Serotonin receptors in depression: From A to B

F1000Research

Volumn 6, Issue , 2017, Pages

  Hen, René ^a,b   Nautiyal, Katherine M ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Howard Hughes Medical Institute   (United States)

Author keywords

5 HT1A; 5 HT1B; 5 HTT; Antidepressant; Major depressive disorder; MDD; Selective serotonin reuptake inhibitors; Serotonin; Serotonin receptor

Indexed keywords

ANTIDEPRESSANT AGENT; AUTORECEPTOR; BUSPIRONE; PINDOLOL; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B AGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 3A RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN 5A RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; VILAZODONE;

ANTIDEPRESSANT ACTIVITY; BRAIN REGION; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR DEPRESSION; MENTAL DISEASE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; TRANQUILIZING ACTIVITY; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 85013832414     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.9736.1     Document Type: Review

References (160)

1. Coppen A: The biochemistry of affective disorders. Br J Psychiatry. 1967;113(504):1237-64. 4169954 10.1192/bjp.113.504.1237
2. Albert PR Benkelfat C: The neurobiology of depression--revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies. Philos Trans R Soc Lond B Biol Sci. 2013;368(1615):20120535. 23440469 10.1098/rstb.2012.0535 3638388
3. De Montigny C: Enhancement of the 5-HT neurotransmission by antidepressant treatments. J Physiol (Paris). 1981;77(2-3):455-61. 6270317
4. AZIMA H VISPO RH: Imipramine; a potent new anti-depressant compound. Am J Psychiatry. 1958;115(3):245-6. 13571443 10.1176/ajp.115.3.245
5. Messing RB Phebus L Fisher LA: Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake. Psychopharmacol Commun. 1975;1(5):511-21. 132683
6. de Montigny C Blier P: Effects of antidepressant treatments on 5-HT neurotransmission: electrophysiological and clinical studies. Adv Biochem Psychopharmacol. 1984;39:223-39. 6087626
7. Lemberger L Rowe H Carmichael R: Pharmacologic effects in man of a specific serotonin-reuptake inhibitor. Science. 1978;199(4327):436-7. 619465 10.1126/science.619465
8. Nackenoff AG Moussa-Tooks AB McMeekin AM: Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology. 2016;41(7):1733-41. 26514584 10.1038/npp.2015.335 4869040 F1000 Recommendation
9. Asberg M Mårtensson B: Serotonin selective antidepressant drugs: past, present, future. Clin Neuropharmacol. 1993;16 Suppl 3:S32-44. 8131153
10. Mann JJ McBride PA Anderson GM: Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology. Biol Psychiatry. 1992;32(3):243-57. 1420642 10.1016/0006-3223(92)90106-A
11. Coppen A Turner P Rowsell AR: 5-Hydroxytryptamine (5-HT) in the whole-blood of patients with depressive illness. Postgrad Med J. 1976;52(605):156-8. 1264939 10.1136/pgmj.52.605.156 2496389
12. van Praag HM de Haan S: Central serotonin metabolism and frequency of depression. Psychiatry Res. 1979;1(3):219-24. 95233 10.1016/0165-1781(79)90002-7
13. Asberg M Bertilsson L Mårtensson B: CSF monoamine metabolites in melancholia. Acta Psychiatr Scand. 1984;69(3):201-19. 6201041 10.1111/j.1600-0447.1984.tb02488.x
14. Karege F Widmer J Bovier P: Platelet serotonin and plasma tryptophan in depressed patients: effect of drug treatment and clinical outcome. Neuropsychopharmacology. 1994;10(3):207-14. 7916918 10.1038/npp.1994.23
15. Ogawa S Fujii T Koga N: Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis. J Clin Psychiatry. 2014;75(9):e906-15. 25295433 10.4088/JCP.13r08908
16. Gaspar P Cases O Maroteaux L: The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci. 2003;4(12):1002-12. 14618156 10.1038/nrn1256
