Bidirectional switch of the valence associated with a hippocampal contextual memory engram

Nature

Volumn 513, Issue 7518, 2014, Pages 426-430

  Redondo, Roger L ^a   Kim, Joshua ^a   Arons, Autumn L ^a   Ramirez, Steve ^a   Liu, Xu ^a   Tonegawa, Susumu ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNELRHODOPSIN 2; DOXYCYCLINE; RHODOPSIN; UNCLASSIFIED DRUG;

BRAIN; CELLS AND CELL COMPONENTS; CONNECTIVITY; LIGHT EFFECT; MEMORY; NEUROLOGY; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; APPETITE; ARTICLE; AVOIDANCE BEHAVIOR; BASOLATERAL AMYGDALA; BEHAVIOR; BLUE LIGHT; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; DENTATE GYRUS; FEAR; FEMALE; FOOTSHOCK; HABITUATION; MALE; MEMORY; MOUSE; NONHUMAN; ONCOGENE C FOS; PHOTOREACTIVATION; PHOTOSTIMULATION; PLACE PREFERENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECALL; REWARD; AFFECT; AMYGDALOID NUCLEUS; ANIMAL; ASSOCIATION; C57BL MOUSE; HIPPOCAMPUS; NERVE CELL PLASTICITY; OPTOGENETICS; PHYSIOLOGY;

MUS;

AFFECT; AMYGDALA; ANIMALS; AVOIDANCE LEARNING; CONDITIONING, CLASSICAL; CUES; DENTATE GYRUS; FEAR; FEMALE; HIPPOCAMPUS; MALE; MEMORY; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; OPTOGENETICS; REWARD;

EID: 84907790422     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13725     Document Type: Article

References (28)

1. Pavlov, I. P. Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex (Oxford Univ. Press, 1927).
2. Wolpe, J. Psychotherapy by Reciprocal Inhibition (Stanford Univ. Press, 1958).
3. Liu, X. et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484, 381-385 (2012).
4. Ramirez, S. et al. Creating a false memory in the hippocampus. Science 341, 387-391 (2013).
5. Muramoto, K., Ono, T., Nishijo, H. & Fukuda, M. Rat amygdaloid neuron responses during auditory discrimination. Neuroscience 52, 621-636 (1993).
6. Schoenbaum, G., Chiba, A. A. & Gallagher, M. Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. J. Neurosci. 19, 1876-1884 (1999).
7. Paton, J. J., Belova, M. A., Morrison, S. E. & Salzman, C. D. The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439, 865-870 (2006).
8. Shabel, S. J. & Janak, P. H. Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal. Proc. Natl Acad. Sci. USA 106, 15031-15036 (2009).
9. Amano, T., Duvarci, S., Popa, D. & Paré, D. The fear circuit revisited: contributions of the basal amygdala nuclei to conditioned fear. J. Neurosci. 31, 15481-15489 (2011).
10. Sangha, S., Chadick, J. Z. & Janak, P. H. Safety encoding in the basal amygdala. J. Neurosci. 33, 3744-3751 (2013).
11. Teyler, T. J. & DiScenna, P. The hippocampal memory indexing theory. Behav. Neurosci. 100, 147-154 (1986).
12. Rudy, J. W. & O'Reilly, R. C. Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus. Behav. Neurosci. 113, 867-880 (1999).
13. Reijmers, L. G., Perkins, B. L., Matsuo, N. & Mayford, M. Localization of a stable neural correlate of associative memory. Science 317, 1230-1233 (2007).
14. Schiltz, C. A., Bremer, Q. Z., Landry, C. F. & Kelley, A. E. Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression. BMC Biol. 5, 16 (2007).
15. Wheeler, A. L. et al. Identification of a functional connectome for long-term fear memory in mice. PLOS Comput. Biol. 9, e1002853 (2013).
16. Kim, J., Kwon, J. T., Kim, H. S., Josselyn, S. A. & Han, J. H. Memory recall and modifications by activating neurons with elevated CREB. Nature Neurosci. 17, 65-72 (2014).
17. Huff, M. L., Miller, R. L., Deisseroth, K., Moorman, D. E. & LaLumiere, R. T. Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats. Proc. Natl Acad. Sci. USA 110, 3597-3602 (2013).
18. Malkesman, O. et al. The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents. Biol. Psychiatry 67, 864-871 (2010).
19. Kiyokawa, Y., Hiroshima, S., Takeuchi, Y. & Mori, Y. Social buffering reduces male rats' behavioral and corticosterone responses to a conditioned stimulus. Horm. Behav. 65, 114-118 (2014).
20. Maren, S. & Fanselow, M. S. Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J. Neurosci. 15, 7548-7564 (1995).
21. Maren, S. & Hobin, J. A. Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala. Learn. Mem. 14, 318-324 (2007).
22. Herry, C. et al. Switching on and off fear by distinct neuronal circuits. Nature 454, 600-606 (2008).
23. Stuber, G. D. et al. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature 475, 377-380 (2011).
24. Han, J. H. et al. Neuronal competition and selection during memory formation. Science 316, 457-460 (2007).
25. Choi, G. B. et al. Driving opposing behaviors with ensembles of piriform neurons. Cell 146, 1004-1015 (2011).
26. Franklin, K. B. J. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates (Academic Press, 2008).
27. Calcagnetti, D. J. & Schechter, M. D. Nicotine place preference using the biased method of conditioning. Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 925-933 (1994).
28. Blumstein, D. T. & Daniel, J. C. Quantifying Behavior the JWatcher Way (Sinauer Associates, 2007).