-
1
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
DOI 10.1126/science.1104742
-
Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. (Pubitemid 40007660)
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.D.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
2
-
-
70450214396
-
The role of hepcidin in iron metabolism
-
Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009;122(2-3):78-86.
-
(2009)
Acta Haematol
, vol.122
, Issue.2-3
, pp. 78-86
-
-
Nemeth, E.1
Ganz, T.2
-
3
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38(5):531-539.
-
(2006)
Nat Genet
, vol.38
, Issue.5
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
-
4
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
DOI 10.1038/ng1274
-
Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36(1):77-82. (Pubitemid 38056211)
-
(2004)
Nature Genetics
, vol.36
, Issue.1
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
MacDonald, M.L.E.4
Franchini, P.L.5
Dube, M.-P.6
Andres, L.7
MacFarlane, J.8
Sakellaropoulos, N.9
Politou, M.10
Nemeth, E.11
Thompson, J.12
Risler, J.K.13
Zaborowska, C.14
Babakaiff, R.15
Radomski, C.C.16
Pape, T.D.17
Davidas, O.18
Christakis, J.19
Brissot, P.20
Lockitch, G.21
Ganz, T.22
Hayden, M.R.23
Goldberg, Y.P.24
more..
-
5
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
-
DOI 10.1016/S0140-6736(03)12602-5
-
Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet. 2003;361(9358):669-673. (Pubitemid 36246550)
-
(2003)
Lancet
, vol.361
, Issue.9358
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
Dixon, J.L.4
Purdie, D.M.5
Crawford, D.H.G.6
Subramaniam, V.N.7
Powell, L.W.8
Anderson, G.J.9
Ramm, G.A.10
-
6
-
-
13544250486
-
Hepcidin is decreased in TFR2 hemochromatosis
-
DOI 10.1182/blood-2004-08-3042
-
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005;105(4):1803-1806. (Pubitemid 40223705)
-
(2005)
Blood
, vol.105
, Issue.4
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
7
-
-
73149083742
-
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
-
Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009;50(6):1992-2000.
-
(2009)
Hepatology
, vol.50
, Issue.6
, pp. 1992-2000
-
-
Wallace, D.F.1
Summerville, L.2
Crampton, E.M.3
Frazer, D.M.4
Anderson, G.J.5
Subramaniam, V.N.6
-
8
-
-
66749183353
-
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
-
Ramey G, Deschemin JC, Vaulont S. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica. 2009;94(6):765-772.
-
(2009)
Haematologica
, vol.94
, Issue.6
, pp. 765-772
-
-
Ramey, G.1
Deschemin, J.C.2
Vaulont, S.3
-
9
-
-
70349494083
-
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
-
Corradini E, Garuti C, Montosi G, et al. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology. 2009;137(4):1489-1497.
-
(2009)
Gastroenterology
, vol.137
, Issue.4
, pp. 1489-1497
-
-
Corradini, E.1
Garuti, C.2
Montosi, G.3
-
10
-
-
77957964766
-
Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis
-
Ryan JD, Ryan E, Fabre A, LawlessMW, Crowe J. Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis. Hepatology. 2010;52(4):1266-1273.
-
(2010)
Hepatology
, vol.52
, Issue.4
, pp. 1266-1273
-
-
Ryan, J.D.1
Ryan, E.2
Fabre, A.3
Lawless, M.W.4
Crowe, J.5
-
11
-
-
78049463632
-
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
-
Corradini E, Schmidt PJ, Meynard D, et al. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology. 2010;139(5):1721-1729.
-
(2010)
Gastroenterology
, vol.139
, Issue.5
, pp. 1721-1729
-
-
Corradini, E.1
Schmidt, P.J.2
Meynard, D.3
-
12
-
-
0034284595
-
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
-
Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480(2-3):147-150.
-
(2000)
FEBS Lett
, vol.480
, Issue.2-3
, pp. 147-150
-
-
Krause, A.1
Neitz, S.2
Magert, H.J.3
-
13
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276(11):7806-7810.
-
(2001)
J Biol Chem
, vol.276
, Issue.11
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
14
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110(7):1037-1044.