17. Barnes NM Sharp T: A review of central 5-HT receptors and their function. Neuropharmacology. 1999;38(8):1083-152. 10462127 10.1016/S0028-3908(99)00010-6
18. Bang SJ Jensen P Dymecki SM: Projections and interconnections of genetically defined serotonin neurons in mice. Eur J Neurosci. 2012;35(1):85-96. 22151329 10.1111/j.1460-9568.2011.07936.x 3268345
19. Carr GV Lucki I: The role of serotonin receptor subtypes in treating depression: a review of animal studies. Psychopharmacology (Berl). 2011;213(2-3):265-87. 21107537 10.1007/s00213-010-2097-z 3374933
20. Caspi A Sugden K Moffitt TE: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386-9. 12869766 10.1126/science.1083968 F1000 Recommendation
21. Karg K Burmeister M Shedden K: The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry. 2011;68(5):444-54. 21199959 10.1001/archgenpsychiatry.2010.189 3740203 F1000 Recommendation
22. Risch N Herrell R Lehner T: Interaction between the serotonin transporter gene ( 5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009;301(23):2462-71. 19531786 10.1001/jama.2009.878 2938776 F1000 Recommendation
23. Pezawas L Meyer-Lindenberg A Drabant EM: 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005;8(6):828-34. 15880108 10.1038/nn1463 F1000 Recommendation
24. Ansorge MS Zhou M Lira A: Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science. 2004;306(5697):879-81. 15514160 10.1126/science.1101678 F1000 Recommendation
25. Albert PR Robillard L: G protein specificity: traffic direction required. Cell Signal. 2002;14(5):407-18. 11882385 10.1016/S0898-6568(01)00259-5
26. Laporte AM Lima L Gozlan H: Selective in vivo labelling of brain 5-HT 1A receptors by [ 3H]WAY 100635 in the mouse. Eur J Pharmacol. 1994;271(2-3):505-14. 7705451 10.1016/0014-2999(94)90812-5
27. Boschert U Amara DA Segu L: The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals. Neuroscience. 1994;58(1):167-82. 8159291 10.1016/0306-4522(94)90164-3
28. Ghavami A Stark KL Jareb M: Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons. J Cell Sci. 1999;112(Pt 6):967-76. 10036246
29. Riad M Garcia S Watkins KC: Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. J Comp Neurol. 2000;417(2):181-94. 10660896 10.1002/(SICI)1096-9861(20000207)417:2<181::AID-CNE4>3.0.CO;2-A
30. Beck SG Choi KC List TJ: Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells. J Pharmacol Exp Ther. 1992;263(1):350-9. 1403796
31. Knobelman DA Kung HF Lucki I: Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT 1A and 5-HT 1B receptors. J Pharmacol Exp Ther. 2000;292(3):1111-7. 10688630
32. Mizutani H Hori T Takahashi T: 5-HT 1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Eur J Neurosci. 2006;24(7):1946-54. 17067296 10.1111/j.1460-9568.2006.05063.x
33. Hagan CE McDevitt RA Liu Y: 5-HT 1B autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse. 2012;66(12):1024-34. 22961814 10.1002/syn.21608 3472085
34. Montanez S Munn JL Owens WA: 5-HT 1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochem Int. 2014;73:127-31. 24246466 10.1016/j.neuint.2013.11.004 4224139 F1000 Recommendation
35. Clark MS McDevitt RA Neumaier JF: Quantitative mapping of tryptophan hydroxylase-2, 5-HT 1A, 5-HT 1B, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei. J Comp Neurol. 2006;498(5):611-23. 16917826 10.1002/cne.21073
36. Maroteaux L Saudou F Amlaiky N: Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992;89(7):3020-4. 1557407 10.1073/pnas.89.7.3020 48795
37. Pompeiano M Palacios JM Mengod G: Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. J Neurosci. 1992;12(2):440-53. 1531498
38. Donaldson ZR Hen R: From psychiatric disorders to animal models: a bidirectional and dimensional approach. Biol Psychiatry. 2015;77(1):15-21. 24650688 10.1016/j.biopsych.2014.02.004 4135025
