-
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
-
Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem 281: 28494–28498, 2006. doi:10.1074/jbc.C600197200.
-
(2006)
J Biol Chem
, vol.281
, pp. 28494-28498
-
-
Goswami, T.1
Rews, N.C.2
-
30
-
-
37849009340
-
Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron
-
Graham RM, Reutens GM, Herbison CE, Delima RD, Chua AC, Olynyk JK, Trinder D. Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron. J Hepatol 48: 327–334, 2008. doi:10.1016/j.jhep.2007.10.009.
-
(2008)
J Hepatol
, vol.48
, pp. 327-334
-
-
Graham, R.M.1
Reutens, G.M.2
Herbison, C.E.3
Delima, R.D.4
Chua, A.C.5
Olynyk, J.K.6
Trinder, D.7
-
31
-
-
84875849962
-
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
-
Guo S, Casu C, Gardenghi S, Booten S, Aghajan M, Peralta R, Watt A, Freier S, Monia BP, Rivella S. Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. J Clin Invest 123: 1531–1541, 2013. doi:10.1172/JCI66969.
-
(2013)
J Clin Invest
, vol.123
, pp. 1531-1541
-
-
Guo, S.1
Casu, C.2
Gardenghi, S.3
Booten, S.4
Aghajan, M.5
Peralta, R.6
Watt, A.7
Freier, S.8
Monia, B.P.9
Rivella, S.10
-
32
-
-
84964282416
-
A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: Correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis
-
Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica 100: 167–177, 2015. doi:10.3324/haematol.2014.116723.
-
(2015)
Haematologica
, vol.100
, pp. 167-177
-
-
Gutschow, P.1
Schmidt, P.J.2
Han, H.3
Ostland, V.4
Bartnikas, T.B.5
Pettiglio, M.A.6
Herrera, C.7
Butler, J.S.8
Nemeth, E.9
Ganz, T.10
Fleming, M.D.11
Westerman, M.12
-
33
-
-
0041567036
-
Mouse matriptase-2: Identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues
-
Hooper JD, Campagnolo L, Goodarzi G, Truong TN, Stuhlmann H, Quigley JP. Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues. Biochem J 373: 689–702, 2003. doi:10.1042/bj20030390.
-
(2003)
Biochem J
, vol.373
, pp. 689-702
-
-
Hooper, J.D.1
Campagnolo, L.2
Goodarzi, G.3
Truong, T.N.4
Stuhlmann, H.5
Quigley, J.P.6
-
34
-
-
23644460325
-
A mouse model of juvenile hemochromatosis
-
Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC. A mouse model of juvenile hemochromatosis. J Clin Invest 115: 2187–2191, 2005. doi:10.1172/JCI25049.
-
(2005)
J Clin Invest
, vol.115
, pp. 2187-2191
-
-
Huang, F.W.1
Pinkus, J.L.2
Pinkus, G.S.3
Fleming, M.D.4
Rews, N.C.5
-
35
-
-
33947111426
-
Transferrin receptor 2: Evidence for ligand-induced stabilization and redirection to a recycling pathway
-
Johnson MB, Chen J, Murchison N, Green FA, Enns CA. Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway. Mol Biol Cell 18: 743–754, 2007. doi:10.1091/mbc.E06-09-0798.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 743-754
-
-
Johnson, M.B.1
Chen, J.2
Murchison, N.3
Green, F.A.4
Enns, C.A.5
-
36
-
-
10244265904
-
Diferric transferrin regulates transferrin receptor 2 protein stability
-
Johnson MB, Enns CA. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 104: 4287–4293, 2004. doi:10.1182/blood-2004-06-2477.
-
(2004)
Blood
, vol.104
, pp. 4287-4293
-
-
Johnson, M.B.1
Enns, C.A.2
-
37
-
-
0035885970
-
Regulation of expression of murine transferrin receptor 2
-
Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF, Koeffler HP. Regulation of expression of murine transferrin receptor 2. Blood 98: 1949–1954, 2001. doi:10.1182/blood.V98.6.1949.
-
(2001)
Blood
, vol.98
, pp. 1949-1954
-
-
Kawabata, H.1
Germain, R.S.2
Ikezoe, T.3
Tong, X.4
Green, E.M.5
Gombart, A.F.6
Koeffler, H.P.7
-
38
-
-
0034595856
-
Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo
-
Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem 275: 16618–16625, 2000. doi:10.1074/jbc.M908846199.
