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Volumn 128, Issue 2, 2016, Pages 265-276

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANEMIC AGENT; DEFERIPRONE; HEMOGLOBIN; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HEPCIDIN; IRON; JANUS KINASE 2; MINIHEPCIDIN M004; MINIHEPCIDIN M009; STAT5 PROTEIN; UNCLASSIFIED DRUG; JAK2 PROTEIN, MOUSE; PEPTIDE;

EID: 84978370086     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-10-676742     Document Type: Article
Times cited : (122)

References (28)
  • 1
    • 84926317302 scopus 로고    scopus 로고
    • β-thalassemias: Paradigmatic diseases for scientific discoveries and development of innovative therapies
    • Rivella S. β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica. 2015;100(4):418-430.
    • (2015) Haematologica , vol.100 , Issue.4 , pp. 418-430
    • Rivella, S.1
  • 2
    • 84875849962 scopus 로고    scopus 로고
    • Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
    • Guo S, Casu C, Gardenghi S, et al. Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. J Clin Invest. 2013;123(4):1531-1541.
    • (2013) J Clin Invest. , vol.123 , Issue.4 , pp. 1531-1541
    • Guo, S.1    Casu, C.2    Gardenghi, S.3
  • 3
    • 78649813036 scopus 로고    scopus 로고
    • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
    • Gardenghi S, Ramos P, Marongiu MF, et al. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest. 2010;120(12):4466-4477.
    • (2010) J Clin Invest. , vol.120 , Issue.12 , pp. 4466-4477
    • Gardenghi, S.1    Ramos, P.2    Marongiu, M.F.3
  • 5
    • 84890288632 scopus 로고    scopus 로고
    • Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia
    • Anderson ER, Taylor M, Xue X, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci USA. 2013;110(50):E4922-E4930.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.50 , pp. E4922-E4930
    • Anderson, E.R.1    Taylor, M.2    Xue, X.3
  • 6
    • 0346433908 scopus 로고    scopus 로고
    • Decreased hepcidin mRNA expression in thalassemic mice
    • Adamsky K, Weizer O, Amariglio N, et al. Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol. 2004;124(1):123-124.
    • (2004) Br J Haematol. , vol.124 , Issue.1 , pp. 123-124
    • Adamsky, K.1    Weizer, O.2    Amariglio, N.3
  • 7
    • 84903578007 scopus 로고    scopus 로고
    • Identification of erythroferrone as an erythroid regulator of iron metabolism
    • Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46(7):678-684.
    • (2014) Nat Genet. , vol.46 , Issue.7 , pp. 678-684
    • Kautz, L.1    Jung, G.2    Valore, E.V.3    Rivella, S.4    Nemeth, E.5    Ganz, T.6
  • 8
    • 84859336675 scopus 로고    scopus 로고
    • Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling
    • Parrow NL, Gardenghi S, Ramos P, et al. Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling. Blood. 2012;119(13):3187-3189.
    • (2012) Blood , vol.119 , Issue.13 , pp. 3187-3189
    • Parrow, N.L.1    Gardenghi, S.2    Ramos, P.3
  • 9
    • 84873361483 scopus 로고    scopus 로고
    • The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption
    • Anderson SA, Nizzi CP, Chang YI, et al. The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab. 2013;17(2):282-290.
    • (2013) Cell Metab. , vol.17 , Issue.2 , pp. 282-290
    • Anderson, S.A.1    Nizzi, C.P.2    Chang, Y.I.3
  • 10
    • 38349111676 scopus 로고    scopus 로고
    • Role of the hypoxia inducible factors HIF in iron metabolism
    • Peyssonnaux C, Nizet V, Johnson RS. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle. 2008;7(1):28-32.
    • (2008) Cell Cycle , vol.7 , Issue.1 , pp. 28-32
    • Peyssonnaux, C.1    Nizet, V.2    Johnson, R.S.3
  • 11
    • 77953274727 scopus 로고    scopus 로고
    • Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    • Mullally A, Lane SW, Ball B, et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell. 2010;17(6):584-596.
    • (2010) Cancer Cell. , vol.17 , Issue.6 , pp. 584-596
    • Mullally, A.1    Lane, S.W.2    Ball, B.3
  • 12
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397.
    • (2005) Cancer Cell. , vol.7 , Issue.4 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 13
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352(17):1779-1790.
    • (2005) N Engl J Med. , vol.352 , Issue.17 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 14
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couédic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couédic, J.P.3
  • 15
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Cancer Genome Project
    • Baxter EJ, Scott LM, Campbell PJ, et al; Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061.
    • (2005) Lancet , vol.365 , Issue.9464 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 16