39. Savitz J Lucki I Drevets WC: 5-HT 1A receptor function in major depressive disorder. Prog Neurobiol. 2009;88(1):17-31. 19428959 10.1016/j.pneurobio.2009.01.009 2736801
40. Parsey RV Ogden RT Miller JM: Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations. Biol Psychiatry. 2010;68(2):170-8. 20497898 10.1016/j.biopsych.2010.03.023 2900398 F1000 Recommendation
41. Kaufman J Sullivan GM Yang J: Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males. Neuropsychopharmacology. 2015;40(7):1692-9. 25578798 10.1038/npp.2015.15 4915251 F1000 Recommendation
42. Stockmeier CA Shapiro LA Dilley GE: Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci. 1998;18(18):7394-401. 9736659
43. Donaldson ZR Le Francois B Santos TL: The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Transl Psychiatry. 2016;6:e746. 26926882 10.1038/tp.2015.226 4872437
44. Albert PR Lemonde S: 5-HT1A receptors, gene repression, and depression: guilt by association. Neuroscientist. 2004;10(6):575-93. 15534042 10.1177/1073858404267382
45. Albert PR: Transcriptional regulation of the 5-HT 1A receptor: implications for mental illness. Philos Trans R Soc Lond B Biol Sci. 2012;367(1601):2402-15. 22826341 10.1098/rstb.2011.0376 3405675
46. Strobel A Gutknecht L Rothe C: Allelic variation in 5-HT 1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm (Vienna). 2003;110(12):1445-53. 14666415 10.1007/s00702-003-0072-0
47. Lemonde S Turecki G Bakish D: Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003;23(25):8788-99. 14507979 F1000 Recommendation
48. Parsey RV Olvet DM Oquendo MA: Higher 5-HT 1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology. 2006;31(8):1745-9. 16395308 10.1038/sj.npp.1300992
49. Robinson DS Rickels K Feighner J: Clinical effects of the 5-HT1A partial agonists in depression: a composite analysis of buspirone in the treatment of depression. J Clin Psychopharmacol. 1990;10(3 Suppl):67S-76S. 2198303
50. Lucki I: Behavioral studies of serotonin receptor agonists as antidepressant drugs. J Clin Psychiatry. 1991;52 Suppl:24-31. 1684363
51. Kennett GA Dourish CT Curzon G: Antidepressant-like action of 5-HT 1A agonists and conventional antidepressants in an animal model of depression. Eur J Pharmacol. 1987;134(3):265-74. 2883013 10.1016/0014-2999(87)90357-8
52. Detke MJ Rickels M Lucki I: Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl). 1995;121(1):66-72. 8539342 10.1007/BF02245592
53. López-Rubalcava C Lucki I: Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacology. 2000;22(2):191-9. 10649831 10.1016/S0893-133X(99)00100-1
54. Detke MJ Wieland S Lucki I: Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT 1A receptor antagonists. Psychopharmacology (Berl). 1995;119(1):47-54. 7675949 10.1007/BF02246053
55. Blier P de Montigny C: Current advances and trends in the treatment of depression. Trends Pharmacol Sci. 1994;15(7):220-6. 7940983 10.1016/0165-6147(94)90315-8
56. Albert PR Lembo P Storring JM: The 5-HT1A receptor: signaling, desensitization, and gene transcription. Neuropsychopharmacology. 1996;14(1):19-25. 8719026 10.1016/S0893-133X(96)80055-8
57. Blier P Ward NM: Is there a role for 5-HT 1A agonists in the treatment of depression? Biol Psychiatry. 2003;53(3):193-203. 12559651 10.1016/S0006-3223(02)01643-8
58. Blier P Piñeyro G el Mansari M: Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Ann N Y Acad Sci. 1998;861:204-16. 9928258 10.1111/j.1749-6632.1998.tb10192.x
59. Tome MB Isaac MT Harte R: Paroxetine and pindolol: a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency. Int Clin Psychopharmacol. 1997;12(2):81-9. 9219043
60. Artigas F Celada P Laruelle M: How does pindolol improve antidepressant action? Trends Pharmacol Sci. 2001;22(5):224-8. 11339972 10.1016/S0165-6147(00)01682-5