-
(2000)
J Biol Chem
, vol.275
, pp. 16618-16625
-
-
Kawabata, H.1
Germain, R.S.2
Vuong, P.T.3
Nakamaki, T.4
Said, J.W.5
Koeffler, H.P.6
-
39
-
-
0035525741
-
Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells
-
Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood 98: 2714–2719, 2001. doi:10.1182/blood.V98.9.2714.
-
(2001)
Blood
, vol.98
, pp. 2714-2719
-
-
Kawabata, H.1
Nakamaki, T.2
Ikonomi, P.3
Smith, R.D.4
Germain, R.S.5
Koeffler, H.P.6
-
40
-
-
0033597780
-
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family
-
Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, Koeffler HP. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem 274: 20826–20832, 1999. doi:10.1074/jbc.274.30.20826.
-
(1999)
J Biol Chem
, vol.274
, pp. 20826-20832
-
-
Kawabata, H.1
Yang, R.2
Hirama, T.3
Vuong, P.T.4
Kawano, S.5
Gombart, A.F.6
Koeffler, H.P.7
-
41
-
-
84939940998
-
Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin
-
Kent P, Wilkinson N, Constante M, Fillebeen C, Gkouvatsos K, Wagner J, Buffler M, Becker C, Schümann K, Santos MM, Pantopoulos K. Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin. J Mol Med (Berl) 93: 489–498, 2015. doi:10.1007/s00109-015-1253-7.
-
(2015)
J Mol Med (Berl)
, vol.93
, pp. 489-498
-
-
Kent, P.1
Wilkinson, N.2
Constante, M.3
Fillebeen, C.4
Gkouvatsos, K.5
Wagner, J.6
Buffler, M.7
Becker, C.8
Schümann, K.9
Santos, M.M.10
Pantopoulos, K.11
-
42
-
-
0027452550
-
Regulating the fate of mRNA: The control of cellular iron metabolism
-
Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72: 19–28, 1993. doi:10.1016/0092-8674(93)90046-S.
-
(1993)
Cell
, vol.72
, pp. 19-28
-
-
Klausner, R.D.1
Rouault, T.A.2
Harford, J.B.3
-
43
-
-
41949115757
-
Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin
-
Kuns-Hashimoto R, Kuninger D, Nili M, Rotwein P. Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin. Am J Physiol Cell Physiol 294: C994–C1003, 2008. doi:10.1152/ajpcell.00563.2007.
-
(2008)
Am J Physiol Cell Physiol
, vol.294
, pp. CC994-C1003
-
-
Kuns-Hashimoto, R.1
Kuninger, D.2
Nili, M.3
Rotwein, P.4
-
44
-
-
84952639186
-
Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin
-
Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H. Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin. Hepatology 63: 126–137, 2016. doi:10.1002/hep.28254.
-
(2016)
Hepatology
, vol.63
, pp. 126-137
-
-
Latour, C.1
Besson-Fournier, C.2
Meynard, D.3
Silvestri, L.4
Gourbeyre, O.5
Aguilar-Martinez, P.6
Schmidt, P.J.7
Fleming, M.D.8
Roth, M.P.9
Coppin, H.10
-
45
-
-
0032478524
-
Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
-
Lebrón JA, Bennett MJ, Vaughn DE, Chirino AJ, Snow PM, Mintier GA, Feder JN, Bjorkman PJ. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93: 111–123, 1998. doi:10.1016/S0092-8674(00)81151-4.
-
(1998)
Cell
, vol.93
, pp. 111-123
-
-
Lebrón, J.A.1
Bennett, M.J.2
Vaughn, D.E.3
Chirino, A.J.4
Snow, P.M.5
Mintier, G.A.6
Feder, J.N.7
Bjorkman, P.J.8
-
46
-
-
84857647438
-
Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6
-
Lee P, Hsu MH, Welser-Alves J, Peng H. Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6. Blood Cells Mol Dis 48: 173–178, 2012. doi:10.1016/j.bcmd.2011.12.005.
-
(2012)
Blood Cells Mol Dis
, vol.48
, pp. 173-178
-
-
Lee, P.1
Hsu, M.H.2
Welser-Alves, J.3
Peng, H.4
-
47
-
-
78751533321
-
Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6
-
Lenoir A, Deschemin JC, Kautz L, Ramsay AJ, Roth MP, Lopez-Otin C, Vaulont S, Nicolas G. Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6. Blood 117: 647–650, 2011. doi:10.1182/blood-2010-07-295147.