    • 84871746842 scopus 로고    scopus 로고
    • Cardiovascular events and intensity of treatment in polycythemia vera
    • Marchioli R, Finazzi G, Specchia G, et al; CYTO-PV Collaborative Group. Cardiovascular events and intensity of treatment in polycythemia vera. N Engl J Med. 2013;368(1):22-33.
    • (2013) N Engl J Med. , vol.368 , Issue.1 , pp. 22-33
    • Marchioli, R.1    Finazzi, G.2    Specchia, G.3
  • 17
    • 84868545645 scopus 로고    scopus 로고
    • Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
    • Ramos E, Ruchala P, Goodnough JB, et al. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012;120(18):3829-3836.
    • (2012) Blood , vol.120 , Issue.18 , pp. 3829-3836
    • Ramos, E.1    Ruchala, P.2    Goodnough, J.B.3
  • 18
    • 84055190801 scopus 로고    scopus 로고
    • Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
    • Preza GC, Ruchala P, Pinon R, et al. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest. 2011;121(12):4880-4888.
    • (2011) J Clin Invest. , vol.121 , Issue.12 , pp. 4880-4888
    • Preza, G.C.1    Ruchala, P.2    Pinon, R.3
  • 19
    • 84944930727 scopus 로고    scopus 로고
    • Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia
    • Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. Blood. 2015;126(17):2031-2037.
    • (2015) Blood , vol.126 , Issue.17 , pp. 2031-2037
    • Kautz, L.1    Jung, G.2    Du, X.3
  • 20
    • 50949133924 scopus 로고    scopus 로고
    • Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia
    • Libani IV, Guy EC, Melchiori L, et al. Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood. 2008;112(3):875-885.
    • (2008) Blood , vol.112 , Issue.3 , pp. 875-885
    • Libani, I.V.1    Guy, E.C.2    Melchiori, L.3
  • 21
    • 34249658982 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
    • Gardenghi S, Marongiu MF, Ramos P, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109(11):5027-5035.
    • (2007) Blood , vol.109 , Issue.11 , pp. 5027-5035
    • Gardenghi, S.1    Marongiu, M.F.2    Ramos, P.3
  • 22
    • 77955870192 scopus 로고    scopus 로고
    • Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models
    • Ramos P, Melchiori L, Gardenghi S, et al. Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models. Ann N Y Acad Sci. 2010;1202:24-30.
    • (2010) Ann N Y Acad Sci. , vol.1202 , pp. 24-30
    • Ramos, P.1    Melchiori, L.2    Gardenghi, S.3
  • 23
    • 84952923690 scopus 로고    scopus 로고
    • Combination of Tmprss6-ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia
    • Casu C, Aghajan M, Oikonomidou PR, Guo S, Monia BP, Rivella S. Combination of Tmprss6-ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia. Haematologica. 2016;101(1):e8-e11.
    • (2016) Haematologica , vol.101 , Issue.1 , pp. e8-e11
    • Casu, C.1    Aghajan, M.2    Oikonomidou, P.R.3    Guo, S.4    Monia, B.P.5    Rivella, S.6
  • 24
    • 77954568361 scopus 로고    scopus 로고
    • beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
    • Melchiori L, Gardenghi S, Rivella S. beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload. Adv Hematol. 2010;2010:938640.
    • (2010) Adv Hematol. , vol.2010 , pp. 938640
    • Melchiori, L.1    Gardenghi, S.2    Rivella, S.3
  • 25
    • 0035760889 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts
    • Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001;98(12):3261-3273.
    • (2001) Blood , vol.98 , Issue.12 , pp. 3261-3273
    • Socolovsky, M.1    Nam, H.2    Fleming, M.D.3    Haase, V.H.4    Brugnara, C.5    Lodish, H.F.6
  • 26
    • 84878439561 scopus 로고    scopus 로고
    • Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia
    • Ramos P, Casu C, Gardenghi S, et al. Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med. 2013;19(4):437-445.
    • (2013) Nat Med. , vol.19 , Issue.4 , pp. 437-445
    • Ramos, P.1    Casu, C.2    Gardenghi, S.3
  • 27
    • 34447306076 scopus 로고    scopus 로고
    • Liver iron concentrations and urinary hepcidin in beta-thalassemia
    • Origa R, Galanello R, Ganz T, et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007;92(5):583-588.
    • (2007) Haematologica , vol.92 , Issue.5 , pp. 583-588
    • Origa, R.1    Galanello, R.2    Ganz, T.3
  • 28
    • 84925303329 scopus 로고    scopus 로고
    • Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia
    • Schmidt PJ, Racie T, Westerman M, Fitzgerald K, Butler JS, Fleming MD. Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia. Am J Hematol. 2015; 90(4):310-313.
    • (2015) Am J Hematol. , vol.90 , Issue.4 , pp. 310-313
    • Schmidt, P.J.1    Racie, T.2    Westerman, M.3    Fitzgerald, K.4    Butler, J.S.5    Fleming, M.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.