61. Sahli ZT Banerjee P Tarazi FI: The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder. Expert Opin Drug Discov. 2016;11(5):515-23. 26971593 10.1517/17460441.2016.1160051 4841022
62. Artigas F Romero L de Montigny C: Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT 1A antagonists. Trends Neurosci. 1996;19(9):378-83. 8873352 10.1016/S0166-2236(96)10037-0
63. Newman-Tancredi A Martel JC Assié MB: Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT 1A receptor agonist. Br J Pharmacol. 2009;156(2):338-53. 19154445 10.1111/j.1476-5381.2008.00001.x 2697830
64. Ramboz S Oosting R Amara DA: Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci U S A. 1998;95(24):14476-81. 9826725 10.1073/pnas.95.24.14476 24398
65. Heisler LK Chu HM Brennan TJ: Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice. Proc Natl Acad Sci U S A. 1998;95(25):15049-54. 9844013 24573
66. Richardson-Jones JW Craige CP Nguyen TH: Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety. J Neurosci. 2011;31(16):6008-18. 21508226 10.1523/JNEUROSCI.5836-10.2011 3102496
67. Santarelli L Saxe M Gross C: Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003;301(5634):805-9. 12907793 10.1126/science.1083328 F1000 Recommendation
68. Richardson-Jones JW Craige CP Guiard BP: 5-HT 1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron. 2010;65(1):40-52. 20152112 10.1016/j.neuron.2009.12.003 2941196
69. Samuels BA Anacker C Hu A: 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response. Nat Neurosci. 2015;18(11):1606-16. 26389840 10.1038/nn.4116 4624493
70. Fava M Rankin MA Wright EC: Anxiety disorders in major depression. Compr Psychiatry. 2000;41(2):97-102. 10741886 10.1016/S0010-440X(00)90140-8
71. de Vry J: 5-HT 1A receptor agonists: recent developments and controversial issues. Psychopharmacology (Berl). 1995;121(1):1-26. 8539333 10.1007/BF02245588
72. Parks CL Robinson PS Sibille E: Increased anxiety of mice lacking the serotonin 1A receptor. Proc Natl Acad Sci U S A. 1998;95(18):10734-9. 9724773 10.1073/pnas.95.18.10734 27964
73. Gross C Zhuang X Stark K: Serotonin 1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature. 2002;416(6879):396-400. 11919622 10.1038/416396a F1000 Recommendation
74. Lo Iacono L Gross C: α-Ca 2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. J Neurosci. 2008;28(24):6250-7. 18550767 10.1523/JNEUROSCI.5219-07.2008 3849425
75. Vinkers CH Oosting RS van Bogaert: Early-life blockade of 5-HT 1A receptors alters adult anxiety behavior and benzodiazepine sensitivity. Biol Psychiatry. 2010;67(4):309-16. 19811773 10.1016/j.biopsych.2009.08.013
76. Garcia-Garcia AL Meng Q Richardson-Jones J: Disruption of 5-HT 1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience. 2016;321:210-21. 26049143 10.1016/j.neuroscience.2015.05.076 4669240 F1000 Recommendation
77. Donaldson ZR Piel DA Santos TL: Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior. Neuropsychopharmacology. 2014;39(2):291-302. 23907404 10.1038/npp.2013.185 3870787
78. Sullivan GM Ogden RT Huang Y: Higher in vivo serotonin-1a binding in posttraumatic stress disorder: a PET study with [ 11C]WAY-100635. Depress Anxiety. 2013;30(3):197-206. 23408467 10.1002/da.22019 3785097
79. Sullivan GM Ogden RT Oquendo MA: Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. Biol Psychiatry. 2009;66(3):223-30. 19278673 10.1016/j.biopsych.2009.01.028 2778225
80. Hjorth S Suchowski CS Galloway MP: Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain. Synapse. 1995;19(3):170-6. 7784957 10.1002/syn.890190304
81. Trillat AC Malagié I Scearce K: Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT 1B receptors: in vivo microdialysis studies. J Neurochem. 1997;69(5):2019-25. 9349547 10.1046/j.1471-4159.1997.69052019.x