-
(2011)
Blood
, vol.117
, pp. 647-650
-
-
Lenoir, A.1
Deschemin, J.C.2
Kautz, L.3
Ramsay, A.J.4
Roth, M.P.5
Lopez-Otin, C.6
Vaulont, S.7
Nicolas, G.8
-
48
-
-
0032959574
-
Transferrin receptor is necessary for development of erythrocytes and the nervous system
-
Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396–399, 1999. doi:10.1038/7727.
-
(1999)
Nat Genet
, vol.21
, pp. 396-399
-
-
Levy, J.E.1
Jin, O.2
Fujiwara, Y.3
Kuo, F.4
Rews, N.C.5
-
49
-
-
27144459908
-
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
-
Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 106: 2884–2889, 2005. doi:10.1182/blood-2005-05-1845.
-
(2005)
Blood
, vol.106
, pp. 2884-2889
-
-
Lin, L.1
Goldberg, Y.P.2
Ganz, T.3
-
50
-
-
36649027658
-
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site
-
Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis 40: 122–131, 2008. doi:10.1016/j.bcmd.2007.06.023.
-
(2008)
Blood Cells Mol Dis
, vol.40
, pp. 122-131
-
-
Lin, L.1
Nemeth, E.2
Goodnough, J.B.3
Thapa, D.R.4
Gabayan, V.5
Ganz, T.6
-
51
-
-
34548825938
-
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
-
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 110: 2182–2189, 2007. doi:10.1182/blood-2007-04-087593.
-
(2007)
Blood
, vol.110
, pp. 2182-2189
-
-
Lin, L.1
Valore, E.V.2
Nemeth, E.3
Goodnough, J.B.4
Gabayan, V.5
Ganz, T.6
-
52
-
-
21544449756
-
Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
-
Liu XB, Nguyen NB, Marquess KD, Yang F, Haile DJ. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis 35: 47–56, 2005. doi:10.1016/j.bcmd.2005.04.006.
-
(2005)
Blood Cells Mol Dis
, vol.35
, pp. 47-56
-
-
Liu, X.B.1
Nguyen, N.B.2
Marquess, K.D.3
Yang, F.4
Haile, D.J.5
-
53
-
-
24344468431
-
Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading
-
Makui H, Soares RJ, Jiang W, Constante M, Santos MM. Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood 106: 2189–2195, 2005. doi:10.1182/blood-2005-02-0629.
-
(2005)
Blood
, vol.106
, pp. 2189-2195
-
-
Makui, H.1
Soares, R.J.2
Jiang, W.3
Constante, M.4
Santos, M.M.5
-
54
-
-
34250850987
-
The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation
-
Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology 148: 2663–2668, 2007. doi: 10.1210/en.2006-1331.
-
(2007)
Endocrinology
, vol.148
, pp. 2663-2668
-
-
Merle, U.1
Fein, E.2
Gehrke, S.G.3
Stremmel, W.4
Kulaksiz, H.5
-
55
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth MP. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478–481, 2009. doi:10.1038/ng.320.
-
(2009)
Nat Genet
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
Roth, M.P.6
-
56
-
-
79960674973
-
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
-
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood 118: 747–756, 2011. doi:10.1182/blood-2011-04-348698.
-
(2011)
Blood
, vol.118
, pp. 747-756
-
-
Meynard, D.1
Vaja, V.2
Sun, C.C.3
Corradini, E.4
Chen, S.5
López-Otín, C.6
Grgurevic, L.7
Hong, C.C.8
Stirnberg, M.9
Gütschow, M.10
Vukicevic, S.11
Babitt, J.L.12
Lin, H.Y.13
-
57
-
-
0018864571
-
Idiopathic hemochromatosis, an interim report
-
Milder MS, Cook JD, Stray S, Finch CA. Idiopathic hemochromatosis, an interim report. Medicine (Baltimore) 59: 34–49, 1980. doi:10.1097/00005792-198001000-00002.
-
(1980)
Medicine (Baltimore)
, vol.59
, pp. 34-49
-
-
Milder, M.S.1
Cook, J.D.2
Stray, S.3
Finch, C.A.4
-
58
-
-
84923293373
-
The second transferrin receptor regulates red blood cell production in mice
-
Nai A, Lidonnici MR, Rausa M, Mandelli G, Pagani A, Silvestri L, Ferrari G, Camaschella C. The second transferrin receptor regulates red blood cell production in mice. Blood 125: 1170–1179, 2015. doi:10.1182/blood-2014-08-596254.
