KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Nature Communications

Volumn 7, Issue , 2016, Pages

  Friedman, Allyson K ^a,b   Juarez, Barbara ^a   Ku, Stacy M ^a   Zhang, Hongxing ^a   Calizo, Rhodora C ^a   Walsh, Jessica J ^a   Chaudhury, Dipesh ^a   Zhang, Song ^a   Hawkins, Angel ^a   Dietz, David M ^a   Murrough, James W ^a   Ribadeneira, Maria ^c   Wong, Erik H ^c   Neve, Rachael L ^d   Han, Ming Hu ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c ASTRAZENECA   (United Kingdom)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; FLINDOKALNER; FLUPIRTINE; POTASSIUM CHANNEL KCNQ3; RETIGABINE; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANTIDEPRESSANT AGENT; CARBAMIC ACID DERIVATIVE; KCNQ3 PROTEIN, MOUSE; PHENYLENEDIAMINE DERIVATIVE;

DISEASE TREATMENT; DRUG USER; GENE EXPRESSION; GENETIC ENGINEERING; MENTAL HEALTH; POTASSIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; COPING BEHAVIOR; DEPRESSION; DOPAMINERGIC NERVE CELL; DRUG EFFICACY; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; MALE; MEDIAL PREFRONTAL CORTEX; MOUSE; NERVE CELL; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PROTEIN EXPRESSION; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL INTERACTION; SOCIAL STRESS; VENTRAL TEGMENTUM; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ELECTROPHYSIOLOGY; HUMAN; MAJOR DEPRESSION; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL RESILIENCE; PSYCHOLOGY;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CARBAMATES; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; KCNQ3 POTASSIUM CHANNEL; MALE; MEMBRANE TRANSPORT MODULATORS; MICE; MICE, INBRED C57BL; PHENYLENEDIAMINES; RESILIENCE, PSYCHOLOGICAL; STRESS, PSYCHOLOGICAL; VENTRAL TEGMENTAL AREA;

EID: 84969922360     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11671     Document Type: Article

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