82. Murrough JW Henry S Hu J: Reduced ventral striatal/ventral pallidal serotonin 1B receptor binding potential in major depressive disorder. Psychopharmacology (Berl). 2011;213(2-3):547-53. 20480149 10.1007/s00213-010-1881-0 3139174
83. Whale R Clifford EM Bhagwagar Z: Decreased sensitivity of 5-HT 1D receptors in melancholic depression. Br J Psychiatry. 2001;178(5):454-7. 11331562 10.1192/bjp.178.5.454
84. Cleare AJ Murray RM Sherwood RA: Abnormal 5-HT 1D receptor function in major depression: a neuropharmacological challenge study using sumatriptan. Psychol Med. 1998;28(2):295-300. 9572087
85. Stern L Zohar J Cohen R: Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT 1D agonist sumatriptan. Eur Neuropsychopharmacol. 1998;8(4):325-8. 9928925 10.1016/S0924-977X(97)00092-8
86. Tatarczynska E Antkiewicz-Michaluk L Klodzinska A: Antidepressant-like effect of the selective 5-HT 1B receptor agonist CP 94253: a possible mechanism of action. Eur J Pharmacol. 2005;516(1):46-50. 15913599 10.1016/j.ejphar.2005.04.025
87. Miranda H Ortiz G Figueroa S: Depression scores following migraine treatment in patients attending a specialized center for headache and neurology. Headache. 2001;41(7):680-4. 11554955 10.1046/j.1526-4610.2001.041007680.x
88. Redrobe JP Bourin M: Evidence of the activity of lithium on 5-HT1B receptors in the mouse forced swimming test: comparison with carbamazepine and sodium valproate. Psychopharmacology (Berl ). 1999;141(4):370-7. 10090644 10.1007/s002130050846
89. O'Neill MF Conway MW: Role of 5-HT 1A and 5-HT 1B receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology. 2001;24(4):391-8. 11182534 10.1016/S0893-133X(00)00196-2
90. Knobelman DA Hen R Lucki I: Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse. J Pharmacol Exp Ther. 2001;298(3):1083-91. 11504805
91. Malagié I Trillat AC Bourin M: 5-HT 1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex. J Neurochem. 2001;76(3):865-71. 11158258 10.1046/j.1471-4159.2001.00083.x
92. Jones MD Lucki I: Sex differences in the regulation of serotonergic transmission and behavior in 5-HT receptor knockout mice. Neuropsychopharmacology. 2005;30(6):1039-47. 15688089 10.1038/sj.npp.1300664
93. Bechtholt AJ Smith K Gaughan S: Sucrose intake and fasting glucose levels in 5-HT 1A and 5-HT 1B receptor mutant mice. Physiol Behav. 2008;93(4-5):659-65. 18155098 10.1016/j.physbeh.2007.11.006 2366078
94. Mayorga AJ Dalvi A Page ME: Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice. J Pharmacol Exp Ther. 2001;298(3):1101-7. 11504807
95. Sari Y: Serotonin 1B receptors: from protein to physiological function and behavior. Neurosci Biobehav Rev. 2004;28(6):565-82. 15527863 10.1016/j.neubiorev.2004.08.008
96. Nautiyal KM Tanaka KF Barr MM: Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity. Neuron. 2015;86(3):813-26. 25892302 10.1016/j.neuron.2015.03.041 4431594
97. Nautiyal KM Tritschler L Ahmari SE: A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors. Neuropsychopharmacology. 2016;41(12):2941-50. 27353308 10.1038/npp.2016.109 5061886
98. Neumaier JF Petty F Kramer GL: Learned helplessness increases 5-hydroxytryptamine1B receptor mRNA levels in the rat dorsal raphe nucleus. Biol Psychiatry. 1997;41(6):668-74. 9066990 10.1016/S0006-3223(96)00114-X
99. Neumaier JF Edwards E Plotsky PM: 5-HT 1B mrna regulation in two animal models of altered stress reactivity. Biol Psychiatry. 2002;51(11):902-8. 12022964 10.1016/S0006-3223(01)01371-3
100. Clark MS Sexton TJ McClain M: Overexpression of 5-HT 1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress. J Neurosci. 2002;22(11):4550-62. 12040062