-
(2015)
Blood
, vol.125
, pp. 1170-1179
-
-
Nai, A.1
Lidonnici, M.R.2
Rausa, M.3
Mandelli, G.4
Pagani, A.5
Silvestri, L.6
Ferrari, G.7
Camaschella, C.8
-
59
-
-
84901707790
-
The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice
-
Nai A, Pellegrino RM, Rausa M, Pagani A, Boero M, Silvestri L, Saglio G, Roetto A, Camaschella C. The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice. Haematologica 99: 1016–1021, 2014. doi:10.3324/haematol.2013.103143.
-
(2014)
Haematologica
, vol.99
, pp. 1016-1021
-
-
Nai, A.1
Pellegrino, R.M.2
Rausa, M.3
Pagani, A.4
Boero, M.5
Silvestri, L.6
Saglio, G.7
Roetto, A.8
Camaschella, C.9
-
60
-
-
33748412748
-
Hepcidin expression and iron transport in alveolar macrophages
-
Nguyen NB, Callaghan KD, Ghio AJ, Haile DJ, Yang F. Hepcidin expression and iron transport in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 291: L417–L425, 2006. doi:10.1152/ajplung.00484.2005.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
, pp. L417-L425
-
-
Nguyen, N.B.1
Callaghan, K.D.2
Ghio, A.J.3
Haile, D.J.4
Yang, F.5
-
61
-
-
23644444316
-
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
-
Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115: 2180–2186, 2005. doi:10.1172/JCI25683.
-
(2005)
J Clin Invest
, vol.115
, pp. 2180-2186
-
-
Niederkofler, V.1
Salie, R.2
Arber, S.3
-
62
-
-
77955298048
-
Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2-and BMP6-mediated signaling and gene expression
-
Nili M, Shinde U, Rotwein P. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2-and BMP6-mediated signaling and gene expression. J Biol Chem 285: 24,783–24,792, 2010. doi:10.1074/jbc.M110.130286.
-
(2010)
J Biol Chem
, vol.285
, pp. 783-824
-
-
Nili, M.1
Shinde, U.2
Rotwein, P.3
-
63
-
-
84925428377
-
Expression of human Hemojuvelin (HJV) is tightly regulated by two upstream open reading frames in HJV mRNA that respond to iron overload in hepatic cells
-
Onofre C, Tomé F, Barbosa C, Silva AL, Romão L. Expression of human Hemojuvelin (HJV) is tightly regulated by two upstream open reading frames in HJV mRNA that respond to iron overload in hepatic cells. Mol Cell Biol 35: 1376–1389, 2015. doi:10.1128/MCB.01462-14.
-
(2015)
Mol Cell Biol
, vol.35
, pp. 1376-1389
-
-
Onofre, C.1
Tomé, F.2
Barbosa, C.3
Silva, A.L.4
Romão, L.5
-
64
-
-
84923291109
-
TfR2 links iron metabolism and erythropoiesis
-
Pantopoulos K. TfR2 links iron metabolism and erythropoiesis. Blood 125: 1055–1056, 2015. doi:10.1182/blood-2014-12-617571.
-
(2015)
Blood
, vol.125
, pp. 1055-1056
-
-
Pantopoulos, K.1
-
65
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 36: 77–82, 2004. doi:10.1038/ng1274.
-
(2004)
Nat Genet
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
Macdonald, M.L.4
Franchini, P.L.5
Dubé, M.P.6
Res, L.7
Macfarlane, J.8
Sakellaropoulos, N.9
Politou, M.10
Nemeth, E.11
Thompson, J.12
Risler, J.K.13
Zaborowska, C.14
Babakaiff, R.15
Radomski, C.C.16
Pape, T.D.17
Davidas, O.18
Christakis, J.19
Brissot, P.20
Lockitch, G.21
Ganz, T.22
Hayden, M.R.23
Goldberg, Y.P.24
more..