-
(2002)
J Clin Invest
, vol.110
, Issue.7
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
-
15
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
DOI 10.1172/JCI200420945
-
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271-1276. (Pubitemid 39069926)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.9
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
Keller, C.4
Taudorf, S.5
Pedersen, B.K.6
Ganz, T.7
-
16
-
-
3442875926
-
Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE
-
DOI 10.1111/j.1365-2141.2004.05044.x
-
Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ. Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol. 2004;126(3):434-436. (Pubitemid 39005725)
-
(2004)
British Journal of Haematology
, vol.126
, Issue.3
, pp. 434-436
-
-
Frazer, D.M.1
Wilkins, S.J.2
Millard, K.N.3
McKie, A.T.4
Vulpe, C.D.5
Anderson, G.J.6
-
17
-
-
13844307889
-
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
-
DOI 10.1073/pnas.0409808102
-
Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci U S A. 2005;102(6):1906-1910. (Pubitemid 40261985)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.6
, pp. 1906-1910
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Wang, L.4
Beutler, E.5
-
18
-
-
33846212344
-
STAT3 Is Required for IL-6-gp130-Dependent Activation of Hepcidin in Vivo
-
DOI 10.1053/j.gastro.2006.10.018, PII S0016508506022414
-
Pietrangelo A, Dierssen U, Valli L, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132(1):294-300. (Pubitemid 46108739)
-
(2007)
Gastroenterology
, vol.132
, Issue.1
, pp. 294-300
-
-
Pietrangelo, A.1
Dierssen, U.2
Valli, L.3
Garuti, C.4
Rump, A.5
Corradini, E.6
Ernst, M.7
Klein, C.8
Trautwein, C.9
-
19
-
-
2442426523
-
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
-
DOI 10.1038/ng1350
-
Roy CN, Custodio AO, de Graaf J, et al. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet. 2004;36(5):481-485. (Pubitemid 38620032)
-
(2004)
Nature Genetics
, vol.36
, Issue.5
, pp. 481-485
-
-
Roy, C.N.1
Custodio, A.O.2
De Graaf, J.3
Schneider, S.4
Akpan, I.5
Montross, L.K.6
Sanchez, M.7
Gaudino, A.8
Hentze, M.W.9
Andrews, N.C.10
Muckenthaler, M.U.11
-
20
-
-
3042636759
-
2-microglobulin-deficient hepatocytes
-
DOI 10.1073/pnas.0403108101
-
Lee P, Peng H, Gelbart T, Beutler E. The IL-6-and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A. 2004;101(25):9263-9265. (Pubitemid 38812863)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.25
, pp. 9263-9265
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Beutler, E.4
-
21
-
-
0014267781
-
A simple technique for measuring storage iron concentrations in formalinised liver samples
-
Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci. 1968;33(1):9-11.
-
(1968)
S Afr J Med Sci
, vol.33
, Issue.1
, pp. 9-11
-
-
Torrance, J.D.1
Bothwell, T.H.2
-
22
-
-
21044434748
-
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
-
DOI 10.1136/gut.2004.062018
-
Wallace DF, Summerville L, Lusby PE, Subramaniam VN. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut. 2005;54(7):980-986. (Pubitemid 40873913)
-
(2005)
Gut
, vol.54
, Issue.7
, pp. 980-986
-
-
Wallace, D.F.1
Summerville, L.2
Lusby, P.E.3
Subramaniam, V.N.4
-
23
-
-
77949707165
-
Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection
-
McDonald CJ, Jones MK, Wallace DF, Summerville L, Nawaratna S, Subramaniam VN. Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection. PLoS ONE. 2010;5(3):e9594.
-
(2010)
PLoS ONE
, vol.5
, Issue.3
-
-
McDonald, C.J.1
Jones, M.K.2
Wallace, D.F.3
Summerville, L.4
Nawaratna, S.5
Subramaniam, V.N.6
-
24
-
-
27644549634
-
Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression
-
DOI 10.1111/j.1365-2443.2005.00900.x
-
Hagihara K, Nishikawa T, Sugamata Y, et al. Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression. Genes Cells. 2005;10(11):1051-1063. (Pubitemid 41556074)
-
(2005)
Genes to Cells
, vol.10
, Issue.11
, pp. 1051-1063
-
-
Hagihara, K.1
Nishikawa, T.2
Sugamata, Y.3
Song, J.4
Isobe, T.5
Taga, T.6
Yoshizaki, K.7
-
25
-
-
0038312385
-
Decreased liver hepcidin expression in the Hfe knockout mouse
-
Ahmad KA, Ahmann JR, Migas MC, et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis. 2002;29(3):361-366.
-
(2002)
Blood Cells Mol Dis
, vol.29
, Issue.3
, pp. 361-366
-
-
Ahmad, K.A.1
Ahmann, J.R.2
Migas, M.C.3
-
26
-
-
19944427107
-
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
-
DOI 10.1182/blood-2004-04-1416
-
Kawabata H, Fleming RE, Gui D, et al. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood. 2005;105(1):376-381. (Pubitemid 40053107)
-
(2005)
Blood
, vol.105
, Issue.1
, pp. 376-381
-
-
Kawabata, H.1
Fleming, R.E.2
Gui, D.3
Moon, S.Y.4
Saitoh, T.5
O'Kelly, J.6
Umehara, Y.7
Wano, Y.8
Said, J.W.9
Koeffler, H.P.10
-
27
-
-
33846164453
-
Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3
-
DOI 10.1152/ajpgi.00278.2006
-
Drake SF, Morgan EH, Herbison CE, et al. Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G323-G328. (Pubitemid 46090274)
-
(2007)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.292
, Issue.1
-
-
Drake, S.F.1
Morgan, E.H.2
Herbison, C.E.3
Delima, R.4
Graham, R.M.5
Chua, A.C.G.6
Leedman, P.J.7
Fleming, R.E.8
Bacon, B.R.9
Olynyk, J.K.10
Trinder, D.11
-
28
-
-
53149123286
-
Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation
-
Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008; 181(4):2723-2731.