101. Neumaier JF Root DC Hamblin MW: Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT 1B mRNA in a sequential manner in the rat dorsal raphe nucleus. Neuropsychopharmacology. 1996;15(5):515-22. 8914125 10.1016/S0893-133X(96)00095-4
102. Anthony JP Sexton TJ Neumaier JF: Antidepressant-induced regulation of 5-HT 1b mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation. J Neurosci Res. 2000;61(1):82-7. 10861803 10.1002/1097-4547(20000701)61:1<82::AID-JNR10>3.0.CO;2-E
103. Davidson C Stamford JA: Effect of chronic paroxetine treatment on 5-HT 1B and 5-HT 1D autoreceptors in rat dorsal raphe nucleus. Neurochem Int. 2000;36(2):91-6. 10676872 10.1016/S0197-0186(99)00115-1
104. Tiger M Rück C Forsberg A: Reduced 5-HT 1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder. Psychiatry Res. 2014;223(2):164-70. 24916155 10.1016/j.pscychresns.2014.05.011 F1000 Recommendation
105. Chenu F David DJ Leroux-Nicollet I: Serotonin 1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system. J Psychiatry Neurosci. 2008;33(6):541-50. 18982177 2575758
106. Svenningsson P Chergui K Rachleff I: Alterations in 5-HT 1B receptor function by p11 in depression-like states. Science. 2006;311(5757):77-80. 16400147 10.1126/science.1117571 F1000 Recommendation
107. Alexander B Warner-Schmidt J Eriksson T: Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Sci Transl Med. 2010;2(54):54ra76. 20962330 10.1126/scitranslmed.3001079 3026098
108. Lim BK Huang KW Grueter BA: Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. Nature. 2012;487(7406):183-9. 22785313 10.1038/nature11160 3397405
109. Brown AS Gershon S: Dopamine and depression. J Neural Transm Gen Sect. 1993;91(2-3):75-109. 8099801 10.1007/BF01245227
110. D'Aquila PS Collu M Gessa GL: The role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol. 2000;405(1-3):365-73. 11033341 10.1016/S0014-2999(00)00566-5
111. Nestler EJ Carlezon WA Jr: The mesolimbic dopamine reward circuit in depression. Biol Psychiatry. 2006;59(12):1151-9. 16566899 10.1016/j.biopsych.2005.09.018
112. Heshmati M Russo SJ: Anhedonia and the brain reward circuitry in depression. Curr Behav Neurosci Rep. 2015;2(3):146-53. 26525751 10.1007/s40473-015-0044-3 4626008
113. Barot SK Ferguson SM Neumaier JF: 5-HT 1B receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Eur J Neurosci. 2007;25(10):3125-31. 17509084 10.1111/j.1460-9568.2007.05568.x
114. Dolen G Darvishzadeh A Huang KW: Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature. 2013;501(7466):179-84. 24025838 10.1038/nature12518 4091761 F1000 Recommendation
115. Zouk H McGirr A Lebel V: The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide. Am J Med Genet B Neuropsychiatr Genet. 2007;144B(8):996-1002. 17510950 10.1002/ajmg.b.30521
116. Potenza MN Walderhaug E Henry S: Serotonin 1B receptor imaging in pathological gambling. World J Biol Psychiatry. 2013;14(2):139-45. 21936763 10.3109/15622975.2011.598559 3595502
117. O'Dell LE Parsons LH: Serotonin 1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. J Pharmacol Exp Ther. 2004;311(2):711-9. 15226384 10.1124/jpet.104.069278
118. Contini V Bertuzzi GP Polina ER: A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. Drug Alcohol Depend. 2012;122(1-2):100-4. 22005095 10.1016/j.drugalcdep.2011.09.020
119. Proudnikov D LaForge KS Hofflich H: Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes. Pharmacogenet Genomics. 2006;16(1):25-36. 16344719 10.1097/01.fpc.0000182782.87932.d6
120. Cao J LaRocque E Li D: Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene ( HTR1B) with alcohol, cocaine, and heroin abuse. Am J Med Genet B Neuropsychiatr Genet. 2013;162B(2):169-76. 23335468 10.1002/ajmg.b.32128 4089973
121. Petry NM Stinson FS Grant BF: Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2005;66(5):564-74. 15889941 10.4088/JCP.v66n0504