-
66
-
-
0030712463
-
Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
-
Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, Fleming RE, Sly WS. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 94: 13198–13202, 1997. doi:10.1073/pnas.94.24.13198.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13198-13202
-
-
Parkkila, S.1
Waheed, A.2
Britton, R.S.3
Bacon, B.R.4
Zhou, X.Y.5
Tomatsu, S.6
Fleming, R.E.7
Sly, W.S.8
-
67
-
-
0031002910
-
Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
-
Parkkila S, Waheed A, Britton RS, Feder JN, Tsuchihashi Z, Schatzman RC, Bacon BR, Sly WS. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci USA 94: 2534–2539, 1997. doi:10.1073/pnas.94.6.2534.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2534-2539
-
-
Parkkila, S.1
Waheed, A.2
Britton, R.S.3
Feder, J.N.4
Tsuchihashi, Z.5
Schatzman, R.C.6
Bacon, B.R.7
Sly, W.S.8
-
68
-
-
84055190801
-
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
-
Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest 121: 4880–4888, 2011. doi:10.1172/JCI57693.
-
(2011)
J Clin Invest
, vol.121
, pp. 4880-4888
-
-
Preza, G.C.1
Ruchala, P.2
Pinon, R.3
Ramos, E.4
Qiao, B.5
Peralta, M.A.6
Sharma, S.7
Waring, A.8
Ganz, T.9
Nemeth, E.10
-
69
-
-
84862002810
-
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination
-
Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab 15: 918–924, 2012. doi:10.1016/j.cmet.2012.03.018.
-
(2012)
Cell Metab
, vol.15
, pp. 918-924
-
-
Qiao, B.1
Sugianto, P.2
Fung, E.3
Del-Castillo-rueda, A.4
Moran-Jimenez, M.J.5
Ganz, T.6
Nemeth, E.7
-
70
-
-
85005921759
-
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease
-
Raha AA, Vaishnav RA, Friedland RP, Bomford A, Raha-Chowdhury R. The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease. Acta Neuropathol Commun 1: 55, 2013. doi:10.1186/2051-5960-1-55.
-
(2013)
Acta Neuropathol Commun
, vol.1
, pp. 55
-
-
Raha, A.A.1
Vaishnav, R.A.2
Friedland, R.P.3
Bomford, A.4
Raha-Chowdhury, R.5
-
71
-
-
79953757053
-
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
-
Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53: 1333–1341, 2011. doi:10.1002/hep.24178.
-
(2011)
Hepatology
, vol.53
, pp. 1333-1341
-
-
Ramos, E.1
Kautz, L.2
Rodriguez, R.3
Hansen, M.4
Gabayan, V.5
Ginzburg, Y.6
Roth, M.P.7
Nemeth, E.8
Ganz, T.9
-
72
-
-
84868545645
-
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
-
Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood 120: 3829–3836, 2012. doi:10.1182/blood-2012-07-440743.
-
(2012)
Blood
, vol.120
, pp. 3829-3836
-
-
Ramos, E.1
Ruchala, P.2
Goodnough, J.B.3
Kautz, L.4
Preza, G.C.5
Nemeth, E.6
Ganz, T.7
-
73
-
-
79251571756
-
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis
-
Ramos P, Guy E, Chen N, Proenca CC, Gardenghi S, Casu C, Follenzi A, Van Rooijen N, Grady RW, de Sousa M, Rivella S. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood 117: 1379–1389, 2011. doi:10.1182/blood-2010-09-307462.
-
(2011)
Blood
, vol.117
, pp. 1379-1389
-
-
Ramos, P.1
Guy, E.2
Chen, N.3
Proenca, C.C.4
Gardenghi, S.5
Casu, C.6
Follenzi, A.7
Van Rooijen, N.8
Grady, R.W.9
De Sousa, M.10
Rivella, S.11
-
74
-
-
84885400359
-
In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact
-
Rishi G, Crampton EM, Wallace DF, Subramaniam VN. In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact. PLoS One 8: e77267, 2013. doi:10.1371/journal.pone.0077267.
-
(2013)
Plos One
, vol.8
-
-
Rishi, G.1
Crampton, E.M.2
Wallace, D.F.3
Subramaniam, V.N.4
-
75
-
-
84978200043
-
Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia
-
Rishi G, Secondes ES, Wallace DF, Subramaniam VN. Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia. Am J Hematol 91: 812–818, 2016. doi:10.1002/ajh.24417.
-
(2016)
Am J Hematol
, vol.91
, pp. 812-818
-
-
Rishi, G.1
Secondes, E.S.2
Wallace, D.F.3
Subramaniam, V.N.4
-
76
-
-
84956935468
-
Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
-
Rishi G, Secondes ES, Wallace DF, Subramaniam VN. Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2. Am J Physiol Gastrointest Liver Physiol 310: G171–G180, 2016.