-
(2008)
J Immunol
, vol.181
, Issue.4
, pp. 2723-2731
-
-
Wang, L.1
Johnson, E.E.2
Shi, H.N.3
Walker, W.A.4
Wessling-Resnick, M.5
Cherayil, B.J.6
-
29
-
-
70449471723
-
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2
-
Nairz M, Theurl I, Schroll A, et al. Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. Blood. 2009;114(17):3642-3651.
-
(2009)
Blood
, vol.114
, Issue.17
, pp. 3642-3651
-
-
Nairz, M.1
Theurl, I.2
Schroll, A.3
-
30
-
-
0025860867
-
Hemochromatosis, iron and septicemia caused by Vibrio vulnificus
-
Bullen JJ, Spalding PB, Ward CG, Gutteridge JM. Hemochromatosis, iron and septicemia caused by Vibrio vulnificus. Arch Intern Med. 1991;151(8):1606-1609.
-
(1991)
Arch Intern Med
, vol.151
, Issue.8
, pp. 1606-1609
-
-
Bullen, J.J.1
Spalding, P.B.2
Ward, C.G.3
Gutteridge, J.M.4
-
31
-
-
0019840322
-
Role of iron in the pathogenesis of Vibrio vulnificus infections
-
Wright AC, Simpson LM, Oliver JD. Role of iron in the pathogenesis of Vibrio vulnificus infections. Infect Immun. 1981;34(2):503-507. (Pubitemid 12117552)
-
(1981)
Infection and Immunity
, vol.34
, Issue.2
, pp. 503-507
-
-
Wright, A.C.1
Simpson, L.M.2
Oliver, J.D.3
-
32
-
-
0344420199
-
Hepcidin: The Missing Link between Hemochromatosis and Infections
-
DOI 10.1128/IAI.71.12.6693-6700.2003
-
Ashrafian H. Hepcidin: the missing link between hemochromatosis and infections. Infect Immun. 2003;71(12):6693-6700. (Pubitemid 37475295)
-
(2003)
Infection and Immunity
, vol.71
, Issue.12
, pp. 6693-6700
-
-
Ashrafian, H.1
-
33
-
-
33646345331
-
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica
-
DOI 10.1128/IAI.74.5.3065-3067.2006
-
Chlosta S, Fishman DS, Harrington L, et al. The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect Immun. 2006;74(5):3065-3067. (Pubitemid 43673024)
-
(2006)
Infection and Immunity
, vol.74
, Issue.5
, pp. 3065-3067
-
-
Chlosta, S.1
Fishman, D.S.2
Harrington, L.3
Johnson, E.E.4
Knutson, M.D.5
Wessling-Resnick, M.6
Cherayil, B.J.7
-
34
-
-
34547863499
-
The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium
-
DOI 10.1111/j.1462-5822.2007.00942.x
-
Nairz M, Theurl I, Ludwiczek S, et al. The coordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium. Cell Microbiol. 2007;9(9):2126-2140. (Pubitemid 47250286)
-
(2007)
Cellular Microbiology
, vol.9
, Issue.9
, pp. 2126-2140
-
-
Nairz, M.1
Theurl, I.2
Ludwiczek, S.3
Theurl, M.4
Mair, S.M.5
Fritsche, G.6
Weiss, G.7
-
35
-
-
33845878232
-
Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages
-
DOI 10.1189/jlb.0606405
-
Olakanmi O, Schlesinger LS, Britigan BE. Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages. J Leukoc Biol. 2007;81(1):195-204. (Pubitemid 46021269)
-
(2007)
Journal of Leukocyte Biology
, vol.81
, Issue.1
, pp. 195-204
-
-
Olakanmi, O.1
Schlesinger, L.S.2
Britigan, B.E.3
-
36
-
-
50949104554
-
Iron depletion limits intracellular bacterial growth in macrophages
-
Paradkar PN, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward DM. Iron depletion limits intracellular bacterial growth in macrophages. Blood. 2008;112(3):866-874.
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 866-874
-
-
Paradkar, P.N.1
De Domenico, I.2
Durchfort, N.3
Zohn, I.4
Kaplan, J.5
Ward, D.M.6
|