122. Matuskey D Bhagwagar Z Planeta B: Reductions in brain 5-HT 1B receptor availability in primarily cocaine-dependent humans. Biol Psychiatry. 2014;76(10):816-22. 24433854 10.1016/j.biopsych.2013.11.022 4037398 F1000 Recommendation
123. Rocha BA Scearce-Levie K Lucas JJ: Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature. 1998;393(6681):175-8. 9603521 10.1038/30259
124. Pentkowski NS Acosta JI Browning JR: Stimulation of 5-HT 1B receptors enhances cocaine reinforcement yet reduces cocaine-seeking behavior. Addict Biol. 2009;14(4):419-30. 19650818 10.1111/j.1369-1600.2009.00162.x 2846432
125. Neumaier JF Vincow ES Arvanitogiannis A: Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. J Neurosci. 2002;22(24):10856-63. 12486179
126. Pentkowski NS Cheung TH Toy WA: Protracted withdrawal from cocaine self-administration flips the switch on 5-HT 1B receptor modulation of cocaine abuse-related behaviors. Biol Psychiatry. 2012;72(5):396-404. 22541946 10.1016/j.biopsych.2012.03.024 4071622
127. Conner TS Jensen KP Tennen H: Functional polymorphisms in the serotonin 1B receptor gene ( HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet. 2010;153B(1):67-78. 19350534 10.1002/ajmg.b.30955 3312780
128. Pattij T Broersen LM van der Linde J: Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT 1A and 5-HT 1B receptor knockout mice. Behav Brain Res. 2003;141(2):137-45. 12742250 10.1016/S0166-4328(02)00345-5
129. Saudou F Amara DA Dierich A: Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science. 1994;265(5180):1875-8. 8091214 10.1126/science.8091214
130. Olivier B Mos J van Oorschot R: Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry. 1995;28(Suppl 2):80-90. 8614705 10.1055/s-2007-979624
131. de Boer SF Koolhaas JM: 5-HT 1A and 5-HT 1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. Eur J Pharmacol. 2005;526(1-3):125-39. 16310183 10.1016/j.ejphar.2005.09.065
132. Rush AJ Trivedi MH Wisniewski SR: Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905-17. 17074942 10.1176/ajp.2006.163.11.1905
133. Quesseveur G Reperant C David DJ: 5-HT 2A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system. Exp Brain Res. 2013;226(2):285-95. 23411676 10.1007/s00221-013-3434-3
134. Patel JG Bartoszyk GD Edwards E: The highly selective 5-hydroxytryptamine (5-HT) 2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test. Synapse. 2004;52(1):73-5. 14755634 10.1002/syn.10308
135. Weisstaub NV Zhou M Lira A: Cortical 5-HT 2A receptor signaling modulates anxiety-like behaviors in mice. Science. 2006;313(5786):536-40. 16873667 10.1126/science.1123432 F1000 Recommendation
136. Meltzer HY: The role of serotonin in antipsychotic drug action. Neuropsychopharmacology. 1999;21(2 Suppl):106S-115S. 10432496 10.1016/S0893-133X(99)00046-9
137. Halberstadt AL Geyer MA: Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. Neuropharmacology. 2011;61(3):364-81. 21256140 10.1016/j.neuropharm.2011.01.017 3110631
138. Diaz SL Doly S Narboux-Neme N: 5-HT 2B receptors are required for serotonin-selective antidepressant actions. Mol Psychiatry. 2012;17(2):154-63. 22158014 10.1038/mp.2011.159 3381222
139. Diaz SL Narboux-Neme N Boutourlinsky K: Mice lacking the serotonin 5-HT 2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants. Eur Neuropsychopharmacol. 2016;26(2):265-79. 26727039 10.1016/j.euroneuro.2015.12.012 F1000 Recommendation
140. Bevilacqua L Doly S Kaprio J: A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature. 2010;468(7327):1061-6. 21179162 10.1038/nature09629 3183507 F1000 Recommendation
141. Cryan JF Lucki I: Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine 2C receptors. J Pharmacol Exp Ther. 2000;295(3):1120-6. 11082448