-
(2016)
Am J Physiol Gastrointest Liver Physiol
, vol.310
, pp. G171-G180
-
-
Rishi, G.1
Secondes, E.S.2
Wallace, D.F.3
Subramaniam, V.N.4
-
77
-
-
84929575005
-
Hepcidin: Regulation of the master iron regulator
-
Rishi G, Wallace DF, Subramaniam VN. Hepcidin: regulation of the master iron regulator. Biosci Rep 35: e00192, 2015. doi:10.1042/BSR20150014.
-
(2015)
Biosci Rep
, vol.35
-
-
Rishi, G.1
Wallace, D.F.2
Subramaniam, V.N.3
-
78
-
-
84862007363
-
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT
-
Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metab 15: 905–917, 2012. doi:10.1016/j.cmet.2012.03.017.
-
(2012)
Cell Metab
, vol.15
, pp. 905-917
-
-
Ross, S.L.1
Tran, L.2
Winters, A.3
Lee, K.J.4
Plewa, C.5
Foltz, I.6
King, C.7
Miranda, L.P.8
Allen, J.9
Beckman, H.10
Cooke, K.S.11
Moody, G.12
Sasu, B.J.13
Nemeth, E.14
Ganz, T.15
Molineux, G.16
Arvedson, T.L.17
-
79
-
-
84861344055
-
Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2
-
Schmidt PJ, Fleming MD. Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. Am J Hematol 87: 588–595, 2012. doi:10.1002/ajh.23173.
-
(2012)
Am J Hematol
, vol.87
, pp. 588-595
-
-
Schmidt, P.J.1
Fleming, M.D.2
-
80
-
-
39649115776
-
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
-
Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab 7: 205–214, 2008. doi:10.1016/j.cmet.2007.11.016.
-
(2008)
Cell Metab
, vol.7
, pp. 205-214
-
-
Schmidt, P.J.1
Toran, P.T.2
Giannetti, A.M.3
Bjorkman, P.J.4
Rews, N.C.5
-
81
-
-
84874066920
-
_/_ mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
-
_/_ mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood 121: 1200–1208, 2013. doi:10.1182/blood-2012-09-453977.
-
(2013)
Blood
, vol.121
, pp. 1200-1208
-
-
Schmidt, P.J.1
Toudjarska, I.2
Sendamarai, A.K.3
Racie, T.4
Milstein, S.5
Bettencourt, B.R.6
Hettinger, J.7
Bumcrot, D.8
Fleming, M.D.9
-
82
-
-
78449299628
-
Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle
-
Severyn CJ, Rotwein P. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle. Genomics 96: 342–351, 2010. doi:10.1016/j.ygeno.2010.09.001.
-
(2010)
Genomics
, vol.96
, pp. 342-351
-
-
Severyn, C.J.1
Rotwein, P.2
-
83
-
-
56449096622
-
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
-
Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 8: 502–511, 2008. doi:10.1016/j.cmet.2008.09.012.
-
(2008)
Cell Metab
, vol.8
, pp. 502-511
-
-
Silvestri, L.1
Pagani, A.2
Nai, A.3
De Domenico, I.4
Kaplan, J.5
Camaschella, C.6
-
84
-
-
0031803414
-
Mice lacking Bmp6 function
-
Solloway MJ, Dudley AT, Bikoff EK, Lyons KM, Hogan BL, Robertson EJ. Mice lacking Bmp6 function. Dev Genet 22: 321–339, 1998. doi:10.1002/(SICI)1520-6408(1998)22:4_321::AID-DVG3_3.0.CO;2-8.
-
(1998)
Dev Genet
, vol.22
, pp. 321-339
-
-
Solloway, M.J.1
Dudley, A.T.2
Bikoff, E.K.3
Lyons, K.M.4
Hogan, B.L.5
Robertson, E.J.6
-
85
-
-
70350482508
-
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
-
Truksa J, Gelbart T, Peng H, Beutler E, Beutler B, Lee P. Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6. Br J Haematol 147: 571–581, 2009. doi:10.1111/j.1365-2141.2009.07873.x.
-
(2009)
Br J Haematol
, vol.147
, pp. 571-581
-
-
Truksa, J.1
Gelbart, T.2
Peng, H.3
Beutler, E.4
Beutler, B.5
Lee, P.6
-
86
-
-
0037020169
-
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins
-
Velasco G, Cal S, Quesada V, Sánchez LM, López-Otín C. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem 277: 37637–37646, 2002. doi:10.1074/jbc.M203007200.
