Treatment resistant depression: A multi-scale, systems biology approach

Neuroscience and Biobehavioral Reviews

Volumn 84, Issue , 2018, Pages 272-288

  Akil, Huda ^a   Gordon, Joshua ^a,b,c   Hen, Rene ^a,b,c   Javitch, Jonathan ^a,b,c   Mayberg, Helen ^a,d   McEwen, Bruce ^a,e   Meaney, Michael J ^a,f,g   Nestler, Eric J ^a,h  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d EMORY UNIVERSITY   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

^f MCGILL UNIVERSITY   (Canada)

^g AGENCY FOR SCIENCE   (Singapore)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; ChIP sequencing; Epigenetics; Gene expression; GWAS; Hippocampus; Major depressive disorder; Neural circuits; Nucleus accumbens; Prefrontal cortex; RNA sequencing

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GLUCOCORTICOID RECEPTOR; LEVACECARNINE; MU OPIATE RECEPTOR; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; TIANEPTINE; TRICYCLIC ANTIDEPRESSANT AGENT;

AMYGDALA; CHRONIC STRESS; COGNITIVE BEHAVIORAL THERAPY; EARLY LIFE STRESS; EPIGENETICS; FUNCTIONAL CONNECTIVITY; GENE EXPRESSION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIATION; GENOMICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR DEPRESSION; MONOTHERAPY; MOUSE MODEL; NERVE CELL PLASTICITY; NEUROIMAGING; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; RNA SEQUENCE; RODENT MODEL; SELECTIVE BREEDING; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMS BIOLOGY; TRANSCRIPTOMICS; TREATMENT RESISTANT DEPRESSION; ANIMAL; BRAIN; DISEASE MODEL; GENETICS; MOLECULARLY TARGETED THERAPY; PATHOPHYSIOLOGY; PROCEDURES;

ANIMALS; BRAIN; DEPRESSIVE DISORDER, TREATMENT-RESISTANT; DISEASE MODELS, ANIMAL; HUMANS; MOLECULAR TARGETED THERAPY; SYSTEMS BIOLOGY;

EID: 85028723500     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2017.08.019     Document Type: Review

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