142. Opal MD Klenotich SC Morais M: Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Mol Psychiatry. 2014;19(10):1106-14. 24166413 10.1038/mp.2013.144 F1000 Recommendation
143. Heisler LK Zhou L Bajwa P: Serotonin 5-HT 2C receptors regulate anxiety-like behavior. Genes Brain Behav. 2007;6(5):491-6. 17451451 10.1111/j.1601-183X.2007.00316.x
144. Higgins GA Silenieks LB Altherr EB: Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT 2C receptor agonists. Psychopharmacology (Berl). 2016;233(14):2841-56. 27241709 10.1007/s00213-016-4329-3
145. Griebel G Perrault G Sanger DJ: A comparative study of the effects of selective and non-selective 5-HT 2 receptor subtype antagonists in rat and mouse models of anxiety. Neuropharmacology. 1997;36(6):793-802. 9225307 10.1016/S0028-3908(97)00034-8
146. Ramamoorthy R Radhakrishnan M Borah M: Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models. Behav Pharmacol. 2008;19(1):29-40. 18195592 10.1097/FBP.0b013e3282f3cfd4
147. Kondo M Nakamura Y Ishida Y: The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Mol Psychiatry. 2015;20(11):1428-37. 25403840 10.1038/mp.2014.153
148. Bhatnagar S Nowak N Babich L: Deletion of the 5-HT 3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests. Behav Brain Res. 2004;153(2):527-35. 15265651 10.1016/j.bbr.2004.01.018
149. Costall B Naylor RJ: Anxiolytic potential of 5-HT 3 receptor antagonists. Pharmacol Toxicol. 1992;70(3):157-62. 1349746 10.1111/j.1600-0773.1992.tb00448.x
150. Lucas G Rymar VV Du J: Serotonin 4 (5-HT 4) receptor agonists are putative antidepressants with a rapid onset of action. Neuron. 2007;55(5):712-25. 17785179 10.1016/j.neuron.2007.07.041 F1000 Recommendation
151. Mendez-David I David DJ Darcet F: Rapid anxiolytic effects of a 5-HT 4 receptor agonist are mediated by a neurogenesis-independent mechanism. Neuropsychopharmacology. 2014;39(6):1366-78. 24287720 10.1038/npp.2013.332 3988540
152. Compan V Zhou M Grailhe R: Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT 4 receptor knock-out mice. J Neurosci. 2004;24(2):412-9. 14724239 10.1523/JNEUROSCI.2806-03.2004
153. Jean A Conductier G Manrique C: Anorexia induced by activation of serotonin 5-HT 4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Acad Sci U S A. 2007;104(41):16335-40. 17913892 10.1073/pnas.0701471104 2042207
154. Waeber C Grailhe R Yu XJ: Putative 5-Ht 5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci. 1998;861:85-90. 9928243 10.1111/j.1749-6632.1998.tb10177.x
155. Svenningsson P Tzavara ET Qi H: Biochemical and behavioral evidence for antidepressant-like effects of 5-HT 6 receptor stimulation. J Neurosci. 2007;27(15):4201-9. 17428998 10.1523/JNEUROSCI.3110-06.2007
156. Carr GV Schechter LE Lucki I: Antidepressant and anxiolytic effects of selective 5-HT 6 receptor agonists in rats. Psychopharmacology (Berl). 2011;213(2-3):499-507. 20217056 10.1007/s00213-010-1798-7 2910165
157. Mitchell ES Neumaier JF: 5-HT 6 receptors: a novel target for cognitive enhancement. Pharmacol Ther. 2005;108(3):320-33. 16005519 10.1016/j.pharmthera.2005.05.001
158. Hamon M Doucet E Lefèvre K: Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT 6 receptors. Neuropsychopharmacology. 1999;21(2 Suppl):68S-76S. 10432491 10.1016/S0893-133X(99)00044-5
159. Guscott M Bristow LJ Hadingham K: Genetic knockout and pharmacological blockade studies of the 5-HT 7 receptor suggest therapeutic potential in depression. Neuropharmacology. 2005;48(4):492-502. 15755477 10.1016/j.neuropharm.2004.11.015 F1000 Recommendation
160. Ballaz SJ Akil H Watson SJ: The 5-HT 7 receptor: role in novel object discrimination and relation to novelty-seeking behavior. Neuroscience. 2007;149(1):192-202. 17869441 10.1016/j.neuroscience.2007.07.043