-
(2002)
J Biol Chem
, vol.277
, pp. 37637-37646
-
-
Velasco, G.1
Cal, S.2
Quesada, V.3
Sánchez, L.M.4
López-Otín, C.5
-
87
-
-
38649128515
-
Hfe acts in hepatocytes to prevent hemochromatosis
-
Vujić Spasić M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 7: 173–178, 2008. doi:10.1016/j.cmet.2007.11.014.
-
(2008)
Cell Metab
, vol.7
, pp. 173-178
-
-
Vujić Spasić, M.1
Kiss, J.2
Herrmann, T.3
Galy, B.4
Martinache, S.5
Stolte, J.6
Gröne, H.J.7
Stremmel, W.8
Hentze, M.W.9
Muckenthaler, M.U.10
-
88
-
-
85002878181
-
Therapeutic potential of hepcidin—the master regulator of iron metabolism
-
Vyoral D, Jiri Petrak. Therapeutic potential of hepcidin—the master regulator of iron metabolism. Pharmacol Res 115: 242–254, 2017. doi:10.1016/j.phrs.2016.11.010.
-
(2017)
Pharmacol Res
, vol.115
, pp. 242-254
-
-
Vyoral, D.1
Petrak, J.2
-
89
-
-
0030732164
-
Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β
-
2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc Natl Acad Sci USA 94: 12384–12389, 1997. doi:10.1073/pnas.94.23.12384.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 12384-12389
-
-
Waheed, A.1
Parkkila, S.2
Zhou, X.Y.3
Tomatsu, S.4
Tsuchihashi, Z.5
Feder, J.N.6
Schatzman, R.C.7
Britton, R.S.8
Bacon, B.R.9
Sly, W.S.10
-
90
-
-
79953121575
-
Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
-
Wallace DF, McDonald CJ, Ostini L, Subramaniam VN. Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2. Blood 117: 2960–2966, 2011. doi:10.1182/blood-2010-08-303859.
-
(2011)
Blood
, vol.117
, pp. 2960-2966
-
-
Wallace, D.F.1
McDonald, C.J.2
Ostini, L.3
Subramaniam, V.N.4
-
91
-
-
84924053200
-
A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction
-
Wallace DF, Secondes ES, Rishi G, Ostini L, McDonald CJ, Lane SW, Vu T, Hooper JD, Velasco G, Ramsay AJ, Lopez-Otin C, Subramaniam VN. A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction. Br J Haematol 168: 891–901, 2015. doi:10.1111/bjh.13225.
-
(2015)
Br J Haematol
, vol.168
, pp. 891-901
-
-
Wallace, D.F.1
Secondes, E.S.2
Rishi, G.3
Ostini, L.4
McDonald, C.J.5
Lane, S.W.6
Vu, T.7
Hooper, J.D.8
Velasco, G.9
Ramsay, A.J.10
Lopez-Otin, C.11
Subramaniam, V.N.12
-
92
-
-
21044434748
-
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
-
Wallace DF, Summerville L, Lusby PE, Subramaniam VN. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54: 980–986, 2005. doi:10.1136/gut.2004.062018.
-
(2005)
Gut
, vol.54
, pp. 980-986
-
-
Wallace, D.F.1
Summerville, L.2
Lusby, P.E.3
Subramaniam, V.N.4
-
93
-
-
33846225653
-
Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload
-
Wallace DF, Summerville L, Subramaniam VN. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology 132: 301–310, 2007. doi:10.1053/j.gastro.2006.11.028.
-
(2007)
Gastroenterology
, vol.132
, pp. 301-310
-
-
Wallace, D.F.1
Summerville, L.2
Subramaniam, V.N.3
-
94
-
-
84958780878
-
Hepcidin regulation in the anemia of inflammation
-
Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol 23: 189–197, 2016. doi:10.1097/MOH.0000000000000236.
-
(2016)
Curr Opin Hematol
, vol.23
, pp. 189-197
-
-
Wang, C.Y.1
Babitt, J.L.2
-
95
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2: 399–409, 2005. doi:10.1016/j.cmet.2005.10.010.
-
(2005)
Cell Metab
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
Zheng, Y.4
Xiao, C.5
Zerfas, P.6
Cooperman, S.7
Eckhaus, M.8
Rouault, T.9
Mishra, L.10
Deng, C.X.11
-
96
-
-
0034623930
-
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
-
West AP Jr., Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 275: 38135–38138, 2000. doi:10.1074/jbc.C000664200.
-
(2000)
J Biol Chem
, vol.275
, pp. 38135-38138
-
-
West, A.P.1
Bennett, M.J.2
Sellers, V.M.3
Rews, N.C.4
Enns, C.A.5
Bjorkman, P.J.6
-
97
-
-
84907321174
-
Interacts with the BMP type I receptor ALK3 to regulate hepcidin expression
-
Wu XG, Wang Y, Wu Q, Cheng WH, Liu W, Zhao Y, Mayeur C, Schmidt PJ, Yu PB, Wang F, Xia Y. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood 124: 1335–1343, 2014. doi:10.1182/blood-2014-01-552281.
-
(2014)
Blood
, vol.124
, pp. 1335-1343
-
-
Wu, X.G.1
Wang, Y.2
Wu, Q.3
Cheng, W.H.4
Liu, W.5
Zhao, Y.6
Mayeur, C.7
Schmidt, P.J.8
Yu, P.B.9
Wang, F.10
Xia, Y.11
-
98
-
-
46749158788
-
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
-
Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111: 5195–5204, 2008. doi:10.1182/blood-2007-09-111567.
-
(2008)
Blood
, vol.111
, pp. 5195-5204
-
-
Xia, Y.1
Babitt, J.L.2
Sidis, Y.3
Chung, R.T.4
Lin, H.Y.5
-
99
-
-
79551629285
-
Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein
-
Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood 117: 1687–1699, 2011. doi:10.1182/blood-2010-06-287292.
-
(2011)
Blood
, vol.117
, pp. 1687-1699
-
-
Zhang, A.S.1
Erson, S.A.2
Wang, J.3
Yang, F.4
Demaster, K.5
Ahmed, R.6
Nizzi, C.P.7
Eisenstein, R.S.8
Tsukamoto, H.9
Enns, C.A.10
-
100
-
-
0842263988
-
Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes
-
Zhang AS, Xiong S, Tsukamoto H, Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood 103: 1509–1514, 2004. doi:10.1182/blood-2003-07-2378.
-
(2004)
Blood
, vol.103
, pp. 1509-1514
-
-
Zhang, A.S.1
Xiong, S.2
Tsukamoto, H.3
Enns, C.A.4
-
101
-
-
84897994449
-
Bmp6 expression can be regulated independently of liver iron in mice
-
Zhang Z, Guo X, Herrera C, Tao Y, Wu Q, Wu A, Wang H, Bartnikas TB, Wang F. Bmp6 expression can be regulated independently of liver iron in mice. PLoS One 9: e84906, 2014. doi:10.1371/journal.pone.0084906.
-
(2014)
Plos One
, vol.9
-
-
Zhang, Z.1
Guo, X.2
Herrera, C.3
Tao, Y.4
Wu, Q.5
Wu, A.6
Wang, H.7
Bartnikas, T.B.8
Wang, F.9
-
102
-
-
84922789739
-
Low intracellular iron increases the stability of matriptase-2
-
Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS. Low intracellular iron increases the stability of matriptase-2. J Biol Chem 290: 4432–4446, 2015. doi: 10.1074/jbc.M114.611913.
-
(2015)
J Biol Chem
, vol.290
, pp. 4432-4446
-
-
Zhao, N.1
Nizzi, C.P.2
Erson, S.A.3
Wang, J.4
Ueno, A.5
Tsukamoto, H.6
Eisenstein, R.S.7
Enns, C.A.8
Zhang, A.S.9
-
103
-
-
0001376313
-
HFE gene knockout produces mouse model of hereditary hemochromatosis
-
Zhou XY, Tomatsu S, Fleming RE, Parkkila S, Waheed A, Jiang J, Fei Y, Brunt EM, Ruddy DA, Prass CE, Schatzman RC, O’Neill R, Britton RS, Bacon BR, Sly WS. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci USA 95: 2492–2497, 1998. doi:10.1073/pnas.95.5.2492.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2492-2497
-
-
Zhou, X.Y.1
Tomatsu, S.2
Fleming, R.E.3
Parkkila, S.4
Waheed, A.5
Jiang, J.6
Fei, Y.7
Brunt, E.M.8
Ruddy, D.A.9
Prass, C.E.10
Schatzman, R.C.11
O’Neill, R.12
Britton, R.S.13
Bacon, B.R.14
Sly, W.S.15
|